Comparison of controlled ovarian stimulation outcomes for fertility preservation in women with breast cancer according to KI-67, histologic grade, pathologic type, and cancer stage

( Eun Ji Oh ),( Yeon Hee Hong ),( Seul Ki Kim ),( Jung Ryeol Lee ),( Byung Chul Jee ),( Chang Suk Suh ),( Seok Hyun Kim ) 대한산부인과학회 2020 대한산부인과학회 학술대회 Vol.106 No.-

Objective: This study aims to analyze that specific prognostic factors such as Ki-67 value, histologic grade, pathology type, and cancer stage can affect controlled ovarian stimulation outcomes(COS) for fertility preservation in women with breast cancer. Methods: This retrospective cohort study included 92 patients with breast cancer aged 21-44 who underwent COS from August 2012 to April 2020, excluding patients with previous gonadotoxic therapy history. All COS cycles were conducted letrozole-combined random start GnRH antagonist protocol. COS outcomes were compared according to prognostic factors;Ki-67 (< 30% vs. ≥ 30%), histologic grade (low vs. high), and pathologic type (intraductal carcinoma(IDC) vs. triple-negative breast cancer(TNBC)), and cancer stage (early (I, II) vs. advanced (III, IV)). Multivariate analysis was also conducted to find any parameter that can impact over 10 mature oocytes acquisition. Results: Among the 92 patients, 42 were Ki-67≥30% compared to 49 of Ki-67<30%. The number of oocytes, and initial mature oocytes were comparable between Ki-67<30% and ≥30 group. The maturation rate was significantly higher in Ki-67≥30% group than Ki-67<30% group (57.4±36.8% vs. 44.8±28.3%, p=0.041). The same results were drawn when divided according to IDC or TNBC. The maturation rate was significantly higher in TNBC than the IDC group (73.0±17.6% vs. 47.0±28.1% p=0.001). However, the histologic grade or stage did not show any difference in COS outcomes between high and low grade or early and advanced stages. With multivariate analysis, age and AMH are parameters associated with the acquisition of over 10 mature oocytes (OR 0.863, 95% CI [0.755-0.987], OR 1.408, 95% CI [1.145-1.732], respectively). Conclusion: Either Ki-67 or pathologic type can be a potential reliable marker for predicting COS outcome, especially maturation rate. Further study with larger sample size with specific conditions is necessary to clarify the correlation between breast cancer prognostic factors and COS outcomes.

간세포암과 감별이 어려웠던 악성중피종 치험 1예

김선문,허원석,채경훈,강윤세,정재훈,김연수,박기오,문희석,이엄석,김석현,성재규,이병석,이헌영,신경숙,조준식,송인상,강대영 충남대학교 의학연구소 2003 충남의대잡지 Vol.30 No.2

Malignant peritoneal mesothelioma is a rare neoplasm that arises from the mesothelium of a serosal cavity and is a rapidly fatal disease with a median survival of 4 to 12 months for untreated cases. Recently, we experienced a case with malignant peritoneal mesothelioma who was suspected hepatocelluar carcioma by abdominal CT scan and was confirmed by biopsy including immunohistochemical stain(calretinin) after surgery. We performed tumor excisions and wedge resection of the liver(segment Ⅷ)and inserted Tencoff catheter in abdominal cavity at 25th day of post-operation. We treated with intraperitoneal paclitaxel(25mg/m^(2)/day for 5 days) six courses monthly. She was well tolerable and is still living without any evidence of recurrence for 14th month of post-operation.

절골술을 이용한 안면교정

오석희,한기환,강진성 大韓成形外科學會 1989 Archives of Plastic Surgery Vol.16 No.5

The most important factor in the beauty of the face is the harmony of the facial skeleton and soft tissue. The postoperative result is not always satisfying after only classic soft tissue surgery. The reason for dissatisfaction is disharmony of the facial skeleton. Recently, the development of maxillofacial surgical techniques enable disharmony of the facial skeleton to be successfully corrected. The authors have had experience with 33 cases of congenital and acquired facial deformities, from March of 1986 to February of 1989, and have followed them from 6 months to 2 years. We used an intraoral approach in most cases and got good results. There were four wound disruptions which were treated conservatively and resolved without sequelae.

수돗물염수액 전기분해에 의한 살균소독

박준오, 김완석, 최영기, 이영민, 김형규, 차은종, 김석용 충북대학교 동물의학연구소 2008 Journal of Biomedical and Translational Research Vol.9 No.2

본문참고

욕창 환자에서 빈혈과 혈청 단백질의 변화

오상향,남기석,이상오,박상일,최은,이양균 순천향의학연구소 2001 Journal of Soonchunhyang Medical Science Vol.7 No.1

Objective : To investigate the pathogenesis of anemia and serum protein alteration in patient with pressure ulcer and proper management method. Method : Eleven patients with pressure ulcer were investigated. To investigate the change of anemia and serum protein between pre- and post-treatment of pressure ulcer, we measured hemoglobin, hematocrit, serum iron, ferritin, transferrin, mean corpuscular volume(MCV), red cell count, serum albumin and globulin before and after healing of pressure ulcer. Result : There was significant increases of hemoglobin, hematocrit, red cell count, MCV, serum iron, ferrtin and transferrin after healing of pressure ulcer(p<0.05). The serum ablumin and A/G ratio were increased significantly(p<0.05). The total globulin and α1-globulin were decreased significantly(p<0.05). There was no statically significant relationship between the ulcer size and the degree of anemia and hypoalbuminemia. Conclusion : This research suggested that anemia and serum protein alteration in patient with pressure ulcer are thought result from chronic inflammatory process. So, anemia and alteration of protein does not require any treatment such as transfusion, iron and albumin supply.

