구개측으로 매복된 상악견치의 교정치료기간에 영향을 미치는 요소

정송화,김성식,조봉혜 대한치과교정학회 2007 대한치과교정학회지 Vol.37 No.2

구개측으로 매복된 견치와 인접구조물 간의 위치관계가 전체적인 교정치료기간에 어떤 영향을 미치는지 알아보고자 편측성 구개측 견치 매복으로 진단받고, 교정적인 견인을 하여 치료를 완료한 환자 36명의 초진 시 파노라마 방사선사진을 대상으로 연구하였다. 전체 치료기간의 평균인 21개월을 기준으로 나누었을 때, 장기치료군에 비해 단기치료군에서 인접 측절치의 치근에 견치의 치관이 겹치는 정도가 더 크게 나타났다. 치료기간을 예측하기 위한 중회귀분석에서 상악견치의 치관에서 치조정까지의 교합면에 대한 수직거리를 나타내는 HCV (Height of the canine crown vertically)와 하악견치간폭경이 각각 0.142와 0.115의 예측상수(r2)를 보였으며, 두 인자를 같이 고려하였을 경우에는 0.208의 예측상수를 보였다. 나이에 따른 분류에서 치료기간, 상악 견치 치관에서 치조정까지의 수직거리 (HCV), 중절치 정중선에 대한 견치의 각도가 초기 영구치열기까지는 점진적으로 감소를 하다가 완성 영구치열기에서 증가하였다. 본 연구의 결과, 구개측으로 매복된 견치의 견인을 시행할 때에는 초기 영구치열기에 견치의 치관첨이 교합면에 가깝고 직립이 되어 있을 경우에 전체 교정치료 기간이 짧아진다는 것을 알 수 있었다. Objective: The aim of this study was to determine the relationship between the status of a unilateral palatally impacted maxillary canine (as seen on the panoramic radiograph) and the orthodontic treatment duration. Methods: A total of 36 subjects were chosen (8 males and 28 females, 13.7 ± 2.5 years). All patients had undergone orthodontic traction of the impacted canine after a closed flap surgery. The position of impacted canine on the panoramic radiograph was traced and calculated with regard to the treatment duration. Results: The canine overlap over the lateral incisor (COGr) had significant statistical difference between the short-term and the long-term treatment duration groups (divided by average treatment time of 21 months) (p < 0.05). Multiple regression indicated that the variables of significance (with treatment duration as the dependent variable) were the canine vertical height from the occlusal plane (HCV, r2 = 0.115; p < 0.05) and the mandibular anterior width (MnDW, r2 = 0.142; p < 0.05). The treatment duration, the canine angle to the incisor midline (CA), and HCV decreased from primary dentition (under 12 yrs) to permanent dentition (15 yrs). Howerer, these increased again at the adolescent ages (over 16 yrs). Conclusion: These findings suggested that orthodontic treatment of a palatally impacted canine would show good prognosis at an age of early permanent dentition with the canine showing smaller CA and HCV.

