일부 초등학생의 아토피피부염 유무에 따른 식습관, 식품섭취양상 및 영양소섭취상태 비교

박남숙(Nam-Suk Park),전유선(Eu Sun Jeon),김영남(Young-Nam Kim),조경동(Kyung-Dong Cho),백옥희(Ok-Hee Baek),이복희(Bog-Hieu Lee) 한국식품영양과학회 2009 한국식품영양과학회지 Vol.38 No.11

본 연구는 아토피피부염을 가지고 있는 아동과 정상 아동의 식습관, 식품섭취양상 및 영양소섭취상태 비교를 위해 서울 소재 1개교와 울산의 2개 초등학교에 재학 중인 5, 6학년 388명을 대상으로 설문지를 이용하여 실시되었다. 조사는 2008년 7월 7일부터 7월 18일까지 총 2주간 실시하였으며, 조사대상자 중 아토피피부염군은 16.7%(65명), 정상 아동군은 83.3%(323명)로 나타났다. 아토피피부염 아동군은 남학생 29명, 여학생 36명으로 남아보다는 여아에게서 더 호발 되었으며 대부분 7~13세에 아토피피부염이 유발된 것으로 나타났다. 아토피피부염 아동군 중 병원치료를 받고 있는 경우는 20.0%였고 아토피피부염 유발에 영향을 주는 식품인 튀김, 패스트푸드, 우유 등의 섭취를 제한하고 있었다. 식습관의 경우, 아토피피부염 아동군이 정상 아동군에 비해 식습관이 불규칙적인 것으로 나타났으며(p<0.05), 아토피피부염의 유발과 연관 있는 식품 중 우유, 돼지고기, 게, 메밀, 닭고기, 고등어, 복숭아, 토마토의 섭취량이 정상 아동군에 비해 아토피피부염 아동군에서 높게 나타났다. 또한, 아토피피부염 아동군이 열량(p<0.001), 총 단백질(p<0.05), 식물성 단백질(p<0.001), 당질(p<0.001), 식이섬유소(p<0.01), 칼륨(p<0.05), 아연(p<0.001), 비타민 B1(p<0.001), 나이아신(p<0.01), 비타민 C(p<0.05) 및 엽산(p<0.01) 등의 섭취량이 정상 아동군에 비해 유의적으로 적었다. 본 연구결과 아토피피부염 아동은 정상아동에 비해 식습관이 불규칙적이고, 아토피피부염 유발식품의 섭취량은 많았으며, 대부분의 영양소 섭취량이 정상아동에 비해 적었다. 이러한 결과는 식품과 연관성이 높은 소아 아토피피부염에 부정적인 영향을 줄 수 있을 것으로 보이며, 아토피피부염 아동에 대해 적절한 식품의 선택과 균형 잡힌 식생활 및 식습관 교정의 필요성이 매우 절실한 것으로 판단된다. 따라서 아토피 피부염을 악화시키는 원인식품의 섭취를 제한하는 것과 더불어 올바른 영양교육 및 지도가 이루어져야할 것으로 생각된다. The aim of this study was to examine and compare the eating habits, dietary intake patterns and nutrient intake status of children with and without atopic dermatitis by questionnaire during July, 2008. A total 388 subjects of 5th and 6th grade elementary school children (AG: atopic group, n=65, NG: non-atopic group, n=323) in Seoul and Ulsan areas participated in this study. The questionnaire included general characteristics, dietary habits, and atopy-related food frequency. One-day 24 hour recall was collected to estimate nutrient intakes of the subjects. The data were analyzed by Chi-square test for food frequency analysis and by t-test for nutrient intakes. Atopy-related foods included milk, buckwheat, beef, pork, chicken, crab, egg, mackerel, peach, and tomato. From the findings, AG had a more irregular eating habit than NG (p<0.05). In case of food frequency, AG tended to consume more atopy-related foods than NG (p>0.05). The nutrient intakes of AG were significantly lower than those of NG (p<0.05), but only intake of animal iron in AG was higher than NG (p<0.05). NG consumed more protein than AG (p<0.05). Although milk was a noted hypersensitive allergic food, frequency and the amount of milk intake were not significantly different between two groups. In conclusion, atopic children had eaten more atopy-related foods and less nutrient intakes. Therefore, it is necessary to educate on good nutrition and guide atopic children and their parents.

