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Yoo, Ji-Hyock,Park, Sang-Won,Kim, Won-Il,Lee, Sang-Beom,Oh, Kyeong-Seok,Moon, Byeong-Churl,Kim, Sung-Chul 한국토양비료학회 2017 한국토양비료학회지 Vol.50 No.6
Heavy metal(loid) contamination of rice is the main issue in abandoned metal mine area with regard to food safety. A field study was conducted in mine area to see if soil amendments treatment including calcium superphosphate, sulfur, steel slag and S-containing fertilizer could reduce As and/or Cd content in rice grain and increase the growth of rice. The As content in brown rice reduced to 60% compared to the control only in $7.0Mg\;ha^{-1}$ of steel slag treatment. Cd reduction in rice was thought to be not the effect of amendments but the result from the difference in growth and development of rice plant and this could be ascribed to low soil Cd availability to rice plant. Compared with control, increased rice yield of cultivar Hwanggeumnuri was 1.3~2.2 and $1.5Mg\;ha^{-1}$ in calcium super phosphate and S-containing fertilizer treatment, respectively and the trend was also observed in cultivar Ungwang. However, steel slag treatment reduced the Ungwang yield by $0.4{\sim}0.9Mg\;ha^{-1}$. Future work will be needed to establish the agricultural measure with which secure the safety and yield of rice simultaneously.
( Won Jun Song ),( Jung Seop Eom ),( Hong Seok Yoo ),( Byeong Ho Jeong ),( Ho Yun Lee ),( Won Jung Koh ),( Kyeong Man Jeon ),( Hye Yun Park ) 대한내과학회 2014 대한내과학회 추계학술대회 Vol.2014 No.1
Background: Because chronic obstructive pulmonary disease (COPD) is a heterogeneous disorder, various factors could be associated with the severity of pneumonia in patients with COPD. Therefore, we examined the risk factors associated with severe pneumonia in a COPD population. Methods: A retrospective observational study with a prospectively collected database of community-acquired pneumonia (CAP) was conducted between 2008 and 2012. Patients with hospital-acquired pneumonia, immunocompromised patients, and those without a baseline computed tomography (CT) scan were excluded. As a result, 150 patients with COPD and CAP were included. Results: Of the 150 patients, 106 (70.7%) and 44 (29.3%) were classified with non-severe and severe pneumonia, respectively. A multivariate logistic regression analysis revealed that the presence of pulmonary emphysema on a CT scan (odds ratio, 2.933; 95% confi dence interval, 1.144 7.516; P = 0.025) was independently associated with severe pneumonia in patients with COPD. However, no signifi cant difference in severity of the air ow limitation, presence of bronchiectasis, previous COPD medicationincluding inhaled corticosteroids, or pathogens was identifi ed between those with non-severe and severe pneumonia. Conclusions: The presence of pulmonary emphysema on a CT scan at the time of admission to the hospital of a patient with COPD was independently associated with severe pneumonia in a COPD population.
( Kyeong Ho Yun ),( Ik Sang Shin ),( Sang Jae Rhee ),( Eun Mi Lee ),( Nam Jin Yoo ),( Nam Ho Kim ),( Seok Kyu Oh ),( Jin Won Jeong ) 대한내과학회 2009 The Korean Journal of Internal Medicine Vol.24 No.4
Background/Aims: The use of statins in patients with acute coronary syndrome (ACS) has increased, and reduced levels of low-density lipoprotein cholesterol (LDL-C) lead to lower coronary event rates. We studied the effect of lipid levels during statin treatment on prognosis in patients with ACS and percutaneous coronary intervention (PCI). Methods: Between January 2005 and May 2007, 325 ACS patients who underwent PCI and received statins were evaluated. We measured serum lipid levels at baseline and 4 weeks. The relationships between on-treatment levels of triglyceride (TG) and LDL-C and one-year major adverse cardiac events (MACE) were assessed. Results: At 4 weeks, the mean LDL-C level was 72.5±23.8 mg/dL and the mean TG was 123.2±62.8 mg/dL. MACE occurred in 41 cases (12.6%). Baseline serum lipid levels were similar between the patients with and those without MACE. However, the patients with MACE showed significantly higher TG level at 4 weeks (149.6±81.4 vs. 119.3±58.9 mg/dL, p=0.026) than those without. High on-treatment TG level (≥150 mg/dL) were associated with increased adverse events compared to lower TG level in a univariate analysis (hazard ratio [HR], 3.3; p<0.001). In a multivariate analysis, high 4-week TG level after statin treatment was an independent predictor for MACE (HR, 4.01; 95% confidence interval, 1.85 to 9.06; p=0.001), however, baseline TG and LDL-C levels were not. Conclusions: High on-treatment TG level (≥150 mg/dL) was associated with a higher risk of MACE. This finding supports the concept that achieving low TG levels may be an important therapeutic parameter in statin-treated patients following ACS and PCI. (Korean J Intern Med 2009;24:330-336)
