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소목(Caesalpinia sappan L.의 心材) 메탄올 추출물의 항influenza virus 활성성분 연구
강현민 龍仁大學校 1999 용인대학교 논문집 Vol.17 No.-
Influenza virus is one of the most common infectious virus of mankind. Though chemotherapeutic reagents and antibiotics against influenza virus have been developed in many countries, none of those reagents is satisfactory to mankind in regard of their toxicity and side effects. To investigate anti-influenza viral compounds amongst Korean traditional medicine, methanol extract of the heartwood of Caesalpinia Sampan L was fractionized by solvent extraction method. Each fraction were then screened against influenza virus by disc diffusion method. Among the fractions, diethyl ether fraction exhibited anti-influenza viral activity. The diethyl ether fraction of the methanol extract was then analyzed by HPLC (C-18 reverse phase) and its chromatogram was compared with the diethyl ether fraction of the water extract.
소목(Caesalpinia sappan L.의 心材) 열수추출물의 항influenza virus 활성 성분에 대한 HPLC 분석
강현민 龍仁大學校 自然科學硏究所 1999 自然科學硏究所論文誌 Vol.4 No.1
Influenza virus is one of the most common infectious virus of mankind. Though chemotherapeutic reagents and antibiotics against influenza virus have been developed in many countries, none of those reagents is satisfactory to mankind in regard of their toxicity and side effects. In order to investigate anti-influenza viral activity of Korean traditional drugs, boiling water extract of the heartwood of Caesalpinia Sappan L was fractionized by solvent extraction method. Each fraction were then screened against influenza virus by disc diffusion method. Among the fractions, diethyl ether fraction exhibited anti-influenza viral activity. The diethyl ether fraction was then analyzed by HPLC(C-18 reverse phase).
강현민,이광호,임청산,권기록 대한약침학회 2014 Journal of pharmacopuncture Vol.17 No.2
Objectives: This study was performed to analyze a 13-week repeated dose toxicity test of Sweet Bee Venom (SBV) extracted from bee venom and administered in Sprague-Dawley (SD) rats. Methods: Male and female 5-week-old SD rats were treated once daily with SBV (high-dosage group: 0.28 mg/kg; medium-dosage group: 0.14 mg/kg; or low-dosage group: 0.07 mg/kg) for 13 weeks. Normal saline was administered to the control group in a similar manner (0.2 mL/kg). We conducted clinical observations, body weight measurements, ophthalmic examinations, urinalyses, hematology and biochemistry tests, and histological observations using hematoxylin and eosin (H&E) staining to identify any abnormalities caused by the SBV treatment. Results: During this study, no mortality was observed in any of the experimental groups. Hyperemia and a movement disorder were observed around the area of in all groups that received SBV treatment, with a higher occurrence in rats treated with a higher dosage. Male rats receiving in the high-dosage group showed a significant decrease in weight during the treatment period. Compared to the control group, no significant changes in the ophthalmic parameters, the urine analyses, the complete blood cell count (CBC), and the biochemistry in the groups treated with SBV. Compared to the control group, some changes in organ weights were observed in the medium-and the high-dosage groups, but the low-dosage group showed no significant changes. Histological examination of thigh muscle indicated cell infiltration, inflammation, degeneration, and necrosis of muscle fiber, as well as fibrosis, in both the medium- and the high-dosage groups. Fatty liver change was observed in the periportal area of rats receiving medium and high dosages of SBV. No other organ abnormalities were observed. Conclusion: Our findings suggest that the NOAEL (No Observed Adverse Effect Level) of SBV is approximately 0.07 mg/kg in male and female SD rats.
용해도 차이 및 크로마토그래피를 이용한 단미한약재 항바이러스 성분의 분획 및 정제
강현민 용인대학교 자연과학연구소 1998 自然科學硏究所論文誌 Vol.3 No.1
Traditional oriental medicines exhibiting antiviral activities were extracted from their sources by hot water treatment or methanol treatment, The extracts were then fractionized by an ion exchange column chromatography or nonionic polymeric adsorbent column chromatography and by utilizing their solubility differences in organic solvents and water. Among these fractions, those with high antiviral activity were analyzed by TLC,fractionized and purified by silica gal column chromatography and / or C-18 reverse phase column chromatography. One of the colume chromatography yielded three pure compounds for further cell culture screening and structural analysis.
국내 프로야구단 상대적 효율성 평가를 통한 발전방안 연구
강현민,장재열,이현섭 한국체육정책학회 2017 한국체육정책학회지 Vol.15 No.1
The purpose of this study was to evaluate the relative managerial efficiency of 10 Korean professional baseball teams in the 2015 season through Data Envelopment Analysis. Each team’s salary including players and coaching staffs for the input variable and the number of wins during the regular season and the size of home game attendance for the output variable were used respectively. And the data were analyzed using Frontier Analyst 4.0 and EnPAS 1.0 program. The results of this study were as follows. First, KT, Doosan, Nexen were measured as the efficiency frontier with the score of 100% based on CCR model. Second, according to BCC model, KIA, KT, NC, Samsung, Nexen and Doosan were recorded 100% efficiency score. Third KIA, NC, Lotte, SK, Samsung, Hanhwa and LG showed scale inefficiency, LG was inefficient under the condition of increasing returns to scale and the rest were inefficient under the condition of decreasing returns to scale. Regarding the results, some practical schemes are made to balance between team’s salary expenditure and performance. Moreover, effective marketing inducements for attracting spectators have to developed consistently to boost the managerial efficiency.