Associations of serotonergic genes with poststroke emotional incontinence

Kim, Jae‐,Min,Stewart, Robert,Kang, Hee‐,Ju,Bae, Kyung‐,Yeol,Kim, Sung‐,Wan,Shin, Il‐,Seon,Kim, Joon‐,Tae,Park, Man‐,Seok,Cho, Ki‐,Hyun,Yoon, Jin‐ John Wiley Sons, Ltd 2012 INTERNATIONAL JOURNAL OF GERIATRIC PSYCHIATRY Vol.27 No.8

<P><B>Objectives</B></P><P>Poststroke emotional incontinence (PSEI) has been associated with serotonergic dysfunction. Polymorphisms of serotonin transporter (5‐HTT) and serotonin 2a receptor (5‐HTR2a) genes may regulate serotonergic signaling at brain synapses, and this study was to investigate associations with PSEI in an East Asian population.</P><P><B>Methods</B></P><P>In 276 stroke cases, PSEI was diagnosed by Kim's criteria. Covariates included age, gender, education, history of depression or stroke, current depression, and stroke severity and location. Genotypes were ascertained for 5‐HTT gene‐linked promoter region (5‐HTTLPR), serotonin transporter intron 2 variable number tandem repeat, 5‐HTR2a 1438A/G, and 5‐HTR2a 102 T/C. Associations with PSEI were estimated by using logistic regression models, and gene–gene interactions were investigated by using the generalized multifactor dimensionality reduction method.</P><P><B>Results</B></P><P>PSEI was present in 37 (13.4%) patients. The 5‐HTT gene‐linked promoter region <I>s</I>/<I>s</I> genotype was independently associated with PSEI. No associations with STin2 VNTR and 5‐HTR2a genes were found, and no significant gene–gene interactions were identified.</P><P><B>Conclusions</B></P><P>Stroke patients with 5‐HTTLPR <I>s</I> allele had higher susceptibility to PSEI, which underlines the potential role of serotonergic pathways in its etiology. Copyright © 2011 John Wiley & Sons, Ltd.</P>

초등학생에서 인두배양과 항-OF 항체 보유율

정현주,김선주,김윤정,맹국영,정현주,김선주,김윤정,맹국영 대한임상병리학회 1998 대한임상병리학회지 Vol.18 No.3

S-542 Indomethacin aggravates the renal injury by inhibition of adenosine-medited renal protection in AKI

( Hyejung Kim ),( Sun-hee Kim ),( Mi Seon Kang ),( Park Seok Ju ),( Min Sung An ),( Ki Beom Bae ) 대한내과학회 2016 대한내과학회 추계학술대회 Vol.2016 No.1

Background: Ischemia-reperfusion injury (IRI) is a leading cause of acute kidney injury with high morbidity and mortality due to limited therapy. AKI emerges in various clinical settings and is complex with outcome linking oxidative stress, inflammation, and cell death. Therefore protection of AKI is still an unsolved problem. Indomethacin is generally known that it inhibits the production of prostaglandins through the inhibition both cyclooxygenase (COX) 1 and 2. Prostaglandins have a wide variety of effect such as regulation of vasodilation, inflammation, regeneration, pain, fever. Therefore effect of indomethacin in AKI is different according to injury model. We investigated whether indomethacin which inhibits the production of prostaglandins aggravate the renal injury in AKI mouse model. Methods: Male C57/BL6 mice (8-10 weeks old, weight 20~25 g) were used. Acute kidney injury is induced by bilateral kidneys pedicle clamping which were subjected to 20 min or 30 min at both kidneys. Mice were treated with indomethacin at before and after injury. Blood and kidney samples were collected at 24 hr after IRI. The expression level of creatinine, N-gal & Kim-1 were detected in serum. And the expression level of PGE2, cAMP and adenosine were detected in kidney. Kidney Injury score were measured by HE staining and TUNEL. Results: In bilateral AKI model, Serum NGAL level and creatinine level were significantly highest in indomethacin treated group compared to non-treated group (NGAL, p<0.05; creatinine, p<0.01). Indomethacin treated group showed significantly more necrosis and apoptosis compared to non-treated group. Furthermore, Indomethacine inhibited the production of prostaglandins, cAMP and adenosine. Conclusions: Indomethacin inhibits adenosine-mediated renal protection by inhibition of prostaglandin production in AKI. Therefore Indomethacin worsened renal injury by inhibition of prostaglandin production in AKI. * This research was supported by a grant of the Korea Health Technology R&D Project through the KHIDI, funded by the Ministry of Health & Welfare, Republic of Korea (grant number :H15C2212)

