Shielding Calculations for Nuclear Ships using Monte Carlo Simulation

길영미,우일국,김교윤,김지호,최순 대한방사선방어학회 2012 대한방사선방어학회 학술발표회 논문요약집 Vol.2012 No.11

Monte-Carlo Simulation of the Charge-Deposition Distribution for Electron-Beam Energy Determinations

길영미,오영도,김상훈,문성익,조무현,남궁원 한국물리학회 2008 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.53 No.6

Electron energy is one of the principal parameters influencing the charge-deposition distribution (abbreviated as CDD) within a material penetrated by electron beams. The CDDs of electrons with energies from 5 to 60 MeV passing through aluminum absorbers have been calculated using the MCNPX 2.4 code and experiments were performed at the Pohang Accelerator Laboratory (PAL) for electron beams of 50, 55 and 60 MeV passing through aluminum absorbers consisting of 4 plates separated by air gaps. To develop a useful device for measuring the electron beam energy, the most probable charge-deposition depth, xm and the maximum charge deposition, ym, have been determined from both the MCNPX and the experimental CDDs.

선박용 원자로 차폐체의 재료 특성에 관한 연구

길영미,김하용,유병용,우일국,오영태,김교윤 대한방사선방어학회 2011 대한방사선방어학회 학술발표회 논문요약집 Vol.2011 No.11

고혈압 청소년의 심혈관계 위험요소로서 Angiotensinogen M235T 유전자 다형

길주현,이정아,박은영,홍영미 대한소아청소년과학회 2009 Clinical and Experimental Pediatrics (CEP) Vol.52 No.1

Purpose : The renin-angiotensin system (RAS) has been demonstrated to play a major role in regulating blood pressure. Therefore, components of the RAS are likely candidate genes that may predispose an individual to essential hypertension and cardiovascular complications. Among them, the M235T polymorphism of the angiotensinogen gene has been speculated to be associated with elevated circulating angiotensinogen concentrations and essential hypertension. This study aimed to analyze the angiotensinogen M235T polymorphism in hypertensive adolescents and investigate its relationship with cardiovascular risks. Methods : Forty Korean hypertensive adolescents (aged 16-17, systolic BP ≥140 mmHg and/or diastolic BP ≥90 mmHg) and fifty seven normal adolescents were included. Obesity index (OI), body mass index (BMI) were calculated. BP was measured by oscillometric methods in resting state. Polymerase chain reaction (PCR) technique was performed on DNA from the hypertensives subjects to analyze the M235T polymorphism. Serum homocysteine, insulin, renin, aldosterone and angiotensin converting enzyme (ACE) were tested according to each genotype. The carotid intima-media thickness (IMT) and carotid artery diameter, Pulse wave velocity (PWV) and ankle-brachial index (ABI) were measured according to each genotype. Results : Genotype frequencies of T/T, M/T and M/M were 62.5%, 35.0%, 2.5%, respectively in hypertensive adolescents. The results were not significantly different compared to control group. Serum insulin, renin levels, BMI and OI were significantly higher in thoses with the M/M genotype as compared to those with the T/T of M/T genotype. Conclusion : This study showed that the M235T polymorphism was not associated with essential hypertension or any cardiovascular risks. Further clinical research is required to ascertain the relationship between this polymorphism and cardiovascular complications in Korean hypertensive adolescents. 목 적 : 레닌-안지오텐신계가 혈압 조절에 있어서 핵심적인 역할을 한다는 것은 이미 잘 알려진 사실이며, 이 체계의 한 구성 요소인 angiotensinogen을 암호화하는 유전자가 고혈압의 유전적 감수성을 결정하고 심혈관계 합병증 발생에 중요한 역할을 할 것으로 생각된다. 본 연구의 목적은 고혈압 청소년에서 angiotensinogen 유전자 다형을 분석하고, 특정 유전자형이 심혈관계 합병증의 예측 인자가 될 수 있는지를 알아보고자 하였다. 방 법 : 16세에서 17세 사이의 수축기 혈압 140 mmHg 이상이거나 이완기 혈압 90 mmHg 이상인 40명의 고혈압 청소년과 57명의 정상 청소년을 대상으로 하였다. 비만도, 체질량지수를 측정하였고, 안정된 상태에서 수축기, 이완기 혈압을 측정하였다. 호모시스테인, 인슐린, 레닌, 알도스테론, 안지오텐신 전환 효소(angiotensin convering enzyme, ACE)를 측정하였고, polymerase chain reaction (PCR)을 이용하여 angiotensinogen (M235T) 유전자형을 분석하였다. 경부 초음파로 경동맥 내중막 두께와 경동맥 직경을 측정하였고, 이를 이용하여 경동맥의 유순도와 신전도를 구하였다. VP-1000을 이용하여 pulse wave velocity (PWV)와 ankle-brachial index (ABI)를 측정하였다. 유전자 다형별로 각 계측치를 비교, 분석하였다. 결 과 : Angiotensinogen 유전자 다형 분석에서 T/T 군 25명(62.5%), M/T 군 14명(35%), M/M 군 1명(2.5%)로 정상 청소년과 유의한 빈도의 차이가 없었다. 고혈압군에서 인슐린, 레닌, 체질량지수, 비만도에서 세 유전형군 간의 유의한 차이가 나타났으나, 경동맥 내중막 두께와 직경, 신전도, 유순도, PWV, ABI에서는 세군 간의 유의한 차이는 없었다. 결 론 : Angiotensinogen의 특정 유전자 다형과 심혈관계 합병증간의 유의한 연관성은 없었으나, 본 연구의 고혈압 청소년 대상이 적었으므로 더 많은 연구가 필요할 것으로 생각된다.

