Insulin-like Growth Factor-1, IGF-binding Protein-3, C-peptide and Colorectal Cancer: a Case-control Study

Joshi, Pankaj,Joshi, Rakhi Kumari,Kim, Woo Jin,Lee, Sang-Ah Asian Pacific Journal of Cancer Prevention 2015 Asian Pacific journal of cancer prevention Vol.16 No.9

Context: Insulin-like growth factor peptides play important roles in regulating cell growth, cell differentiation, and apoptosis, and have been demonstrated to promote the development of colorectal cancer (CRC). Objective: To examine the association of insulin-related biomarkers including insulin-like growth factor-1 (IGF-1), insulin-like growth factor binding protein-3 (IGFBP-3) and C-peptide with CRC risk and assess their relevance in predictive models. Materials and Methods: The odds ratios of colorectal cancer for serum levels of IGF-1, IGFBP-3 and C-peptide were estimated using unconditional logistic regression models in 100 colorectal cancer cases and 100 control subjects. Areas under the receiving curve (AUC) and integrated discrimination improvement (IDI) statistics were used to assess the discriminatory potential of the models. Results: Serum levels of IGF-1 and IGFBP-3 were negatively associated with colorectal cancer risk (OR=0.07, 95%CI: 0.03-0.16, P for trend <.01, OR=0.06, 95%CI: 0.03-0.15, P for trend <.01 respectively) and serum C-peptide was positively associated with risk of colorectal cancer (OR=4.38, 95%CI: 2.13-9.06, P for trend <.01). Compared to the risk model, prediction for the risk of colorectal cancer had substantially improved when all selected biomarkers IGF-1, IGFBP-3 and inverse value of C-peptide were simultaneously included inthe reference model [P for AUC improvement was 0.02 and the combined IDI reached 0.166% (95 % CI; 0.114-0.219)]. Conclusions: The results provide evidence for an association of insulin-related biomarkers with colorectal cancer risk and point to consideration as candidate predictor markers.

P-71 Association of macronutrients with COPD prognosis in Korean population: a prospective cohort study

( Pankaj Joshi ),( Sang-ah Lee ) 대한결핵 및 호흡기학회 2016 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.121 No.0

Purpose: Lung function has been recognized as an independent indicator of chronic obstructive pulmonary disease (COPD) prognosis. Since a diet deficient in calories and protein has a negative effect on immune function in COPD, the aim of the study was to determine the association between daily intake of macronutrients and COPD prognosis prospectively. Methods: The study used the data from community-based Korean Genome and Epidemiology Study (KoGES) cohort. Lung function was assessed by forced expiratory volume (FEV1) and forced vital capacity (FVC). The dietary intake of macronutrients was estimated from validated Food-Frequency Questionnaire. For the analysis, 668 COPD subjects and 6445 non-COPD subjects were selected from the cohort of 10,030 subjects. Multiple logistic regression models were used to examine the odds ratio (OR) after adjusting in three models. Results: The height, BMI, job, education, type of house, smoking, and history of tuberculosis affected the lung function prognosis in non-COPD subjects. History of asthma was significantly associated with COPD prognosis among COPD subjects. Intake of energy (P trend= 0.004), protein (P trend= 0.009), and carbohydrate (P trend= 0.003) were associated with increase in lung function of non-COPD subjects. Protein intake was significantly associated in improvement of COPD prognosis in COPD (P trend= 0.04) and combined study subjects (P trend= 0.006). Conclusion: Our results suggest that the daily intake of protein has a beneficial effect in the improvement of COPD prognosis especially in COPD subjects.

