Risperidone 유발 지연성 운동장애 1례(一例)

김헌수,김현실,민병근,Kim, Hun-Soo,Kim, Hyun-Sil,Min, Byung-Kun 대한생물정신의학회 1998 생물정신의학 Vol.5 No.1

Objective : Base on clinical practice, the authors report a case of tardive dyskinesia arising during the course of treatment with resperidal. Methods : This article was review and analysis of a case on risperidone-induced tardive dyskinea. Results : Mrs K, a 51-year-old woman with a 1-year history of schizophrenic disorder, gradually developed tardive dyskinetic movement of the mouth, lip, and tongue over a 4 month period(From July, 1996 to June, 1997) while taking risperidone. Initially she was treated with haloperidol and alprazolam. However, the haloperidol was subsequently discontinued because of EPS developed. From 11th March, 1997, she was observed to have a severe form of tardive dyskinesia involving her tongue, lip, and mouth. After risperidone was withdrawn at 9th May 1997, her tardive dyskinetic movement was disappeared. Conclusions : This is, to our knowledge, the first report of the onset of tardive dyskinesia in a patient taking risperidone. However, additional controlled studies of specific questions are needed ; e.g., the dose-response curves for produce tardive dyskinesia and the mechanism of producing risperidone-induced tardive dyskinea and so on.

만성(慢性) B형(型) 간염환자(肝炎患者) 삶의 질(質)

김헌수,이민규,Kim, Hun-Soo,Lee, Min-Kyu 한국정신신체의학회 1998 정신신체의학 Vol.6 No.1

Objectives : The purpose of this study was to determine correlation between coping strategies to disease and quality of life in chrome viral B hepatitis patients ; to investigate difference of coping strategies to disease and quality in life between chronic viral B hepatitis patients and normal persons ; and to identify major variables related to quality in life of chronic viral B hepatitis patients. Methods: The authors used Weisman coping strategy scale for measuring coping ability and efficacies, and the questionnaire for measuring quality of life including physical, psychological, social and economical aspects and satisfaction of sexual life was made by authors based on related literatures. Data were collected through questionnaire survey over a period from Sep 15, 1994 to Nov 11, 1994. Subjects served for this study consisted of 94 chronic viral B hepatitis patients visited to department of internal medicine at one general hospital and 100 normal persons visited to one general hospital for routine check up of health. The collected data were analyzed by SAS and the statistical methods for analysis were Chisquare, t-test and multiple regression analysis. Results : 1) It was revealed that coping strategies to disease significantly correlated to individual's quality of life. 2) There was no significant difference in coping strategies to disease between chronic viral B hepatitis patients and normal persons. However, chronic viral B hepatitis patients showed the lower scroes of quality of life in physical, psychological and economical aspects. 3) The most important variables which were influenced upon quality of life were coping strategies to disease and satisfaction of sexual life. That is, the more active coping strategies to diseases and the higher satisfaction of sexual life, consequently the higher quality of life was. Especially male patient group or normal persons showed each other the higher scores of quality of life in physical and psychological area than female group or patient group. 4) No statistically significant difference in coping strategies to disease and quality of life was found between HBeAg positive group and HBeAg negative group. Conclusions : The authors suggest that chronic viral B hepatitis patients may show the lower score of quality of life than normal person. Therefore, quality of life assessment should become an integral part of all clinical area that seek to assess the effectiveness of treatment. Also, through the interdisciplinary approach, a comprehensive paradigm that can better account for the effects of chronic disease on the individual' s quality of life should be developed.

