Projections of summertime ozone concentration over East Asia under multiple IPCC SRES emission scenarios

Lee, Jae-Bum,Cha, Jun-Seok,Hong, Sung-Chul,Choi, Jin-Young,Myoung, Ji-Su,Park, Rokjin J.,Woo, Jung-Hun,Ho, Changhoi,Han, Jin-Seok,Song, Chang-Keun Elsevier 2015 Atmospheric environment Vol.106 No.-

<P><B>Abstract</B></P> <P>We have developed the Integrated Climate and Air Quality Modeling System (ICAMS) through the one-way nesting of global–regional models to examine the changes in the surface ozone concentrations over East Asia under future climate scenarios. Model simulations have been conducted for the present period of 1996–2005 to evaluate the performance of ICAMS. The simulated surface ozone concentrations reproduced the observed monthly mean concentrations at sites in East Asia with high R<SUP>2</SUP> values (0.4–0.9), indicating a successful simulation to capture both spatial and temporal variability. We then performed several model simulations with the six IPCC SRES scenarios (A2, A1B, A1FI, A1T, B1, and B2) for the next three periods, 2016–2025 (the 2020s), 2046–2055 (the 2050s), and 2091–2100 (the 2090s). The model results show that the projected changes of the annual daily mean maximum eight-hour (DM8H) surface ozone concentrations in summertime for East Asia are in the range of 2–8 ppb, −3 to 8 ppb, and −7 to 9 ppb for the 2020s, the 2050s, and the 2090s, respectively, and are primarily determined based on the emission changes of NO<SUB>x</SUB> and NMVOC. The maximum increases in the annual DM8H surface ozone and high-ozone events occur in the 2020s for all scenarios except for A2, implying that the air quality over East Asia is likely to get worse in the near future period (the 2020s) than in the far future periods (the 2050s and the 2090s). The changes in the future environment based on IPCC SRES scenarios would also influence the change in the occurrences of high-concentrations events more greatly than that of the annual DM8H surface ozone concentrations. Sensitivity simulations show that the emissions increase is the key factor in determining future regional surface ozone concentrations in the case of a developing country, China, whereas a developed country, Japan would be influenced more greatly by effects of the regional climate change than the increase in emissions.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Change in ozone level is determined by the combination of NO<SUB>x</SUB> and NMVOC emissions. </LI> <LI> Ozone level over East Asia would get worse in the near future (the 2020s) than far future. </LI> <LI> A high-concentration event generally increases and more frequently occurs in the future. </LI> <LI> Change in ozone air quality in a developing country depends more on emissions change. </LI> <LI> Change in ozone air quality in a developed country depends more on climate change. </LI> </UL> </P>

Effect of Changing Amniotic Fluid Osmolarity on the Li⁺ Transport Through the Membrane Surrounding Amniotic Fluid in the Rabbit