CIS 고려인 디아스포라 소설 연구

장사선(Jang Sa Seon),김현주(Kim Hyeon Ju) 한국현대소설학회 2004 현대소설연구 Vol.- No.21

This study aims to examine the general trend of novels written by Soviet-Korean in C I S. Soviet-Koreans in this Central Asian area have moved from the Far Eastern area of Russia by the enforcement of the Stalinian policy of deportation in 1937. The authors have written a number of novels describing the life of diaspora experienced by Korean residents. To be more specific, the main focus of these novels is centered onto the issues such as the adaptation to the socialist system, the discord or accord with the different nation, the self-identity, and so on. The representative authors and their works are as follow: Seil Kim`s HongBeomDo and Jun Kim`s A happening of one hundred and fifty thousand won that depict the heros of anti-Japanese fight, Gicheol Kim`s When red stars were seen and a group works, The melody of Syrdarya that praise the socialism, sunflower and ``자말러, you are my life that treat the agony of identity as Koreans in a foreign country, and several works of Anatoli Kim and Lee-Jin that reflect the times of the various open door, On the whole, each novel expresses successfully the scenes of life with a different ideology and in the unfamiliar environment and embodies such troubles adequately into the form of literature. However, there also exist some problems of the plain development of plot. the dichotomic way of thinking, the excessive exposure of the theme, and so forth. After the collapse of the Soviet Union around 1990. a rapid conversion of direction toward modernism has occurred. With the opening of the exchange gate between Korea and CIS, there have been many changes in the content and publication of the works. More extensive research is needed.

셋트 제품의 컨테이너 적재 알고리즘 개발에 관한 연구

김홍배,노재정,강주선 慶星大學校 1998 論文集 Vol.19 No.1

This study is focused on the methodology for the determination of the loading pattern for set products which can be charactertized by the fact that various kinds of parts should be provided together in order to function as one product such as home appliances or military supplies. This study is composed of the development of the mathematical model and its solution algorithm. The model tries to maximize the utilization rate of the loading space under the condition that the same number of the components of each set product should be loaded. This study can give the loading pattern and present the quantity information on the sub-set products to the user. The result of this study is compared with George & Robinson's algorithm under the same condition that this study is performed.

UR 보조금 협정과 정보통신진흥기금의 개편방향

김동주,최선규 高麗大學校 産業開發硏究所 1995 産業開發硏究 Vol.4 No.-

연령별 Antistreptolysin O 분포 및 정상치

김선주,정명아,정현주,김윤정,맹국영 대한감염학회 1998 감염 Vol.30 No.4

배 경 : ASO 검사는 S. pyogenes 감염과 류마티스열이나 급성 사구체신염 등 후유증을 진단하는데 매우 유용하다. ASO 정상치는 연령에 따라 달라지는 것으로 알려져 있으므로, 단회의 ASO 결과를 올바로 해석하기 위해서는 같은 지역의 동일한 연령의 정상치를 알고 있어야 한다. 방 법 : 저자들은 진주지역 학동기전 아동 (162명), 초등학생 (436명)과 성인 (231명) 세 군에서 ASO 정상치와 분포를 살펴보았다. 연쇄구균 감염 증상이나 징후가 없는 진주 지역 주민들을 대상으로 혈청내 ASO치를 자동화학분석기 (Cobas Mira, Roche)와 비탁기 (Behring Nephelometer 100 Analyzer)를 이용하여 정량 분석하였다. 결 과 : 학동기전 아동, 초등학생 및 성인에서의 평균 ASO치는 각각 71 IU/mL (표준편차 107), 285 IU/mL (표준편차 246) 및 80 IU/mL (표준편차 64) 이었고, 정상상한치는 각각 131 IU/mL, 433 IU/mL, 136 IU/mL 이었다. 결 론 : ASO 정상치 및 분포는 각 연령군에 따라 크게 다르므로, ASO 정상치는 연령에 따라 다르게 설정되어야 할 것이다. A군 연쇄구균 감염은 학동기전 아동이나 성인에서는 매우 드문 반면, 초등학생에서는 빈번함을 알 수 있었다. Background : Antistreptolysin O (ASO) is very useful as an indicator of recent streptococcal infection and its sequelae, such as rheumatic fever and acute glomerulonephritis. Becuase the upper limit of normal (ULN) value of ASO varies according to age, the ULN value of ASO in an area should be evaluated to accurately interpret single ASO levels of patients. Methods : The ULN value and distribution of ASO concentrations were investigated in three age groups of preschool children (N=162), elementary school children (N=436), and adults (N=231) in Chinju. ASO concentrations were measured quantitatively by autoanalyzer or nephelometer from sera of healthy population in Chinju who had no symptoms or signs of streptococcal infections. Results : The mean (±SD) ASO concentrations were 71 (±107) IU/mL, 285 (±246)IU/mL, and the UNL value of ASO concentratios were 131IU/mL, 433IU/mL, and 136 IU/mL in each group of preschool children, elementary school children, and adults, respectively. Conclusion : The distributio and ULN value of ASO concentrations varied according to age group. The ULN value of ASO concentrations should be set differently according to the patient's age. Group A streptococcal infections might be quite common in elementary school children, while very rare in preschool children or adults.