스테인레스강 절삭가공에서 공구의 온도 특성에 대한 실험적 연구

권용기,오석형,김동현 한국공작기계학회 1996 한국생산제조학회지 Vol.5 No.1

This is an experimental investigation of the temperature generated in a cutting tool during the machining of stainless steel. The temperature results from the wear of the cutting tool are considered in order to investigate the relation between cause and effect of these factors. This possibility has been tested using a thermocouple technique to record temperature vs. time curves for a variety of cutting conditions. This is done by employing a thermocouple inserted on the tool tip near the major cutting edge. Temperature distributions are calculated using finite element method and compared to the contour maps measured by an optical system. It suggests that the temperature gradients and the tool performance will be dependent on certain factors in tool geometry when cutting this material.

馬山灣에서의 燐과 窒素의 動態에 관하여

안태석,안태영,권오섭,조기성 江原大學校 附設 環境硏究所 1989 環境硏究 Vol.6 No.-

1978년 부터 1982년 까지 마산만 4개 정점에서 인산에 인과 질소 상태에 대한 조사 결과, 인산태 인과 질소 상태에 대한 조사 결과, 인산태 인은 각 정점별 평균치가 0.86∼2.70 μg at - P/ℓ이였고, Ammonia + amino 산태 질소는 1.21 ∼4.36 μg at - L/ℓ이였고, 질산태 질소는 0.94 ∼ μg at - N/ℓ 로 비교적 높은 값을 보였다. 마산시에 인접한 정점 1, 2에서는 질소의 농도가 점차로 증가하고 있는 경향을 보였다. 또한 질소와 인의 비율은 정점 1과 2에서 40을 넘는 값을 보여주어, 질소의 유입이 큰 것을 뜻하므로 이에대한 방지대책이 시급히 요구된다. The concentrations of phosphate-P, ammonia + amino acid-N, nitrite-N, and nitrate-N were measured at 4 sites in the polluted Masan Bay from 1978 to 1982. The mean concentration of phosphate-P, ammonia + amino acid-N, nitrine-N and nitrate-N in each site varied 0.68-1.90 ug at P/1, 1.21-4.36 ug at-N/1, 0.36-3.23 ug at-N/1 and 2.17-29.45 ug at-N/1, respectively. At site 1 and 2, nearyby Masan City, the concentration of nitrogen was gradually increasing according to the increase of the population of the city and the N/P ratios at site 1 and 2 reached more than 40.

반도체 BGA(Ball Grid Array) 패키지의 Solder Ball 검사를 위한 영상처리 알고리즘에 관한 연구

김기태,오영석 금오공과대학교 산업기술개발연구원 2000 産業技術開發硏究 Vol.16 No.-

Inspection techniques for monitoring the characteristics of solder balls on ball-grid-array(BGA) package have been described. Inspection process based on gray-scale vision system with ring shaped LED's is used. Inspection algorithms were developed to measure BGA solder ball characteristics, including ball presence, width quality and pitch, determine whether the solder balls are defective.

프로그람의 최적화 기법에 관한 연구

이용석,김기철,오성균 全北大學校 基礎科學硏究所 1986 基礎科學 Vol.9 No.1

In this paper, we briefly discuss a number of machine-independent optimizations, program transformations that can be performed on programs to increase the efficiency of the target code without taking into considerration any properties of the target machine.

마우스 종양발생에서 Nitric Oxide의 역할에 관한 연구 Ⅲ : Helicobacter pylori에 의해 유발된 마우스 위암에서 염증매개인자의 역할 The role of inducible nitric oxide synthase and cyclooxygenase-2 in H. Pylori-associated gastric carcinogenesis

