분편 인플루엔자백신(split influenza vaccine)의 임상효과 및 면역원성에 관한 연구

우흥정,김동림,정희진,천병철,이주연,안정배,김지희,박찬,신영규,김우주,김민자,박승철 대한화학요법학회 1999 대한화학요법학회지 Vol.17 No.1

목적 : 아단위 인플루엔자 백신 접종 후 백신의 인플루엔자 예방효과, 인플루엔자 방어 항체형성, 인플루엔자 백신의 안전성을 조사하고자 하였다. 방법 : 총 571명을 대상으로 인플루엔자 백신 접종을 하였고, 이들 접종자에서 인플루엔자 양질환의 이환을 조사하여 인플루엔자 백신의 인플루엔자예방효과를 알아보았고, 백신의 접종 전 및 접종 4주 후 혈청에서 혈구응집억제물(Hemagglutination Inhibition : HAI) 항체 검사를 실시하여 백신의 방어항체생성을 조사하였고, 백신의 안전성을 알아보기 위해 백신접종 후 1주일 이내의 부작용을 조사하였다. 결과 :백신 접종군과 백신 비접종군에서 인플루엔자 양 질환의 이환을 조사한 결과 접종군 28.35%, 비접종군 35.88%으로 나왔으며, p 값이 0.001로 통계적으로 접종군에서 유의하게 낮았고, 인플루엔자 양 질환의 예방 효과는 20.97%를 보였다. 백신의 방어항체 형성의 평가를 위해 유럽의 인플루엔자 백신 허가 기준을 조사하였는데 B/Guangdong/5/94균주의 백신접종 후 항체가 40이상의 비율을 제외한 다른 기준은 모두 만족 시켰다. 부작용은 전체 조사자 521명중 149명(29%)으로 주로 접종 부위의 국소 부작용을 호소했고, 전신 부작용은 2% 내외였으며 특별히 심각한 부작용은 발견되지 않았다. 결론 : 분편 인플루엔자 백신은 인플루엔자양질환의 예방과 방어항체생성에 효과 있으며 안전한 것으로 사료된다. Background : The safety and effectiveness of influenza vaccine are well known in developed country. The influenza vaccination has been recommended as one of the tentative immunization schedule for indicated persons since 1997 in Korea. But there are still no available data about them, even though nearly 5 million doses of influenza vaccine were used in 1997-1998 season. So it is immediately needed to investigate the safety. efficacy and immunogenicity of influenza vaccine among Korean. Methods : We studied the clinical efficacy of influenza vaccine by monitoring Occurrence of influenza-like illness in influenza risk group(vaccination ; 300, non-vaccination; 215) from December in 1997 to March in 1998. We used the split quadrivalent influenza vaccine containing 15 microgram of hemagglutinin of A/Beijing/262/95(HlNl), A/Wuhan/359/95(H3N2), B/Mie/1/93 and B/Guangdong/5/94. Hemagglutination inhibition(HA1) antibody titers were determined before immunization and 1 months after vaccination And we evaluated adverse effect of influenza vaccination at 7 days after vaccination. Results : Influenza vaccination was associated with si@icant reductions in influenza-like spptoms(vaccination group; 28.35%, non-vaccination group, 35.88%, p=0.001). The preventive effect of influenza-like i3lne.s among influenza risk goup was 20.97%. And immunogenicity of influenza A and B exceeded all of the European licensure criteria for immunogenicity except postvaccination proportion of titers 240 of B/Guangdong/5/94 strain. And the adverse effects were mainly local injection site problem and no serious adverse effect was noted. Conclusion : Split influenza vaccine is safe, inmunogenic and eff'tive in influenza risk group in Korea.

RSA 암호화 알고리즘의 구현에 관한 연구

신인철,이민섭,박창섭,김범식,우찬일,최춘수 단국대학교 1998 論文集 Vol.33 No.-

Recently, the information exchange through a communication network has been increased rapidly. When the sensitive information being sent or stored, the cryptographic technique can be employed in order to prevent it from being exposed or modified by the illegal third party. To implement public key encryption systems based on the integer factorization and the discrete logaritm problem, an efficient exponential arithmetic is mandatory due to large numbers involved. In this paper, the general analysis about the high­speed implementation of primality testing and exponentiations are investigated as well as implementing RSA public­key system. The public­key cryptosystem can be applied to any applications which need both the privacy and the authentication. Finally, suing the software package named MIRACL which provides the basic number theoretic routines for cryptographic software developers. we have implemented the RSA encryption and decryption with Blum­Goldwasser probabilistic algorithm under various key and message size.

고속주축 모니터링용 광파이버 변위센서의 레이저 다이오드 출력에 따른 성능평가

박찬규,신우철,홍준희,이동주 한국공작기계학회 2004 한국공작기계학회 춘계학술대회논문집 Vol.2004 No.-

This paper is to develop an optical fiber displacement sensor for monitoring high speed spindle. Proper magnitude of optical power as well as amplification of output signal are necessary to improve sensitivity of the sensor. In this paper, to meet the need of improvement of the sensor resolution, we choose proper optical power and amplification level through speculating on optical power of a laser diode.

파장분할 광교환을 위한 SOA 파장변환기에 관한 연구

김우찬,김수환,신서용 明知大學校 産業技術硏究所 1996 産業技術硏究所論文集 Vol.15 No.-

All optical wavelength conversion is demonstrated using a cross-gain modulation characteristics of semiconductor optical amplifier(SOA). Input signal wavelength of 1.30684um has been shifted to the wavelength of 1.30496um. Power penalty was about 5dB. When considering the low power level of the source lasers, fixed injection current to SOA, and the limited selection of laser wavelengths. we expect penalty free and wider range of wavelength conversion in the near future by improving experimental circumstances.