불소적용시 법랑질과 상아질에서 불화칼슘형성의 차이에 관한 실험적 연구

김재곤,권선자,윤현두,안수현,백병주 大韓小兒齒科學會 1998 大韓小兒齒科學會誌 Vol.25 No.1

The purpose of this study was to compare the amount of calcium fluoride deposited on the enamel and dentin surface and to obtain information on the morphological change and crystallographic details of mineral deposition after 12,000ppm APF application in vitro. The bovine enamel and dentin blocks were randomly assigned to eight groups according to artificial caries lesion formation and difference of fluoride application time. The fluoride concentration and morphological characteristics on the treated enamel and dentin surface were investigated by using fluoride quantitative analysis and SEM. The powdered enamel and dentin of the intact bovine incisors were prepared for the X-ray diffraction analysis. The following results were obtained. 1. The amounts of KOH-soluble fluoride on the carious enamel and dentin surface after 24h APF application were higher than after only 5min APF application(P<0.05), but in the case of the sound enamel and dentin surface were similar after 5min and 24h application (P>0.05). The fluoride content was highly increased in the carious dentin as compared with sound dentin after APF application(P<0.05). 2. The caruous enamel surface after APF application, the demineralized enamel surface were recovered a more dense enamel surface and precipitation of crystal was observed a distintive surface layer of spherical globules of about 1 m diameter. In the case of the fluorided carious dentin surface, precipitation of calcium fluoride-like material was deposited both inside the dentinal tubules as well as in the intertubular regions. 3. The crystallographic structure of powdered enamel and dentin after 24h APF application had large crystallities of apatite and CaF2 diffraction peaks in the enamel as compared with dentin. The diffraction data collected from the 27.50-29.50(2) angular range of the powdered enamel, the (105) apatite, (225) apatite and (111) CaF2 peaks of the enamel crystallities were detected after 24h APF application.

진주지역에서 연쇄구균감염후 사구체신염의 재유행 : 최근 10년간의 임상적 고찰 Clinical Review of Recent 10 Years

김선주,김윤정 대한감염학회 1998 감염 Vol.30 No.6

목적 : 최근 구미에서 류마티스열이 재유행하고 A군 연쇄구균의 침습성 감염이 증가하고 있다. A군 연쇄구균 감염의 비화농성 후유증의 하나인 PSAGN이 재유행하는지 살펴보기 위해 진주지역에서 PSAGN의 발생 빈도를 조사하였다. 방법 : 1988년 1월부터 1998년 8월까지 경상대학교병원에 입원한 환자 중 PSAGN으로 진단받은 90명의 의무기록을 후향적으로 조사하여 PSAGN의 연도별 발생율과 환자들의 임상적 특성 및 검사 결과를 살펴보았다. 결과 : PSAGN의 발생빈도는 1993년까지 점차 감소하여 1993년에는 0.09%이었다가 1994년부터 다시 증가하였는데, 특히 1996년에는 1.83%로 유의하게 증가하였다(P<0.01). 월별로 보면 10월부터 1월까지 주로발생하여 전체 발생율의 64.4%를 차지하였다. 증상은 부종 78.9%, 육안적 혈뇨 65.6%, 핍뇨 22.2%, 발열이 16.7%에서 있었고, 내원당시 혹은 입원 중에 고혈압이 나타난 예는 28.9%이었다. ASO 증가가 92.0% (80/87)에서 있었고, C3와 CH50의 감소는 각각 94.4% (85/90)와 93.2% (41/44)에서 나타났다. 결론 : PSAGN의 발생은 1993년까지 감소하였지만 1994년 이후 다시 증가하는 추세임을 알 수 있었다. PSAGN의 재유행이 한 지역에 국한된 현상인지 전국적인 현상인지에 대한 신속한 조사가 필요하다. PSAGN의 원인균을 규명하기 위해 A군 연쇄구균에 대한 혈청학적 연구 등 역학적 조사가 필요하며, 비화농성 후유증을 예방하기 위해 A군 연쇄구균 인두염에 대한 적절합한 항생제 치료가 요구된다. Background : Rheumatic fever (RF) or streptococcal invasive disease have surged in developed countries recently. Incidence of poststreptococcal acute glomerulonephritis (PSAGN), a sequelae of group A streptococci (GAS) infection was investigated to evaluate the resurgence of PSAGN in Chinju. Methods : Medical records of 90 patients with PSAGN from January 1988 to August 1998 were reviewed retrospectively. Annual incidence, clinical characteristics, and laboratory findings were analyzed. Results : Annual incidence of PSAGN decreased until 1993, to as low as 0.09%, but started to increase in 1994 and became significantly high (1.83%) in 1996 (p<0.01). Most (64.6%) of PSAGN cases occurred from October to January. Major symptoms were edema (78.9%), gross hematuria (65.6%), oliguria (22.2%), and fever (16.7%). Hypertension was observed in 28.9% during admission. Increase of ASO were observed in 92.0% (80/87), decrease of C3 and CH50 in 94.4% (85/90) and 93.2% (41/44), respectively. Conclusion : Annual incidence of PSAGN decreased until 1993, but increased from 1994. Whether this resurgence of PSAGN is merely regional or part of a national epidemic should be investigated.