Chang. Jin-Keun,Lee. Sang-Jin,Sung. Ho-Kyung 대한생리학회 1993 대한생리학회지 Vol.27 No.1

To study the regulation of amniotic fluid volume and electrolyte concentration by the Membranes surrounding the amniotic fluid, the rate of Li⁺ disappearance from amniotic sac of expired fetuses were examined while increasing the amniotic volume and osmolarity in rabbits. After intraamniotic injection of 1 ml isosmotic saline (about 20% of the amniotic fluid volume) containing 15 mM LiCl and 0.5 g/L Censored, the time courses of Li⁺ and Censored disappearance were determined. From there the Li⁺ clearance through the extrafetal routes was estimated and compared with that obtained from living fetuses. The volume, Na⁺ concentration and osmolarity of amniotic fluid were measured and their relationships with Li⁺ disappearance were evaluated. The fellowing results were obtained: 1. The rate of disappearance from amniotic fluid of living fetuses during the first 30 minutes was strikingly higher for Li⁺ than for Censored, suggesting that extrafetal routes exist. At 60 and 90 minutes, however, the disappearance rate of Li⁺ was less than that of Censored, suggesting the possibility of Li⁺ reentry through fetal urination. 2. The disappearance of Li⁺ from the amniotic fluid of the expired fetus was substantial, although lower than that of living fetuses, throughout the experimental period. 3. The Na⁺ concentration and the osmolarity of the amniotic fluid of expired fetus measured 30 minutes after an intraamniotic injection of isoosmotic saline showed wide variation, but thereafter they changed gradually towards the normal extracellular fluid level. 4. When the amniotic fluid was iso- or hyposmolar, the rate of Li⁺ disappearance from the amniotic fluid of the expired fetuses showed little variation. However, when the amniotic fluid was hyperosmolar, the rate at 30 minutes was markedly lower than those of isosmotic or hyposmotic amniotic fluid. At 90 minutes, the rate of Li⁺ disappearance in hyperosmolar fluid reached a similar level to the rate in isosmolar fluid. 5. The intraamniotic injection of 400 mOsm/L saline solution decreased the disappearance rate of Li⁺ from expired fetuses, while the injection of mannitol into the maternal vein induced no significant change. From these results it is concluded that: 1) a significant amount of Li⁺ may leave the amniotic fluid via filtration through the membranes surrounding the amniotic fluid, 2) during hyperosmolar challenge to amniotic fluid, osmotic bulk flow might counteract the filterable loss, and 3) Li⁺ disappearance might continue even after the volume and osmolarity of the amniotic fluid have recovered to control values.

Effect of Changing Amniotic Fluid Osmolarity on the $Li^+$ Transport Through the Membrane Surrounding Amniotic Fluid in the Rabbit

Chang, Jin-Keun,Lee, Sang-Jin,Sung, Ho-Kyung The Korean Physiological Society 1993 대한생리학회지 Vol.27 No.1

To study the regulation of amniotic fluid volume and electrolyte concentration by the Membranes surrounding the amniotic fluid, the rate of $Li^+$ disappearance from amniotic sac of expired fetuses were examined while increasing the amniotic volume and osmolarity in rabbits. After intraamniotic injection of 1 ml isosmotic saline (about 20% of the amniotic fluid volume) containing 15 mM LiCl and 0.5 g/L Censored, the time courses of $Li^+$ and Censored disappearance were determined. From there the $Li^+$ clearance through the extrafetal routes was estimated and compared with that obtained from living fetuses. The volume, $Na^+$ concentration and osmolarity of amniotic fluid were measured and their relationships with $Li^+$ disappearance were evaluated. The fellowing results were obtained: 1. The rate of disappearance from amniotic fluid of living fetuses during the first 30 minutes was strikingly higher for $Li^+$ than for Censored, suggesting that extrafetal routes exist. At 60 and 90 minutes, however, the disappearance rate of $Li^+$ was less than that of Censored, suggesting the possibility of $Li^+$ reentry through fetal urination. 2. The disappearance of $Li^+$ from the amniotic fluid of the expired fetus was substantial, although lower than that of living fetuses, throughout the experimental period. 3. The $Na^+$ concentration and the osmolarity of the amniotic fluid of expired fetus measured 30 minutes after an intraamniotic injection of isoosmotic saline showed wide variation, but thereafter they changed gradually towards the normal extracellular fluid level. 4. When the amniotic fluid was iso- or hyposmolar, the rate of $Li^+$ disappearance from the amniotic fluid of the expired fetuses showed little variation. However, when the amniotic fluid was hyperosmolar, the rate at 30 minutes was markedly lower than those of isosmotic or hyposmotic amniotic fluid. At 90 minutes, the rate of $Li^+$ disappearance in hyperosmolar fluid reached a similar level to the rate in isosmolar fluid. 5. The intraamniotic injection of 400 mOsm/L saline solution decreased the disappearance rate of $Li^+$ from expired fetuses, while the injection of mannitol into the maternal vein induced no significant change. From these results it is concluded that: 1) a significant amount of $Li^+$ may leave the amniotic fluid via filtration through the membranes surrounding the amniotic fluid, 2) during hyperosmolar challenge to amniotic fluid, osmotic bulk flow might counteract the filterable loss, and 3) $Li^+$ disappearance might continue even after the volume and osmolarity of the amniotic fluid have recovered to control values.

