요관압 상승시 신혈류량 조절에 prostaglandin이 미치는 효과

민영기,양훈모,김종규,이석호 순천향의학연구소 2001 Journal of Soonchunhyang Medical Science Vol.7 No.1

Higher ureteral pressure than in normal condition causes increase in renal blood flow (RBF) and partial impairment of the autoregulation of RBF. Higher ureteral pressure increased renal prostaglandin production, it is not clear whether or not it is also responsible for partial impairment of the autoregulation of RBF. Therefore, we investigated the role which prostaglandin play in the autoregulation of RBF, studying the interaction between ureteral pressure and RBF autoregulation may reveal the role of prostaglandin in tubuloglomerular feedback. For the purpose of this experiment, six anesthetized mongrel dogs were prepared for the measurements of RBF, mean systemic and renal arterial pressure (RAP) and the manipulation of ureteral pressure to 0 cmH20, 20 cmH20 and 40 cmH20. The autoregulation curves were determined during both control and elevation of the ureteral pressure, before and after the pretreatment with indomethacin, a cyclooxygenase inhibitor. The desired ureteral pressure was achieved by vertically elevating the water-filled reservoir connected to the ureteral catheter to 20 cm and 40 cm above the kidney level. In response to the elevation of the ureteral pressure, RBF increased from 167±11 ml/min to 185±8 ml/min, 204±11 ml/min respectively and the renal arterial pressure and the systemic arterial pressure didn't change significantly. During 0 mmHg of ureteral presure threshold pressure of RBF autoregulation was 59±3 mmHg. On the other hand, during 20 cmH20, 40 cmH20 of ureteral pressure, the autoregulation curves shifted upward and rightward from control, threshold pressure is elevated by 74±3 mmHg. The pretreatment of the dogs with indomethacin failed to affect the lower limit of RBF autoregulation during both control (63±5 mmHg) and the elevated ureteral pressure (77±5 mmHg). Since RBF failed to increase in response to the elevated ureteral pressure, RBF autoregulation curves obtained during the elevated ureteral pressure shifted only rightward from indomethacin control. The results indicate that the increased intrarenal level of prostaglandin by increased ureteral pressure or prostaglandin-induced vasodilation does not appear to bear any relation to the reduction in the autoregulatore capacity during elevated ureteral pressure. It seems that the partial impairment of the autoregulation during acute ureteral obstruction is due to the consumption of tubuloglomerular feedback mechanism at 0 mmHg of ureteral pressure and that prostaglandin is neither mediator nor effector of tubuloglomerular feedback mechanism.

播種과 收穫時期에 따른 들깨(Perilla ocymoides)의 脂肪酸 組成變化

梁敏錫,全永式 慶尙大學校 1987 論文集 Vol.26 No.1

播種 및 收穫時期에 따른 들깨의 脂肪酸 組成 變化를 要約하면 다음과 같다. 1.油脂含量은 5月30日 播種區와 10月5日 收穫區에서 가장 높았다. 2.總 脂質의 主要脂酸은 palmitic, oleic, linoleic, linolenic acid로 이中linolenic acid의 含量이 가장 많았다. 3.不飽和度 및 C?/C? 比는 播種적기인 5月30日과 10月5日이 가장 높았다. 4.結合形態別 脂質은 植物脂質의 저장形態인 triglyceride의 含量이 가장 높았으며 主要脂?은 linolenic acid였는데 播種時期가 늦어질수록 增加하는 傾向이었다. 5.本 硏究의 結果로 南部地方의 播種 및 收穫 적기는 各各 5月30日과 10月5日로 생각된다. This experiments are carried out obtain the effects of different snowing and harvesting dates on the oil contents and fatty acids compositions of perlla cultivar. Total lipid was extracted from perilla seed with diethylether and sepsarated into glycolipid, sterylester, triglyceride, free fatty acid and phospholipid. Fatty acids compositions of each fraction of lipid were analyzed by gas chromatography(GLC). The results are summrized as follow: Oil contents were the highest at snowing treatment on May 30 and harvesting treatment on Oct, 5. Main fatty acid Compositions of total lipid were palmitic, oleic, linoleic and linolenic acid. Linolenic acid was the highest. Ratio of UFA/SFA and C?/C? were the highest at sowing date May 30 and harvesting date Oct.5. Trglyceride was predominant composition of total lipid and main fatty acid was linolenic acid as snowing dates delayed, its contents decreased. As a result of study, an opportunity of sowing and harvesting dates were regarded as on May 30 andOct. 5 in Southern District.

