Propylthiouracil에 의한 중증 급성간염 1예

임종주,심미령,이명수,김태현,오석규,안선호,박무림,김남호,박병현,조성구 圓光大學校 醫科學硏究所 2002 圓光醫科學 Vol.17 No.2

PTU에 의한 간염의 발생은 매우 드물게 발생하는 것으로 알려져 있으나 저자들은 Graves씨 병으로 진단 받고 propylthiouracil 투여를 받고있던 환자에서 중증의 급성 간염이 발생한 1예를 경험하였기에 보고하는 바이다. Propylthiouracil is widely used to treat patients with hyperthyroidism. This drug has been associated with severe hepatotoxicity rarely. We presented the case of jaundice and profound liver dysfunction from a 23-year old woman treated with propylthiouracil for hyperthyroidism. Viral, metabolic, and autoimmune liver disease could be excluded and liver biopsy revealed a pattern of acute hepatitis. After discontinuing the drug, there was a progressive resolution of hepatic symptoms and decrease in biochemical data of the liver. Despite propylthiouracil induced hepatitis in rare case, patients receiving propylthiouracil are exposed to develope severe hepatotoxicity. Therefore it might be advisable to monitor level of the transaminase on regular base from patients receiving propylthiouracil.

당뇨병성 케톤산증에 병발한 횡문근융해증 1예

장근영,이명수,최용원,최경숙,김상욱,김기훈,박병현,형근영,김경년,정병화,조정구 대한당뇨병학회 2000 임상당뇨병 Vol.1 No.1

당뇨병성 케톤산증이나 비삼투압성 비케톤성 혼수환자에서 횡문근융해에 의한 급성신부전이 동반될 수 있으며 이러한 기전은 확실히 밝혀져 있지 않다. 저자들은 당뇨병성 케톤산증 환자에서 횡문근융해증 및 근색소뇨증, 급성신부전을 보인 1예를 경험하였기에 문헌고찰과 함께 보고하는 바이다. Since osmotic diuresis, which is provoked by a high renal glucose load, prevents the development of acute tubular necrosis; there have been a few case reports connecting diabetic ketoacidosis with acute renal failure, secondary to rhabdomyolysis. Rhabdomyolysis is a clinical and biochemical syndrome, resulting from skeletal muscle injury with release of muscle contents, specifically myoglobin into the plasma and it has been implicated as a major cause of acute renal failure. Rhabdomyolysis is diagnosed in the presence of myoglobinuria and raised level of serum creatinine phosphokinase (CPK). We report a case of diabetic ketoacidosis which developed acute renal failure secondary to rhabdomyolysis and myoglobinuria with review of the literature. A 67-year-old man suffering from somnolence was admitted to our hospital. He had had coughing, sputum, chills for 7 days prior to the onset of somnolence. He was a type 2 diabetic patient and had been omitting oral hypoglycemic agent for two months. Laboratory data an admission reveled elevated serum levels of glucose (>27 mmol/L), myoglobin (>500 ng/㎗), creatinine phosphokinase (2,156IU/L), lactate dehydrogenase (1,679 IU/L), blood urea nitrogen (12.4 mmol/L) and creatinine (247 mmol/L). Ketone and myoglobin (75 ng/㎗) was defected in urine. Arterial blood gas analysis reveled pH 7.104, PCO₂ 15 mmHg, PO₂ 108.3 mmHg, HCO₃ 4.8 mmol/L, Chest film showed pneumonic consolidation on right lower lung. Treatment with subcutaneous insulin and intravenous administration of electrolyte fluid and the systemic antiobiotics was begun immediately. After initiation of treatment, there was increase in serum creatinine 0(707 mmol/L), blood urea nitrogen (56.7 mmol/L), and anuria w as observed. Despite of care, he died.