청소년 약물남용의 상관변수

김헌수(Hun-Soo Kim),김현실(Hyun-Sil Kim) 한국중독정신의학회 1998 중독정신의학 Vol.2 No.1

Object:The present study intended to discriminate correlates of juvenile substance abuse and to search for relationship between substance abuse and juvenile delinquency. Methods:A questionnaire survey was performed to the subjects of 1.690 students including 1,184 student adolescents from middle school to senior high school and 506 delinquent adolescents in randomly selected corrective institution for a period of 1 month. The age of subject ranged between 12 and 18 years. The collected data were analysed by SAS program using Chisquare and t-test. Results:① Delinquent adolescents (43.1%) show the higher frequency of substance abuse than student adolescents (15.1%). ② It revealed that the family member of substance abuser has the more mental problems and legal problems such as chronic disease, alcoholism, depression, suicidal attempt, committed suicide, criminal acts than the family member of non substance abuser. ③ Substance abuser were inclined to show the depressive trend, restlessness and psychosomatic symptoms, whereas nonsubstance abusers did not. ④ Substance abuser of adolescents showed the more unstable mood, impulsiveness, resistance, and committed the higher frequency of delinquent behavior than nonsubstance abuser. ⑤ In the motivation of substance abuse in this study, out of curiosity (53.8%), social purpose with one’s friend (12.3%), for the peace seeking (11.4%), for the power seeking (8.5%), for the sexual purpose (4.7%) and for the transcendental experience(3.4%)and so on was in this order. Conclusions:At present time, the substance abuse of children and adolescents raise a social issue in Korea. However, there are few literatures in the area of substance abuse in adolescent population. Accordingly, it will be necessary to investigate the causes of substance abuse in adolescents, and practitioner recognize the comprehensive meaning of the substance abuse of adolescents in their environmental and developmental context as well. Additionally, effective multidisciplinary approach toward a therapeutic and a preventive strategies should be developed, because of a multifactorial causes of substance abuse.

지적재산권 보호와 R&D 투자의 경제적 효과 분석

김헌수 ( Hun Soo Kim ) 순천향대학교 사회과학연구소 2004 사회과학연구 Vol.10 No.2

정구 후위 플랫서비스 동작의 운동역학적 분석

김헌수(Hun Soo Kim),진성근(Sun Gun Jin) 한국사회체육학회 2002 한국사회체육학회지 Vol.18 No.2

The purpose of this study was to analyze the kinetic factors of the flat service of the soft tennis by using the 2 force plates. The 4 male soft tennis backward players who have technique of the top class was participated in the subjects of the this study. The results were as following ; 1. In the case of anterior ground reaction forces, it was that a right and left foot were 47.7%, 14.3% before toss phase, 35.4%, 57.1% after toss phase, and forward swing phase 16.9%, 28.6% in respectively. In the case of posterior ground reaction forces, it was that a right and left foot were 51.1%, 10.0% before toss phase 41.5%, 50.0% after toss phase, and forward swing phase 7.4%, 40.0% in respectively. There were nothing change it for left foot. 2. In the case of lateral ground reaction forces, it was that a right and left foot were 20.8%, 37.5% before toss phase, 56.1%, 41.7% after toss phase, and forward swing phase 23.1%, 20.8% in respectively. In the case of medial ground reaction forces, it was that a right and left foot were 1.9%, 20.0% before toss phase, 75.0%, 60.0% after toss phase, and forward swing phase 23.1%, 20.0% in respectively. 3. In the case of vertical ground reaction forces, it was that a right and left foot were 86.4%, 13.6% before toss phase, 77.0%, 23.0% after toss phase, and forward swing phase 43.2%, 56.8% in respectively. Vertical ground reaction forces was larger than a horizontal and lateral ground reaction forces, and the change of the weight from rear foot to fore foot was moved rhythmically in general.

벤처기업 R&D투자 활성화를 위한 연구개발보험의 도입방안

김헌수 ( Hun Soo Kim ) 순천향대학교 사회과학연구소 2001 사회과학연구 Vol.7 No.1

Identification of the Polymorphisms in IFITM2 and IFITM5 Genes and their Association with Ulcerative Colitis

Hun-Soo Kim(김헌수),Ji-Su Mo(모지수),Khondoker Jahengir Alam(알롬 콘도칼자항길),Won-Cheol Park(박원철),Keun Young Kim(김권영),Soo-Cheon Chae(채수천) 한국생명과학회 2015 생명과학회지 Vol.25 No.1