냉기 치료에 따른 둔근에서의 피부 및 근육내 온도 변화

정우성,김미정,박시복,이상건,김영호,양길태,장윤희 大韓再活醫學會 1998 Annals of Rehabilitation Medicine Vol.22 No.2

Diagnostic Significance of Brainstem Auditory Evoked Potentials in Microvascular Decompression of Patients with Hemifacial Spasm or Trigeminal Neuralgia

( Sang-koo Park ),( Sung-hyuk Lim ),( Chan-woo Park ),( Jin-woo Park ),( Sung-ho Chang ),( Keun-hye Park ),( Hae-ja Park ),( Ji-hye Song ),( Dong-ok Uhm ),( Ki-bong Kim ) 대한임상검사과학회 2011 대한임상검사과학회지(KJCLS) Vol.43 No.1

The purpose of this study was to analyse brainstem auditory evoked potentials (BAEP) wave change data during microvascular decompression (MVD). The nerve function of Cranial Nerve VIII is at risk during MVD. Intraoperative monitoring of BAEP can be a useful tool to decrease the danger of hearing loss. Between January and December 2009, 242 patients had MVD for hemifacial spasm (HFS) and trigeminal neuralgia (TN). Among intraoperative BAEP changes, amplitude of V-V’ was the most frequently observed during cerebellar retraction and decompression step of the MVD procedure. 138 patients (57%) had no BAEP change while 104 patients (42.98%) had BAEP change. 69 patients (28.5%) had Type A-I, 16 patients (6.6%) had Type A-II, 5 patients (2.1%) had Type B, and 13 patients (5.37%) had Type C. MVD is a surgical procedure to relieve the symptoms (e.g. pain, muscle twitching) caused by compression of a nerve by an artery or vein. During BAEP intraoperative monitoring, the surgical step is important in interpreting the changes of wave V. Several potential mechanisms of injury may affect the cochlear nerve, and complete loss of BAEP is often associated with postoperative hearing loss. Intraoperative BAEP monitoring may provide an early warning of hearing disturbance after MVD.

A proposal of the Optimal Angle of Standing Assistant Chair for the Elderly by Comparing of Pressure Distribution on Hip

Sung-Ho Chang(장성호),Ji-Hoon Baek(백지훈),Jung-Eon Lee(이중언),Nematov Mirazamjon(Nematov Mirazamjon),Seok-Wan-Kang(강석완),Wang-Bum Lee(이왕범) 한국산업경영시스템학회 2018 한국산업경영시스템학회지 Vol.41 No.3

One of the most performed action in daily life is standing up from sitting position. As the population of the world is aging at the high rates, people may face problems with reduced muscle strength as well as psychological changes. This can lead elderly people having difficulties with standing up from chair. Now, with the aging trend worldwide, products are being developed that can support the lives of the elderly. This study examines the distribution of hip pressure in relation to the seating positions of the standing assistance seats under development to prevent standing up accidents in older adults. The currently developing standing assistant chair designed to tilt to a maximum angle of 25 degrees. At over 25°, design considers that older people are at risk of thrown back out of that force and that the forces exerted on their arms and legs can be a significant burden to older people. By considering danger of higher than 25° for older people which is experimented in the basis of static capturing approach in previous papers, it is experimented people with age group of 20~60 on 0° to 25° tilting angle on the basis of dynamic capturing method in order to pick convenient angle of inclination. Moreover, tried to find the optimum angle by comparing the hip pressure distribution when seated at the edge of the seat and at the center of the seat with the pressure distribution sensor.