스마트 단말을 위한 상황 인지형 비디오 스트리밍 서비스

이길범(Gil-beom Lee),강명구(Myeung-gu Kang),정상진(Sang-jin Jeong),이명진(Myeong-jin Lee) 한국방송·미디어공학회 2013 한국방송공학회 학술발표대회 논문집 Vol.2013 No.6

횡문근 융해증과 동반된 갑상선 중독성 주기성 마비 1예

권경희,이창훈,최경숙,백승훈,이명수,박병현,조정구 대한내과학회 2004 대한내과학회지 Vol.66 No.2

갑상선 항진증에서 횡문근 융해증은 아주 드물게 동반되며 근효소의 상승 또한 드물다. 갑상선 중독성 마비는 여러 선생인자에 의해 유발될 수 있고 마비 당시 저칼륨혈증을 자주 동반한다. 저자들은 갑상선 중독성 주기성 마비로 내원한 23세 남자 환자에서 저칼륨혈증과 하지마비가 회복되는 과정에서 일시적인 횡문근 융해증을 보인 증례를 경험하였기에 문헌고찰과 함께 보고하는 바이다. Hyperthyroidism has been associated with changes in muscle function such as thyrotoxic myopathy, thyrotoxic periodic paralysis and thyroid opthalomopathy, but rarely rhabdomyolysis. Usually serum creatinine kinase is either normal or low in Hyperthyroidism. Only 3 reports described association between rhabdomyolysis and Hyperthyroidism, no previous literatures have thyrotoxic periodic paralysis associated rhadbomyolysis. Patients with hypokalemic periodic paralysis sometimes elevated serum muscle protein during recovery from paralytic attack, but the mechanism was not well known. We report a patient who presented with clinical feature of thyrotoxic periodic paralysis and increasing serum CK, myoglobin during recovery from paralysis.

The Bond Strength of Ni-Cr Free Alloys of Recasting for Porcelain Fused to Metal

Ji-Heui Yoo,Myeung-Gu Lee,Young-Il Kim 대한예방치과학회 2012 International Journal of Clinical Preventive Denti Vol.8 No.1

Objective: This study was to find out the effect on bond strength to porcelain of reusing some Ni-Cr alloys that do not include Beryllium, as a harmful substance. Methods: Alphaloy (Alpha Dent. KOREA), Vera Bond 2V (AlbaDent, Inc. USA), T4 (Ticonum. USA) as non precious alloys without Beryllium and Noritake Super Porcelain EX-3 porcelain powder were used as experimental materials. 3 point flexual rigidity test was done using universal tester (Houndsfield, England) to measure bond strength of metal to porcelain and the following results were gained. Results: 1. In case of Alphaloy, significant discrepancy was shown with mean value being the highest in single use. And as a result of post-examination, it has been shown that there was difference between single use and 3 time reuse. 2. In case of Vera Bond 2V, the mean value was the highest in single use. But it was not a significant discrepancy. 3. In case of T4, there was significant discrepancy with the mean value being the highest in single use. The results of post-examination showed there was difference between single use, 3 time reuse and 5 time reuse. Conclusion: Establishing strategies on how we will use Ni-Cr alloys from now on and advanced studies for more systematic future study results should be done.

신경섬유종증에 병발된 다발성 악성 신경초종 1예

박병현,고혁재,이명수,국향,구기선,김학렬,정은택 圓光大學校 醫科學硏究所 1998 圓光醫科學 Vol.14 No.2

Neurofibromatosis, which was described by von Recklinghausen in 1882, is a hereditary, hamartomatous disorder that primarily involves neuroectoderm and mesoderm. The clinical features are skin manifestations such as cafe-au-lait spots, skeletal manifestations primarily involving vertebrae, central and peripheral nervous manifestations, and other associated abnormalities with increased risk of malignancy. Malignant transformation in neurofibromatosis is estimated at 2-29 %, with malignant schwannoma being the most common malignancy. Malignant schwannoma associated with von Recklinghausen's disease has been rarely reported in Korea. We herein report a case of multiple malignant schwannoma associated with neurofibromatosis report this case with a review of literatures.

저나트륨증을 동반한 Wernicke`s encephalopathy

안선호(Seon Ho Ahn),이재홍(Jae Hong Lee),이명수(Myeung Su Lee),송주홍(Ju Hung Song),이성근(Seong Keun Lee),박병현(Byoung Hyun Park),구기선(Ki Seon Gu) 대한신장학회 2000 Kidney Research and Clinical Practice Vol.19 No.1

Thiamine deficiency is known to lead to certain neurologic sequales including Wernicke-Korsakoff syndrome. Wernicke's encephalapathy is charac-terized by ataxia, ophthalmoplegia, nystagmus, and mental change. Although classically associated with chronic alcoholism, a number of other predisposing conditions exist such as hyperemesis gravidarum, thyrotoxicosis, starvation, anorexia nervosa, prolonged total parenteral nutrition, gastric plication and renal dialysis. We have experienced a case of Wernicke's encephalopathy associated with prolonged starvation which was misdiagnosed by hyponatremic ence-phalopathy at first, and which seemed to be developed by thiamine-free dextrose infusion in 39-year-old male patient. We report the case with review of the literature and emphasize the need for thiamine supplementation with slow correction of hyponatremia before the infusion of dextrose solution in the prolonged starved hyponatremic patient.