Yoo, Jong-Sun,Lee, Yun-Jung,Yoon, Joo-Won,Hyung, Kyeong-Eun,Hwang, Kwang-Woo The Korean Society of Pharmacology 2012 The Korean Journal of Physiology & Pharmacology Vol.16 No.5
Activated T cells express inhibitory receptors such as CTLA-4 that can downregulate immune responses. Blockade of or genetic deficiency in CTLA-4 can result in autoimmunity. Therefore, strategies to increase the inhibitory function of CTLA-4 may be attractive in settings of undesirable T cell responses such as autoimmunity or transplant rejection. We have tested the hypothesis that transgenic constitutive expression of CTLA-4 can further attenuate immune responses when compared with normal inducible expression. Our results indicate that transgenic expression of CTLA-4 in mouse T cells (CTLA-4-Tg T cells) results in reduced cell cycle progression and increased apoptosis of TCR-stimulated T cells. CTLA-4-Tg T cells display reduced T cell proliferation in an in vivo model of graft versus host disease (GVHD). These results further our understanding of how CTLA-4 can be manipulated to inhibit immune responses and may help development of new therapeutic strategies for clinical settings of autoimmunity and transplantation.
Yoo Kyeong Kim,Hyeon-A Kim,Dae-Hun Park,Kyu-Shik Jeong,Jeong-ae Lee,Won-il Jeong 한국로고스경영학회 2005 한국로고스경영학회 학술발표대회논문집 Vol.- No.-
We investigated the effects of genistein in mammary gland carcinogenesis by incoporation of 2H from ²H₂O into the deoxyribose (dR) moiety of purine deoxyribonucleotides in dividing cells. Female Sprague?Dawley rats were fed estrogen free AIN-93G diet starting on 1 week before breeding and continuing through pregnancy and lactation. Female pups were assigned to the following groups on postnatal day 16 and fed AIN-93G diet: vehicle (dimethylsulfoxide) (DMSO); genistein; estradiol benzoate(EB). On postnatal days 16, 18 and 20, female pups were injected subcutaneously with 250 μg genistein/g body wt, 500 ng EB/g body wt or an equivalent volume of the vehicle. At day 50 postpartum, half of each group were gavaged with 60mg dimethylbenz[a]anthracene(DMBA) in perila oil. After 1 week of DMBA treatment, all animals were labeled with ²H₂O by administration of 4% ²H₂O in drinking water after single intraperitonial bolus injection with 99.9% ²H₂O until sacrifice on postnatal day 81. The timedependent weight gains were observed in all groups throughout the experimental period. The enrichment of body ²H₂O was attained at 1.84-2.47% through oral administration of ²H₂O. Mammary epithelial cell proliferation was measured by enrichment (EM1) of dA from rats. DMBA treated groups showed higher fractional synthesis than DMBA non-treated groups. The group exposed only to genistein showed significantly lower EM1 (1.46±0.87%) than those of control groups, i.e. DMBA non-treated group (2.28±0.29%) and DMBA treated group(2.32±0.28%). Bromodeoxyuridine (BrdU) immunostaining of mammary tissue revealed that genistein reduced proliferation of the mammary epithelial, and the number of cells stained positive for BrdU both in DMBA treated groups and DMBA non-treated groups. H&E staining of mammary epithelium also showed that the exposure to genistein decreased proliferation of the mammary epithelium. The epithelium in the rats treated with DMBA showed mostly multiple cell layers, in contrast to the mostly double layer shown in the DMBA non-treated rats. In conclusion, exposure to genistein in the prepubertal period inhibited mammary epithelial cell proliferation. The ²H₂O labeling results were in good agreement with the results of BrdU incorporation and histomorphometry.