3차 의료기관을 방문한 천식 환자에서 아토피 유병률의 변화

박흥우(Heung Woo Park),김상헌(Sang Heon Kim),김상훈(Sang Hoon Kim),장윤혜(Yoon Hae Chang),정희(Hee Chung),이병재(Byung Jae Lee),김윤근(Yoon Keun Kim),조상헌(Sang Heon Cho),민경업(Kyung Up Min),김유영(You Young Kim) 대한천식알레르기학회 2000 천식 및 알레르기 Vol.20 No.1

N/A Background: The prevalence of atopy and atopy-related disease has been known to increase during the past decade. Objective : This study was desinged to evaluate the changes of atopy prevalence among asthmatic patients and the causative allergens. Method : A total of 698 asthmatic patients visiting Seoul National University Hospital in 1983, 1990 and 1997 was recruited. Skin prick test with common inhalant allergens was carried out and interpreted as positive when the mean wheal size formed by allergen was larger than 3 mm. Atopy was defined when skin reaction to one or more allegens was positive. Result. The prevalence of atopy among asthmatic patients was 54% in 1983, 48.8% in 1990 and 58% in 1997, respectively. The prevalence of atopy decreased as the age of patients in- creased. Recently, old asthmatic patients ( >55 years) showed a higher tendency to visit the tertiary referral hospital. When the data were analyzed according to age, the prevalence of atopy significantly increased among asthmatic patients aged 15-35 years, in whom the prevalence was 60.4% in 1988 and 81.3% in 1997 (p< 0.05). The positive rate of skin test to Dermatophagoides pteronyssinus, cat fur, mugwort, ragweed, and grass pollen were significantly higher in 1997 than in 1983 (p < 0.05). Conclusion : The prevalence of atopy among asthmatic patients aged 15-85 years showed significant increase in 1997 compared to 1983. The changes of skin response to Dermatophagoides pteronyssinus, cat fur, mugwort, ragweed, and grass pollen contributed to the increase of atopy.

Inverse Relationship between Adenoid Size and Asthma or Atopy in Children: A Preliminary Study

노양섭,최지은,이경은,정승규,홍상덕,김효열 대한이비인후과학회 2020 대한이비인후과학회지 두경부외과학 Vol.63 No.9

Background and Objectives One of the most common surgical procedures in children isadenoidectomy, but the causes of adenoid hypertrophy are not fully understood. Some studieshave found that allergies can be a risk factor for adenoid hypertrophy, asthma being one of theseallergic diseases. This study aimed to investigate the relationship between adenoid size andasthma in a group of children. Subjects and Method This study reviewed a total of 2063 pediatric patients with or withoutatopy and asthma who visited the Otorhinolaryngology and Pediatric unit at a tertiary medicalcenter from January 2011 to June 2016. We classified these patients into 4 groups according tothe presence of asthma or atopy and randomly selected 100 patients from each group (to a totalof 400 pts): group 1 (asthma-, atopy-); group 2 (asthma-, atopy+); group 3 (asthma+, atopy-)and group 4 (asthma+, atopy+). The presence of allergic sensitization (atopy) was evaluated byCAP test and total IgE. Asthma was diagnosed according to the diagnosis criteria in the Koreanguideline for asthma. Adenoid size was evaluated with the adenoidal-nasopharyngeal ratio(A/N ratio) by the adenoid view. Results The four groups did not differ from each other significantly in age or sex. There wasa negative correlation between adenoid size and atopic and asthmatic condition. Group 1 had asignificantly larger A/N ratio than the other groups (group 1=0.534±0.138; group 2=0.469±0.140; group 3=0.476±0.135; group 4=0.482±0.128, p<0.05). However, group 4 showed nearlyidentical results to groups 2 and 3, despite the combination of asthma and atopy in group 4. Conclusion Large adenoids were negatively associated with atopy and asthma. This findingmay be explained by a decrease in adenoid stimulation by nasal obstruction and a differencein the immune system, including allergic immune reactions. Further studies are needed.

