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돼지 H-FABP 유전자의 다형성 및 경제 형질과의 연관성 구명
최봉환,김태헌,이지웅,조용민,이혜영,조병욱,정일정 한국동물자원과학회 2003 한국축산학회지 Vol.45 No.5
The purpose of this study was to detect association between genetic variation and economic trait in the porcine heart type fatty acid-binding protein gene as a candidate gene for the traits related with growth and meat quality in pigs. The H-FABP is a 15-kDa protein expressed in several tissues with high demand for fat metabolism such as cardiac and skeletal muscle and lactating mammary gland. H-FABP is small intracellular protein involved in fatty acid transport from the plasma membrane to the site of β-oxidation and/or triacylglycerol or phospholipid synthesis. In this study, H-FABP PCR-RFLP was performed in F_(2) population composed of 214 individuals form an intercross between Korean Native Boars and Landrace sows. PCR products form tow primer sets within H-FABP gene were amplified in 850bp and 700bp. Digestion of PCR products with the restriction digestion enzymes HaeⅢ and Hinf Ⅰ, revealed fragment length polymorphisms(RFL. Ps). The genotype frequencies from H-FABP/HaeⅢ was .29 for genotype DD, .53 for genotype Dd, and .15 for genotype dd, respectively. The genotype frequencies of HH, Hh, and hh from H-FABP(hinf Ⅰ was .38, .41, and .20, respectively, in the population.Relationships between their genotypes and economic traits were estimated. In H-FABP/HaeⅢ locus, there were specific genotypes(Dd and dd) associated with economic traits such as body weight. In H-FABP/Hinf Ⅰ Iocus, Genotypes of HH and Hh associated with growth traits such as body weights at 5, 12, and 30 week of age (p<.05 or p<.001) and back fat thickness, body fat including abdominal and trimmed fat (p<.001) and intramuscular fat(p<.05). The 'H'allele was positivecly associated with gaining of body weight and fatness deposition. In conclusion, a significant association of the H-FABP gene from its genetic variation was found on body weight, intramuscular fat and backfat thickness.
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A Study on /h/-deletion in Korean
( Hong Won Seo ) 대한언어학회 2014 언어학 Vol.22 No.3
The goal of this paper is to investigate some aspects of /h/-deletion in Korean within the framework of Optimality Theory. Although many studies have been conducted regarding /h/-deletion in Korean phonology, some problems have not been satisfactorily solved until now. In particular, /h/ can be optionally deleted intervocalically in h-regular stems, while /h/ must be deleted obligatorily in h-irregular stems. For instance, only [noramy?n], rather than *[norah?my?n] is a possible form irrespective of any speech rate; however in case of h-regular stems, three forms such as [coh?my?n], [co?my?n], and [co:my?n] can be attested depending on the speech rate. In order to account for two different asymmetries, we approach the analysis for /h/-deletion by positing two different underlying structures and by ranking combinations of constraints. This study has more explanatory advantages than the previous analyses, in that a few alternants of h-regular verbs can be dealt with by the proper constraint ranking hierarchy within the framework of OT and the limitations of the constraint, *vhv governing the fact that intervocalic /h/ is not allowed, can be overcome by positing the different underlying structures
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소화효소가 Helicobacter pylori의 증식과 공포화독소 생성에 미치는 영향
홍대식,강경희,장명웅 고신대학교(의대) 고신대학교 의과대학 학술지 2001 고신대학교 의과대학 학술지 Vol.16 No.1
Background : Global high prevalence rate of Helicobacter pylori infection is well-known fact. However, a large discrepancies exist between the diagnostic data obtained by the PCR and culture method, because the coccoid form of H.pylori which represent the majority form in the biological samples are not viable in the standard BHI broth with 5% horse serum. The component parts of saliva and gastric juice acted as neither stimulator nor inhibitor to the growth of H.pylori remain unclear. Objective : The purpose of this study was to evaluate the influence of amylase, pepsin, mucin, and lysozyme on the growth and vacuolating toxin production and titer of H.pylori in vitro. Materials and Methods : H.pylori 13,39,46,59,72,94,98 and 125 strains were isolated from patients with gastric disease. The digestive enzymes were inoculated in the 5% horse serum-BHI broth following final concentration of amylase (A; 0.20ug/ml), pepsin (P; 0.25ug/ml), mucin (M; 2,5ug/ml), and lysozyme (L; 1.5ug/ml). The vacuolating toxin titers of the culture supernatant were evaluated in the monolayer culture of RK-13 cells. Results : The morphologic conversion from bacillary to horse-shoe to coccoid forms of H.pylori was observed in the BHI broth containing 5% horse serum on day 5 culture. Half of H.pylori was changed from bacillary to coccoidal form on day 7 culture, most population of H.pylori was changed to coccoidal form on day 10 culture, and almost all H.pylori was changed to coccoidal form on day 14 culture. The growth of H.pylori 72, and 94 strains was increased in BHI broth containing each enzyme such as amylase, pepsin, mucin and mixture of two or three enzymes on day 5 and 7 culture. The growth of H.pylori 94 strains was increased in BHI broth containing each enzyme such as amylase, pepsin, mucin, and mixture of two or three enzymes on day 10 and 14 culture. The vacuolating toxin production of H.pylori strains was not influenced by the addition of amylase, pepsin, mucin, and lysozye or mixture of two or three enzymes. The neutralization of vacuolating toxin of H.pylori was not affected by the addition of amylase, pepsin, mucin, and lysozyme or mixture of two or three enzymes. Conclusion : We found that coccoid forms of H.pylori were viable in the standard 5% horse serum BHI media in the presence of amylase, pepsin, mucin, and lysozyme. The present study demonstrates that gastric juice of the stomach supports the viability of H.pylori and that oral route of infection is a plausible hypothesis. This work also demonstrates that gastric environment may not provide a selective advantage for the toxigenic strains of H.pylori.