Effect of PRX-1 Downregulation in the Type 1 Diabetes Microenvironment
Yoo, Jong-Sun,Lee, Yun-Jung,Hyung, Kyeong Eun,Yoon, Joo Won,Lee, Ik Hee,Park, So-Young,Hwang, Kwang Woo The Korean Society of Pharmacology 2012 The Korean Journal of Physiology & Pharmacology Vol.16 No.6
Type 1 diabetes (T1D) is caused by dysregulation of the immune system in the pancreatic islets, which eventually leads to insulin-producing pancreatic ${\beta}$-cell death and destabilization of glucose homeostasis. One of the major characteristics of T1D pathogenesis is the production of inflammatory mediators by macrophages that result in destruction or damage of pancreatic ${\beta}$-cells. In this study the inflammatory microenvironment of T1D was simulated with RAW264.7 cells and MIN6 cells, acting as macrophages and pancreatic ${\beta}$-cells respectably. In this setting, peroxiredoxin-1, an anti-oxidant enzyme was knocked down to observe its functions in the pathogenesis of T1D. RAW264.7 cells were primed with lipopolysaccharide and co-cultured with MIN6 cells while PRX-1 was knocked down in one or both cell types. Our results suggest that hindrance of PRX-1 activity or the deficiency of this enzyme in inflammatory conditions negatively affects pancreatic ${\beta}$-cell survival. The observed decrease in viability of MIN6 cells seems to be caused by nitric oxide production. Additionally, it seems that PRX-1 affects previously reported protective activity of IL-6 in pancreatic ${\beta}$ cells as well. These results signify new, undiscovered roles for PRX-1 in inflammatory conditions and may contribute toward our understanding of autoimmunity.
( Won Jun Song ),( Jung Seop Eom ),( Hong Seok Yoo ),( Byeong Ho Jeong ),( Ho Yun Lee ),( Won Jung Koh ),( Kyeong Man Jeon ),( Hye Yun Park ) 대한결핵 및 호흡기학회 2014 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.118 No.-
Background: Because chronic obstructive pulmonary disease (COPD) is a heterogeneous disorder, various factors could be associated with the severity of pneumonia in patients with COPD. Therefore, we examined the risk factors associated with severe pneumonia in a COPD population. Methods: A retrospective observational study with a prospectively collected database of community-acquired pneumonia (CAP) was conducted between 2008 and 2012. Patients with hospital-acquired pneumonia, immunocompromised patients, and those without a baseline computed tomography (CT) scan were excluded. As a result, 150 patients with COPD and CAP were included. Results: Of the 150 patients, 106 (70.7%) and 44 (29.3%) were classified with non-severe and severe pneumonia, respectively. A multivariate logistic regression analysis revealed that the presence of pulmonary emphysema on a CT scan (odds ratio, 2.933; 95% confidence interval, 1.144-7.516; P = 0.025) was independently associated with severe pneumonia in patients with COPD. However, no significant difference in severity of the airflow limitation, presence of bronchiectasis, previous COPD medication including inhaled corticosteroids, or pathogens was identified between those with non-severe and severe pneumonia. Conclusions: The presence of pulmonary emphysema on a CT scan at the time of admission to the hospital of a patient with COPD was independently associated with severe pneumonia in a COPD population.
Won, Tae Joon,Kim, Bongjoon,Oh, Eun Seul,Bang, Joon Seok,Lee, Yoon Jeong,Yoo, Jong-Sun,Yu, Hyunmin,Yoon, Joowon,Hyung, Kyeong Eun,Park, So-Young,Hwang, Kwang Woo Canadian Science Publishing 2011 Canadian journal of physiology and pharmacology Vol.89 No.6
<P> Four Lactobacillus strains - Lactobacillus plantarum CJLP133, L. plantarum CJLP243, L. plantarum CJNR26, and Lactobacillus gasseri CJMF3 - were isolated from Korean fermented food or healthy infant feces, and their capacity to modulate cellular and humoral immune responses was studied. Feeding of the tested lactobacilli for 8 weeks did not alter the weight of and cell numbers in the spleen of mice. However, CJLP133 and CJLP243 strains increased the T lymphocyte population in the spleen of mice, while CJNR26 and CJMF3 increased the B lymphocyte population. In splenocytes treated with concanavalin A, ingestion of CJLP133 and CJLP243 promoted T lymphocyte proliferation and secretion of T cell cytokines, whereas feeding of the CJNR26 and CJMF3 strains enhanced B lymphocyte proliferation in splenocytes treated with lipopolysaccharide and plaque formation. These results suggest that CJLP133 and CJLP243 have immunostimulating activity through the enhancement of T cell activation, while CJNR26 and CJMF3 exhibit immunopotentiation through the increment of B cell activation. </P>