부신피질 자극호르몬 단독결핍 1례

박경식,이승현,최석영,박태규,이동화,이찬우,정성복,이인규 啓明大學校 醫科大學 1997 계명의대학술지 Vol.16 No.3

부신피질 자극호르몬 단독결핍은 국내에서 7례만이 보고된 희귀 질환이며 병인 및 경과 등 아직 불분명한 측면이 많다. 이는 질환지체의 희귀성도 있지만 치료후 자연경과에 대한 장기적인 추적검사가 이루어진 경우가 드물기 때문이기도 하다. 저자들은 비특이적인 전신증상을 주소로 내원한 폐경기후의 56세 여자 환자에서 자가면역질환의 증거없이 고프로릭틴혈증을 보인 부신피질 자극호르몬 단독결핍 1례를 경험하고 1년간의 부신피질호르몬 대치요법후 추적검사를 실시하였기에 문헌 고찰과 함께 보고하는 바이다. Isolated ACTH deficiency is a rare disorder which shows secondary adrenal insufficiency with normal states of other pituitary hormones. A 56-year-old postmenopausal woman complaining general weakness and intermittent mental confusion presented negligible serum cortisol and ACTH level with hyperprolactinemia and mild hyponatremia. Rapid ACTH stimulation test did not show significant increase of serum cortisol level. Combined pituitary stimulation test showed negligible response of cortisol and ACTH, and slightly decreased response of prolactin and gonadotropin. But the responses of TSH and GH were normal. There was no evidence of organic pituitary of hypothalamic lesion in brain MRI and antithyroid autoantibody was not detected in serum. After receiving 12 months of glucocorticoid replacement therapy, she skipped the medicine for 3 weeks and we performed follow-up endocrinologic tests. Serum ACTH and cortisol level was also negligible and prolonged ACTH simulation test showed normal response of serum cortisol. CRF stimulation test showed no response of serum ACTH. Basal prolactin level was decreased to near normal and combined pituitary stimulation test showed normal response of prolactin with slightly blunted response of TSH and GH. We concluded that the case was nonautoimmune origined isolated ACTH deficiency which was accompanied by hyperprolactinemia and resultant deficiency of gonadotropin, so we report this case with review of literatures.

백서의 치아이동 시 피질골 천공이 치주조직의 MMP-1,-8, -13 mRNA의 발현에 미치는 영향

곽춘,김성식,박수병,손우성,김용덕,전은숙,박미화 대한치과교정학회 2008 대한치과교정학회지 Vol.38 No.3

Objective: The aim of this study was to determine whether cortical punching stimulates the expression of matrix metalloproteinase-1, -8, and -13 in orthodontic tooth movement in rats. Methods: A total of 32 male sprague-dawley rats at 15 weeks old were divided into two groups of 16 rats each, to form the tooth movement with cortical punching (TMC) group and tooth movement only (TM) group. A total of 20 gm of orthodontic force was applied to rat incisors to cause experimental tooth movement. Cortical punching was performed on the palatal side near the central incisor with a 1.0 mm width microscrew in the TMC group. The duration of tooth movement was 1, 4, 7, and 14 days. Results: Measurements of the mRNA expression were selected as the means to determine the identification of expression of MMP-1, -8, and -13. In the TMC group, the expression of collagen type I was greater than that of the TM group from day 4 to day 14. Expression of TIMP-1 in the TM group was greater than that of the TMC group in the pressure side of PDL and alveolar bone cell at day 4. In the TMC group, TIMP-1 was expressed at the osteoclast, but not at the tooth surface of the TM group at day 14. Maximum induction of the mRNA of MMP-1 was observed on day 4 in the TMC group, but it was observed on day 7 in the TM group. MMP-8 mRNA of the TMC group was twice greater than that of the TM group at 4 days. In the TMC group, maximum induction of MMP-13 mRNA was observed on day 1. Conclusions: These findings suggested that cortical punching can stimulate remodeling of PDL and alveolar bone connective tissues during experimental orthodontic tooth movement in rats. 본 연구는 피질골 천공을 동반한 교정적인 치아이동이 통상의 교정적인 치아이동과 조직 재형성의 정도에 차이가 존재하는지 알아보기 위하여 시행하였다. 실험동물은 15주령 군 300 - 350 g의 자성 백서(Sprague-Dawley Rat)를 사용하였으며 피질골 천공을 동반한 치아이동 실험군(TMC group, n = 16)과 단순 치아이동 대조군(TM group, n =16)으로 나누었다. 모든 실험동물에 20 gm 이하의 힘으로 전치부를 이개시키는 치아 이동을 시행하였으며, 실험군은 상악전치부의 직후방 구개측에서 치근을 손상시키지 않도록 직경 1.0 mm의 microscrew를 사용하여 피질골 천공을하였다. 모든 실험동물은 1, 4, 7, 14일에 희생시켜서 matrix metalloproteinase (MMP)-1, -8, -13 효소의 RT-PCR과 I형 교원질(Collagen type I)과 Tissue inhibitor of metalloproteinase-1 (TIMP-1)의 면역조직화학염색(immunohistochemistry) 을 시행하였다. MMP-1은 실험군에서 4일째에 가장 활발한 발현을 보이다가 7일째와 14일째에 조금씩 감소하는 경향을 보인 반면에, 대조군에서는 실험 7일째에 가장 높은 발현을 보이다가 14일째 들어서 감소하는 양상을 보였다. MMP-8은 실험 1일째부터 실험군이 대조군에 비해서 더 많은 발현을 보였으며, 특히 4일째의 실험군에서는 대조군보다 두 배 이상 발현되었다. MMP-13은 실험 1일째의 실험군에서 가장 높은 발현도를 보였으며, 대조군에서는 오히려 미처치 대조군에 비해 더 낮게 발현되었다. I형 교원질의 면역조직화학염색 결과는 실험 4일째부터 압박측 에서는 실험군에서 대조군보다 더 많은 교원질의 소실을 보였고, 인장측에서는 대조군이 실험군보다 더 많은 교원질의 염색 소견을 보였다. TIMP-1은 실험 4일째에는 압박측에서 대조군이 실험군보다 치주인대와 치조골의 골세포에서 좀 더 균일한 염색 소견을 보였다. 이상의 실험 결과에서 피질골 천공은 백서의 실험적 치아이동에 있어 치주인대와 치조골 결합 조직의 재형성 속도를 증가시키는 것으로 판단된다.