Interferon inducible transmembrane protein (IFITM) family 유전자는 인터페론(IFNs)의 동형 세포부착 기능 및 세포의 항-증식 활성과 같은 몇 가지 세포증식 과정에 연관되어 있다. 본 연구에서는 IFITM2 및 IFITM5 SNPs이 궤양성대장염의 감수성과 연관되어 있는지 알아 보고자 했다. 본 연구에서 직접 염기서열 분석법을 사용하여 IFITM2 유전자에서 총 13개, IFITM5 유전자에서는 12개의 유전적 변이를 발굴하였다. 이들의 SNPs의 유전자형 분석은 PCR-RFLP 법과 Taq-Man probe 분석법을 사용하였고, 일배체형 빈도 분석은 EM algorithm을 사용하여 분석하였다. 궤양성대장염 환자에서 IFITM2 및 IFITM5 SNPs의 유전자형과 대립유전자 빈도는 건강인 대조군과 비교했을 때 유의성이 없었다. 궤양성대장염 환자와 정상인 대조군에서 IFITM1의 rs77537847, IFITM2의 rs909097, IFITM5의 rs56069858을 지표로 하는 유전자형 조합 빈도를 분석한 결과 주된 유전자형 조합빈도에서는 유의성이 없는 것으로 나타났으나, 궤양성대장염 환자와 건강인 대조군의 GGT 유전자형조합 빈도 분석에서는 유의하게 다른 차이를 보였다(p=0.002). 이러한 결과에 의거하여 IFITMs의 SNPs 유전자형 조합이 궤양성대장염의 감수성과 연관성이 있고, 궤양성대장염의 유용한 유전자 마커로 사용 할 수 있다고 생각된다. Interferon inducible transmembrane protein (IFITM) family genes have been implicated in various cellular processes such as the homotypic cell adhesion functions of IFNs and cellular anti-proliferative activities. The present study aimed to investigate whether the polymorphisms of the IFITM2 and IFITM5 genes are associated with susceptibility to UC. We identified a total of thirteen polymorphisms (eleven SNPs and two variations) in the IFITM2 gene and twelve polymorphisms (eleven SNPs and one variation) in the IFITM5 gene, by the direct sequencing method. Genotype analysis in the IFITM2 and IFITM5 SNPs was performed by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) and Taq-Man probe analysis, and the haplotype frequencies of IFITM2 and IFITM5 SNPs for multiple loci were estimated using the expectation maximization (EM) algorithm. The genotype and allele frequencies of IFITM2 SNPs, as well as IFITM5 SNPs, in UC patients were not significantly different from those of the healthy controls. We also analyzed the combined frequencies of rs77537847 of IFITM1, rs909097 of IFITM2, and rs56069858 of IFITM5 in the UC patients and the healthy controls. Although the distribution of the major combined genotype frequency did not differ significantly between the healthy controls and the UC patients, the GGT combined frequency in the healthy controls was significantly different from that in the UC patients (P=0.002). This result suggests that the combined genotype of the IFITMs polymorphisms may be associated with a susceptibility to UC and could be a useful genetic marker for UC.

시장 퇴출 형태와 의사결정 요인에 관한 연구 -미국 손해보험시장을 중심으로-

김헌수 ( Hun Soo Kim ),권욱진 ( Wook Jean Kwon ) 보험연구원 2009 보험금융연구 Vol.20 No.2

본 연구의 목적은 경쟁적인 손해보험시장에서 사업 유지, M&A, 자발적 청산 및 비자발적 청산이라는 시장 퇴출(잔류) 결정을 하는 보험회사들 사이에 재무적, 경영적 및 환경적요인 차이가 존재하는 지를 분석하는 것이다. 먼저 손해보험시장 퇴출 관련 규제와 시장 환경에서 규제의 중요성에 대해서 정리하였다. 실증분석을 위해서 1999년부터 2004년까지 미국 손해보험회사 데이터(t-1)를 AM Best 데이터베이스로부터 추출하였으며 분석모형은 다항로짓모형을 사용하였다. 분석 결과 첫째, 자산 규모는 시장 잔류 결정과 유의하게 관련되어 있을 뿐만 아니라 비자발적 퇴출 형태 대신 M&A와 자발적 퇴출을 선택할 가능성이 높은 것으로 분석되었다. 나아가 수익성과 재무건전성(capital adequacy)도 퇴출 의사결정에 유의한 영향을 끼친다는 것이 밝혀졌다. 인수성과(underwriting performance)는 퇴출의사 결정에 영향을 끼치는 것으로 나타났지만 일관성은 없었다. This paper examines financial, managerial and market factors that insurance companies and regulators use to reach a decision of business continuance, merger/ acquisition, or voluntary or involuntary liquidation of the entire business (i.e., a complete exit from the market). For this, we describe exit regulation in the insurance market and the importance of it on insurer operations. We then use the A.M. Best database of the U.S. property-liability insurance industry for 1999-2004 (for t-1) and a multinomial logit regression approach to empirically estimate the impact of financial (profitability, underwriting performance, liquidity, capital adequacy and capital measurement), managerial and political environments on the market stay/exit decision making process. The results show that asset size is not only positively related to the probability of business continuance but also likely leads insurers to choose voluntary liquidation or merger instead of involuntary liquidation when they have decided to leave the market. Profitability and capital adequacy also affect market exit decisions. Underwriting performance seems to affect the decisions but not necessarily consistently across the market stay/exit choices.

