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한국산 구멍쟁이버섯과(多孔菌科)에 관한 본초학적(本草學的)연구
박장필 ( Jang Pil Park ),이숭인 ( Soon In Lee ),정종길 ( Jong Gil Jeong ) 대한본초학회 2012 大韓本草學會誌 Vol.27 No.3
Objective: For the purpose of developing Korean herbology of the plants to Polyporaceae in Korea, the literatures of the successive generations have been thoroughly investigated to prepare this article. Methods: The examined herbological books and research paper which published domestically and abroad. Results: 1. Polyporacease plants (raised in Korea) are devided into 31 classes with 59 species. Among them, 26 species in 19 classes were found serviceable, which indicates 44 % of all Polyporacease plants. 2. Among those 59 species, Coriolus·Phellinus·Trametes includes 5 species. Ganoderma, a medicinal plant, includes 3 species. 3. Dividing the serviceable plants of Polyporacease, the fruit body family had the largest number; 25. 4. Out of plants Polyporacease, neutral taste plants was 17 species and sweet taste was 14 species. 5. Only 8 species of Polyporaceae plants were found to enterd into the spleen and heart. 6. 11 species were found to prevent cancer, 7 species were found to dispel wind-dampness and Alleviate edem antittusive and antasth matic. 7. There were no toxic species in the Plyporaceae. Conclusion: There were totaled to 31 genera and 59 species in Polyporaceae in Korea and among them medicinal plants are 19genera, 26 species, some 44% in total.
영지버섯(Ganoderma lucidum)으로 부터 분리한 이차대사산물 및 이들의 항 염증 활성
윤의중,김혜지,구만형,이준혁,서승석 한국생약학회 2019 생약학회지 Vol.50 No.3
Phytochemical study of Ganoderma lucidum (Polyporaceae) let to the isolation of five lanostane triterpenoid (1-5), along with two nitrogen derived phenolic compounds, N-phenylethylformamide (6) and N-acetylphenethylamine (7). The structures of the compounds were determined by 1D and 2D NMR, and MS experiments, as well as by comparison of their data with published values. Compounds 6 and 7 were isolated for the first time from the genus Ganoderma and this species. All the compounds were evaluated for cancer chemopreventive potential based on their ability to inhibit nitric oxide (NO) production induced by lipopolysaccharide (LPS) in mouse macrophage RAW 264.7 cells in vitro. Among the isolates, compounds 2 and 3 showed moderate inhibitory activity against NO production.
Hyo Won Seo,Tran Manh Hung,나민균,정현주,Jin Cheol Kim,최재수,김정희,이형규,IkSoo Lee,배기환,Masao Hattori,민병선 대한약학회 2009 Archives of Pharmacal Research Vol.32 No.11
To determine the anti-complement activity of natural triterpenes, chromatographic separation of the EtOAc-soluble fraction from the fruiting body of Ganoderma lucidum led to the isolation of three steroids and five triterpenoids. They were identified as ergosterol peroxide (1), ergosterol (2), genoderic acid Sz (3), stella sterol (4), ganoderic aic C1 (5), ganoderic acid A (6), methyl ganoderate A (7), and lucidenic acid A (8) based on spectroscopic evidence and physicochemical properties. These compounds were examined for their anti-complement activity against the classical pathway of the complement system. Compounds 2 and 3 showed potent anti-complement activity with IC50 values of 52.0 and 44.6 μM, respectively. Compound 1 exhibited significant inhibitory activity with an IC50 value of 126.8 μM, whereas compounds 4-8 were inactive. Our findings suggested that in addition to the ketone group at C-3, the Δ7(8), Δ9(11)-lanostadiene type triterpene also plays an important role in inhibiting the hemolytic activity of human serum against erythrocytes.
