고령자 급성 췌장염의 임상적 고찰

백용한,서정훈,송건훈,이진헌,송시영,정재복,강진경,박인서,이수진 大韓消化器病學會 1998 大韓消化器病學會誌 Vol.32 No.3

정신분열병에 대한 리스페리돈의 효과 및 안정성

이민수,김용구,김영훈,연병길,오병훈,윤도준,윤진상,이철,정희연,강병조,김광수,김동언,김명정,김상훈,김희철,나철,노승호,민경준,박기창,박두병,백기청,백인호,손봉기,손진욱,양병환,양창국,우행원,이정호,이종범,이홍식,임기영,전태연,정영조,정영철,정인과,정인원,지익성,채정호,한상익,한선호,한진희,서광윤 大韓神經精神醫學會 1998 신경정신의학 Vol.37 No.1

연구목적 : 본 시험의 목적은 임상시험 시작전에 연구자들을 대상으로 PANSS Workshop을 통하여 PANSS, ESRS에 대한 국내에서의 표준화 작업을 구축하고 새로운 정신병 치료제인 리스페리돈의 효과와 안정성을 재확인하여 리스페리돈 사용에 대한 적정화를 이루는데 있다. 연구방법 : 1996년 4월부터 1996년 9월까지 국내 39개 대학병원 정신과에 입원중인 혹은 증상이 악화되어 입원하는 정신분열병 환자 377명을 대상으로 다시설 개방 연구를 시행하였다. 1주일간의 약물 배설기간을 가진후, 리스페리돈을 8주간 투여하였고, 기준점, 1주, 2주, 4주, 그리고 8주후에 평가되었다. 용량은 제1일에는 리스페리돈 1mg씩 1일 2회, 제2일에는 2mg씩 1일 2회, 제3∼7일에는 3mg씩 1일 2회 투여하였다. 이후 환자의 임상상태에 따라 임의로 증량할 수 있으며, 최대 일일 16mg을 초과하지 않도록 하였다. 추체외로 증상을 조절하기 위한 투약을 허용하였다. 임상증상 및 부작용의 평가는 PANSS(Positive and Negative Syndrome Scale), CGI(Clinical Global Impression) 그리고 ESRS(Extrapyramidal Symptom Rating Scale)을 사용하였다. 연구결과 : 377명중 343명(91%)이 8주간의 연구를 완결하였다. 치료 종결시점인 8주후 PANSS 총점수가 20% 이상 호전된 경우를 약물 반응군으로 정의할때, 약물반응군은 81.3%였다. 리스페리돈에 반응하는 예측인자로는 발병연령, 이전의 입원 횟수, 유병기간이 관련 있었다. 리스페리돈은 1주후부터 PANSS양성, 음성, 및 일반정신병리 점수상에 유의한 호전을 보여 효과가 빨랐다. CGI의 경우도 기준점에 비해 1주후부터 유의한 감소를 나타내었다. ESRS의 경우, 파킨슨 평가점수는 기준점과 비교해 투여 1주, 2주, 4주후 유의하게 증가되었다가 8주후 기준점과 차이가 없었다. Dystonia 평가점수는 1주후만 유의한 증가를 보였으며, dyskinesia 평가점수는 유의한 차이가 없었다. 혈압, 맥박수의 생명징후 및 일반 혈액학 검사, 생화학적 검사, 심전도 검사에서 유의한 변화는 없었다. 결 론 : 이상의 다시설 개방 임상 연구를 통해 리스페리돈은 정신분열병 환자에서 양성증상뿐만 아니라 음성증상 및 전반적인 증상에도 효과적인 것으로 사료된다. 보다 명확한 평가를 위해서는 다른 항정신병약물과의 이중맹검 연구가 필요할 것으로 생각되며, 또한 장기적 치료에 대한 평가도 함께 이루어져야 하겠다. Objective : The purpose of this study was to investigate the efficacy and safety of risperidone in the treatment of Korean schizophrenic patients. Method : This multicenter open study included 377 schizophrenic patients drawn from 39 university hospitals. After a wash-out period of 1 week, the schizophrenic patients were treated with risperidone for 8 weeks and evaluated at 5 points ; at baseline, and 1, 2, 4 and 8 weeks of treatment. The dose was increased from 2mg/day(1mg twice daily) to 6mg/day(3mg twice daily) during the first week and adjusted to a maximum of 16mg/day over the next 7 weeks according to the patient's clinical response. Medication to control extrapyramidal symptoms was permitted. The psychiatric and neurological status of the patients was assessed by PANSS, CGI, and ESRS scales. Results : 343(91%) of 377 patients completed the 8-week trial period. Clinical improvement, as defined by a 20% or more reduction in total PANSS score at end point, was shown by 81.3% of patients. The predictors of response to risperidone were associated older age, shorter duration of illness, fewer previous hospitalization. Risperidone had rapid onset of action ; a significant decrease of the total PANSS and three PANSS factor(positive, negative, general), and CGI was already noticed at the end of first week. For the ESRS, parkinsonism rating scores were significantly increased until week 4 comparing with baseline. Dystonia rating scores were significantly increased until week 1, and dyskinesia rating scores were not significantly changed during the study. Laboratory parameters including vital sign, EKG, hematological, and biochemical values showed no significant changes during the trial. Conclusions : This study suggests that risperidone is generally safe and effective against both the positive and negative symptoms in our group of patients.

