생체분해성 망막압정을 이용한 망막고정에 대한 실험적 연구

김용백,민병무,김창식,박근성,김승영,길숙종,조항진,이성복,노승무,송규상,강대영,조준식,양준묵,정경수,최선웅,이진호,김학용,인현빈 충남대학교 의과대학 지역사회의학연구소 1998 충남의대잡지 Vol.25 No.1

Biodegradable retinal fixation devices obtain mechnical fixation of the retina with desirable chorioretinal scarring and with the potential for local, sustained release of antimetabolites and steroids to inhibit proliferative vitreoretinopathy. We manufactured a biodegradable retinal tack with barb that was designed in order to prevent intrusion from implantation of retinal tacks. This study was carried to evaluate the efficacy for retinal fixation and the capability for sustained release of drugs with a newly designed biodegradable retinal tack Biodegradable retinal tacks were made of polymers of glycolic acids and were designed with barbs in a shape to prevent the disinsertion. Biodegradale retinal tacks are divided into 3 parts, a conical portion that is inserted into the sclera, a cylinder portion that remains in the vitreous, and a neck portion between the pin and the cylinder. The tapered conical end was manufactured to allow easy insertion through the retina and choroid into the sclera. A cylinder portion was manufactured with a tapered angle that fixes firmly into the orifice of 19 gauge spinal needle. A neck portion, 0.4 mm in diameter, was designed to prevent disinsertion from following implantation of retinal tack. The applicator was a 19 gauge spinal needle and its orifice was prepared to 15°angle to accept the tapered cylinder portion of the retinal tack. The retinal tacks, secured in the needles, were passed through the formed vitreous and inserted into the retina, choroid, and sclera and were released by pushing the internal needle, usually within 2-3mm of the medullary ray of the posterior rabbit retina A retinal tack was placed in each of 8 pigmented rabbit eyes. Slit-lamp biomicroscopy, indirect ophthalmoscopy and fundus photography were performed periodically from 1 day to 8 weeks after surgery. Eight eyes were enucleated and studied by light microscopy at 8 weeks. Biomicroscopic evaluation of the animals revealed edemas adjacent to the retinal surfaces immediately after insertion of the biodegradable retinal tacks in all the animals. These edemas disappeared after 1 week. The first noticeable change in the size of retinal tacks was shown after 2weeks. The size of the retinal tacks gradually got smaller, decreasing to about one-half at 4 weeks and about one-third at 8 weeks. All retinal tacks remained in inserted places without any movement for an 8 week period. On light microscopy, epiretinal proliferations were seen to extend into the vitreous cavity. Cellular capsules that lined the inner aspect of the scleral defect caused by tack insertion were found. However the adjacent retina had a normal cytologic appearance and architecture in all specimens. We manufactured a biodegradable retinal tack that is designed to prevent intrusion from implantation of retinal tacks. All biodegradable retinal tacks reduce in size with time, but no retinal tacks extruded from the inserted place. The newly designed biodegradable retinal tack can be used for retinal fixation and may be used as a vehicle for the introduction of pharmacologic agents to prevent the cellular events that promote proliferative vitreoretinopathy.

Proteomic Approach to Analyzing Flooding Stress in Soybean (Glycine max(L.) Merr.)

Kim,Tae-Seon,Cho,Seong-Woo,Lee,Jae-Eun,Kim,Yook-Han,Cho,Kun,Choi,Jong-Soon,Chung,Keun-Yook,Song,Beom-Heon,Jong,Seung-Keun,Kim,Hong-Sig,Woo,Sun-Hee 한국작물학회 2005 한국작물학회 학술발표대회 논문집 Vol.2005 No.-

8년간(1992~1999) 산업안전보건연구원에 의뢰된 직업병 심의 사례 분석

강성규,김규상,김양호,최정근,안연순,진영우,최병순,양정선,김은아,채창호,최용휴,김대성,박정선,정호근 대한산업의학회 2000 대한직업환경의학회지 Vol.12 No.2