백서의 치아이동 시 피질골 천공이 치주조직의 OPG, RANK, RANKL의 발현에 미치는 영향

박우경,김성식,박수병,손우성,김용덕,전은숙,박미화 대한치과교정학회 2008 대한치과교정학회지 Vol.38 No.3

치아이동 시 피질골 천공이 치조골 재형성에 미치는 영향을 알아보기 위해서 생후 15주된 자성백서를 사용하여 피질골 천공 후 치아이동을 실시한 실험군(Tooth movement with cortical punching: TMC group, n = 16)과 교정적 치아이동만 실시한 대조군(Tooth movement only group: TM group, n = 16)의 치아주위조직을 면역조직화학염색을 통하여 관찰하였다. 실험군과 대조군의 실험동물에 20 gm의 힘으로 상악 전치부 사이를 이개시키는 치아이동을 시행하였으며 실험군에서는 상악 전치부 구개부위에 피질골 천공을 실시하였다. 치아이동 후 1, 4, 7, 14일째에 실험군과 대조군의 실험동물을 희생시켰다. 면역조직화학염색법으로 OPG, RANK, RANKL의 발현을 비교한 결과, OPG의 발현은 양 군 모두에서 미처치 대조군에 비하여 감소되었으나, 실험군에서의 발현이 대조군보다 컸으며, RANK, RANKL은 피질골 천공을 시행한 경우에 더 강한 발현을 보이는 것이 관찰되었다. 따라서 피질골 천공이 치주조직의 OPG, RANK, RANKL의 발현에 영향을 미치며 치조골의 재형성을 향상시키는 것을 알 수 있었다. Objective: The purpose of this study was to investigate whether cortical punching could stimulate the expression of OPG, RANK, and RANKL during tooth movement by immunohistochemistry. Methods: 34 sprague-dawley rats (15 weeks old) were allocated into 3 groups: TMC group (experimental group; Tooth Movement with Corticotomy, n = 16), TM group (control group; Tooth Movement only group, n = 16), and non-treatment group (n = 2). 20 gm of orthodontic force was applied to rat incisors by inserting elastic bands. The duration of force application was 1, 4, 7 and 14 days. A microscrew (diameter 1.2 mm) was used for cortical punching of the palatal side of the upper incisors in the TMC group. Results: Distributions of OPG, RANK, and RANKL were evaluated by immunohistochemistry. OPG, RANK and RANKL were observed on experimental and control groups. On the compression side, the degree of the expression of OPG decreased in both groups. The expression of RANK was most prominent in the experimental group of day 4. The expression of RANKL was most intensive and extensive in the experimental group of day 7. However, the expression of OPG was decreased in the experimental and control groups compared to the non treatment group. The expression of OPG, RANK and RANKL after force application were decreased at day 14. Conclusions: These findings suggested that cortical punching might stimulate remodeling of alveolar bone during a 2 week period of tooth movement without any pathologic change.