쇄골하 정맥 카테터 제거 후 발생한 일과성 피질맹

김지훈,이규환,한시령,최영빈,김영인 대한신경과학회 1999 대한신경과학회지 Vol.17 No.5

신생아에서의 HDL-C와 LDL-C 値에 관한 연구

한병길,정용헌 충남대학교 의과대학 지역사회의학연구소 1996 충남의대잡지 Vol.23 No.1

The values of serum HDL-C and LDL-C were measured in 70 newborn infants with gestational ages from 35-43 weeks, birth weight from 2000 to 4500 gm, Apgar score 7 or more at 1 & 5 minutes and normal physical examination. 1. In all newborn infants, the mean HDL-C values & ranges were 31.99 ±6.67 mg/dl, from 21.5 to 49.8mg/dl, and the mean LDL-C values & ranges were 41.42 ±21.39mg/dl from 15.1 to 94.3mg/dl. 2. In term newborns with AGA, the mean HDL-C & LDL-C values were 32.85 ±6.75mg/dl and 45.85 ±21.39mg/dl respectively. 3. The HDL-C and LDI-C values of female were significantly higher than those of male. 4. The correlation of HDL-C by weight for gestational age was not significant, but that of LDL-C value was significantly lower in SGA than those of AGA & LGA. 5. The correlations of HDL-C & LDL-C according to birth weight, gestational age and Ponderal Indices were not significant.

스피커 특성 및 오차경로의 온라인 인식을 이용한 새로운 적응 능동소음제어

한찬호,최덕규,정영헌 경운대학교 산업기술연구소 2001 産業技術硏究論文誌 Vol.3 No.2(B)

In active noise control system, the error path transfer function is much more likely to change rapidly due to in temperature or flow rate. The loudspeaker response also changes due to aging and the other factors. Therefore, an improved solution to obtaining both the loudspeaker and the error path transfer functions on an on-line basis is required. In this paper, a new filtered-X least mean square(LMS) algorithm considering the loudspeaker and the error path characteristics is proposed for active noise control system. The transfer functions of the loudspeaker and the error path are obtained by an adaptively estimated error signal and the error path output signal on an on-line basis. In the computer simulation using the sinusoidal and the practical duct noise, the proposed algorithm reduces noise level about 29.1dB and 10.4dB, respectively. We observed an improvement of about 2.5dB in noise level compared with that obtained using the Eriksson's filtered-X LMS algorithm.