태권도 우수선수와 비우수선수의 돌개차기 비교를 통한 성공적인 운동역학적 변인 분석

김헌수(Hun Soo Kim),박찬호(Chan Ho Park),정익수(Ik Su Jeong),이건희(Gun Hee Lee) 한국사회체육학회 2013 한국사회체육학회지 Vol.0 No.54

Regarding the tornado-kicks of 6 excellent and 6 non-excellent players in Taekwondo male contests, this study aims to compare and analyze the necessary time for the motion, the angles and angular velocity of joints, the tiptoe speed of a kicking (right) leg, the twist angle of a trunk and inclination angle, ground reaction force and electromyogram. Significant difference was found among preparation time period, the angles and angular velocity of joints, the tiptoe speed of a kicking (right) leg, the twist angle of a trunk and inclination angle, Also Excellent players showed the greater force than non-excellent players. At the moments of the kick, the order in which legs` muscles were employed were as follows; tibialis anterior, gastrocnemius, biceps femoris and rectus femoris.

생명보험산업의 연대적 성격에 관한 질적 연구

김헌수 ( Hun Soo Kim ),김재현 ( Jae Hyun Kim ),김기덕 ( Gi Duk Kim ) 보험연구원 2016 보험금융연구 Vol.27 No.2

생명보험산업에 대한 기존 연구는 경쟁력, 성과 및 효율성을 중심으로 한 경제·경영학적 측면의 양적 연구가 대부분이었다. 이 논문은 질적 연구(qualitativeresearch)를 활용하여 생명보험산업이 담고 있는 사회적 연대(solidarity)의 성격을 탐구한다. 우리나라 생명보험산업은 국가 주도로 과점적 시장으로 성장하다가 1980년대후반 시장개방 이후 매우 경쟁적인 시장으로 발전하였다. 따라서 생명보험산업의 연대적성격 역시 시대적으로 변화하였을 것이라는 가설을 생명보험협회장의 신년사에 대한 내용분석(content analysis) 방법으로 검증해 보았다. 강수택(2006)의 연대성 분류 기준을 사용하여 분석한 결과 우리나라 생명보험산업은 1970년대 국가경제발전을 내세운관료적 연대에서 1986년 시장개방을 기점으로 전술적 연대로의 변화를 강하게 보였다. 그리고 1990년대 이후에는 소비자의 영향력이 증가하면서 한편으로 고객의 자율성을 존중하면서도 고객의 감정과 정서에 호소하는 전술적 연대와 도덕적 연대의 성격이 동시에 드러나는 것으로 분석되었다. Most literature on the Korean life insurance industry have focused on economic and management concepts such as competitiveness, performance, and efficiency. This study; however, qualitatively investigates the characteristics of the Korean life insurance industry based on the social solidarity concept. In the beginning, the Korean life insurance industry had grown oligopolistically but it has developed very competitively after the market opening in late 1980s. This paper examines the solidarity characteristics of the life insurance industry in Korea by a content analysis with a hypothesis that it must be changed over the decades. The research result shows that the life insurance industry in 1970s could be viewed as ‘bureaucratic solidarity’ strongly, which is evidenced based on Kang(2006)’s solidarity classification standard. It demonstrated the characteristics of ‘strategic solidarity’ right after the life insurance market opening in 1986. However, it also pursued ‘moral solidarity while respecting consumers’ autonomy since 1990s when the influence of consumers became stronger.