흰쥐에서 알코홀의 전투여가 halothane 마취시 간에 미치는 영향

이상동,공명훈,장성호 고려대학교 의과대학 1991 고려대 의대 잡지 Vol.28 No.3

Fifty nine male Sprague-Dawley rats were used to investigate the hepatic effects of halothane anesthesia in alcohol-treated rats. Sampling was done before intravenous injection of ethyl alcohol(400mg/kg) or saline(5m1/kg) through tail vein. And 24 hours laterall rats were exposed to halothane-N_(2)/O_(2) (1%-2ℓ/2ℓ) for two hours. Intracardiac puncture for blood sampling was done after intraperitioneal injection of pentobarbital (50mg/kg) and hepatectomy was done to get the tissue sample for microscopic examination 24hours or 96 hours after halothane anesthesia. Biochemical studies including liver and renal function variables (protein, albumin, total bilirubln, direct bilirubin, aspartate aminotransferase, alanine aminotransferse, alkaline phosphatase, BUN, creatinine) were done and the hepatic tissue was examined with light microscopy. The results are summarized as follows: 1) Twenty four hours after halothane anesthesia. protein albumin. total bilirubin. and alkaline phosphatase were significantly changed in both saline- and alcohol-treated rats. Serum transaminases level were not significantly changed in alcohol-treated group compared with saline-treated group (i.e. aspartate aminotransferase. alanine aminotransferase). Other parameters indicative of hepatic and renal function such as cholesterol. BUN and creatinine were not significantly changed. 2) There is no significant difference of histologic evidence of hepatic damage between alcohol- and saline-treated rats 24 hours after halothane anesthesia. 3) Ninety six hours after halothane anesthesia. protein. albumin and total bilirubin were significantly changed in both saline- and alcohol-treated rats. Serum transaminases and alkaline phosphatase level were not significantly changed in alcohol-treated group compared with saline-treated group (i.e., aspartate aminotransferase. alanine aminotransferase). Other parameters indicative of hepatic and renal function such as cholesterol. BUN, and creatinine were not significantly changed. 4) There is no significant difference of histologic evidence of hepatic damage between alcohol-and saline-treated rats 96 hours after halothand anesthesia.

소아 고관절 병변에 대한 골주사의 임상적 의의

박상원,허창룡,박정호 中央醫學社 1989 中央醫學 Vol.54 No.1

The purpose of this study is to evaluate the possibility of bone scanning in early diagnosis of Legg-Perthes disease and transient synovitis of hip joint prior to radiological changes, and also to observe scintigraphic changes in early and late stage of Legg-Perthes disease. The authors observed the uptake ratio of technetium-99m-methylene diphosphonate and the scintigraphic findings in fifteen cases of Legg-Perthes disease and ten cases of transient synovitis of the hip joint. The obtained results were as follows: 1. In fifteen Legg-Perthes disease, scintigraphic findings showed three decreased uptake and one normal uptake in four cases without bone changes on the plain radiograph, and seven decreased uptake and four increased uptake in the eleven cases with bone changes. 2. In ten transient synovitis of the hip joint, scintigraphic findings showed four slight increased uptake but no changes in six cases. Above findings suggest that bone scanning is valuable diagnostic method in early stage of Legg-Perthes disease, but it has limited value in its advanced stage and has no value in transient synovitis of the hip joint.