그람음성 간균의 수술후 상기도 정착에 관한 연구

석민호,김완식,조양자 한양대학교 의과대학 1987 한양의대 학술지 Vol.7 No.1

Upper respiratory colonization and subsequent postoperative pneumonia caused by gram-negative bacilli are increased in patients undergoing surgical procedure. The present study was to investigate the effect of surgical procedure on postoperative respiratory colonization and subsequent infection caused by gram-negative bacilli. Among patients undergoing various major and minor operations at Hanyang university hospital during the months of November and December of 1985, 50 patients were chosen to evaluate the changes in upper respirtory colonization by gram-negative bacilli and receptivity of buccal epithelial cells to Pseudomonas aeruginosa, a common respiratory colonizer and pathogen. Upper respiratory colonization by gram-negative bacilli was significantly increased from preoperative 10% (5/50) to postoperative 29% (13/45). Klebisiella pneumoniae was the most frequent postopertative isolate (4 strains). Viability of buccal epithelial cells was decresed postoperaively (P<0.05). Receptivity of buccal epithelial cell to Pseudomonas aeruginosa was increased postoperatively (P<0.001) in mean numbers of attached bacteria per cell and in numbers of cells with minimal numbers of attached bacteria and these two parameters were extremely correlated (=0.999). Upper respiratory colonization rate of gram-negative bacilli and increase in receptivity of buccal epithelial cells to Pseudomonas aeruginosa was significantly greater in patients whose operation took more than 2 hours than in those whose operation lasted less than 2 hours (P<0.001). Data obtained in the present study suggest that changes in surface binding properties of upper respiratory epithelium may be an important factor in predisposing to postoperative respiratory infection by gram-negative bacilli.

enalapril의 혈압하강효과에 대한 renomedullary depressor system의 역할

민영기,양훈모,김종규,이석호 순천향의학연구소;Soonchunhyang Medical Research Institute 2000 Journal of Soonchunhyang Medical Science Vol.6 No.1

It has long been recognised that renin-angiotensin system(RAS) takes part in blood pressure control. It was previously known that the physiological effects of the renomedullary depressor mechanism are in virtually all aspects the very opposite of those of RAS. Muirhead proposed that there was a negative-feedback interaction between two systems, RAS and renomedullary antihypertensive depressor system, and they balance each other. If true, as the suppression of angiotensin Ⅱ(ANG Ⅱ)by angiotensin converting enzyme(ACE) inhibitor activates the renomedullary antihypertensive function, we can assume the blood pressure lowering effects of ACE inhibitor due to an increased secretion of medullary depressor substance. After rats with intact and chemically destroyed renal medulla received either saline or the ACE inhibitor, mean arterial pressure(MAP) was clearly decreased after ACE inhibitor administration in controls with intact medulla, but MAP in rats with chemically destroyed renal medullar was not changed. According to these results, we can come to a conclusion that renomedullary depressor substance plays an important role to normal blood pressure control.

생약성분 항암제 Tianxian의 흡수동태에 관한 연구

양은정,김원배,심창구,이민화,정석재 서울대학교 1995 藥學論文集 Vol.20 No.-

L - NAME 주입시 신 교감신경이 신혈류량 변화에 미치는 영향

민영기,양훈모,이석호,김종규 순천향의학연구소 2000 Journal of Soonchunhyang Medical Science Vol.6 No.2

Recently it is known renal medullar will be play a important role of blood pressure control and pressure natriuresis. Renomedullary antihypertensive mechanism is activated by increasing perfusion pressure of kidney and can be inhibited by sympathetic nerve stimulation or blockade of nitric oxide(NO) formation. It is important to know what is affect on renal regional blood flow, especially renal medullary blood flow(MBF). For the purpose of investigating the effect of the renal sympathetic nerve on regional blood flow during infusion of blocking NO synthesis(by N^(ω)-nitro-L-arginine methylester:L-NAME) in spontaneous hypertensive rat(SHR) and Wistar rats normal control, Mean arterial pressure(MAP), total renal blood flow(TRBF), midcortical blood flow(CBF), inner medullary blood flow were measured in innervated or denervated renal sympathetic nerve group of SHR and Wister rats. All group that received the L-NAME were seen increasing MAP while TRBF, CBF and MBF decreased and the decrease of TRBF in SHR is more marked than in Wistar rat. In spite of increasing the MAP, MBF in all four group decreased, respectively C: 220 ± 3 U, 205 ± 2 U Wi : 215 ± 4 U, 165 ± 12 U Wd :218 ± 3 U, 170 ± 10 U Si :195 ± 4 U, 98 ± 15 U Sd : 200 ± 3 U, 120 ± 14 U, especially the most remarkable decrease about 50 % in SHR innervated group. Thus, according to these result, NO seems to maintain the MBF and the partial interaction between renal sympathetic nerve and NO in medullary blood flow can be suggested in innervated SHR.