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Hyun Ju Song,Ji Hoon Jeong,Dong Kyu Lee,Tai Sang Lee,Young Sil Min,Uy Dong Sohn 대한생리학회-대한약리학회 2004 The Korean Journal of Physiology & Pharmacology Vol.8 No.6
Recent data have shown the importance of oxidative stresses in the pathogenesis of inflammatory bowel disease, crohn s disease and ulcerative colitis. H<SUB>2</SUB>O<SUB>2</SUB>, reactive oxygen species (ROS) donor, has been reported to act as a signaling molecule involved in a variety of cellular functions such as apoptosis and proliferation. In the present study, we investigated viability of cultured ileal smooth muscle cells (ISMC) after stimulation with H<SUB>2</SUB>O<SUB>2</SUB>. Trypan blue method revealed that the cell viability of ISMC treated with 1 mM H<SUB>2</SUB>O<SUB>2</SUB> was not different from that of controls at up to 2 h time point, while treatment of ISMC with 1 mM H<SUB>2</SUB>O<SUB>2</SUB> for 48 h finally induced significant decrease in the cell viability. Therefore, we evaluated whether H<SUB>2</SUB>O<SUB>2</SUB> was capable of ERKs activation in ISMC for the short-term exposure and examined whether tyrosine kinase was involved in the process of ERK activation by H<SUB>2</SUB>O<SUB>2</SUB> in ISMC. We also investigated the effects of H<SUB>2</SUB>O<SUB>2</SUB> on activation of SAPK/JNK and p38 MAP kinase in ISMC. Thus, ISMC were cultured and exposed to H<SUB>2</SUB>O<SUB>2</SUB>, and western blot analysis was performed with phospho- specific MAP kinase antibodies. Robust activation of ERK occurred within 30 min of 1 mM H<SUB>2</SUB>O<SUB>2</SUB> treatment. H<SUB>2</SUB>O<SUB>2</SUB>-induced ERK activation was attenuated by a tyrosine kinase inhibitor, genistein, indicating that tyrosine kinase was probably involved in the ERK activation by H<SUB>2</SUB>O<SUB>2</SUB>. H<SUB>2</SUB>O<SUB>2</SUB> was a moderate activator of SAPK/JNK, while p38 MAP kinase was not activated by H<SUB>2</SUB>O<SUB>2</SUB>. We suggest that ERK activation induced by short-term H<SUB>2</SUB>O<SUB>2</SUB> treatment plays a critical role in cellular protection in the early stage of response to oxidative stress. The present study suggests the necessity of identification of MAPK signaling pathways affected by ROS, since it could ultimately elucidate cellular consequences involved in initiation and perpetuation of intestinal tissue damage in the diseases such as crohn s disease and ulcerative colitis, resulted from excessive ROS.
