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폐경 주변기 여성에서 골밀도와 생화학적 골대사지표의 변화 -후향적 코호트 연구-
강성욱,황성욱,김문종,최승권,이진,강영곤,이영진,배철영 대한가정의학회 2002 Korean Journal of Family Medicine Vol.23 No.7
Background: Although it is well known that bone mineral density (BMD) loss occurs after menopausal transition, there are only few previous studies that describe differences of BMD and biochemical bone markers in women of pre- and postmenopausal periods. The purpose of this study was to find factors that contribute to loss of BMD after menopause and to show changes of BMD and biochemical bone markers during pre- and postmenopausal periods by retrospective cohort study. Methods: This retrospective cohort study was performed from Jan. 1995 to Jan. 2001 at a health promotion center. Twenty one healthy perimenopausal women were enrolled. BMD and biochemical bone markers were checked more than two times during the study period. Changes of BMD and biochemical bone markers between pre- and postmenopausal state were compared by paired t-test. Pearson correlation and multiple regression were performed to find the contributing factors to loss of BMD after menopause. Results: Postmenopausal BMD (164.65±36.34 mg/cm3) was significantly decreased to 16.49±16.91 mg/cm3 (P<0.001) as compared with premenopausal BMD (181.14±40.81 mg/cm3). In biochemical bone markers only urine deoxypyridinoline had a significant difference (3.30±3.97 nMDP/mMcre, P<0.05) Only premenopausal BMD contributed to decreasing rate of BMD between the two states and the loss of BMD after menopause (P<0.05). Conclusion: In perimenopausal healthy women, postmenopausal BMD was significantly decreased as compared with premenopausal BMD. And only premenopausal BMD was shown to be a contributing factor to decreasing rate of BMD between the two states and the loss of BMD after menopause. It suggests that premenopausal BMD is important in predicting postmenopausal osteoporosis and efforts to prevent loss of BMD before menopause can prevent progress of postmenopausal osteoporosis. (J Korean Acad Fam Med 2002;23:897-904) 연구배경: 폐경으로 인한 골밀도의 감소와 생화학적 골대사지표의 변화는 잘 알려진 사실이지만, 건강한 폐경 주변기 여성을 대상으로 폐경 전과 후에 골밀도 및 생화학적 골대사지표를 추적관찰한 연구는 많지 않다. 이에 본 연구는 폐경 주변기 여성에서의 골밀도와 생화학적 골대사지표를 추적관찰함으로써, 폐경으로 인한 골밀도 감소와 생화학적 골대사지표의 변화를 관찰하고 골밀도의 변화에 영향을 주는 요인을 조사하고자 한다. 방법: 1995년 1월부터 2001년 7월까지 1개 종합병원의 건강증진센터에서 갱년기 여성검진을 받았던 여성들 중, 자연폐경을 경험한 건강한 폐경 주변기 여성을 대상으로 폐경 전과 후에 골밀도와 생화학적 골대사지표를 측정한 21명을 선정하여 후향적 코호트 연구를 시행하였다. 폐경 전후의 골밀도와 생화학적 골대사지표의 변화는 paired t 검정으로 비교하였으며, 골밀도 변화와 폐경 후 골밀도에 영향을 주는 요인을 알아보고자 각 변수들 간의 상관성을 피어슨의 상관분석 후, 다중회귀 분석을 시행하였다. 결과: 연구대상자의 폐경 전후 골밀도의 감소는 16.49±16.91 mg/cm3이었으며, 이는 통계학적으로 유의하였다(P<0.01). 생화학적 골대사지표의 폐경 전후 변화는 요중 deoxypyridinoline의 경우 평균 3.30±3.97 nMDP/mMcre으로 통계학적으로 유의한 증가를 보였다(P<0.05). 한편 골밀도의 감소량과 폐경 후 골밀도에 영향을 주는 요인으로는 각각에서 폐경 전 골밀도만이 의의 있는 영향을 미쳤다(P<0.05). 결론: 폐경 주변기 여성에서 폐경 전후 골밀도는 의의 있게 감소하였으며, 폐경 전 골밀도만이 골밀도의 감소량과 폐경 후 골밀도에 영향을 미치는 요인으로 나타났다. 이는 폐경에 따른 골밀도의 감소에 있어 폐경 전 골밀도가 중요한 역할을 한다는 것을 의미하며, 나아가 폐경 후 골다공증의 조기진단과 치료에 있어 폐경 전 골밀도에 대한 적절한 평가와 관리의 중요성을 시사한다 하겠다. (가정의학회지 2002;23:897-904)
열탄소성 해석을 이용한 전기차 배터리 하우징 마찰교반용접에 관한 연구
강성욱,김환진,김재웅,이창연,유현수 한국기계기술학회 2020 한국기계기술학회지 Vol.22 No.2
In this study, the deformation of friction stir welding on the aluminum battery housing material(AL6063-T5) applied to the electric vehicle was effectively predicted through experiments and numerical simulations. The temperature data were measured during the friction stir welding experiment, and the numerical simulation was carried out using the experimental temperature data. In the heat transfer analysis, the temperature distribution of the structure over time was calculated using the Reynolds equation. The final friction stir welding deformation was calculated by performing the structural analysis using the calculated temperature distribution data over time. The thermal elasto-plastic analysis was performed according to the friction stir welding process conditions and the welding sequences. Finally, the optimum welding condition was derived that the welding speed is 1000 mm/min and the rotation speed of the tool is 2000 RPM.