남기택,오상연,조현무,이국경,강진석,제정환,최미나,한상욱,김대용,장동덕,양기화,안병우 식품의약품안전청 2001 식품의약품안전청 연보 Vol.5 No.-

feficotorfer fyf☞ri(Hp)가 위암파 관련이 있다는 역학적인 증거는 많이 있지만 이에 대한 정확한 기전에 대해선 밝혀져 있지 않고 있으며 실험동물 모델도 적절하지 못한 것으로 알려져있다. 본 실험에서는 위암의 원인으로 알려져 있는 f, fyforf'(Hp)를 이용하여 마우스에서 위암 모델을 확립하고 만성염증과정 중에 생성되는 리0와 COX-2 등의 발현이 위암발생에 미치는 명향을 통하여 예방과 치료를 위한 점근을 시도하고자 하였다. 마우스를 7군으로 나누어서 1, 2, 3, 4군의 등물은 MNU를 증류수에 200ppm 농도로 음수병득 이용하띤 10주간 격주로 투여하였으며 MHU 음술 투여 1주 휴씩 후 배양한 f. fyrofi 를 약 109cru/rfll 로 맞춰 한 마리당 0.1ml 씩 이틀 간격으로 세 번에 걸쳐 하룻방 금식시킨 1, 2, 3, 5, 6, 7군기 마우스의 위장에 투입하떴다. 균 투입을 마친 후 다응 날부터 2군쏙 6군은 iNOS 억제제인 aminoguanidine(AG)을 음수병으로 툰여하였으며 3군과 7군은 COX-2 척제제인 nimesulide(NSD)를 투여하였다. 위의 종양발생양상을 샅최보면 bfNU와 Hp만을 투여한 1 관 ; (hfNU +Hp), 2군 : iNO을 inhibitor 투여군(MNU+HP+AG'1. 3군 ;CO딘-2 Inilibitor 투여군(MNU누Hp누 NSD), 4군 ,MNlf 단독투여군, 5군 ;Hp 단독투여춘, 6군 ; 러p 단독에 AG투여군, 7군 , Hp 단독에 NSD투여군의 종양발샐을은 각각 쁜.Bff(l1/16), 70.6%f12/ti), 했.9ff(7/18), 10%(1/10), Off(O/IS)0%(O/S), 0%(O/5)의 발쟁율을 보여 iNOS 억제제인 AC은 좁양발생을 억계하지 못하였으며, COX-2억제제인 NSD 는 종양발생을 유의적으로 감소시켰다. 콩양발생개수에서는 2.62±0.36, 1.41츠0.14, 0.44 르0.12, 0.10±0.10을 보여 AC와 NSD에서 유의성 있게 발생개수를 줄였다. Hp 단독투여에 의해즌는 종양발생이 나타나지 않았으며 HP+AG, Hp+ IfSD 추여군에콕 시험증료 시점에 약물에 의해 Hp의 제균효과가 있는지의 여부를 확인끓기 위하여 PCR을 이용하여 확인한 결과 모두 양성인 것으로 나타나 Hp의 제균효과에 의한 촐양발생 억제가 일어나지는 않았다. 위의 결과로 볼 때 Hp는 위암발생을 촉진하는 것으로 나타났고 딘p 감염시 매개되는 염증인자를 억제하였을 때 종양발생을 억제하는 것으로 위암 발생에서 염증매개인자는 종양을 촉진하는 것으로 나타났으며 it,705 억제제쓱 COX-』 억제제의 위알 예밭효과fl는 효과적일 것으로 사료된다 In spite of a large volume of epidemiological evidence indicating significant relationship between H. pylori infection and gastric adenocarcinoma, a doubt still exists on an elevated risk of stomach cancer by H. pylori infection due to lack of direct evidence of their exact mechanistic link. It is, therefore, essential to have an appropriate animal model for detailed analysis of the role of H. pylori played in gastric carcinogenesis. There is a wealth of evidence to support that over production of inducible nitric oxide synthase(iNOS) and cyclooxygenase-2(COX-2) is involved in the pathogensis of various cancer in both rodents and humans. The aim of this study was to establish a mouse model for H. pylori-associated gastric carcinogenesis and to identify the role of inducible nitric oxide synthase(iNOS) and cyclooxygenase-2(COX-2) played during the gastric carcinogenesis in mice. Eighty-three specific pathogen free, six-week-old male C57BL/6 mice were randomly divided into seven groups. Animals of the group 1, 2, 3, 4 were given MNU in their drinking water at the concentration of 200 p.p.m. for total five cycles of one-week regimen with one-week pause. After completion of MNU administration, they were given autoclaved distilled water for one weeks, and groups 1, 2, 3, 5, 6, 7 were inoculated with H. pylori. After completion of H. pylori. inoculation, groups 2 and 6 were given aminoguanidine in their drinking water at concentration of 1000p.p.m. and animals of group 3 and 7 were given the diet containing 200 ppm nimesulide at 12 weeks of age. All animals were killed at 50 weeks of age. The incidences of the glandular stomach tumors in the group 1, 2, 3 and 4 were 87.5%(14/16), 76.4%(13/17), 44.4(8/18), 10.0%(1/10), respectively and the tumor incidence of group 3(MNU→Hp+nimesulide) was significantly lower than those of group 1(MNU→Hp) at the value of P<0.01. The average numbers of tumors of group 2(MNU→Hp+AG : 1.41±0.24) and group 3(MNU→Hp+nimesulide : 0.44±0.12) were significantly lower than those of group 1(MNU→Hp : 2.62±0.36) at the value of P<0.05. Therefore, overproduced iNOS and COX-2 plays an important role in mice gastric carcinogenesis. We concluded iNOS and COX-2 inhibitor have good effects on gastric carcinogenesis.