아토피 소아와 아토피 부모에서 피부 단자 시험 결과의 일치도

강희,유진호,유영,고영률 대한알레르기학회 2004 천식 및 알레르기 Vol.24 No.2

아토피친화학교와 일반학교에 재학 중인 초등학생들의 친환경농산물에 대한 지식도와 식생활 지침 실천도 비교

이상미(Lee, Sang-Mi),김회경(Kim, Hoikyung) 한국생활과학회 2014 한국생활과학회지 Vol.23 No.4

Atopic dermatitis is a chronic relapsing inflammatory skin disease. In the past years, numbers of children with atopic dermatitis has increased all over the world. Objective of this study was to evaluate awareness of students in atopy-friendly elementary schools about environmentally-friendly grown agricultural products and their practice levels for dietary guidelines. This study was conducted by using a questionnaire on 116 students from three atopy-friendly schools in Jin-an, Jeong-eup, and Gwang-ju and 124 students from general elementary schools. According to the results, the numbers of children who suffer from atopic dermatitis between atopy-friendly schools and general schools were not significantly different. Among, students with atopic dermatitis, more students in atopy-friendly school, compared to general school, restricted foods. Since different school feeding services have been provided, students in atopy-friendly schools generally get more information about the environmentally-friendly agricultural products through nutrition education. However, most results did not show differences in knowledge levels and practice levels for dietary guidelines for children between students in atopy-friendly schools and general schools about environmentally -friendly produces. However, students in atopy-friendly schools less frequently eat cookies, soda drinks, or fast foods. In conclusion, appropriate program for nutrition education should be provided to elementary school students with atopic dermatitis.

천식 소아에서 아토피 유무가 기관지확장제 반응에 미치는 영향

서동인 ( Dong In Suh ),이의준 ( Eui Jun Lee ),이지원 ( Ji Won Lee ),이주경 ( Ju Kyung Lee ),고영률 ( Young Yull Koh ) 대한소아알레르기호흡기학회(구 대한소아알레르기 및 호흡기학회) 2011 소아알레르기 및 호흡기학회지 Vol.21 No.1

목적: 천식 소아에서 진단 및 천식 상태 평가의 도구로 사용되는 기관지확장제 반응이 아토피 유무에 따라 서로 다른 값을 보이는 가를 확인하고자 하였다. 방법: 서울대학교병원 소아청소년과에 내원하여 천식을 확진 받은 6-16세의 환자 207명의 자료를 후향적으로 분석하였다. 환자들은 천식 진단을 위해 자세한 병력청취와 혈액검사, 피부단자시험, 기관지 유발시험을 시행받았고, 이후 기관지확장제 반응을 측정받았다. 피부단자시험 결과로 판정한 아토피 유무에 따라 환자들을 두 군으로 나누어 천식 진단시 시행한 기관지확장제 반응의 값을 비교했으며, 전체 환자를 대상으로 기관지확장제 반응과 호산구 염증 지표 사이의 상관관계를 통계 검정하였다. 결과: 기관지확장제 흡입 전 FEV1은 두 군간 차이를 보이지 않았으나 아토피성 천식군에서 기관지확장제 반응이 비아토피성 천식군보다 더 크게 관찰되었다(9.12±5.69 % vs. 6.93±3.80%, P=0.03). 또한 천식 환자 전체에서 기관지확장제 반응은 혈청 총 IgE (r=0.192, P=0.01), 호산구 수(r=0.192, P=0.01) 및 호산구 양이온 단백(r=0.200, P<0.01)과 약한 양의 상관관계를 나타내었다. 결론: 천식 소아는 진단 초기 안정상태에서 기도가역성 평가시 아토피 유무에 따라 기관지확장제 반응에 차이를 보였다. 따라서 진단 초기 천식 소아에서 천식 상태의 평가 및 대처방안 결정에 있어 기관지확장제 반응을 참고할 경우 아토피 여부에 대한 고려가 함께 필요하다. Purpose: The bronchodilator response (BDR) is frequently measured to assess the severity of asthma and to help facilitate therapeutic decisions, as well as to confirm the diagnosis. Few reports are available on the impact of atopy, one of the most important risk factors for childhood asthma, on the BDR. Methods: The medical records of 207 asthmatic children (174 with atopic asthma and 33 with non-atopic asthma) were retrospectively reviewed. At the time of asthma diagnosis, the subjects underwent blood tests, bronchial provocation tests, and spirometry before and 15 minutes after inhalation of 4 puffs of salbutamol. We compared the mean BDR levels between the children with atopic and non-atopic asthma, then determined the correlations between the BDR and serum markers of eosinophilic inflammation. Results: While the mean pre-bronchodilator FEV1 was not different between children with atopic and non-atopic asthma, atopic asthmatics had a higher mean BDR than non-atopic asthmatics (9.12±5.69% vs. 6.93±3.80%, P=0.03). There were weak, but significant correlations between the BDR and the serum markers of eosinophilic inflammation (total immunoglobulin E, r=0.192, P=0.01; total eosinophil count, r=0.192, P=0.01; eosinophil cationic protein, r=0.200, P<0.01). Conclusion: Asthmatic children had different mean levels of BDR based on atopic status at the time of asthma diagnosis. When the BDR was assessed to aid therapeutic decisions, the presence of atopy should be taken into consideration in children with asthma. [Pediatr Allergy Respir Dis(Korea) 2011;21:39-46]