비만아에서의 leptin, adiponectin, interleukin-6, tumor necrosis factor-α에 대한 연구

길주현,이정아,김지영,홍영미,Gil, Joo Hyun,Lee, Jung Ah,Kim, Ji Young,Hong, Young Mi 대한소아청소년과학회 2008 Clinical and Experimental Pediatrics (CEP) Vol.51 No.6

목 적 : 비만은 지방세포의 축적과 인슐린 내성으로 제 2형 당뇨병을 초래하고, 고 인슐린혈증과 고혈당이 염증 과정의 전구 물질과 함께 작용하여 혈관 내피의 이상, 혈청 지질의 이상, 고혈압과 혈관 염증을 일으켜 동맥경화와 심혈관 질환을 야기하는 것으로 알려져 왔다. Leptin은 adiopnectin과 함께 지방 세포로부터 생산되는 가장 풍부한 adipocytokine으로서, 일차적으로는 식욕 조절과 체내 지방 축적 조절의 기능을 하지만, IL-6, IL-12, TNF-${\alpha}$와 같은 다른 사이토카인과 함께 염증과정의 전구 물질이 되며 여러 면역 관련 질환에서 중요한 매개체가 된다. 이번 연구에서는 비만 청소년에서 leptin과 여러 cytokine과의 상관관계를 알아보고자 하였다. 방 법 : 16세 이상부터 18세 미만의 66명의 중등도 이상의 비만 청소년을 대상군으로 하였고, 같은 연령의 정상 청소년 26명을 대조군으로 하였다. 신장, 체중을 이용하여 비만도와 체질량지수를 산출하였고, 혈청 지질, 간 효소치를 측정하였다. 효소면역 측정법을 이용하여 IL-6, TNF-${\alpha}$를 측정하였고, 방사면역 측정법을 이용하여 adiponectin, leptin, 인슐린을 측정하였다. 이 후 leptin과 각 측정치와의 상관성을 알아보았다. 결 과 : Leptin은 비만군에서 대조군보다 유의하게 높았고, TNF-${\alpha}$와 IL-6도 비만군에서 대조군보다 유의하게 높았다. 인슐린도 비만군에서 대조군보다 유의하게 높았고 adiponectin은 비만군에서 유의하게 낮았다. Leptin은 비만도, 체질량지수, IL-6과 유의한 양의 상관관계를 보였으며, 또한 IL-6와 TNF-${\alpha}$간에 유의한 양의 상관관계를 보였다. 결 론 : 비만 청소년에서 leptin, TNF-${\alpha}$, IL-6와 같은 cytokine과 insulin이 성인병으로 진행되는데 중요한 요소가 될 것이며, leptin을 성인병의 예측 인자 및 임상치료의 척도로 사용하기 위해 더 많은 연구가 필요할 것으로 생각된다. Purpose : Obesity is associated with insulin resistance. Insulin resistance and the presence of pro-inflammatory mediators are thought to cause a state of vascular endothelial dysfunction, an abnormal lipid profile, hypertension, and vascular inflammation. These chronic inflammatory responses, which are characterized by abnormal cytokine production, lead to activation of a pro-inflammatory signaling pathway. Leptin is an important mediator of inflammatory processes and immune-mediated diseases. The purpose of this study was to investigate the relationship between leptin and various cytokines associated with obesity in adolescents. Methods : Sixty-six obese adolescents (between 16-17 years of age, obesity index >130%) and 26 normal controls were included in this study. Obesity index and body mass index (BMI) were calculated. Serum lipid profile, AST and ALT were tested after 10 hours of fasting. Tumor necrosis factor alpha (TNF-${\alpha}$) and Interleukin-6 (IL-6) levels were measured by ELISA. Insulin, adiponectin, and leptin levels were estimated by radioimmunoassay. Results : Leptin was significantly higher in the obese adolescents compared to the control adolescents ($12.0{\pm}6.8ng/mL$ vs $6.3{\pm}1.0ng/mL$). TNF-${\alpha}$, IL-6, and insulin were significantly higher in the obese adolescents. Adiponectin was significantly lower in the obese group than the control group ($3.3{\pm}1.9{\mu}g/mL$ vs $5.0{\pm}1.4{\mu}g/mL$). Leptin had positive correlations with obesity index, BMI, and IL-6. Conclusion : In obese adolescents, leptin, TNF-${\alpha}$, IL-6, and insulin might be important mediators of obesity. Further clinical research is necessary to ascertain leptin as a predictor of cardiovascular diseases and to develop a guideline for clinical intervention.