완제품에 대한 수요가 Compound Poisson 과정에 따라 발생하는 CONWIP System의 성능분석

박찬우,신경화,이효성 한국경영과학회 2002 한국경영과학회 학술대회논문집 Vol.- No.1(2)

In this study we consider a flow-line CONWIP System with Compound Poisson Demands. The processing times of each workstation follow a Coxian-2 distribution. The demands that are not satisfied instantaneously are either backordered or lost according to the number of backordered demands that exist at their arrival instants. For this system we develop an approximation method to obtain the performance measures such as steady state probabilities of the number of parts at each station, the average number of backordered demands and the proportion of the lost demands. Comparisons with simulation have shown that the approximate method provides fairly good results.

고속주축 모니터링용 광파이버 변위센서의 파이버 특성에 따른 센서 성능 연구

박찬규,신우철,배완성,홍준희,이동주 한국공작기계학회 2003 한국공작기계학회 추계학술대회논문집 Vol.2003 No.-

To make high speed spindle system work properly, sensors with outstanding resolution and dynamic characteristics are essential. An optical fiber displacement sensor is based on simple principles. Electrical signal responds to the optical flux change due to the displacement change between a target and a sensor probe. In this paper, the performance of optical fiber displacement sensor has been investigated according to properties of optical fiber. Firstly, optical loss has been measured before and after polishing optical fiber endface. Secondly, allowance of optical fiber bending has been tested. thirdly sensitivity and linear range of the sensor has been found out according to the shape of cross section of optical fiber.

복어중독에 의한 가사 상태에서 소생한 1예

송승찬,신진호,강석우,박경남,최호순,박근태,문희식,기춘석,이성희,윤병철,노우균,조균석,이민호 大韓應急醫學會 1998 대한응급의학회지 Vol.9 No.3

Tetrodotoxin is a neurotoxin produced by about 90 species of puffer fish and causes paralysis of central nervous system and peripheral nerves by blocking the movement of all monovalent cation. Ingestion of tetrodotoxin produces clinical manifestations such as paresthesias(within 10-45 min), vomiting, lightheadedness, salivation, muscle twitching, dysphagia, difficulty in speaking, convulsion and death that expressed by cardiopulmonary arrest with loss of brain stem reflex sometimes. Tetrodotoxin prevents or delays ischemia induced neuronal death by way of following 3 mechanisms. Firstly, it reduces the energy demand of the brain tissues. Secondly, it delays or even prevents anoxic depolarization. Finally, it deminishes ischemia induced cell swelling and cerebral edema. We report a case of puffer fish poisoning which presented with cardiopulmonary arrest and loss of brain stem reflex, but completely recovered by aggressive cardiopulmonary resuscitation.

만성 견비통에 대한 동씨침 치료의 무작위 대조군의 임상 연구

김찬영,권나현,신예지,남동우,김건형,김종인,최도영,이윤호,이재동 WHO COLLABORATING CENTRE FOR TRADITIONAL MEDICINE 2007 東西醫學硏究所 論文集 Vol.2007 No.-

Objectives : To observe the effect of acupuncture treatment in chronic shoulder pain patients. Methods : 36 voluntary patients were randomly assigned to an acupuncture treatment group(E GrouP, n=18) and a control group(C GrouP, n=18). The E Group patients received acupuncture treatment on LI_(15), TE_(14), GB_(21) and Master Dong's acupuncture points, Shin-gwan and Gyun-joong, twice a week for four weeks. The C Group patients received no treatment. All patients in both groups were instructed to practise self exercise in their daily lives. Evaluations were made at baseline and after four weeks of study. The Constant Shoulder Assessment(CSA), Shoulder Pain and Disability Index(SPADI) and the patient's subjective pain was measured by Visual Analogue Scale(VAS). The obtained data was analyzed. Results '. The E Group showed significant(p<0.05) improvement in CSA, SPADI and VAS after four weeks of treatment. The C Group showed significant(p<0.05) improvement in CSA, but the change of SPADI and VAS was insignificant(P>0.05). CSA and SPADI of E Group significantly(p<0.05) improved compared to the C GrouP, but the difference of VAS change in the two groups was insignificant(p>0.05). Conclusions : Four weeks of acupuncture treatment significantly improved CSA, SPADI and VAS. The improvement of CSA and SPADI was significant(p<0.05) compared to untreated patients.

광파이버 변위센서 성능에 관한 연구

박찬규,신우철,홍준희,김기수 충남대학교 공업교육연구소 2003 論文集 Vol.26 No.1

The purpose of this paper is to develop an optical fiber displacement sensor. An optical fiber displacement sensor is based on simple principles. Electrical signal responds to the optical flux change due to the displacement change between a target and a sensor probe. In this paper, the performance of optical fiber displacement sensor has been investigated. Firstly, optical loss has been measured before and after polishing optical fiber endface. Secondly, allowance of optical fiber bending has been tested. Thirdly sensitivity and linear range of the sensor has been found out according to the shape of cross section of optical fiber.

스포츠種目別運動選手의 體格, 體型 및 體組成에 관한 硏究

李相于,趙在基,朴贊熙,朴俊東,辛尙根 東亞大學校附設스포츠科學硏究所 1989 스포츠科學硏究論文集 Vol.7 No.-