당뇨병 백서의 간세포에서 Glucokinase 활성도 및 유전자 발현에 대한 인슐린의 영향

강성이(Sung Yi Kang),서광식(Kwang Sik Seo),팽정령(Jeong Ryung Paeng),우정택(Jeong Taek Woo),김성운(Sung Woon Kim),양인명(In Myung Yang),김진우(Jin Woo Kim),김영설(Young Seol Kim),김광원(Kwang Won Kim),최영길(Young Kil Choi) 대한내과학회 1994 대한내과학회지 Vol.47 No.2

N/A Introduction: The liver-specific hexokinase isoenzyme, referred to as glucokinase, is thought to play a key reglulatory role in hepatic glucose metabolism. The glucokinase gene is, therefore, of interest both because of its tissue-specific expression and because of the several regulatory processes that can be analyzed. The level of hepatic glucokinase activity appers to be determined essentially by regulation of the rate of enzyme sythesis, with insulin playing a leading role as an inducer. We investigated the role of insulin for the induction of glucokinase in the liver of diabetic rats. Methods: Experimental diabetes was induced by injection of streptozotocin 7 days before the experiment. Regular insulin was given by three days intraperitoneal injection at 8-h interval. The glucokinase mRNA in the liver was estimated by Nothern blot assay, as well as by fluorometric enzyme activity assay. Results: Glucokinase activity was not reduced in the liver of normal fasting rats as compared to normal fed rats. But glucokinase activity was recuced in the liver of daibetic rats as compared to normal rats. In diabetic rats treated with insulin, glucokinase enzyme activity were increased. But glucokinase mRNA expression was only increased in normogycemic diabetic rat with treated with insulin as compared to hyperglycemic rat. Conclusion: These data indicate that insulin stimulates hepatic glucokinase enzyme activity and mRNA expression. But other hormonal or metabolic factors may be contribute to regulation of glucokinase mRNA expressiom.

음양오행론에서 『회남자(淮南子)』와 『오행대의(五行大義)』의 위상과 상이점

강성인 ( Sung In Kang ),김만태 ( Man Tae Kim ) 단국대학교 동양학연구원 2016 東洋學 Vol.62 No.-

This study conducted comparative research on Huainanzi, which can represent Yin-yang and Five Elements in the Qin Dynasty(秦代) and the Han Dynasty(漢代), and Wuxingdayi in the Sui Dynasty(隋代). Huainanzi including Shicheukhun(時則訓) mentioned the Ruling with Times-Theory, contains a variety of the Theory of Yin-yang and Five Elements in Cheonmunhun·Jihyeonghun· Jusulhun(天文訓·지形訓·主術訓), etc. So the Theory of Yin-yang and Five Elements is the most developed among literature up to the Han Dynasty. Wuxingdayi is the representative record ofthe Thory of Yin-yang and Five Elements that organizied and compiled the Yin-yang and FiveElements of ancient times generally. In the Theory of Yin-yang and Five-Elements discussed in Huainanzi, the Sheng·Geuk of the Five Elements and most of Wangsanghyususa(旺相休囚死) and ‘Putting things into Five Phases’ are similar with those of Wuxingdayi. However, Ganhap(干合) and Jihap(支合) theories, which were not exactly identified in Huainanzi, were established in Wuxingdayi. In Huainanzi, the Sheng(生) and Geuk(剋) theory was completed but the Hap(合) and Chung(沖) theory was not established, while in Wuxingdayi, the Sheng·Geuk·Hap·Chung theory was defined and it was developed to the Hyeong(刑) and Hai(害) theory. In the former, Haihap(會合) of the Earth(土) was called Osulin(午戌寅), which was arranged to Jinsulchukmi(辰戌丑未) in the latter. In Huainanzi, the period during which the Earth governs a year was not defined, thus it was described in various ways such as Sagyewolseol(四季 月說)·72Ilgyehaseol(72日季夏說)·30Ilgyehaseol(30日季夏說). But in Wuxingdayi, Jinmisulchukwol (辰未戌丑月) referring to Sagye (四季) was designated as the month when the Earth prevailed.