Serum level of the adiponectin and adiponectin I164T polymorphism in hypertensive adolescents

이정아,길주현,홍영미 대한소아청소년과학회 2009 Clinical and Experimental Pediatrics (CEP) Vol.52 No.2

Purpose : Adiponectin is a molecule that plays an important role in the metabolic syndrome. In addition, its concentration is known to be decreased in obesity, type 2 diabetes, and coronary artery disease. Although a relationship between hypertension and serum adiponectin concentrations has been reported by several authors, such findings continue to be debated. We investigated whether hypoadiponectinemia is related to hypertension in adolescents and studied the associated genetic polymorphism. Methods : Forty hypertensive adolescents (Age 16-17 years old) and twenty normotensive matched subjects were included. Serum adipo-nectin, insulin, renin, aldosterone and angiotensin converting enzyme (ACE) levels were compared. Their carotid intima-media thickness (cIMT) and pulse wave velocity (PWV) were measured. Polymorphisms of the adiponectin I164T gene were investigated using polymerase chain reaction (PCR). Results : The hypertensive adolescents had significantly greater cIMT and PWV. In addition, the serum aldosterone, renin and insulin levels were significantly higher in the hypertensive group. The plasma concentrations of adiponectin did not differ significantly between the two groups. TC genotype was not found in our study subjects; they all had the TT genotype of the adiponectine gene. Conclusion : The results of our study showed that adiponectin levels were not significantly different in adolescents with hypertension. There was no distinctive genetic polymorphism observed in this group of patients. Further large scale studies are needed to clarify the association between genetic variations and adiponectin in hypertensive adolescents. Purpose : Adiponectin is a molecule that plays an important role in the metabolic syndrome. In addition, its concentration is known to be decreased in obesity, type 2 diabetes, and coronary artery disease. Although a relationship between hypertension and serum adiponectin concentrations has been reported by several authors, such findings continue to be debated. We investigated whether hypoadiponectinemia is related to hypertension in adolescents and studied the associated genetic polymorphism. Methods : Forty hypertensive adolescents (Age 16-17 years old) and twenty normotensive matched subjects were included. Serum adipo-nectin, insulin, renin, aldosterone and angiotensin converting enzyme (ACE) levels were compared. Their carotid intima-media thickness (cIMT) and pulse wave velocity (PWV) were measured. Polymorphisms of the adiponectin I164T gene were investigated using polymerase chain reaction (PCR). Results : The hypertensive adolescents had significantly greater cIMT and PWV. In addition, the serum aldosterone, renin and insulin levels were significantly higher in the hypertensive group. The plasma concentrations of adiponectin did not differ significantly between the two groups. TC genotype was not found in our study subjects; they all had the TT genotype of the adiponectine gene. Conclusion : The results of our study showed that adiponectin levels were not significantly different in adolescents with hypertension. There was no distinctive genetic polymorphism observed in this group of patients. Further large scale studies are needed to clarify the association between genetic variations and adiponectin in hypertensive adolescents.