Lee, Sang-Hyun,Shim, Sang-Hee,Kim, Ju-Sun,Kang, Sam-Sik The Pharmaceutical Society of Korea 2006 Archives of Pharmacal Research Vol.29 No.6
Eight compounds were isolated from the fruiting bodies of Ganoderma applanatum, and were identified as 2-methoxyfatty acids (1), 5-dihydroergosterol (2), ergosterol peroxide (3) $3{\beta},7{\beta},20,23{\zeta}-tetrahydroxy-11,15-dioxolanosta-8-en-26-oic$ acid (4), $7{\beta},20,23{\zeta}-trihydroxy-3,11,15-trioxolanosta-8-en-26-oic$ acid (5), cerevisterol (6), $7{\beta},23{\zeta}-dihydroxy-3,11,15-trioxolanosta-8,20E(22)-dien-26-oic$ acid (7), and $7{\beta}-hydroxy-3,11,15,23-tetraoxolanosta-8,20E(22)-dien-26-oic$ acid methyl ester (8) by spectral analysis. All compounds were isolated for the first time from this fruiting bodies, and their effect on rat lens aldose reductase (RLAR) activity was tested. Among these eight compounds, ergosterol peroxide (3) was found to exhibit potent RLAR inhibition, its $IC_{50}$ value being $15.4\;{\mu}g/mL$.
Steroids and Triterpenoid from the Fruit Bodies of Ganoderma lucidum and Their Cytotoxic Activity
Joon Seok Lee,이미경,Ik Soo Lee,배기환,민병선,Tran Manh Hung 한국생약학회 2009 Natural Product Sciences Vol.15 No.3
To determine the cytotoxic activity of natural compounds, chromatographic separation of the hexanesoluble fraction from the fruiting body of Ganoderma lucidum led to the isolation of four steroids and one triterpenoid. They were identified as ergosterol peroxide (1), stella sterol (2), ergosterol (3), 9(11)- dehydroergostrol peroxide (4), and ganodermanontriol (5) based on spectroscopic evidence and physicochemical properties. These compounds were examined for their cytotoxic activity against HL-60, MCF-7, and LLC cancer cell lines. Ganodermanontriol (5) showed cytotoxic activity with IC50 values of 24.8 and 22.9 µg/mL against HL- 60 and MCF-7 cancer cell lines, respectively, whereas compounds 1 - 4 were inactive.
Li, Gao,Xu, Ming-Lu,Lee, Chong-Soon,Woo, Mi-Hee,Chang, Hyun-Wook,Son, Jong-Keun The Pharmaceutical Society of Korea 2004 Archives of Pharmacal Research Vol.27 No.8
The bioactivity-guided fractionation of the methylene chloride extract of the sclerotium of Poria cocos led to the isolation of (S)-(+)-turmerone (1), ergosterol peroxide (2), polyporenic acid C (3), dehydropachymic acid (4), pachymic acid (5), and tumulosic acid (6). Compounds 4-6 exhibited moderate cytotoxicities, with $IC_{50}$ values of 20.5, 29.1, and $10.4{\;}\mu\textrm{m}$, respectively, against a human colon carcinoma cell line. However, 3-6 not only showed inhibitory activities as potent as etoposide used as a positive control on DNA topoisomerase II (36.1, 36.2, 43.9 and 66.7% inhibition at a concentration of $20{\;}\mu\textrm{m}$, respectively), but also inhibition of DNA topoisomerase I (55.8, 60.7, 43.5, and 83.3% inhibition at a concentration of $100{\;}\mu\textrm{m}$, respec-tively).