Effect of dietary patterns on the blood/urine concentration of the selected toxic metals (Cd, Hg, Pb) in Korean children

우병욱,김봄,Pankaj Joshi,권성옥,김연진,오정숙,김정선,오세영,임지애,최병선,김유미,엄상용,홍영섭,손석준,박경수,표희수,김호,하미나,박정덕,권호장,이상아 한국식품과학회 2018 Food Science and Biotechnology Vol.27 No.4

This study was aimed to examine the association the blood/urinary concentration of toxic metal (Hg, Pb, and Cd) with children’s dietary patterns. This cross-sectional study included 1026 school children aged 8–17 years. Dietary patterns were defined using factor loading scores for 108 foods from a Semi-Quantitative Food Frequency Questionnaire. A high blood Hg level was found in boys with a high score in the ‘fish’ pattern (p = 0.02), and in girls with a high score in ‘fruit’ pattern (p = 0.04). The concentration of Pb was related to the ‘imprudent’ pattern in high school boys (p = 0.02). The effect of the ‘vegetable’ pattern on high excretion of urinary Cd was observed in low grade elementary (p = 0.04) and middle school students (p\0.0001), and the effect of the ‘fruit’ pattern on the urinary Cd was observed in high grade elementary school students (p = 0.02). This study suggests that the concentration of selected toxic metals in blood/ urine could be affected by children’s dietary pattern.

Mechanical, Thermal and Thermomechanical Properties of Sponge Iron Slag filled Needle-Punched Nonwoven Jute Epoxy Hybrid Composites

Ankush Sharma,Mahavir Choudhary,Pankaj Agarwal,Shivam Joshi,S.K. Biswas,Amar Patnaik 한국섬유공학회 2021 Fibers and polymers Vol.22 No.4

In the present research work, the needle-punched nonwoven jute epoxy composites are fabricated by varying theweight percentages of sponge iron slag in vacuum assisted resin transfer molding technique. This study examines thephysical, mechanical and thermomechanical properties (i.e., density, water absorption, tensile, flexural, inter-laminar shearstrength, compression, impact, fracture toughness and dynamic mechanical analysis) of unfilled and 8 wt.%, 16 wt.% and24 wt.% of sponge iron slag filled composites under controlled operating conditions. Moreover, it is shown that all themechanical properties improved with the increased in sponge iron slag content except for tensile strength which increasedonly upto 16 wt.%. This study also attempted for the analysis of thermal conductivity of the unfilled and particulate filledcomposites in experimentally by hot disc method. This work also presents both existing empirical models and numericalsimulation analysis to evaluate the thermal conductivity of the developed composites. The numerical simulation values of thethermal conductivity demonstrated good agreement with the experimental values. At the end, Cole-Cole plot is drawnbetween loss modulus and storage modulus to understand the nature of the proposed composites.

Leptin DNA Methylation and Its Association with Metabolic Risk Factors in a Northwest Indian Obese Population

Sadashiv,Anupama Modi,Manoj Khokhar,Praveen Sharma,Rajnish Joshi,Sudhanshu Shekhar Mishra,Rajay N Bharshankar,Sunita Tiwari,Pankaj Kumar Singh,Vivek Vidyadhar Bhosale,Mahendra Pal Singh Negi 대한비만학회 2021 The Korean journal of obesity Vol.30 No.3

Background: It is well established that obesity is a major health risk in diabetes and associated diseases. Epigenetic changes, specially DNA methylation, play an important role in regulation of adipokines. The objective of the present study was to evaluate the DNA methylation status at the promoter region of the leptin gene in obese individuals and its association with metabolic risk factors. Methods: The study included obese (n=100) and non-obese (n=75) individuals aged 25–45 years, and measured their physical, biochemical parameters (glucose, insulin, and lipid profiles) and leptin, DNA methyltransferase 1 (DNMT1), and DNA methyltransferase 3 beta (DNMT3b) mRNA expressions with real-time reverse transcription-polymerase chain reaction (qRT-PCR). DNA methylation of the leptin gene at the promoter region was analyzed by methyl-specific qPCR . Results: The study found that the DNA methylation level at the promoter area of the leptin gene was negatively associated with weight in obese subjects. Furthermore, study findings showed that the DNA methylation level was negatively associated with fasting insulin, glucose, homeostatic model assessment for insulin resistance, and total cholesterol. There was also a higher expression of DNMT1 and DNMT-3b in obese subjects as compared with non-obese subjects. Conclusion: The leptin epigenetic profile may be associated with obesity and its associated metabolic risk factors.