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보건관리대행 기관의 사업장내 진료에 대한 근로자 요구 및 실시 의향
원종욱,송재석,정선아,박화미,노재훈 大韓産業醫學會 2001 대한직업환경의학회지 Vol.13 No.1
목적 : 본 연구에서는 보건관리대행 사업에 있어 사업장내 진료에 대한 수요와 보건관리대행기관의 방문진료 제공에 대한 의향을 조사하여 사업장내 진료에 대한 욕구를 파악하고, 이를 토대로 사업장내 진료에 대한 기초적인 자료를 제공하는데 목적이 있다. 방법 : 근로자들의 의료이용 행태와 방문진료에 대한 요구도를 파악하기 위해 167개 보건관리대행 사업장의 사업주와 보건담당자, 그리고 1,350명의 근로자에게 설문 조사를 실시하였고, 사업주 121명(72.5%), 보건담당자 145명(86.8%), 근로자 816명(60.5%)이 응답하였다. 일차진료의 제공 가능성을 파악하기 위해서 전국의 66개 보건관리대행기관의 의사와 간호사 및 행정책임자에게 우편 설문조사를 실시하여 의사 31명 (47.0%), 간호사 38명(57.6%) 및 행정책임자 34명(51.5%)이 응답하였다. 결과 : 보건관리대행 사업을 수행하고 있는 의사의 87%와 간호사의 94%가 보건관리대행 업무를 담당하면서 많은 근로자들로부터 투약 등 진료를 요구받고 있었고, 100 %의 간호사와 행정책임자 94%, 의사의 76 %가 보건관리대행 사업에서 진료를 수행하는 것이 필요하다고 생각하고 있었다. 한편사업주의 85 %, 보건관리 담당자 86 %와 근로자81 %가 보건관리대행기관에서 사업장내 진료를 시행 할 때 이를 수용하겠다고 응답하였다.결론 대다수의 근로자와 사업주가 보건관리대행기관의 진료를 요구하고 있었고, 보건관리대행 기관의 의사와 간호사가 사업장에서의 진료를 수용할 의향이 있고, 직업성 뇌심혈 관계질환의 예방 등 필요성이 인정된다면 보건관리대행 의사의 사업장내 진료를 인정해야 한다고 생각된다. Objectives : This study was performed to survey worker's demands for worksite medical care and agency's intention for offering worksite medical care in Group Health Service Agency. Methods : One study subjects were employers, workers and office personnels in 167 factories. They were asked for medical care utilization behavior and worksite medical care demand. 121 employers(72.5%), 145 office personnels(86.8%) and 816 workers(60.5%) answered the questionnaire. The other subjects were doctors, nurses and administrators in 66 Group Health Service Agencies nationwide. They were asked for intention of offering worksite medical care in Group Health Service Agency through the mail survey. 31 doctors (47.0%), 38 nurses (57.6%) and 34 administrators answered the questionnaire. Results : 87 percentage of doctors and 94 percentage of nurses had experiences of being requested to prescribe and laboratory examination. All nurses, 94 percentage of administrators and 76 percentage of doctors thought that it was necessary to give medical treatment at worksite. Also in worksite 85 percentage of employers, 86 percentage of office personnels and 81 percentage of workers answered that they accepted the worksite medical care when it would be given. Conclusions : Worksite medical care should be permitted because almost of all workers and employers requested worksite medical care, and doctors and nurses in Group Health Service Agency were willing to give worksite medical care and there was necessity to prevent occupational cerebrovascular disease.