만성신부전 환자의 신세뇨관에서의 전해질 조절

고정곤 ( Jeong Gon Ko ),이강휴 ( Kang Hyu Lee ),김인희 ( In Hee Kim ),이식 ( Sik Lee ),김원 ( Won Kim ),강성귀 ( Sung Kyew Kang ) 대한신장학회 2003 Kidney Research and Clinical Practice Vol.22 No.1

목적 : 만성신부전 환자가 말기신부전에 이를 때까지 세포외액량과 전해질이 정상인의 혈잘량과 전해질치가 거의 유사하게 유지되는 것에 대한 연구가 동물실험에서 진행되어 오고 있으나 사람에서의 연구 (한국)는 극히 제한적이어서 저자들은 만성 신부전증 환자 19명을 대상으로 잔여 신장의 세뇨관에서 전해질 조절이 어떻게 되는가의 기전을 관찰하고자 하였다. 방법 : 만성신부전의 19명의기저질환은 당뇨병성 신중 (42.1%), 만성 사구체신염 (31.6%), 역류성 신수종 (10.5%), IgA신중 (5.3%), 신증후군 (5.3%)의 순이였고, 평균연령은 54.6세이고 남자 13명, 여자 6명이었다. 대조군은 23명으로 평균 50.1세이고 남자19명, 여자 4명으로 여러가지 신기능의 지표를 검사하였다. 결과 : 만성신부전시 혈철 Na^+ 평균 농도는 139.9±3.2 mEq/L이고 대조군은 141.1±2.1 mEq/L로 유의하게 감소하는 경향이고, 혈청 K^+ 평균농도는 4.7±0.8 mEq/L로 정상대조군 4.2± mEq/L에 비하여 유의하게 증가하는 경향이었다. 사구체여과율은 9.7±6.3 mL/min이고 대조군의 75.9±42.9 mL/min에 비하여 유의한 감소가 있었다. 만성신부전시 소변내 배설되는 Na^+의 평균농도는 89.9±31.6 mEq/L이고 정산대조군은 175.4±68.5 mEq/L로서 유의하게 감소하였으며 (p<0.05), thqusso qotjfehlsms K^+ 평균농도는 24.3±14.8 mEq/L으로 대조군 32.1±22.7 mEq/L보다 감소하는 경향이였다. 소변 osmolality는 평균 397.7±119.1 mOsm.kg로서 정상대조군 610.6±210.9 mOsm/kg에 비하여 유의하게 감소하였는데 이는 소변 농축력이 감소 하였음을 반영한다. 만성신부전에서 단위 네프론당 전해질 배설량을 알아보기 위해 측정한 fractional excretion of Na^+ (FENa)의 평균치는 3.4±5.4%이고 정상대조군은 0.6±0.6%로서 유의하게 증가하였으며 fractional excretion of K^+ (FEK)의 평균치는 15.4±20.8%로서 정상 대조군의 2.2±22.9% 보다 유의하게 증가하였다. Transtubular K^+ gradient (TTKG)는 7.1±6.9%로서 정상대조군 3.2±2.8%보다 유의하게 증가하였다. 혈액 가스 분석 소견은 만성신부전시에는 pH가 7.4±0.1로서 대조군 7.4±0.02에 비하여 변화가 없었고, HCO_3^- 는 18.9±2.8mEqL으로 정상대조군 24.1±2.2mEq/L보다 유의하게 감소하였다. 결론 : 만성신부전 환자의 혈액내 전해질 특히 Na^+ 농도는 감소하고 K^+와 C1^- 농도는 증가 하였으나, 정상치에 가깝게 유지되고 있었으묘, 이는 FENa와 FEK의 유의한 증가로 보아 신세뇨관에서의 Na^+는 재흡수 억제에 기인하고, 또 혈장내 K^+의 증가는 세뇨관에서 K^+ 분비의 증가를 초래하였는데 이는 TTKG의 활성화에 기인한 것으로 사료되었다. Purpose : In chronic renal failure (CRF), extracellular fluid (ECF) volume is maintained close to normal, often until end-stage renal disease is imminent. This remarkable feat is accomplished by increase in fractional excretion of sodium (FENa) in inverse proportion to the decline in glomerular filtration rate (GRF). Many researchers have carried out to try to indentify in animal study but human study was not done in Korea. Methods : The study is an investigation of the changes of plamse and urine electrolytes and FENa and fractional excretion of potassium (FEX) in 19patints (13 men and 6 women) with chronic renal failure. Ages of 19 patients were average 54.6 yearold (range, 29-74 years). Underlying renal disease of the CRF was 42,1% in diabetic nephropathy, 31.6% in chronic glomerulonephritis, 10.5% in hydronephrosis with ureter reflux, and 5.3% in IgA nephropathy. Results : In CRF, plasma Na^+ is decreased significantly from normal control 141±2.1 mEq/L to 139.9±3.2 mEq/L and GER from 75.9±42.9 mL/min to 9.7±6.3 mL/min, but plasma K^+ is increased significantly from 4.2±0.4 mEq/L to 4.7±0.8 mEq/L. In CRF however, urine Na^+ is decreased significantly from normal control 175.4±58.5 mEq/L to 89.9±31.6 mEq/L and osmolality from 610.6±210.9 mOsm/kg to 397.7±119.1 mOsm/kg, but urine K^+ is devreased tendency from control 32.1±22.7 mEq/L to 24.3±14.8 mEq/L FENa, FEK, and transtubular potassium gradient (TTKG) on CRF were 3.4±5.4% 15.4±20.8% 7.1±6.9% each and 0.6±0.6%, 2.2±2.3% 3.2±2.8% on normal persons. The difference between CRF and normal control in FENa, FEK, TTKG and osmolar clearance were statistically significant. Conclusion : These results suggest that renal tubular cells of CRF were responsible for the decreased Na^+ and K^+ reabsorption and enhance K^+ secretion.