진주 지역 초등학생의 Antistreptolysin O 분포 및 정상치 : 인두배양 결과에 따른 분석 analyzed by throat culture

김선주 대한감염학회 1997 감염 Vol.29 No.3

배경: ASO 검사는 S. pyogenes 감염과 후유증을 진단하는데 많이 사용되고 잇지만 대개 단회의 검사를 하므로 그 결과를 판정하는데 어려움이 있다. 환자의 ASO치 결과를 올바로 해석하기 위해서는 같은 지역의 동일한 연령의 정상치를 알고 있어야 한다. 초등학생에서 S. pyogenes 감염이 매우 흔한 것을 감안하면, 이 연령에서 인두배양과 ASO 검사는 충분히 잘 연구되어야 한다. 방법: 진주 지역 초등학생 436명에 대해 비탁법(nephelometry)을 이용하여 ASO치를 정량 측정하였다. 동시에 인두배양도 실시하여 세균배양 결과 각 혈청군과 집락수, M 단백형에 따라 ASO치를 분석하였다. 결과: 평균 ASO치는 285IU/ml이었고, 정상상한치는 433IU/ml이었다. 5학년(350IU/ml)을 제외하고는 전학년의 ASO치가 253-285IU/ml로 비슷하였다. A군뿐만 아니라 C군 및 G군 보균자도 비보균자에 비해 ASO치가 높았다. 집락수가 10개(A군), 혹은 50개(비A군) 이상 가지고 있는 아동은 그 이하의 집락수를 가진 아동에 비해 ASO치가 높았다. M22는 M 12 및 M 28에 비하여 ASO치가 높았다. 결론: 진주 지역 초등학생의 ASO 정상상한치는 433IU/ml이었고, 이는 서울 (326IU/ml)과 충남 (499IU/ml)의 사이이었다. 집락수가 10개 혹은 50개 이상인 경우 ASO치가 높아 무증상감염을 의심해야 하고, C군과 G군 분리자에서도 ASO치가 상승할 수 있음을 알 수 있었다. 어떤 M 단백형은 streptolysin O 항원을 더 많이 분비하여 병독력이 강한 것을 추정할 수 있었다. Background: Antistreptolysin O(ASO) is very useful as an indicator of recent streptococcal infections and their sequelae, such as rheumatic fever and acute glomerulonephritis. To interpret single ASO level of patients , the upper limit of normal(ULN) ASO from the same age group in the area should be known. As Streptococcus pyogenes infections are quite common in elementary school, we measured ASO and analyzed them by the results of throat culture to determine upper limit of normal ASO of school children in Chinju area. Methods: ASO concentrations were measured quantitatively by nephelometry on 436 sera of healthy elementary school children in Chinju area. Throat cultures were taken at the same time to evaluate the relationship between ASO concentrations and throat culture results, including serogroup, colony forming units(CFU), and M types. Results: The mean ASO concentration was 285IU/ml and the upper limit of normal ASO was 4331iU/ml. The ASO levels were even (253-285IU/ML) thorough whole school grades except the 5th grade(350IU/ml). Not only the carriers of group A streptococci, but also those of group C or group G streptococci had higher ASO levels. The children from whom more than 10 CFU of S. pyogenes were isolated showed higher ASO levels than those who had less than 10 CFU. The ASO levels were higher in M type 6 or 22 compared to M type 12 or 28. Conclusion: The upper limit of normal ASO of children in Chinju was 4331IU/ml, that is between Seoul(326IU/ml) and Chungnam(4991IU/ml). The children who had more than 10 CFU tended to have higher ASO levels, which indicate asymptomatic infections are associated with burden of bacteria. Group C of Group G streptococci implicated as strong producer of streptolysin O.