Objectives : Pneumoconisis and noise-induced hearing loss (NIHL) have been reported as main occupational diseases by the Special Health Examination. The Industrial Accident Compensation Insurance has reported various work-related diseases, however, these two diseases occupied almost a half of compensated cases. Therefore, it was not well known about the status of occupational diseases other than pneumoconiosis, NIHL, and cardio-cerebrovascular accident (CVA). This study was conducted to analyze claimed cases as an occupational disease, that was requested to the Korea Industrial Safety and Health Agency (KOSHA). Methods : The local office of the Korea Labor Welfare Corporation (KLWC) has asked the KOSHA for confirmation of claimed cases as an occupational disease. We analyzed 379 cases requested from KLWC, the Ministry of Labor, employers, unions and occupational health agencies from 1992 to 1999. Results : Male was 80.7 % of the requested cases. Their mean age was 42 years old and 75.5 % of them were more than 35 years old. The requested cases were increased rapidly from 25 cases in 1992 to 108 cases in 1999 and the accept rate was 50.7 %. The majority of requested cases were respiratory diseases(22.4%), cancers(18.5%), Neuropsychiatric problems(14.5%), and musculoskeletal problems(13.5%). The accept rate was high in reproductive, respiratory, musculoskeletal and digestive disorders and low in neuropsychiatric, renal and otologic problems and occupational cancers. 73.6% of them were caused by chemical agents, especially 28.5 % were by organic solvents. 67% of them were clinically confirmed at university hospitals. A half of the cases were from KyongIn area, even the request came from the whole country. Conclusions : A claim was common in workers whose age was over 35 years old and exposure history was over 10 years. The respiratory diseases and neuropsychiatric disorders were still main problems in occupational health and occupational cancers was increasing even though its accept rate was not high yet.

생체분해성 고분자를 이용한 사시수술용 제형개발 및 효용성에 대한 연구

민병무,김용백,김승영,김창식,박근성,길숙종,조항진,이성복,노승무,송규상,강대영,조준식,양준묵,정경수,최선웅,이진호,김학용,인현빈 충남대학교 의과대학 지역사회의학연구소 1998 충남의대잡지 Vol.25 No.1

A new device, muscle clamping system was developed to facilitate exact quatifying technique A strabismus surgery, and reduce the risk of complications. The device is composed of a lower fixing body with three jaws and an upper supporting body. They are used to clip an extraocular muscle and fix it to the sclera with a single bite. Superior rectus recession on 16 rabbit eyes were performed with this new device. Conjunctival injection, muscle adhesion strength, and light microscopic findings were examined at 1, 2, 4 and 8 weeks postoperatively. The Conjunctival injection were minimal, adhesion power ranged from 420 to 600 gram gravity, which is sufficient in withstand the normal pull of human extraocular muscle. In microscopic exam, some Inflammatory cells and fibrosis were found. The new device was technically easy, fast, and accurate, so it may be useful in stabismus surgery.

VITAMIN E劑가 全身持久力 向上에 미치는 影響

金敎成,曺根鍾 漢陽大學校 體育科學硏究所 1986 體育科學 Vol.6 No.6

The purpose of this study was to investigate effect of Vitamin E on improvement of cardiovascular endurance. Selected subiects-12 soccer players and 12 general high school boys were divided into 4 groups as follows. A; Soccer players who were trained after taking Vitamin E, (6 persons) B; Soccer players who were trained only, not dosage. (6 persons) C: General students who were trained after dosed Vitamin E, (6 persons) D; General students who were not trained, but taking Vitamin E. (6 persons) Each group was trained for 5 weeks by training program. (17 mins/day, 3 days/ week), after training measured and analysised heart-rate, vital-capacity, 1000m race-record, heart-rate after 1000m race in every 5 weeks. The conclusions are as follows: 1. Resting heart-rate lowed 4. 0 beats/min in A, C group (P<0.05) after training but control group was not lowed. 2. Vital-capacity increased in C group(287cc, P<0.001) and A group (149cc, P<0.05). 3. 1000m race record improved in order of C-A-B group so, each group was shortened 17 sec (P<0.05) , 12 sec (P<0.05) 11 sec (P<0.05) 4. Heart-rate after 1000m race improved in order of C-A-K group so, each group was lowed 6.6 beats/min, 6.0 beats/min, 5.6 beats/min(P<0.05). Synthetically cardiovascular endurance improved both players and general group but general group rather than players. The result indicated that Vitamin E was effected to improvement of cardiovascular endurance. But there was no improvement of cardiovascular endurance in K group except 1000m race record. It was that the result was not dosage effect but training effect.