인슐린 비의존형 당뇨병 환자에서 혈장 Endothelin-1농도의 변화

신양수,조희충,김원식,국기용,김용화,정종훈,문철웅,배학연,양성훈 朝鮮大學校 附設 醫學硏究所 1992 The Medical Journal of Chosun University Vol.17 No.2

Endothelin(ET) is a 21-residue peptide originally isolated from the cultured porcine endothelial cells. There are at least three genes for endothelin:endothelin-1(ET-1), endothelin-2(ET-2), and endothelin-3(ET-3). Endothelins are present in various human biological fluids including plasma, urine, breast milk, and saliva and have been found elevated plasma ET concentrations in patients with diabetes mellitus, Patients undergoing maintenance hemodialysis due to chronic renal failure, patients with acute myocardial infarction, and patients with subarachnoid hemorrhage. Endothelial cell damage is suspected to occur in diabetic patients and may be one important cause of angiopathy, a major complication in diabetes mellitus. The elevation of ET in diabetic patients may be a marker of, and further exacerbate, their vascular disease. We measured the levels of ET-1 in plasma of 50 patients with non-insulin dependent diabetes mellitus(NIDDM) and 25 normal subjects by radioimmunoassay. The plasma ET-1 concentration (mean±S.D.) in NIDDM was 6.461 A2.510 f㏖/ ㎖, and was significantly higher than in normal subjects (4.567±1.155f㏖/㎖) (P<0.05). The plasma ET-1 concentration (mean±S.D.) in diabetic retinopathy group( 7.15±2.454 f㏖/ml) was significantly elevated than those in otherwise uncomplicated groups (5.348±2.390 f㏖/㎖)(P<0.01). The correlation between any clinical parameters and plasma ET-1 levels in NIDDM was not significant, In conclusion, this study suggest that the elevated levels of ET-1 in diabetic patients may be play a important role in the pathogenesis of diabetic complications.

Preoperative Levels of Uric Acid and Its Association to Some Perioperative Parameters in the Patients with Unstable Angina or Myocardial Infarction

Chan-Sik Kang,Seong-Ja Seok,Hwa-Sik Choi,Dae-Sik Kim,Seok-Cheol Choi,Seong-Min Moon 대한의생명과학회 2011 Biomedical Science Letters Vol.17 No.2

Several studies have reported a relation between serum levels of uric acid and a wide variety of cardiovascular conditions. But, the relationship between serum levels of uric acid and coronary artery disease (CAD) is still controversial. The present study was retrospectively designed to investigate whether CAD can be stratified by the level of uric acid and there are the relationships between preoperative levels of uric acid and perioperative biochemical markers in fifty-adult patients that underwent coronary artery bypass grafting surgery (CABG) and twenty-normal subjects. They were divided into the control, the unstable angina (UA-group) and the myocardial infarction group (MI-group). In preoperative levels of uric acid, the MI-group was higher than control and the UA-group. The MI-group had significantly higher correlations than the UA-group between preoperative levels of uric acid and left ventricular ejection fraction, cardiac markers (creatine kinase, lactate dehydrogenase and brain natriuretic peptide), renal markers (blood urea nitrogen and creatinine) or total leukocyte levels. At postoperative periods, the MI-group had higher relationships of uric acid with aspartate aminotransferase, blood urea nitrogen or creatinine levels. Although there was not statistically significant, the UA-group tended to have higher correlation coefficients than the MI-group between preoperative levels of uric acid and intensive care unit-stay (ICU), or postoperative mechanical ventilation time. These results reflect that increased levels of serum uric acid may be a tool for the diagnosis of coronary heart disease and may be considered as a good predictor in assessing the cardiac and renal functions in patients with myocardial infarction or unstable angina at the preoperative period. However, further studies should be performed in a large patient population.

