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Carnosine Promotes Exhaustive Swimming Capacity in Mice
Jong-Soo Kim, Ki Nam Lee, Jin-Joo Hue, Jun-Hyeong Kim, Bong Soo Kang, Sang Yoon Nam, Young Won Yun, Jae-Hwang Jeong2, Beom Jun Lee 충북대학교 동물의학연구소 2011 Journal of Biomedical and Translational Research Vol.12 No.1
To investigate the effect of carnosine on exhaustive exercise, swimming tests were conducted weekly with loads corresponding to 5% of body weight attached to the tails of mice, and the swimming time to exhaustion was measured. Eighty male ICR mice were divided into four groups, to which carnosine was administered at doses of 0 (control), 10, 50, and 250 mg/kg/day, respectively, for a period of four weeks. At the end of swimming exercise challenges, serum biochemistry, oxidative stress enzyme activity, and antioxidant enzyme activity in tissues were determined. Treatment with 250 mg/kg carnosine resulted in a significant increase in swimming times to exhaustion, compared to the control group in the first (P<0.01) and third week (P<0.05). Significantly lower serum lactate levels were observed after the swimming exercise in the carnosine-treated groups (10 and 250 mg/kg), compared with the control (P<0.01). Malondialdehyde levels in the liver (10 and 50 mg/kg carnosine treated groups) and skeletal muscle (250 mg/kg carnosine treated group) were significantly lower, compared with the control (P<0.05). Significantly lower protein carbonyl levels in skeletal muscle were observed in the 50 and 250 mg/kg carnosine treated groups, compared with the control (P<0.01). Superoxide dismutase and glutathione peroxidase activities in skeletal muscle did not differ significantly among the groups. These results indicate that carnosine may improve swimming exercise capacity by attenuating production of lactate and reducing oxidative stress in mice.
정길수,박병수,홍영길,유남재 江原大學校 産業技術硏究所 2004 産業技術硏究 Vol.24 No.B
This Study is results of experimental works to investigate the characteristics of vibro-compaction of crushed stones having coarse grain sizes. For testing material, crushed stone, sieved within very narrow ranges of grain size distribution, was used. Cyclic loading apparatus was used to apply cyclic loading to the specimen prepared in the mold. Tests were performed by changing the ratio of the maximum to the minimum stress, frequency and the magnitude of the maximum and the minimum stresses. Settlement of specimen due to cyclic loading was measured to analyze the compaction efficiency and sieve analysis test after cyclic loading test was also carried out to find the crushing rate of the specimen. As results of cyclic loading test, normalized settlement in terms of specimen height tends to be converged around loading cycle number of 1500. The magnitude of normalized settlement is in the range of 3.11 ~ 8.57%. The crushing rate is in the range of 4.46 ~ 8.78%. Normalize settlement and the crushing rate tend to increase with decreasing the ratio of the maximum to the minimum stresses and they tend to increase with increasing the frequency and the magnitude of the maximum and the minimum stresses for the given ratio. In conclusions, compaction rate of crushed stone is controlled by the dynamic stress (difference between the maximum and the minimum stresses) and the crushing rate is dominated by applied energy to the specimen.
Saccharomyces cerevisiae에서 Trichoderma Endoglucanase의 발현과 분비
남수완,김병우,신동하,김재범,신지원,정대균,정춘수 동의대학교 기초과학연구소 1999 基礎科學硏究論文集 Vol.9 No.1
The endoglucanase gene, egl6, of Trichoderma sp. was connected with the yeast ADH1 promoter, and the resultant plasmid, pVT-C4, was introduced into three S. cerevisiae host strains (YNN27, 2805, and SEY2102). Among each 80 transformants, the cell growth and expression level of endoglucanase were compared in test-tube cultivation, and three respective transformants for each host cells showing the highest expression level and cell growth were selected. When three recombinant yeast cells were batchwise cultivated for 48 hr in flask, the total activities of endoglucanase expressed were about 1140 unit/1 with 2805/pVT-C4, 1020 unit/l with SEY2102/pVT-C4, and 590 unit/l with (YNN27/pVT-C4. Irrespective of host strain, about 80% of the expressed endoglucanase was detected in the extracellular medium. In addition, it was also found that the recombinant enzyme was secreted into the culture medium as two major forms of lightly and heavily glycosylated proteins.