고효율 LLC 직렬공진 컨버터

강성인(Sung-In Kang),윤광호(Kwang-Ho Yoon),김은수(Eun-Soo Kim),박준호(Jun-Ho Park),임대호(Dae-Ho Lim) 전력전자학회 2007 전력전자학술대회 논문집 Vol.- No.-

The LLC series resonant converter with a LLT (Inductor-Inductor-Transformer) transformer for PDP power supply is presented. LLT transformer used to combine the inductor and transformer into one unit has the increased leakage inductance in the primary and secondary due to the winding method and the use of the gaped core. The increased leakage inductance in the primary and secondary of LLT transformer can be impacted on the DC voltage gain characteristics of LLC series resonant converter. In this paper, DC gain characteristics and the experimental results of the LLC series resonant converter with a LLT transformer are verified on the Math-CAD simulation based on the theoretical analysis and the 600W experimental prototype.

토사자가 혈압(血壓), 국소뇌혈류량(局所腦血流量) 및 뇌연막동맥(腦軟膜動脈)에 미치는 영향(影響)

강성용,김경수,김경요,이인,Kang Sung-Yong,Kim Kyung-Soo,Kim Kyong-Yoo,Lee In 대한한의학방제학회 1998 大韓韓醫學方劑學會誌 Vol.6 No.1

The study was aimed to investigate the effect cuscutae semen(CS) on the vascular systems including changes in blood pressure (BP), regional cerebral blood flow(rCBF) and pial arteriolar diameter of male Sprague-Dawely rats. The changes in rCBF were determinated by laser-Doppler flowmetry, and the changes in diameter of pial arteriole were measured through a closed crainal window. 1. Blood pressure was not affected by CS in rats. 2. rCBF was increased by CS in a dose-dependent manner. 3. Pretreatment with methylene blue(Img/kg), and propranolol(1mg/kg) significantly inhibited CS induced increased in rCBF. 4. Pretreatment with indomethacin(1mg/kg) did not inhibited CS induced increased in rCBF. 5. Pial arterial diameter was increased by CS in a dose-dependent manner. These results suggest that CS causes a diverse response of blood pressure, regional cerebral blood flow(rCBF), and pial arteral diameter. The increased in rCBF is also mediated by adrenergic ${\beta}-receptor $ and guanylate cyclase.

고온에서의 Steel H-형강 보의 처짐 및 파괴온도

강성덕(Kang Seong-Deok),남상철(Nam Sang-Chul),김인기(Kim In-Ki),민병직(Min Byung-Jik) 대한건축학회 2009 대한건축학회 학술발표대회 논문집 - 계획계/구조계 Vol.29 No.1(구조계)

This paper is on the Mid-span deflection and the failure temperature of H-beams in fire that investigated mainly on the parameters of load ratios and simply supported boundary condition in considering the behaviour of steel beams at predicted uniformly elevated temperatures. The physical properties of steel material at elevated temperatures are according to EC3 Part 1.2 and the strength of the steel beams in fire show that they are governed by the ratios of lateral length to the radius of gyration about minor axis.