치성 각화낭종의 임상적 연구

성화식(Hwa-Sik Seong),이주민(Ju-Min Lee),황대석(Dae-Seok Hwang),김용덕(Yong-Deok Kim),김욱규(Uk-kyu Kim),김종렬(Jong-Ryoul Kim),정인교(In-Kyo Chung),신상훈(Sang-Hun Shin) 대한구강악안면외과학회 2009 대한구강악안면외과학회지 Vol.35 No.2

Purpose: The purpose of this study is to investigate the clinical and histological features of odontogenic keratocyst Patients and Methods: A retrosective review of 100 patients who were diagnosed as odontogenic keratocyst by hitological findings during the period of January 2000 and December 2005 in the Dept. of Oral and Maxillofacial surgery Pusan National University was consecuted. For each patient, age, sex, location of lesion, initial diagnosis by radiographic features, treatment procedure, hitologic findings and recurrance rate were evaluated. Results: In this study, OKC has male prevalance to female by 1.38:1, and most likely occurs during third decade. The most common site of lesion was mandibular ramus region(34.6%) and the most common symptom was swelling(50%). The most common initial diagnosis by radiographic findings was OKC and cyst enucleation was the most common treatment method. The recurrance rate was 28% and existence of daugther cyst is thought to be most convincing factor for prediction of recurrence. Conclusion: In this study, total recurrence rate was 28% and existence of daugther cyst is thought to be most convincing factor for prediction of recurrence. But, since 97% of patients were treated by enucleation and adjuntive excision, further styudy is need about concordance of recurrence rate with surgical method.

The Efficacy of Radical Hysterectomy plus Tailored Adjuvant Therapy in non-Bulky Node-positive Early Cervical Cancer

( Seong-hee Kim ),( Yong-man Kim ),( Ju-hyeon Nam ),( Yeong-tak Kim ),( Jong-hyeok Kim ),( Dae-sik Suh ),( Jeong-yeol Park ),( Shin-hwa Lee ),( Ju-hee Kim ),( Ji-hoon Lee ),( Oak-ju Kang ),( Dae-yeon 대한산부인과학회 2018 대한산부인과학회 학술대회 Vol.104 No.-

Objective: The controversy between the proponents of radical pelvic surgery and those of radiotherapy for primary treatment in early cervical cancer still exists for a long time. The aim of this study is to demonstrate the efficacy of radical hysterectomy as primary treatment in non-bulky node-positive early cervical patients. Methods: Patients that were diagnosed with cervical cancer and received RH at Asan Medical Center between January 2013 and December 2015 were identified from an electronic database at our center, and their medical records were reviewed retrospectively. The eligibility criteria for patients inclusion in this study were as follows: previously untreated; pathologically diagnosed cervical cancer; an age of 20-80 years at the time of surgery; laparoscopic or open radical hysterectomy with pelvic and/or para-aortic lymphadenectomy; clinical tumor or MIR tumor size under 4cm and lymph node positive in imaging study. Patients whose cell type was small cell carcinoma or neuroendocrine carcinoma, who underwent neoadjuvant chemotherapy, or who had other coexisting malignancies were excluded. Results: Of the 53 patients, 6 patients (11.3%) were recurred, and 4 patients were died among the recurred patients. 15 patients (28.3%) were not received any adjuvant therapy after radical hysterectomy. 2years overall survival was 93%, and 3years overall survival was 90% in non-bulky lymphadenopathy cervical cancer patients. 2years recurrence-free survival rate was 86%. 15 patients (28.3%) were not received any adjuvant therapy after radical hysterectomy. Conclusion: In non-bulky lymphadenopathy cervical patients who received radical hysterectomy as primary treatment, it presented good overall survival and recurrence-free survival rates. It was single-arm study. The necessity of multicenter prospective randomized controlled comparative study between radical pelvic surgery and radiotherapy as primary treatment in high risk early cervical cancer was highly required.