Antitumor Constituents of Polyporus giganteus
Kim, Byong-Kak,Shim, Mi-Ja,Kim, Ha-Won,Woo, Myoung-Sik,Choi, Eung-Chil The Pharmaceutical Society of Korea 1987 Archives of Pharmacal Research Vol.10 No.3
To investigate antitumor constituents of higher fungi, the carpophores of Polyporus giganteus Pers. ex. Fr. (81 g, dry weight) which were collected in Indiana, U. S. A. were examined for antitumor activity. Two protein-bound-polysaccharide fractions (I and II) were prepared from the hot water extract and one fraction (III) from the 0.1 N NaOH extract of the carpophores. The antitumor effect of each fraction was tested against sarcoma 180 implanted subcutaneously in female ICR mice. Of three fractions, Fraction II showed 85.2% inhibition ratio at the dose of 20 mg/kg/day for 10 days and was named gigantan. Gigantan was found to contain 59% polysaccharide and 27% protein. Its polysaccharide moity was a heteroglycan that consisted of mainly glucose (89.3%), galactose (7.7%), minaose (2.0%) and fructose (1.0%).
Cytotoxic Triterpenoids from the Fruiting Bodies of Ganoderma lucidum
Nguyen The Tung,우미희,Tran Thi Thu Trang,TODAO CUONG,NGUYENVAN THU,민병선 한국생약학회 2014 Natural Product Sciences Vol.20 No.1
Twelve triterpenoids (1 - 12) were isolated from CHCl3-soluble fraction of fruiting bodies of Ganoderma lucidum. Extensive spectroscopic and chemical studies established the structures of these compounds as butyl lucidenate P (1), butyl lucidenate E2 (2), butyl lucidenate D2 (3), butyl lucidenate Q (4), ganoderiol F (5), methyl ganoderate H (6), methyl ganoderate J (7), lucidumol B (8), ganodermanondiol (9), methyl lucidenate N (10), methyl lucidenate A (11) and butyl lucidenate N (12). All of the compounds were examined for their cytotoxic activity against HL-60, HeLa, and MCF-7 cancer cell lines. Among them, compounds 4 and 8 showed cytotoxic activity with IC50 values of 6.6 and 1.6 ?M against HL-60, respectively. In addition, compound 8 also showed cytotoxic activity with IC50 values of 2.0 ?M against HeLa cancer cell line, other compounds were moderate or inactive.
Lee, Seulah,Lee, Dahae,Lee, Sung Ok,Ryu, Ja-Young,Choi, Sang-Zin,Kang, Ki Sung,Kim, Ki Hyun Elsevier 2017 Journal of Functional Foods Vol.32 No.-
<P><B>Abstract</B></P> <P> <I>Poria cocos</I> Wolf confers large, edible sclerotia, known as ‘Indian bread’ in North America. Chemical investigation of EtOH extract of the sclerotia of <I>P. cocos</I> resulted in the identification of four new lanostane triterpenoids (<B>1–4</B>), coriacoic acids A-D, and 10 known compounds (<B>5–14</B>). The structures of the new compounds were determined by spectroscopic analysis, including 1D and 2D NMR spectra, and HRMS. Among the known isolates, compounds <B>8</B> and <B>13</B> were isolated for the first time from <I>P. cocos</I>. All compounds <B>1–14</B> were tested for their inhibitory effects on nitric oxide (NO) production in lipopolysaccharide (LPS)-activated RAW264.7 macrophages. Compounds <B>1</B>, <B>2</B>, <B>6</B>, <B>12</B>, and <B>14</B> inhibited NO production with IC<SUB>50</SUB> values ranging from 49.43 to 82.32μM. Among them, compound <B>14</B> was the most active compound, and its anti-inflammatory effect was found to be mediated through the inhibition of iNOS and COX-2 expression via downregulation of NF-kappaB.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Fourteen lanostane triterpenoids were identified from the sclerotia of edible fungus <I>Poria cocos</I>. </LI> <LI> Four new lanostane triterpenoids (<B>1</B>–<B>4</B>) were structurally elucidated. </LI> <LI> Compounds <B>8</B> and <B>13</B> were isolated for the first time from <I>P. cocos</I>. </LI> <LI> Compounds <B>1</B>, <B>2</B>, <B>6</B>, <B>12</B>, and <B>14</B> inhibited NO production in LPS-activated RAW264.7 macrophages. </LI> <LI> The mechanism of action for the most active compound <B>14</B> was examined. </LI> </UL> </P>