U-헬스케어 시스템을 위한 UPnP기반센서 네트워크의 설계 및 구현

강성인,전재환,김관형,최성욱,김해영,오암석,Kang, Sung-In,Jean, Je-Hwan,Kim, Gwan-Hyung,Choi, Sung-Uk,Kim, Hae-Young,Oh, Am-Suk 한국정보통신학회 2009 한국정보통신학회논문지 Vol.13 No.4

최근 헬스케어는 사용자에게 보다 다양한 서비스를 위해서 다양한 생체센서 및 무선네트워크 기술이 도입되고 있는 실정이다. 따라서 다양한 생체센서들의 효율적인 관리 및 제어를 위한 미들웨어의 필요성이 제기되고 있다. 또한 네트워크 구성의 확장 및 다양한 응용시스템과의 상호운용은 앞으로 헬스케어 서비스의 중요한 요인이라 할 수 있다. 본 논문에서는 ZigBee 기반 무선 센서모듈의 표준화된 연결성, 관리 및 제어의 효율성 등을 제공하기 위해서, UPnP-ZigBee 브릿지를 설계 구현하여 UPnP 기반 네트워크와 연동할 수 있는 방법을 제안한다. 그리고 헬스케어 서비스에 적용가능 하도록, Zigbee 무선 네트워크 기반의 ECG, PPG센서 및 환경 센서 모듈을 구현하여 테스트하였다. Recently, To provide various service for user, there are some trends to construct health care system using bio-sensors and wireless network technologies. Accordingly, An effective middleware is needed to manage and control the various bio-sensors. Also, it is important to extend network and interoperate the various application system in healthcare service. In this paper, we propose to be connected with network based on UPnP by design and implementation of UPnP-ZigBee bridge. The proposed UPnP-ZigBee bridge manage and control ZigBee sensor module effectively. we implemented and tested ECG, PPG, and environment sensor module based on ZigBee wireless network to apply in health care service.

AGT 시스템 안내레일 요철에 의한 교량 응답에 관한 실험적 연구

강성원(Kang Sung-Won),한상철(Han Sang-Chul),이안호(Lee An-Ho),정인근(Jung In-Keun) 한국철도학회 2007 한국철도학회 학술발표대회논문집 Vol.- No.-

AGT system is a kind of light railway train. AGT system use of concrete track and rubber tire, so it can be reduce the noise and vibration, compare to the normal train system. And, the dynamic responses of normal bridge are influenced by the dynamic characteristics of bridge, the speed of vehicle and the surface roughness of railway. But the AGT system bridge is influenced not only the above facts but also the guiderail unevenness, because, AGT vehicle steered by guiderail. So, in this study, optimized service condition is suggested for the design and operation of AGT system, by the means of experimental study. The experiments are executed for PSC bridge with length of 30m, at the AGT test line in Kyongsan. The test results are compared and investigated according to the prominence. In the test result, the guiderail prominence influenced on the dynamic response of bridge. It shows a increase as compared with no guiderail prominence in the dynamic response value acceleration, displacement, stain.

자연재해에 의한 관망사고 복구 매뉴얼

강성원 ( Sung Won Kang ),공명식 ( Myeong Sik Kong ),박은주 ( Eun Zoo Park ),이준형 ( Joon Hyung Lee ),이현동 ( Hyun Dong Lee ),최종인 ( Jong In Choi ),곽필재 ( Pil Jae Kwak ),강성원 ( Sung Won Kang ),이준형 ( Jun Hyung Lee ),이현 한국물환경학회(구 한국수질보전학회) 2014 한국물환경학회·대한상하수도학회 공동 춘계학술발표회 Vol.2014 No.-

LLC 직렬공진 컨버터 동작특성

姜聲仁(Sung-In Kang),尹光鎬(Kwang-Ho Yoon),金恩洙(Eun-Soo Kim),朴俊浩(Jun-Ho Park),許東榮(Dong-Young Huh) 전력전자학회 2007 전력전자학회 논문지 Vol.12 No.6