울산광역시 일개 초등학교 소아들의 알레르기 및 아토피질환의 유병률

윤재국 ( Jae Kook Yoon ),심창선 ( Chang Sun Sim ),최승원 ( Seung Won Choi ),오인보 ( In Bo Oh ),이지호 ( Ji Ho Lee ),김양호 ( Yang Ho Kim ) 대한천식알레르기학회 2011 천식 및 알레르기 Vol.31 No.2

Background: Ulsan is the most industrialized city in Korea. Although many investigations as to which factors are related to allergy and atopy have been performed so far, these factors are still uncertain. Studies of industrialized environment can help to understand an atopic disorder. Objective: This study was undertaken to investigate the prevalence of allergic and atopic disorders in an industrial city, Ulsan and to estimate the proportion of ``real`` atopyto so-called ``allergy and atopy``. Also, we examined the validity of some items of blood tests, such as serum total IgE levels and eosinophil counts for the diagnosis of the atopic disorder. Method: We conducted the questionnaire survey based on the ISAAC protocol along with demographic variables at an elementary school in the central area of Ulsan. The questionnaires were completed by patients of 1,323 children, of whom 570 participated in skin prick test and blood test. Atopic disorder was defined as the presence of allergic symptoms and the presence of sensitization to any allergens by skin prick test. Result: The lifetime prevalence of atopic wheeze was 8.8%and the proportion of atopy of asthma was 60.4%. The lifetime symptom prevalence of ``real`` atopic dermatitis (atopiceczema) was 16.1% and the proportion of atopy of atopic dermatitis was 49.4%. The prevalence of ``real`` allergic rhinitis (atopic rhinitis) was 28.0% and the proportion of atopy of allergic rhinitis was 51.8%. The prevalence of overall atopic disorder was 37.0%, and the proportion of atopy of overall allergic disorder was 51.4%. The area under receiver operating characteristic curve of serum total IgE for the diagnosis of the atopic disorder was 0.770. Also, we observed the selective bias from the differences in prevalence between groups of complete participants and incomplete participants. Conclusion: The prevalence of asthma was similar to those of other regions in Korea. However, atopic dermatitis and allergic rhinitis were more prevalent than other regions. About half of so-called allergic disorders may be an atopic disorder. (Korean J Asthma Allergy Clin Immunol 2011;31:105-115)

학동전기 소아 천식의 천명 유형에 따른 아토피 및 폐기능 특성

송영화,김병주,권지원,유진호,홍수종 대한 소아알레르기 호흡기학회 2009 Allergy Asthma & Respiratory Disease Vol.19 No.4