당뇨병성신증 환자에서 Fenoverine 에 의해 발생한 횡문근융해증 1예

김태현,안선호,조정구,이명수,박병현,계영하,송주흥,오석규,김기훈,심미령 대한내과학회 2002 대한내과학회지 Vol.62 No.4

재발성 심실빈맥으로 발현된 쉬한증후군 1예

권경희,김현정,양봉준,백승훈,이명수,박병현,조정구 대한내과학회 2004 대한내과학회지 Vol.66 No.2

쉬한증후군 환자에서 T파 역전, QT간격 연장과 함께 재발성 심실빈맥이 발생하였고, 적절한 호르몬 보충 치료후 심전도 이상이 정상으로 회복된 예를 경험하였기에 문헌고찰과 함께 보고하는 바이다. Electrocardiographic abnormalities commonly associated with hypopituitarism are low QRS voltage, ST-segment depression, inverted T waves and a prolonged QT interval. Although the mechanism remains unclear, glucocorticoid therapy, an intracelluar-extracellular electrolyte imbalance of myocytes, and histopathological changes in the myocardium are thought to play a role in this disorder. We discribe a 64 year old woman with recurrent ventricular tachycardia associated with QT prolongation in Sheehan's syndrome. Ventricualr tachycardia was treated by lidocain and direct current cardioversion. Sheehan's syndrome was confirmed by past history, anterior pituirary stimulation test and brain MRI showed empty sella. After hormone replacement treatment, inverted T waves and prolonged QT interval was normalized and ventricular tachycardia did not recur.

Effect of the calcineurin inhibitor FK506 on K+-Cl- cotransporter 2 expression in the mouse hippocampus after kainic acid-induced status epilepticus.

Shin, Hyun Joo,Jeon, Byeong Tak,Kim, Jungmee,Jeong, Eun Ae,Kim, Myeung Ju,Lee, Dong Hoon,Kim, Hyun Joon,Kang, Sang Soo,Cho, Gyeong Jae,Choi, Wan Sung,Roh, Gu Seob Springer 2012 Journal of neural transmission Vol.119 No.6

<P>Calcineurin (CaN)-mediated excitotoxicity impairs 관-aminobutyric acid (GABA) transmission and induces neuronal apoptosis. Ca(2+)-dependent K(+)-Cl(-) cotransporter 2 (KCC2) participates in GABAergic inhibitory transmission. However, the mechanism by which CaN mediates GABA receptor-mediated KCC2 in seizures is not fully understood. In the present study, we investigated the altered expression of KCC2 and the effects of the CaN inhibitor FK506 on KCC2 expression in the mouse hippocampus following kainic acid (KA) treatment. FK506 was injected twice 24 h and 30 min before KA treatment and then mice were treated with KA and killed 2 days later. FK506 had anticonvulsant effect on KA-induced seizure activities. CaN cleavage was evident in the hippocampus 24 h after KA treatment. FK506 pretreatment blocked the truncation of CaN in the KA-treated hippocampus. Cresyl violet and TUNEL staining showed that FK506 prevented KA-induced hippocampal cell death. In particular, Western blot analysis showed that KCC2 expression was time dependent, with a peak at 6 h and a return to decreased levels at 48 h, whereas FK506 pretreatment inhibited the KA-induced decrease in KCC2 expression in the hippocampus. Immunofluorescence showed that FK506 pretreatment protected the loss of inhibitory GABAergic KCC2-expressing neurons following KA treatment. Taken together, these results provide evidence that altered KCC2 expression may be associated with Ca(2+)-mediated seizure activity and indicate that neuron-specific KCC2 may be involved in neuroprotection after seizures.</P>