A Promoter SNP (rs1800682, -670C/T) of FAS Is Associated with Stroke in a Korean Population
강성욱,정주호,김동환,윤동환,유승돈,서완,윤지상,백형환,김희상 한국유전체학회 2010 Genomics & informatics Vol.8 No.4
The Fas (TNF receptor superfamily, member 6) (FAS)/ FAS ligand (FASLG) interaction plays a central role in the regulation of programmed cell death. FAS and FASLG polymorphisms in promoter regions affect transcriptional activities. To investigate whether FAS and FASLG polymorphisms are associated with the development and clinical phenotypes of stroke, 2 promoter single nucleotide polymorphisms (SNPs) in FAS (rs1800682, −670C/T) and FASLG (rs763110, −844C/T) were selected and genotyped by direct sequencing in 220 stroke patients [107 ischemic stroke (IS), 77 intracerebral hemorrhage (ICH), and 36 subarachnoid hemorrhage (SAH)] and 369 control subjects. For the analysis of clinical symptoms, all stroke patients were divided into 3 clinical phenotypes according to the respective results of the National Institutes of Health Stroke Survey (NIHSS) and the Modified Barthel Index (MBI) and the presence or absence of complex regional pain syndrome (CRPS). The SNPStats, SNPAnalyzer, and Helixtree programs were used to analyze the genetic data. Multiple logistic regression models (codominant, dominant, and recessive) were used to estimate odds ratios (ORs), 95% confidence intervals (CIs), and p-values. The promoter SNP rs1800682 was associated with stroke in the codominant (OR=0.48, 95% CI=0.25-0.94, p=0.04) and dominant models (OR=0.51, 95% CI=0.30-0.87, p=0.011). However, a FASLG SNP (rs763110) was not in Hardy-Weinberg equilibrium (p<0.05). In the analysis of stroke types, rs1800682 was associated with IS in the codominant (OR=0.30, 95% CI=0.12-0.74, p=0.025), dominant (OR=0.44, 95% CI=0.23-0.88, p=0.018), and recessive models (OR=0.45, 95% CI=0.21-0.99, p=0.042). The genotype frequencies of rs1800682 were different between ICH and controls in the dominant model (OR=0.49, 95% CI=0.26-0.94, p=0.031) but not between SAH and controls. In the analysis of clinical symptoms, however, rs1800682 was not related to the 3 clinical phenotypes (NIHSS, MBI, and CRPS). These results suggest that a promoter SNP (rs1800682, −670C/T) in FAS may be associated with the development of stroke in the Korean population.
복시(複視)(Diplopia)를 호소하는 Guillain-Barre Syndrome(GBS) 환자 치험 1례 증례보고
강성욱,문미현,홍석훈,황충연,강정란,박준영,Kang, Sung-Wook,Moon, Mi-Hyun,Hong, Suk-Hoon,Hwang, Chung-Yeon,Kang, Jeong-Ran,Park, Joon-Young 대한한방안이비인후피부과학회 2005 한방안이비인후피부과학회지 Vol.18 No.3
Guillain-Barre Syndrome (GBS) is an acute inflammatory demyelinating polyneuropathy. It is disorder in which the body's immune system, attacks parts of the peripheral nervous system. It is characterized by the rapid onset of weakness, paralysis of the legs, arms, breathing muscles and face. But the analysis of CSF and electrical tests on nerve and muscle function can be performed to confirm the diagnosis. Most cases occur shortly after a viral infection. This is a clinical ease report on Cuillain-Barre Syndrome with diplopia. The patient, a 52-year-old man had a weakness in both legs and diplopia. His weakness and diplopia improved after oriental medical treatment, so this is reported as a potential treatment. Objective: This study was designed to evaluate the effects on oriental medicine therapy on Guillain-Barre Syndrome with diplopia. Methods & Result: The Clinical data was analyzed on a patient with Cuillain-Barre Syndrome whose main symptoms were diplopia. The patient was treated by acupuncture and oriental medicine. As a result, symptoms was improved remarkably. Conclusion: The patient showed weakness and diplopia. After acupuncture and oriental medicine treatment, weakness and diplopia was improved in 4weeks after visit to clinic. The study suggests that oriental medicine treatment is effective on Cuillain-Barre Syndrome.
도로 유지보수를 위한 열 방출 차단형 적재함 내 아스팔트 콘크리트의 열전달 특성 연구
강성욱,조민구,김현수,김호진,고영봉,홍기철,장홍래 한국기계기술학회 2022 한국기계기술학회지 Vol.24 No.1
Asphalt concrete(Ascon) is used to repair potholes and cracks. Special truck-mounted cargo boxes transport 200℃ asphalt concrete to repair potholes and cracks. However, long working and transportation hours to repair wide roads decrease the temperature of the asphalt concrete inside the cargo boxes. If the asphalt concrete temperature drops below 170℃, the adhesion with roads that need repair decreases. Therefore, the temperature of the asphalt concrete needs to be maintained for a long time. Conventional asphalt concrete cargo boxes are mostly burner-type models using hot air to prevent the temperature of the asphalt concrete from dropping. However, there are significant temperature differences between the asphalt concrete near and far away from the hot air, so the temperature decreases over time and leads to the disposal of large amounts of asphalt concrete. This causes waste of resources and environmental pollution. Therefore, this study proposed a heat dissipation cut-off type cargo box model to solve this problem and demonstrated its performance over conventional burner-type models through tests and analysis.