목 적 : 학동전기 아이들에서 보이는 천명은 다양한 형태를 보이며 모두 천식으로 진행하지 않는다. 그러나, 우리나라에서는 재발성 천명을 보이는 이들을 대상으로 천명의 표현형과 천식과의 관련성에 관한 연구가 많지 않다. 방 법 : 1998년 1월부터 2007년 8월까지 서울아산병원 소아 천식아토피센터를 재발성 천명으로 방문한 3-6세 소아 272명을 대상으로 전향적 추적조사 하였다(Asan Asthma Allergy Cohort). 이들을 세 군으로 분류하여 조기 발현 지속성 천명에서 천식진행군(조기천명 천식군), 조기 발현 지속성 천명에서 천식으로 진행하지 않은 군(조기천명 완해군), 후기 발현 천명에서 천식진행군(후기천명 천식군)으로 나누어 7세때 폐기능 검사, 메타콜린 유발검사 그리고 알레르기 관련 혈액검사를 시행하였다. 결 과 : 조기천명 천식군에서 노력성 호기 중간 유량(FEF25-75%)이 후기천명 천식군에 비해 현저하게 감소되어 있었으나 조기천명 완해군에 비해서는 낮은 경향만 보였다. 기도과민성은 조기천명 천식군과 후기천명 천식군 모두 조기천명 완해군과 비교하여 의미있게 증가되었다. 혈청 내 D.p와 D.f-특이 IgE 농도와 항원특이 IgE 항체 농도합은 후기천명 천식군이 조기천명 천식군과 조기천명 완해군에 비해 의미있게 높았다. 결 론 : 영유아 천식 중 조기천명 천식군과 후기천명 천식군은 아토피, 기도과민성과 유의한 상관관계를 보이는 것이 공통된 특징이지만 후기천명 천식군이 보다 더 아토피와 연관성이 높다. 또한 조기천명 천식군은 후기천명 천식군에 비해 유의한 폐기능의 감소를 보였다. 이는 우리나라 학동전기 아이들에서의 천식으로의 진행은 아토피와 관련되고 그 중 조기천명 천식군에서는 7세 이전에 이미 기도개형이 시작됨을 시사한다. Purpose : The wheezing phenotype in early childhood is heterogeneous and does not always develop asthma. However, the severity of the disease associated with these phenotypes has not been extensively studied in Korean children. Methods : Two hundred seventy-two children with recurrent wheezing aged 3-6 yrears who visited the Childhood Asthma and Atopy Center in Asan Medical Center from January 1998 to August 2007 were enrolled and followed up prospectively. The patients were divided into 3 groups: early-onset persistent wheezers (E/P) with asthma, E/P wheezers without asthma and late-onset wheezers with asthma. We investigated asthma-related biomarkers, pulmonary function and methacholine challenge at the age of 7. Results : FEF25-75% in the E/P wheezers with asthma was significantly lower than that in the late-onset wheezers with asthma. However, there was no significant difference in FEF25- 75% between the E/P wheezers with asthna and those without. The E/P wheezers with asthma and the late-onset wheezers with asthma demonstrated enhanced Bronchial Hyperrsponsiveness (BHR) compared with E/P wheezers without asthma. Dermatophagoides farinae (D.f) or Dermatophagoides pteronyssinus (D.p)-specific IgE and sum of specific IgE in the late-onset wheezers with asthma were significantly higher than in the E/P wheezers with or without asthma. Conclusion : The E/P wheezers with asthma and late-onset wheezers with asthma were associated with high levels of atopy and BHR, even though the late-onset wheezers with asthma were more related to atopy. The E/P wheezers with asthma showed decreased pulmonary function. These findings suggest that the development of asthma in Korean preschool children may be strongly associated with atopy and that E/P wheezers with asthma may show airway remodeling even before the age of 7.

