http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
2-[(4-Cyanophenyl)amino]-3-chloro-1,4-naphthalenedione(NQ-Y15)의 돌연변이원성
김봉희,정기화,유충규,창동신,이기선,전선덕,소동수,채상호,문창규 한국환경독성학회 2000 환경독성보건학회지 Vol.15 No.4
2-[(4-Cyanophenyl)amino]-3-chloro-1, 4-naphthalenedione (NQ-Y15) was asssayed for its genotoxic potential by using Salmonella typhimurium reversion assay and in vitro chromosome aberration test on Chinese hamster lung cells. In the Ames test, NQ-Y 15 induced his+ revertants of Salmonella typhimurium TA 98 and TA1537, reaching levels twice the negative control values. But, NQ-Y15 induced only his^(+) revertants of Salmonella typhimurium TA1537 more than twice the control values under the condition with metabolic activation system. In the cytogenetic test on chinese hamster lung cells, NQ-Y15 showed significant chromosomal aberrations, but the incidence was significantly reduced in the presence of metabolic activation.
암브록솔과 세티리진의 Cytochrome P450 저해 활성 평가
김봉희,류창선,장힘찬,이상윤,이지윤,채정우,권광일,김상겸 대한약학회 2013 약학회지 Vol.57 No.3
In the present study we evaluated drug-drug interaction potential of ambroxol and cetirizine mediated by inhi-bition of CYP isoforms including CYP1A2, CYP2A6, CYP2B6, CYP2C9, CYP2C19, CYP2D6, CYP2E1 and CYP3A4 using pooled human liver microsomes (HLMs). As measured by liquid chromatography-electrospray ionization tandem mass pec- trometry, cetirizine and ambroxol inhibited significantly CYP2E1 but the maximal inhibition was approximately 36% at 10 µM cetirizine and 28% at 3 µM ambroxol. In addition, CYP2D6 activity was decreased to approximately 83% of ontrol activity in pooled HLM incubated with 3 µM ambroxol. Activities of CYP1A2, CYP2A6, CYP2B6, CYP2C9, CYP2C19, and CYP3A4 were not significantly inhibited by cetirizine and ambroxol. Considering their maximal plasma concentration in human (Cmax of cetirizine is approximately 0.67 µM and Cmax of ambroxol is 0.044 µM), these two drugs have very low pos- sibility in drug-drug interaction by CYP inhibition in clinical situations.
김봉희,서영희 한국인간복지실천학회 2015 한국인간복지실천연구 Vol.15 No.-
본 연구는 여성장애인의 사회경제적 특성이 삶의 질에 미치는 영향을 분석해봄으로써 여성장애인의 삶의 질 향상을 위한 대안을 제시하고자 하였다. 분석결과 여성장애인의 개인특성 중에서 학력이 높을수록, 배우자와 부모, 자녀와 동거하는 경우일수록, 장애특성 중에서 장애발생원인이 후천적일수록, 장애진단시기는 연령이 적을수록, 보험이용 특성 중에서는 민간보험을 가입하지 않거나 모르는 경우일수 록, 지역국민연금에 가입한 경우일수록, 접근성 및 편의시설 특성 중에서 접근을 위해 타인 도움을 청하지 않을수록, 자가용이나 장애인콜택시 등의 교통수단을 이용할수록 여성 장애인이 인식하는 삶의 질은 증가하고 있음을 알 수 있었다. 연구결과를 바탕으로 제언하면 삶의 질 영향요인으로 사회적 낙인 및 권리침해 여부, 인식된 심리적 요인 등을 고 려할 수 있고, 여성장애인에 대한 사회적 차별과 편견에 대한 인식 개선사업이 요구되고, 각종 계단 및 전철 출입구 등에 1m짜리 봉 손잡이를 설치하여 경증장애인이 스스로 이용할 수 있도록 하는 배려가 필요하다. This study analyzed the socioeconomic characteristics of disabled woman is the impact on quality of life by looking to improve the quality of life for disabled woman tried to make a counter-offer. Analysis of the individual characteristics of disabled women living with higher literacy rates, spouse, parents, children and disability on disability characteristics can cause, the more cases Acquired the more use characteristics, private insurance, the smaller the age, disability diagnosis time is not with insurance or join the more cases, local, national pension Among the characteristics of the more cases, clicking Ease of Access and amenities not ask for help others to access, the private car transportation means such as the longer use the disabled person or call taxis Disabled woman would recognize that increasing the quality of life which could know. Factors Influencing the quality of life when a suggestion, based on the research findings into account the social stigma and psychological factors, whether perceived impairment can and women for the disabled Social discrimination and prejudice against the project is required and the various steps and subway entrance and improve their perception of the installation using a mild case for the disabled themselves the handle bars 1s m Cares to take back the needed.