또래학습을 통한 또래교사와 또래학습자의 인지구조 변화 -초등 도형영역에 대하여-

김미정 ( Mi Jung Kim ),이광호 ( Kwang Ho Lee ),이미진 ( Mi Jin Lee ),성창근 ( Chang Geun Sung ) 한국수학교육학회 2013 初等 數學敎育 Vol.16 No.2

본 연구는 또래교수 활동을 통하여 변화된 도형의 개념 및 성질, 도형간의 관계에서 인지구조를 관찰하고 어떻게 정교화 해 가는지에 대해 또래교사와 또래학습자의 인지 구조의 차이를 알아보았다. 연구 문제를 해결하기 위해 보은의 S초등학교 5학년 학생 6명을 대상으로 또래교수와 학습자 3팀을 선정하고 도형영역에 대한 사전·사후검사를 실시하고 자료를 분석하였으며 심층면담을 실시하여 인지구조를 분석하였다. 또래교사와 또래학습자 모두 도형영역에서 인지구조가 변화되었으며 특히 또래교사의 인지구조의 변화가 더욱 뚜렷이 나타났다. 따라서 또래교수활동은 체계적인 계획하에 일관성 있는 교수활동 뿐만이 아니라 학습활동에 더욱더 많은 교사의 지속적인 노력과 지원이 필요하다. The purpose of the study is finding the effective teaching and learning methods on the concepts of figures through exploring the change of students` cognitive structures before and after the peer teaching activities. The difference of the peer teacher`s and student`s cognitive structures was investigated for the activities. Three teams, six students of 5th grade, were selected from the S elementary school in Boyeon. To figure out the students` cognitive structures, pre and post in-depth interviews were conducted and analyzed. Both peer teachers` and learners` cognitive structures were changed. Peer teachers` cognitive structures were changed more positively than peer learners. A consistent systematic planation and continuous teacher support and effort are needed for the activities.

출산에 따른 그레이브스병의 재발 및 관련이자

임창훈,최현아,한승석,김해성,이창욱,정호연,한기옥,장학철,박원근,윤현구,한인권 대한내분비학회 2002 Endocrinology and metabolism Vol.17 No.2

Background: Pregnancy affects the course of Graves' Disease (GD), and patients who initially maintain euthyroid function into their middle trimester with minimum doses of antithyroid drugs become exacerbated after delivery. Even patients who are completely cured, requiring no treatment during pregnancy, can relapse after delivery. In this study, we examined the postpartum changes in the thyroid functions of patients with GD, and attempted to determine the factors contributing to these changes. Methods: The study subjects were recruited from pregnant women visiting our outpatient clinic for routine prenatal evaluations. 45 women previously diagnosed with GD, who had been treated and cured with hyperthyroidism, and were no longer taking any thyroid medications, were evaluated for 1 year post delivery. Results: Among 45 patients, 20 (44.4%) developed thyroid disorders following delivery. Postpartum thyroiditis (PPT) developed in 8 patients (17.8%), and GD developed in 12 (26.0%). The onset of the PPT disease 3.1 ± 1.4 months following delivery, which was significantly earlier than the 6.7 ± 2.7 months required for the post delivery onset of GD (p=0.003). The TBII values, measured during the thyrotoxic state in each womaen, were negative in women with PPT and positive in 71.4% of women with GD (p=0.030). The duration of treatment for hyperthyroidism prior or pregnancy, the number of recurrences, and the time interval without treatment, were not associated with the development of postpartum thyroid disorders. Whereas, the mean number of past pregnancies for women who developed PPT was 3.9 ± 2.1, and was significantly higher than the 2.2 ± 1.7 for women developing no thyroid dysfunctions (p=0.044). In 13 women their initial onset of GD occurred within one year postpartum, 7 (53.8%) having had a recurrence, which was significantly higher than in women whose disease onset occurred unrelated to delivery (5 of 32 women: 15.6%). Conclusion: Women with GD developed postpartum thyroid dysfunctions in 44.4% of cases. Women whose initial disease onset occurred within one year postpartum had higher recurrences of GD, and women who developed PPT had a history of higher gravidity compared to the euthyroid women postpartum. Therefore, if women with GD develop postpartum thyroid dysfunctions, the diagnosis should be made, and a treatment modality planned, following careful considerations of the patients' past obstetric history, changes in clinical manifestations and the TBII values