학동전기 소아 천식의 천명 유형에 따른 아토피 및 폐기능 특성

송영화 ( Young Hwa Song ),김병주 ( Byoung Ju Kim ),권지원 ( Ji Won Kwon ),유진호 ( Jin Ho Yu ),홍수종 ( Soo Jong Hong ) 대한소아알레르기호흡기학회(구 대한소아알레르기 및 호흡기학회) 2009 소아알레르기 및 호흡기학회지 Vol.19 No.4

목적: 학동전기 아이들에서 보이는 천명은 다양한 형태를 보이며 모두 천식으로 진행하지 않는다. 그러나, 우리나라에서는 재발성 천명을 보이는 이들을 대상으로 천명의 표현형과 천식과의 관련성에 관한 연구가 많지 않다. 방법: 1988년 1월부터 2007년 8월까지 서울아산병원 소아 천식아토피센터를 재발성 천명으로 방문한 3-6세 소아 272명을 대상으로 전향적 추적조사 하였다(Asan Asthma Allergy Cohort). 이들을 세 군으로 분류하여 조기 발현 지속성 천명에서 천식진행군(조기천명 천식군), 조기 발현 지속성 천명에서 천식으로 진행하지 않은 군(조기천명 완해군), 후기 발현 천명에서 천식진행군(후기천명 천식군)으로 나누어 7세때 폐기능 검사, 메타콜린 유발검사 그리고 알레르기 관련 혈액검사를 시행하였다. 결과: 조기천명 천식군에서 노력성 호기 중간 유량(FEF25-75%)이 후기천명 천식군에 비해 현저하게 감소되어 있었으나 조기천명 완해군에 비해서는 낮은 경향만 보였다. 기도과민성은 조기천명과 비교하여 의미있게 증가되었다. 혈청 내 D.p와 Df-특히 IgE 농도와 항원특이 IgE 항체 농도합은 후기천명 천식군이 조기천명 천식군과 조기천명 완해군에 비해 의미있게 높았다. 결론: 영유아 천식 중 조기천명 천식군과 후기천명 천식군은 아토피, 기도과민성과 유의한 상관관계를 보이는 것이 공통된 특징이지만 후기천명 천식군이 보다 더 아토피와 연관성이 높다. 또한 조기천명 천식군은 후기천명 천식군에 비해 유의한 폐기능의 감소를 보였다. 이는 우리나라 학동전기 아이들에서의 천식으로의 진행은 아토피와 관련되고 그 중 조기천명 천식군에서는 7세 이전에 이미 기도개형이 시작됨을 시사한다. Purpose: The wheezing phenotype in early childhood is heterogeneous and does not always develop asthma. However, the severity of the disease associated with these phenotypes has not been extensively studied in Korean children. Methods: Two hundred seventy-two children with recurrent wheezing aged 3-6 yrears who visited the Childhood Asthma and Atopy Center in Asan Medical Center from January 1988 to August 2007 were enrolled and followed up prospectively. The patients were divided into 3 groups: early-onset persistent wheezers (E/P) with asthma, E/P wheezers without asthma and late-onset wheezers with asthma. We investigated asthma-related biomarkers, pulmonary function and methacholine challenge at the age of 7. Results: FEF25-75% in the E/P wheezers with asthma was significantly lower than that in the late-onset wheezers with asthma. However, there was no significant difference in FEF25-75% between the E/P wheezers with asthma and those without. The E/P wheezers with asthma and the late-onset wheezers with asthma demonstrated enhanced Bronchial Hyperrsponsiveness (BHR) compared with E/P wheezers without asthma. Dermatophagoides farinae (D.f) or Dermatophagoides pteronyssinus (D.p)-specific IgE and sum of specific IgE in the late-onset wheezers with asthma were significantly higher than in the E/P wheezers with or without asthma. Conclusion: The E/P wheezers with asthma and late-onset wheezers with asthma were associated with high levels of atopy and BHR, even though the late-onset wheezers with asthma were more related to atopy. The E/P wheezers with asthma showed decreased pulmonary function. These findings suggest that the development of asthma in Korean preschool children may be strongly associated with atopy and that E/P wheezers with asthma may show airway remodeling even before the age of 7. [Pediatr Allergy Respir Dis(Korea) 2009;19:335-344]

