http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
한국인 정신분열병 환자의 지연성 운동장애와 $CYP2D6^*4$ 및 $CYP2D6^*10$ 다형성들의 연합에 대한 고찰
우성일,강동우,서한길,김봉조,이인상,정근화,박소영,정치영,이환철,정경천,손진욱,Woo, Sung-Il,Kang, Dong-Woo,Seo, Han-Gil,Kim, Bong-Jo,Lee, In-Sang,Jeong, Geun-Hoa,Park, So-Young,Jung, Chi-Yeong,Lee, Hwan-Cheol,Jeong, Kyeong-Cheon,Sohn, 대한생물정신의학회 2000 생물정신의학 Vol.7 No.2
P450 CYP2D6 enzyme(=debrisoquine hydroxylase) is known to metabolize many neuroleptics and some genetic polymorphisms in the CYP2D6 gene were reported to be associated with tardive dyskinesia(TD). We investigeted the association of two genetic polymorphisms in the CYP2D6 gene, $CYP2D6^*4$ and $CYP2D6^*10$, with TD in Korean schizophrenic subjects. Subjects consisted of 71 Korean schizophrenics and TD was evaluated using the Abnormal Involuntary Movement Scale (AIMS). There were no statistically significant differences in the demographic variables of age, male to female percentage and the current antipsychotic(CPZ equivalent) dose between the group with TD and the group without TD. But the duration of antipsychotic drug exposure was significantly higher in the group without TD(p=0.000, by independent t-test). The mean AIMS score in the group with TD was $11.2{\pm}6.6$(S.D.). Genotypings for the presence of $CYP2D6^*4$ and $CYP2D6^*10$ were done using PCR amplifications and endonuclease digestions. There were no statistically significant genotypic and alleleic associations between TD and $CYP2D6^*4$(by chisquare tests), and between TD and $CYP2D6^*10$(by chi-square tests). These results indicate that the $CYP2D6^*4$ and $CYP2D6^*10$ polymorphisms have no significant roles in the causation of TD.
Park, Miyeong,Jeong, Sang-Ho,Lee, Young-Joon,Park, Ji-Ho,Choi, Sang-Kyung,Hong, Soon-Chan,Jung, Eun-Jung,Ju, Young-tae,Jeong, Chi-Young,Lee, Jeong-Hee,Ha, Woo-Song The Korean Gastric Cancer Association 2017 Journal of gastric cancer Vol.17 No.1
An 84-year-old man was diagnosed with two synchronous adenocarcinomas, a Borrmann type IV advanced gastric adenocarcinoma in his antrum and a well-differentiated Borrmann type I carcinoma on the anterior wall of the higher body of his stomach. Pre-operatively, computed tomography of the abdomen revealed the presence of advanced gastric cancer with peri-gastric and para-aortic lymph node (LN) metastasis. He planned for palliative total gastrectomy owing to the risk of obstruction by the antral lesion. We performed a frozen biopsy of a para-aortic LN during surgery and found that the origin of the para-aortic LN metastasis was from undiagnosed prostate cancer. Thus, we performed radical total gastrectomy and D2 LN dissection. Post-operatively, his total prostate-specific antigen levels were high (227 ng/mL) and he was discharged 8 days after surgery without any complications.
A Case Study on an Inspection of Non-rigid Part
Chi- Sang Park,Sung-Ho Chang,Ki-Youn Kwon,Wang-Bum Lee 한국산업경영시스템학회 2018 한국산업경영시스템학회 학술대회 Vol.2018 No.추계
Manufactured part based on the drawing must be inspected for quality control. If no restraint note is specified on the drawing, the part should be inspected without any clamping(restraining). However if there is a restraint note, the part is non-rigid part. When inspecting non-rigid parts, there are two areas that need special attention: proper restraining of the part and determining which tolerances are checked in the retrained state. Mounting and restraining the part on the appropriate datum features is the first area. When retraining the part, the only forces that should be used are the ones described in the restraint note. The sequence for applying the restraining force specified on the drawing should be followed. The location, direction and amount of force should be in accordance with the restraint note. Once the part is restrained, the tolerances can be verified. When inspecting non-rigid part, the inspector needs to determine which dimensions and tolerances are to be checked in the retrained state. Careful reading of the restraint note will indicate if all or certain tolerances are to be checked in the restrained condition. Each feature control frame should be examined for the use of free state modifier. If a free state modifier is specified, the geometric control should be inspected with the part in the free state. When inspecting a non-rigid part on a coordinate measuring machine(CMM), fixture and clamp should be used to locate and clamp the part. The fixture will establish the proper part restraint conditions and datums. If a fixture is not used when inspecting non-rigid parts, it will be difficult or impossible repeatable measurements.
Chi-Min Park,Ho-Kyung Chun,Dae-Sang Lee,Kyeongman Jeon,Gee Young Suh,Jin Cheol Jeong 대한외과학회 2014 Annals of Surgical Treatment and Research(ASRT) Vol.86 No.6
Purpose: An intensivist is a key factor in the mortality of patients admitted to the intensive care unit (ICU). The aim of this study was to evaluate the effect of an intensivist on clinical outcomes of patients admitted to a surgical ICU. Methods: During the study period, the surgical ICU was converted from an open ICU to an intensivist-directed ICU managed by an intensivist who was board certified in both general surgery and critical care medicine. We compared consecutive patients admitted to the surgical ICU before and after implementing the intensivist-directed care. The primary outcome was ICU mortality, and secondary outcomes were hospital mortality, 90-day mortality, length of hospital stay, ICU-free days, ventilator-free days, and ICU readmission rate. Results: A total of 441 patients were included in this study: 188 before implementation of the intensivist and 253 after implementation. Clinical characteristics were not different between the two groups. ICU mortality decreased from 11.7% to 6.3% (P = 0.047) after implementation, and 90-day mortality also decreased significantly (P = 0.008). The adjusted hazard ratio of the intensivist for ICU mortality was 0.43 (95% confidence interval, 0.22?0.87; P = 0.020). ICU-free days (P = 0.013) and the hospital length of stay (P = 0.032) were significantly improved after implementing the intensivist-directed care. Before implementation period, 16.0% of patients were readmitted, compared with only 9.9% after implementation (P = 0.05). Conclusion: Implementing intensivist-directed care in the surgical ICU was associated with significant improvements in ICU mortality and significant clinical outcomes.