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Kang, Jin,Kim, Yea Woon,Kim, AeRi Elsevier 2018 Biochimica et biophysica acta. Gene regulatory mec Vol.1861 No.7
<P><B>Abstract</B></P> <P>Histone variants H3.3 and H2A.Z are often enriched in enhancers and transcriptionally active genes. However, the incorporation dynamics of these variants and the mechanisms of their incorporation are unclear. Here, we examined the distribution of H3.3 and H2A.Z in the human β-globin locus and analyzed their incorporation dynamics during transcription activation. Locus control region hypersensitive sites (LCR HSs), acting as enhancers, and active globin genes were enriched by H3.3 and H2A.Z in erythroid K562 cells, but inactive globin genes were not. Both variants were dynamically incorporated into the β-globin locus after transcription induction in MEL/ch11 cells, and prior to gene transcription the LCR HSs became enriched with the variants. In the activated β-globin gene, H3.3 was highly incorporated during transcription, whereas H2A.Z incorporation appeared to precede it. To further explore the relationship between gene transcription and variant incorporation, we deleted the LCR HS3 enhancer or the β-globin proximal promoter from the β-globin locus using the CRISPR-Cas9 genome editing system. H2A.Z was incorporated into the β-globin gene in the locus lacking promoter, even though the β-globin gene transcription was abolished by these deletions. However, H3.3 incorporation was reduced in the untranscribed β-globin gene. These results suggest that H3.3 and H2A.Z are systematically incorporated into the LCR enhancer and β-globin gene as part of transcription activation, but that their incorporation is carried out via different mechanisms.</P> <P><B>Highlights</B></P> <P> <UL> <LI> The β-globin LCR HSs and active globin gene are enriched by histones H3.3 and H2A.Z. </LI> <LI> H3.3 & H2A.Z are incorporated into the HSs and gene during transcription induction. </LI> <LI> H3.3 incorporation into the β-globin gene is reduced by lack of proximal promoter. </LI> <LI> However, H2A.Z incorporation into the gene is not affected by the lack of promoter. </LI> </UL> </P>
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Chengtang Liu,Huaming Li,Hui Xu,Ling Liu,Li Xu,Zhixiang Ye 한국화학공학회 2011 Korean Journal of Chemical Engineering Vol.28 No.4
Na_8Nb_6O_19.13H_2O particles were synthesized by a simple hydrothermal method. The catalysts were characterized by X-ray diffraction (XRD), scanning electronic microscopy (SEM) and thermogravimetric and differential scanning (TG-DSC). The XRD and TG-DSC analyses indicated that Na_8Nb_6O_19.13H-2O was an intermediate hexaniobate during the preparation of NaNbO_3 powders. Methylene blue (MB) dye degradation using Na_8Nb_6O_19.13H_2O/H_2O_2,Nb_2O_5/H_2O_2 and NaNbO_3/H_2O_2 systems were investigated, respectively. Among the catalytic oxidation systems, Na_8Nb_6O_19·13H_2O showed the highest activity for degradation of MB in the presence of H_2O_2. The results indicated that the dye degradation efficiency could be 93.5% at 30 ℃ after 60 min in the presence of the Na_8Nb_6O_19·13H_2O/H_2O-2 system. It was also found that the degradation of MB over the catalytic systems followed pseudo-first-order kinetics, and the degradation rate was 0.02376 min−1 in the Na_8Nb_6O_19.13H_2O/H_2O_2 system, which was higher than that in the Nb_2O_5/H_2O_2and NaNbO_3/H_2O_2 systems. A possible mechanism for MB catalytic oxidation degradation using the Na_8Nb_6O_19.13H-2O/H_2O_2 system was proposed.
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류승훈 ( Sung Hun Ryu ),최원석 ( Won Seok Choi ),김건완 ( Gun Wan Kim ),도제성 ( Je Sung Do ),유명우 ( Myung Ho Yoo ) 한국고무학회 2011 엘라스토머 및 콤포지트 Vol.46 No.2
In the present investigation, thermal aging behavior of H-NBR/NBR blend with various H-NBR content was investigated. Mixture of dicumyl peroxide and sulfur were used as a curing agent. The influence of the thermal aging of the H-NBR/NBR blends on the solid state properties such as tensile strength, elongation at break, hardness and abrasion resistance was investigated. Tensile strength was increased with increasing H-NBR content, while abrasion resistance was decreased. Both elongation at break and hardness were not affected by the addition of H-NBR. The properties such as hardness, tensile strength and elongation at break of the aged samples were lower than unaged samples. However, the rate of deterioration of those properties was decreased by increasing the H-NBR content, which indicated that improved thermal aging behavior was obtained by the addition of H-NBR. Abrasion loss was increased with increasing aging time, but it became less by the addition of H-NBR addition. 본 연구는 H-NBR 함량 변화에 따른 H-NBR/NBR 블렌드의 열노화 거동에 대하여 살펴보았다. 이 때 가교제로는 dicumyl peroxide와 황 혼합물을 사용하였으며, 열노화에 따른 H-NBR/NBR 블렌드의 인장강도, 파괴신율, 경도 그리고 내마모성의 변화를 살펴보았다. H-NBR을 첨가함에 따라 인장강도는 증가하였으나 내마모성은 감소하는 현상을 나타내었다. 파괴신율과 경도는 H-NBR의 영향을 받지 않았다. 노화가 진행된 모든 시편은 초기 시편보다 낮은 인장강도, 파괴신율, 경도를 나타내었다. 그러나 H-NBR의 함량이 증가함에 따라 이러한 물성저하 속도가 감소함을 알 수 있었다. 즉 H-NBR 첨가에의해 열노화 특성이 향상됨을 알 수 있었다. 모든 NBR/H-NBR 블렌드는 노화시간이 증가함에 따라 내마모성이 감소하였으며, H-NBR을 첨가한 경우 내마모성의 저하가 상대적으로 낮음을 알 수 있었다.
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