천식 및 알레르기성 비염 환아에서의 호기 일산화질소 농도 : 아토피 및 기도과민성과의 연관성

나규민,박양,강은경,강희,고영률,이선화,백도명,Nah, Kyu Min,Park, Yang,Kang, Eun Kyeong,Kang, Hee,Koh, Young Yull,Lee, Sun Wha,Paek, Domyung 대한소아청소년과학회 2003 Clinical and Experimental Pediatrics (CEP) Vol.46 No.3

목 적 : 호기 NO 농도는 비침습적인 하기도 염증의 지표로 주목받고 있으며 기도과민성과 아토피와의 관련성이 보고되고 있다. 이에 저자들은 만성천식 및 알레르기성 비염 환아에서 호기 NO 농도를 측정하고 기도과민성과 아토피 여부에 따른 차이를 분석하였다. 방 법 : 기관지 천식(n=55), 알레르기성 비염(n=17)으로 진단 된 환아 및 대조군(n=14)을 대상으로 2001년 1월부터 4월까지 호기 NO 농도를 측정하여 비교하였으며 다시 천식환아군은 아토피성(n=37) 및 비아토피성 천식군(n=18)으로 나누어 비교하였고 알레르기성 비염군은 기도과민성 유무에 따라 나누어 비교하였다(각각, n=7, n=10). 또한 천식군과 알레르기성 비염군을 대상으로 각각 피부 단자시험에서 양성항원 수 및 메타콜린 $PC_{20}$과 호기 NO 농도의 상관관계를 분석하였다. 결 과 : 호기 NO 농도는 천식군과 알레르기성 비염군이 대조군보다 유의하게 높았으며(P<0.01), 아토피성 천식군이 비아토피성 천식군보다, 비아토피성 천식군은 대조군보다 유의하게 높았다(P<0.01). 알레르기성 비염군은 기도과민성 유무에 따른 차이는 없었다(P=0.50). 천식군에서는 피부 단자시험에서 양성항원 수 및 메타콜린 $PC_{20}$과 호기 NO 농도간에 유의한 상관관계가 있었으나 (r=0.32, P=0.02; r=-0.38, P<0.01), 알레르기성 비염군에서는 유의한 상관관계가 없었다(r=0.42, P=0.09; r=-0.06, P=0.83). 결 론 : 호기 NO 농도는 천식환자에서 아토피에 의한 병태생리와 연관성이 있으며 기도과민성과 유의한 상관관계가 있다. 그러나 알레르기성 비염에서는 기도과민성 이외의 다른 인자가 호기 NO 농도와 관련성을 가질 것으로 추정되며 향후 이에 대한 연구가 필요하다. Purpose : A new airway inflammatory marker, exhaled nitric oxide(ENO) has been reported to correlate with bronchial hyperresponsiveness(BHR) and atopy. The purpose of this study was to analyze the relationship of ENO with BHR or atopy in patients with asthma and with allergic rhinitis. Methods : The subjects consisted of 55 children with asthma, 17 with allergic rhinitis, and 14 healthy controls. The asthma group was subdivided into the atopic asthma group(n=37) and the nonatopic asthma group(n=18) and the allergic rhinitis group into BHR group(n=7) and non-BHR group(n=10). All were investigated with spirometry and measurements of ENO concentration. The correlations between ENO concentration and both methacholine $PC_{20}$(provocative concentration causing a 20% decrease in forced expiratory volume in one second) and the number of allergen skin test positivity were analyzed. Results : ENO concentrations of both asthma and allergic rhinitis groups were significantly greater than that of control(P<0.01). ENO concentration of atopic asthma was significantly greater than that of nonatopic asthma(P<0.01). In allergic rhinitis, ENO concentration did not differ according to the presence or absence of BHR(P=0.50). ENO concentrations correlated significantly with the number of skin test positivity(r=0.32, P=0.02) or methacholine $PC_{20}$(r=-0.38, P<0.01) in asthma group, but not in the allergic rhinitis group(r=0.42, P=0.09; r=-0.06, P=0.83). Conclusion : In asthma patients, some pathogenetic mechanisms associated with atopy and BHR seem to influence ENO concentration. In allergic rhinitis patients, some factors other than BHR may be important in determining ENO concentration.