A crucial role of ROCK for alleviation of senescence-associated phenotype
Park, Joon Tae,Kang, Hyun Tae,Park, Chi Hyun,Lee, Young-Sam,Cho, Kyung A.,Park, Sang Chul Elsevier 2018 Experimental Gerontology Vol.106 No.-
<P><B>Abstract</B></P> <P>In our previous study, we uncovered a novel mechanism in which amelioration of Hutchinson-Gilford progeria syndrome (HGPS) phenotype is mediated by mitochondrial functional recovery upon <I>rho-associated protein kinase</I> (ROCK) inhibition. However, it remains elusive whether this mechanism is also applied to the amelioration of normal aging cells. In this study, we used Y-27632 and fasudil as effective ROCK inhibitors, and examined their role in senescence. We found that ROCK inhibition induced the functional recovery of the mitochondria as well as the metabolic reprogramming, which are two salient features that are altered in normal aging cells. Moreover, microarray analysis revealed that the up-regulated pathway upon ROCK inhibition is enriched for chromatin remodeling genes, which may play an important role in the alleviation of senescence-associated cell cycle arrest. Indeed, ROCK inhibition induced cellular proliferation, concomitant with the amelioration of senescent phenotype. Furthermore, the restorative effect by ROCK inhibition was observed <I>in vivo</I> as evidenced by the facilitated cutaneous wound healing. Taken together, our data indicate that ROCK inhibition might be utilized to ameliorate normal aging process and to treat age-related disease.</P> <P><B>Highlights</B></P> <P> <UL> <LI> ROCK inhibition induced the functional recovery of the mitochondria as well as the metabolic reprogramming </LI> <LI> The up-regulated pathways after ROCK inhibition were enriched for genes involved in chromatin remodeling. </LI> <LI> ROCK inhibition induced cellular proliferation, concomitant with the amelioration of senescent phenotype. </LI> </UL> </P>
Preparation and in vivo evaluation of immediate-release pellet containing celecoxib solid dispersion
Park, Chun-Woong,Tung, Nguyen-Thach,Son, Dao-Danh,Kim, Ju-Young,Rhee, Yun-Seok,Kang, Seung-Yeop,Park, Shin-Ae,Hwang, Kyu-Mok,Oh, Tack-Oon,Ha, Jung-Myung,Chi, Sang-Cheol,Park, Eun-Seok 한국약제학회 2012 Journal of Pharmaceutical Investigation Vol.42 No.3
The aim of this study was to make use of small size of immediate-release (IR) pellet and amorphous state of solid dispersion to increase solubility of celecoxib (CLX), a drug in BCS class II. Primary, binary and ternary solid dispersions were developed to choose the final components for solid dispersion. A ternary novel solid dispersion was prepared by incorporation of one aqueous soluble polymer (povidone k17; PVP 17PF), Methacrylate copolymer-based gastric soluble polymer ($Eudragit^{(R)}$ EPO) and one pH modulator (MgO). This combination was effective to increase solubility in pH 1.2 up to 25-30 %. The mechanism of solubility enhancement was proven by DSC, PRXD, and FT-IR. Accordingly, hydrogen bonding or electrostatic interaction of CLX with PVP/$Eudragit^{(R)}$ EPO was the main cause to form the amorphous state of CLX within polymer cluster which increasing solubility of drug. Besides, MgO played an important role to change microenviroment for solid dispersion. Pellets containing this solid dispersion were prepared by extrusion and spheronization technique. Effect of four kinds of additive (calcium hydrogen phosphate dihydrate,$NaHCO_3$, crospovidone, and sodium dodecyl sulfate) on dissolution of CLX from IR pellet was also determined. Because of highest dissolution rate, formulation using sodium dodecyl sulfate was used for pharmacokinetics study. Solid dispersion-IR pellet formulation presented bioequivalence and lower variability in comparison with reference product.
( Sung Soo Park ),( Seung Hoon Kim ),( Mihee Kim ),( Jong Wook Kim ),( Yoo Mi Ko ),( Sung Kyoung Kim ),( So Hyang Kim ),( Chi Hong Kim ) 대한결핵 및 호흡기학회 2015 Tuberculosis and Respiratory Diseases Vol.78 No.4
Although influenza A (H1N1) virus leads to self-limiting illness, co-infection with bacteria may result in cases of severe respiratory failure due to inflammation and necrosis of intra-airway, as pseudomembranous tracheobronchitis. Pseudomembranous tracheobronchitis is usually developed in immunocompromised patients, but it can also occur in immunocompetent patients on a very rare basis. We report a case of pseudomembranous tracheobronchitis complicated by co-infection of inflenaza A and Staphylococcus aureus, causing acute respiratory failure in immunocompetent patients.