Hemoperitoneum caused by ectopic location of adenomyomatous polyp

( Hwa Sook Moon ),( Ja Seong Koo ),( Gyeong Il Nam ),( Gun Sik Park ),( Sang Gap Kim ),( Jin Kuk Choi ) 대한산부인과학회 2018 대한산부인과학회 학술대회 Vol.104 No.-

Common causes of hemoperitoneum in women include rupture of ovarian cyst and ectopic pregnancy. Recently we experienced a very unusual case of adenomyomatous polyp(AMP) which penetrated through the whole myometrium and caused hemoperitoneum. Case: A 46-year-old multiparous woman was diagnosed with hemoperitoneum at a private clinic and transferred to our hospital. Her chief complaint was abdominal pain for 3days. She had a previous history of left salpingectomy and appendectomy. She was taking oral pills for contraception. Both tenderness and rebound tenderness of the whole abdomen were present on physical examination, but the abdomen was soft and flat. Her vital signs were stable and hemoglobin level was 12.7g/dL, serum-hCG level below 1.2 mIU/ml. Transvaginal ultrasound demonstrated free fluid in cul de sac, slightly enlarged uterus (5.33cm in anteroposterior dimensions) due to two intramural myomas (1.96 x 1.33cm, 2.89 x 3.48cm) and thin endometrium. She underwent operative laparoscopy. Approxiamtely 500cc of blood and blood clots were noted in the abdomino-pelvic cavity. A brown-colored soft tissue lesion suspected to be a pregnant product or an old ruptured pregnant tissue was noted in the right cornua. Removed tissue was sent for frozen biopsy of which result was endometrial tissue. The myometrial lesion showed connection to the endometrial cavity. Resection site was closed with interrupted endosutures. The postoperative course was uneventful and the final pathologic report was AMP. Postoperative ultrasound revealed no abnormal finding at the site of operation. Conclusion: AMP of the endometrium is a rare benign disease, with an incidence as low as 1.3% of all endometrial polyps. Grossly AMP cannot be dintinguished from an ordinary endometrial polyp. It is histologically characterized by endometrial glands and stroma admixed with smooth muscle cells. To our knowledge, this is the first report of a AMP growing through the myometrium into the pelvic cavity.

Enhancement of the Cyclability of a Si Anode through Co₃O₄ Coating by the Sol–Gel Method

Hwa, Yoon,Kim, Won-Sik,Yu, Byeong-Chul,Hong, Seong-Hyeon,Sohn, Hun-Joon American Chemical Society 2013 JOURNAL OF PHYSICAL CHEMISTRY C - Vol.117 No.14

<P>A nano-Si/Co<SUB>3</SUB>O<SUB>4</SUB> core–shell nanostructured material has been successfully prepared using the sol–gel method. The reaction mechanism between Li and the nano-Si/Co<SUB>3</SUB>O<SUB>4</SUB> core–shell nanostructured electrode was investigated by ex situ analyses. Metallic Co, Li<SUB>21</SUB>Si<SUB>8</SUB>, and amorphous Li<SUB>2</SUB>O phases were formed when fully lithiated, and an amorphous Si, Co<SUB>3</SUB>O<SUB>4</SUB>, and Co phases were identified after charge, indicating that the Co<SUB>3</SUB>O<SUB>4</SUB> was partially reversible. The nano-Si/Co<SUB>3</SUB>O<SUB>4</SUB> core–shell nanostructured electrode showed excellent cyclability, with a reversible capacity of ca. 850 mAh/g over 100 cycles.</P><P><B>Graphic Abstract</B> <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/jpccck/2013/jpccck.2013.117.issue-14/jp401333v/production/images/medium/jp-2013-01333v_0006.gif'></P>