남호수,조증성,주철민 東西大學校 1998 동서논문집 Vol.4 No.-
일반적인 위치모수의 추정문제에서 로버스트 방법으로 흔히 고려되는 것이 M-추정법이다. M-추정법에서는 추정량이 명시적 형태로 주어지지 않으며, 특히 비볼록(non-convex)목적함수에서의 M-추정에 기존의 뉴튼 방법을 적용할 경우 목적함수의 대역최소점에서 해를 찾는데 실패할 위험이 있다. 본 논문에서는 이런 문제점을 유전자 알고리즘(genetic algorithm)을 이용하여 해결하고자 한다. 즉, M-추정에서 고려하는 목적함수를 미분하지 않고 목적함수 자체를 최적화(최소화)시키는 방법으로 해를 구하는 방안을 제시하고자 한다. 또한, M-추정에서 널리 쓰이는 뉴튼 방법에 의한 해의 문제점을 지적하고 제안된 방법에 의한 M-추정의 타당성을 예를 들어 보이고자 한다. The M-estimation is frequently considered as a robust procedure in the estimation of location parameter. Usually the M-estimator can not be represented as an explicit form. In this paper, we propose an M-estimation method in non-convex object function by using the genetic algorithm. The proposed method cirectly optimizes(minimizes)the object function without differentiating the function, and it approximates the global solution regardless of the initialization. An illustrative example shows that the proposed estimation method is stable and has elegant behavior, compared to the classical M-estimation.
정길수,박병수,전상현,유남재 강원대학교 산업기술연구소 2006 産業技術硏究 Vol.26 No.B
This study is the result of experimental and numerical study on the consolidational behavior of multi-layered soft soil ground installed with plastic board drains (PBD). Centrifuge model tests with a marine clay sampled from field were performed to investigate the consolidational behavior of multi layered ground where a dredged soil was placed on the soft clay ground and PBDs were installed. Test results were compared with those of numerical analyses, using the 2-D equivalent model previously proposed. From test resuts, it was found that the amount of consolidation settlement occurred in the original ground due to embankment surcharge loads was in the range of 38% of total settlement in the whole ground. From the results of cone penetration tests executed after finishing the centrifuge model tests, the cone resistance was found to increase with depth. The measured water contents inbetween PBDs were in the ranges of 38~50% and their values tended to increase with increasing the distance between PBDs.
정응기,이기환,원용재,박향미,전남수,최준호,구연충,한창덕,은무영,김태산,남민희 Plant molecular biology and biotechnology research 2005 Plant molecular biology and biotechnology research Vol.2005 No.
This study was conducted to investigated the major characteristics of genetically modified rice of "Milyang 204" originated from Dongjinbyeo compared to a non-transgenic rice varieties Dongjinbyeo and Junambyeo. Basta resistant transgenic rice lines carrying bar gene produced by the Yeongnam Agricultural Research Institute were evaluated for their agronomic characters. The transgenic Japonica rice of "Milyang 204" showed inferior phenotypic traits compared to a non-transgenic rice variety Dongjinbyeo and Junambyeo. On the basis of UPOV (Union Internationale Pour la Protaection des Obtentions Vegetables) and NSMO(National Seed Management Office) the transgenic "Milyang 204" showed difference in some traits out of some agronomic traits, such as leaf color, angle of flag leaf, number of spikelets, culm length, white core and white belly compared to the nontransgenic varieties rice.
이담자균 효모의 성분화 과정중 인지질의 작용과 배지조성의 제한이 성분화에 미치는 영향
정영기,강원대,남수완 동의대학교 기초과학연구소 1997 基礎科學硏究論文集 Vol.7 No.1
The action of phospholipid on the rhodotorucine A(Rh.A) acceptance by heterobasidiomyceteous yeast Rhodospori-dium toruloides mating type a cells and the effect of medium composition during sexual differentiation were investigated. Activation of trigger peptidase(TPase) was very sensitive to the originated phospholipid from R. toruloides and was more sensitive to phospholipid liposome made up of phospholipid. Phospholipid present on the membrane of mating type a cells consists of phospatidylglycerol(PG), phosphatidylethanolamine(PE), phospatidylcholine(PC), phospatidylinositol(PI), and phosphatidylserine(PS) of 12.9, suprisingly 45.4, 11.0, and 13.9%, respectively. As the result of using C-1 and N-1 mediums which limited C and N sources capable of inhibiting the synthesis of phospholipid. it resulted inhibiting sexual differentiation and production of Rh.A from mating type A cells.