생체분해성 고분자를 이용한 사시수술용 제형개발 및 효용성에 대한 연구

민병무,김용백,김승영,김창식,박근성,길숙종,조항진,이성복,노승무,송규상,강대영,조준식,양준묵,정경수,최선웅,이진호,김학용,인현빈 충남대학교 의과대학 지역사회의학연구소 1998 충남의대잡지 Vol.25 No.1

A new device, muscle clamping system was developed to facilitate exact quatifying technique A strabismus surgery, and reduce the risk of complications. The device is composed of a lower fixing body with three jaws and an upper supporting body. They are used to clip an extraocular muscle and fix it to the sclera with a single bite. Superior rectus recession on 16 rabbit eyes were performed with this new device. Conjunctival injection, muscle adhesion strength, and light microscopic findings were examined at 1, 2, 4 and 8 weeks postoperatively. The Conjunctival injection were minimal, adhesion power ranged from 420 to 600 gram gravity, which is sufficient in withstand the normal pull of human extraocular muscle. In microscopic exam, some Inflammatory cells and fibrosis were found. The new device was technically easy, fast, and accurate, so it may be useful in stabismus surgery.

고추 種子油中의 脂肪酸과 Sterol 組成에 關한 硏究

梁敏錫 慶尙大學校 1976 論文集 Vol.15 No.-

The unsaponifiables seperated from red pepper seed oil were divided into less polar compounds (hydrocarbon, etc., fraction 1), 4, 4-dimethyl sterol (fraction 2), 4-monomethyl sterol (fraction 3), and 4-desmethyl sterol (fraction 4) by preparative thin layer chraomatography and the sterol fractions, i.e., fraction 2,3,and 4, were further analyzed by gas liquid chromatography and combined gas liquid chromatography-mass spectrometry and also fatty acids were determined by gas liquid chromatography. The results obtained were summarized as follows; 1. From the analsis of fatty acid, it was found that palmitic acid and oleic acid were major fatty acid. 2. It was noted that 4-desmethyl sterol fraction from red pepper seed oil contained far more cholesterol (8%) than that from most of seed oils, and compesterol by gas liquid chromatography was identified to be mixed with 24-methylenecholesteral by combined gas liquied chromatography-mass spectrometry. 3. No seed oils have been repored to contain 4α-methylzymostenol. however, it were coourred in 4-mononomethyl strerol fraction from red pepper seed oil in the present study, and popheno was the major component(52%) of the faction. 4. Lanostenol was identified in 4,4-dimethyl sterol fraction but no detectable or trace amounts of lanotenol was reportd to present in most of seed oils.

생체분해성 안과제형의 안구내흡수정도와 안독성

민병무,김용백,박근성,송규상,양준묵,이성복,조항진,길숙종,김승영,김학용 충남대학교 의과대학 지역사회의학연구소 1998 충남의대잡지 Vol.25 No.1

An improved retinal tack can be used to fix the retina in complicated retinal detachment and proliferative vitreoretinopathy. We used the retinal tack made by biodegradable polyglycolic acid, polylactic acid and copolymers. The tacks with polyglycolic acid were placed in the retina the right eyes of 10 rabbits as group 1, with polylactic-polyglycolic acid copolymers as group 2 in each left eyes. We examined the absorption rates and degree of intraocular inflammation at 1 day, 1, 2, 4, and 8 weeks and compared both eyes. The tacks were absorbed with time in both eyes, but more rapid in copolymers. And there was no inflammation in both eyes. Now, this study will be a base on the drug delivery system in intraocular pharmacological and surgical management.

딥러닝 기반의 미세먼지 농도 예측

최준영(JunYoung Choi),이동현(Donghyeon Lee),김준영(Joonyoung Kim),정교민(Kyomin Jung) 한국정보과학회 2019 한국정보과학회 학술발표논문집 Vol.2019 No.6