수면무호흡증의 다원수면기록 소견

김용조,이선우,왕성근 대한생물치료정신의학회 1996 생물치료정신의학 Vol.2 No.2

To identify the clinical characteristics of sleep apnea syndrome in Korean, author analyzed 24 cases of polysomnographic findings statistically, diagnosed as sleep apnea syndrome during May, 1995 to July,1996. The results were summarized as follows: 1. The mean age of subjects was 35.7 years, the distribution of age was 12 to 64 years, and male to female sex ratio was 5:1. 2. As for mean values of sleep parameters, total bed time was 429.8 minutes, waking after sleep onset was 93.4 minutes, total sleep time was 336.1 minutes and sleep efficiency was 77.7%. 3. The proportions of sleep stage 1, stage2,slow wave sleep, REM sleep, and movement time to total sleep time were 13.1%, 39.4%, 24.4%, 20.8%, and 2.2% respectively. 4. Mean AI(apnea index) was 28.7 and RD(respiration disturbance index ) was 34.3. 5. Waking after sleep onset correlated with total sleep time and sleep efficiency negatively, and with sleep stage 1 positively. Sleep efficiency correlated with sleep stage 1 negatively, and sleep stage 1 correlated with slow wave sleep negatively.

진단방사선영역에서 Ho 여과판 사용시 피폭선량 감소와 화질개선에 관한 연구

김영근,이성길 광주보건대학 2000 論文集 Vol.25 No.-

This work was reduction of exposure dose and improvement of image quality by use of Ho filter in diagnostic fadiology, From the results of experimental evaluation, it was founded that in the case of the Ho filter, the variety of X-ray property with kVp was less than those of Cu and Al. And the ratio of transit to surface-dose and the load of X-ray tube were increased in the order Al, Cu, Gd and Ho. The contrast of X-ray image showed the higher value in the order of Cu, Al, Gd and Ho.

6차 교육 과정에 따른 고등학교 공통 과학 (화학 부분) 교과서의 탐구 활동 분석

김윤희,정경규,문경근,문성배 부산대학교 사범대학 과학교육연구소 1998 科學敎育硏究報 Vol.25 No.-

In order to obtain the fundamental data for developing an ideal chemistry curriculum in the common science, four kind of common science textbooks were analyzed. Particularly, inquiry activities part was analyzed by the three dimension framework which consists of inquiry content dimension, inquiry process dimension and inquiry context dimension. The average volume of chemistry part in the common science text books was 13% (56 page). In the analysis of the inquiry content dimension of inquiry activities, the total number of themes in four kinds of textbook had similar inquiry activities. For the analysis of inquiry process dimension, 'interpreting data and formulating generalizations' category(39.1%) was most emphasized and the categories of 'observation and measuring'(30.8%), and 'building, testing and revising the theoretical model'(16.5%), 'seeing a problem and seeking ways to solve it'(13.5%) follow in order. As for the analysis of the inquiry context dimension, the scientific context was 82%, the individual context 1.8%, the social context 7.8% and the technical context 7.8%. It showed that the proportion of STS related contents in inquiry activities was 18%. For the purpose of common science text book in the 6th curriculum, it is expected to increase the proportion of the high level inquiry process and the proportion of STS related contents.

加味牛膝湯이 實驗動物의 鎭痛에 미치는 影響

金炯均,權文鉉,오로사,金成宰,李彦政,李峰根 圓光大學校 韓醫學硏究所 1996 원광한의학 Vol.6 No.1

다중 경로 채널에서의 ATC를 적용한 DMF 초기동기 장치의 성능분석

김성철,송인근 우송대학교 1998 우송대학교 논문집 Vol.3 No.-

To analyze the DS/SS reciever performance with respect to coed acquisition, multipath fading channel is characterized as a two-ray Rayleigh fading channel. In the code acquisition loop, the performance is evaluated in terms of the acquisition time and detection probability with the acquisition time is taken into account. To improve the performance, ATC (automatic gain control) algorithm is proposed. The simulation results show that high sampling rate improves the performance and in case of high SNR, the performance of the DMF acquisition system has a little difference between AWGN and Rayleigh fading channel.