흰쥐 중격핵의 아미노산 함량에 대한 해마 제거의 영향

한영길,김종규,양훈모 순천향의학연구소 1995 Journal of Soonchunhyang Medical Science Vol.1 No.2

A study was planned to analyze amino acid in target structure -the septal mucleus-of hippocampectomized rats by high-performance liquid chromatograph (HPLC). 33 female rats were divided into 3 groups, of which 8 rats had their hippocampal tissue on both sides removed through an opening in the parieto-occipital cortex (hippocampal group), 7 rats received damage to the parieto-occipital cortex only (cortical control group), and 8 rats serveed as normal control animals. One week later, the animals were sacrificed by decapitationin the cold room. Two to three mg of tissue was obtained from the septal nucleus in one side of the brain. The tissue three mg of tissue was obtained from the septal nucleus in one side of the brain. The tissue samples were homogenized in 200 of 0.5M perchloric acid in 1mM EDTA with ground-glass homogenizers. After centrifugation at 3.500 rpm for 15 min, an aliquot of 80 supernatant was neutralized with 40㎕ of 2.0M KHCO and then centrifuged again at 3,500 rpm for 10min. An aliquot of 20㎕ was taken and diluted with 350㎕ β-mercaptopropionic acid in 10 ml of 100 mM sodium borate buffer (Ph 9.1) and 350㎕ of OPA solved in ethanol which was diluted with 10ml of 100 mM sodium borate buffer (Ph 9.1) Then 400㎕ of the resulting sample was injected auto injector. Peak areas were automatically integrated and calculated by chromatopac. In the septal nucleus, aspartate increased a little in the hippocampla group and the cortical control group than in the normal control group . while there were no significant difference between the 3 groups. Glutamate decreased significantly in the hippocampla group than in the normal control group (P<0.001) and the cortical control group (P<0.005), while there were no significant difference between the 2 control groups. In the serine, glycine, threonine and alanine, the differences among 3 group values were nonsignificant. It is inferred from the above mentioned results that excitatory transmitter substances employ the glutamate in the septal nucleus, and that the hippocampus was facilitatory to the septal nucleus.

UCC를 통한 효율적인 안전교육 방안

한영근,김성훈,이동녘,구범회,김연범 明知大學校 産業技術硏究所 2008 産業技術硏究所論文集 Vol.27 No.-

There are many potential dangers around our life, but we are laking in the consciousness of safety because accidents do no happen frequently. If an accidents occurs, an ability to deal with it is so weak that it can be enlarges to a disaster. Therefore it is important to accustom ourselves to manage dangers and this can be realized by traing. In this study, the traditional traing methodologies are compared and analyszed in order to find an efficient traing way for the public. Also, we propose a traing method by using UCC(User Created Contest) which is a growing communication and content tool in the Internet environment nowadays.

골프선수들의 심리적(PSIS) 비교 분석에 관한 연구

한정훈,배진희,최영수 한국스포츠리서치 2004 한국 스포츠 리서치 Vol.15 No.3

The purpose of this study was to compare the PSIS factors and to development the norms of golf players in competition. Subjects were 180 golf players. For PSIS adopted Mahoncy(1989) was used in this research. The main findings of this study were as follows. First, there was significant mean difference in the confidence factor between university and business players, however there were no differences in other factors. Second, there was significant mean difference in the confidence factor among under 3.48th, 3.49th~9.65th years by career, however there were no differences in other factors. Third, there was significant mean difference in the confidence factor between one and none by representative career, however there were no differences in other factors. Fourth, there were 11~26 norm scores of university players and 17~28 norm scores of business players in the anxiety factor. Fifth, there were 6~20 norm scores of university players and 7~18 norm scores of business players in the concentration factor. Sixth, there were 12~27 norm scores of university players and 16 ~27 norm scores of business players in the confidence factor. Seventh, there were 4~20 norm scores of university players and 10~23 norm scores of Eighth, there were 9 ~23 norm scores of university players and 10~23 norm scores of business players in the motivation factor. Ninth, there were 5~18 norm scores of university players and 9~18 norm scores of business players in the team emphasis factor.

전자 빔 프로파일에 의한 밝은 영역에서의 명암 보정

한찬호,정영헌,최덕규 경운대학교 산업기술연구소 2001 産業技術硏究論文誌 Vol.3 No.2(B)

In this paper, we present a compensation method of contrast loss in highly bright region by CPT beam profile. In the proposed method, the local difference signal for the compensation is transformed according to the local mean of luminance. In computer simulation, clear image is obtained by the compensation of contrast loss in highly bright region.

KRISS의 광 측정시스템을 이용한 단일모드 광섬유의 색분산 및 편광모드분산 측정과 불확도 평가

이성헌,김용평,유한영,서호성 慶熙大學校 레이저 工學硏究所 2007 레이저공학 Vol.18 No.-

We demonstrate the uncertainty comparison and analysis of NPL chromatic dispersion(CD) and NIST polarization mode dispersion(PMD) Certified Reference Material(CRM) in the KRISS. The uncertainty of each quantity was evaluated as the combined standard uncertainty multiplied by a coverage factor k=2. Modulation phase shift techniques are used to measure CD in the 1300 nm and 1500 nm region , PMD in the 1500 nm region. CD and PMD uncertainty are 2.64 ps/nm · km, 0.002 ps, respectively. The measurement uncertainty was a good agreement between CD & PMD CRM and PDLA system of KRISS.