PE10)유전체 장벽 방전 공정 내에서 가스 조성이 에너지 전달 효율과 NO 전환에 미치는 영향

이용환,고경보,최유리,길영미,조무현,남궁원 한국대기환경학회 2003 한국대기환경학회 학술대회논문집 Vol.- No.-

플라즈마 촉매 복합공정 내에서 NO/NO₂ 비율이 NOX 제거에 미치는 영향 연구

이용한,고경보,최유리,길영미,조무현,남궁원 대한환경공학회 2003 대한환경공학회 학술발표논문집 Vol.2003 No.12

한국인의 이중 사회정체성과 내집단 투사, 남북한 통일태도 간 관계

이하연,권영미,서정길,박주화,최훈석 한국사회및성격심리학회 2022 한국심리학회지 사회 및 성격 Vol.36 No.4

The present study investigated the relationship between dual social identity, ingroup projection, and attitudes toward the unification of Korea. We hypothesized that South Koreans who are characterized as having dual social identity, namely, those who identify themselves strongly with both the superordinate category (i.e., ethnic identity) and the subordinate category (i.e., national identity), would show high levels of ingroup projection, which in turn would predict negatively their attitudes toward unification of North and South Korea. In addition, we examined the moderating effect of the centrality of the superordinate and the subgroup identity on the relationship between dual identity and ingroup projection. Data from a stratified sample of South Korean adults (N = 1,600) revealed that, as expected, ingroup projection negatively mediated the relationship between dual identity and attitudes toward the unification of Korea. Importantly, the relationship between dual identity and ingroup projection was attenuated among those who perceived their superordinate identity as a more central aspect of themselves than their subgroup identity. We discuss the implications of our findings for the role of social identity in social integration research in the context of the unification of Korea. 본 연구는 상위수준 한민족 범주와 하위수준 국가(남북한) 범주로 구분되는 층소된 사회정체성 구조에서 상위범주-하위범주 동일시 수준 간 상호작용과 내집단 투사, 남북한 통일에 대한 태도 간의 관계를 조사하였다. 한국인들이 남북한을 포섭하는 공동 상위범주인 한민족에 강하게 동일시하더라도 동시에 하위범주인 남한에 강하게 동일시할 경우, 남한이 북한보다 한민족의 전형적이고 필수적인 집단이라고 지각하는 내집단 투사가 발생하며, 내집단 투사는 통일태도를 부적으로 예측할 것으로 예상했다. 이에 더해 내집단 투사를 완화하는 기제로 상위범주와 하위범주 정체성 중심성의 역할을 검증했다. 인구비례할당표집으로 수집된 한국 거주 성인 1,600명의 자료를 분석한 결과, 가설과 일관되게 남한사람들이 한민족과 남한에 동시에 강하게 동일시할수록(즉, 이중 정체성이 우세할수록) 내집단 투사 수준이 높았으며, 이중 정체성은 내집단 투사를 매개로 통일태도를 부적으로 예측했다. 또한, 이중 정체성이 내집단 투사를 예측하는 효과는 구성원들이 하위범주 정체성을 상위범주 정체성보다 중시할 경우 유의했고, 하위범주 정체성을 상대적으로 덜 중시할 경우에는 유의하지 않았다. 이러한 결과는 남북한 관계에 관한 심리학 연구에서 층소된 사회정체성의 효과를 체계적으로 검증해야 하며 이를 반영하는 개입 전략이 필요함을 시사한다.

자동차 산업의 PBS(Painted Body Storage) 자동화 시스템 개발의 사례연구

최원준,박혜규,임영미,강정선,강부수,신현오,남동길,송근안,박기홍,이태훈,심기룡,김용기 대한산업공학회 1994 대한산업공학회 춘계학술대회논문집 Vol.1994 No.4