한의진단명과 진단요건의 표준화 연구 III : 3차년도 연구결과 보고
최선미,양기상,최승훈,박경모,박종현,심범상,김성우,노석선,이인선,정진홍,이진용,김달래,임형호,김윤범,박성식,송태원,김종우,이승기,최윤정,신순식 한국한의학연구원 1997 한국한의학연구원논문집 Vol.3 No.1
The diagnostic requirements were suggested and explained regarding the systems of differentiation of symptoms and signs in the third year study of standardization and unification of the terms and conditions used for diagnosis in oriental medicine. The systems were as follows : - analyzing and differentiating of epidemic febrile disease - analyzing and differentiating in accordance with the Sasang constitution medicine based on four-type recognition - differentiation of disease according to pathological changes of Chong and Ren channels - standards for diagnosis of women's disease - standards for diagnosis of children's disease - standards for diagnosis of motor and sensor disturbance (-muscle. born, joint, etc.) - standards for diagnosis of neuropsychiatric disease - standards for diagnosis of five sense organ disease - standards for diagnosis of external disease The indivisual diagnosis pattern was arranged by the diagnostic requirements in the following order : another name, notion of diagnosis pattern, index of differentiation of symptoms and signs, the main point of diagnosis, analysis of diagnosis pattern, discrimination of diagnosis pattern, prognosis, a way of curing a disease, prescription, herbs in common use, disease appearing the diagnosis pattern, documents. The standards for diagnosis of each disease was arranged by the diagnostic requirements in the following order : another name, notion of disease, the main point of diagnosis, analyzing and differentiating of disease, analysis of disease, discrimination of disease, prognosis, a way of curing and prescription of disease, disease in western medicine appearing the disease in oriental medicine, documents.
Stimulation of the Extracellular Matrix Production in Dermal Fibroblasts by Velvet Antler Extract
( Seok Seon Roh ),( Min Ho Lee ),( Yul Lye Hwang ),( Hyun Hee Song ),( Mu Hyun Jin ),( Sun Gyoo Park ),( Cheon Koo Lee ),( Chang Deok Kim ),( Tae Jin Yoon ),( Jeung Hoon Lee ) 대한피부과학회 2010 Annals of Dermatology Vol.22 No.2
Background: Fibroblasts produce many components of the extracellular matrix (ECM) and so they contribute to the maintenance of connective tissue integrity. Objective: The aim of this study is to evaluate the effect of velvet antler extract (VAE) on the ECM production of dermal fibroblasts cultured in vitro. Methods: Primary cultured human dermal fibroblasts were treated with VAE, and then the ECM production was determined by RT-PCR, ELISA and Western blot analysis. Furthermore, the change of gene expression according to VAE treatment was evaluated by cDNA microarray. Results: VAE accelerated the growth of fibroblasts in a dose-dependent manner. VAE increased the production of several ECM components, including type 1 collagen, fibronectin and elastin. In line with these results, the phosphorylations of p42/44 ERK and p38 mitogen-activated protein kinase were markedly increased by VAE, suggesting that the enhancement of ECM production may be linked to the activation of intracellular signaling cascades. VAE also significantly increased cell migration on an in vitro scratch wound test. In cDNA microarray, many genes related with connective tissue integrity were identified to be up-regulated by VAE. Conclusion: These results suggest that VAE has a potential to stimulate ECM production, and VAE may be applicable for maintaining the skin`s texture. (Ann Dermatol 22(2) 173~179, 2010)
Expression of miR-200c and its clinicopathological significance in patients with colorectal cancer
Roh, Mee Sook,Lee, Hyoun Wook,Jung, Sang Bong,Kim, Kyungeun,Lee, Eun Hee,Park, Moon-il,Lee, Jae Seok,Kim, Mee-Seon Elsevier 2018 Pathology, research and practice Vol.214 No.3
<P>MicroRNA-200c (miR-200c) is known to play a pivotal role in the regulation of epithelial-to-mesenchymal and mesenchymal-to-epithelial transition processes. However, the biological function of miR-200c in human carcinogenesis remains controversial. We examined the association of miR-200c expression with various clinicopathological factors, including KRAS mutation status and survival, in patients with colorectal cancer (CRC). The expression level of miR-200c was evaluated in 109 paired CRC and normal tissue samples using quantitative reverse transcription polymerase chain reaction. The KRAS mutation status of the CRC samples was determined using the PNAClamp (TM) KRAS Mutation Detection kit. Compared with the normal tissue group, miR-200c expression was significantly upregulated in the CRCs (P<.001). The expression of miR-200c was increased in CRCs with higher grade (P=.009), advanced stage (P=.042), and lymphovascular invasion (P=.003). Thirty-one CRCs (28.4%) had KRAS mutations in codon 12 or 13. CRCs with KRAS mutations had significantly higher miR-200c expression than CRCs with wild-type KRAS (P=.003). In survival analysis, high miR-200c expression was correlated with worse overall survival (P=.017) and recurrence-free survival (P=.048). Our results indicate that miR-200c is involved in tumor progression and aggressiveness in CRCs, and this oncogenic role of miR-200c may be triggered by activation of the KRAS signaling pathway.</P>