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Gene expression profile in mesenchymal stem cells derived from dental tissues and bone marrow
Kim, Su-Hwan,Kim, Young-Sung,Lee, Su-Yeon,Kim, Kyoung-Hwa,Lee, Yong-Moo,Kim, Won-Kyung,Lee, Young-Kyoo Korean Academy of Periodontology 2011 Journal of Periodontal & Implant Science Vol.41 No.4
Purpose: The aim of this study is to compare the gene expression profile in mesenchymal stem cells derived from dental tissues and bone marrow for characterization of dental stem cells. Methods: We employed GeneChip analysis to the expression levels of approximately 32,321 kinds of transcripts in 5 samples of bone-marrow-derived mesenchymal stem cells (BMSCs) (n=1), periodontal ligament stem cells (PDLSCs) (n=2), and dental pulp stem cells (DPSCs) (n=2). Each cell was sorted by a FACS Vantage Sorter using immunocytochemical staining of the early mesenchymal stem cell surface marker STRO-1 before the microarray analysis. Results: We identified 379 up-regulated and 133 down-regulated transcripts in BMSCs, 68 up-regulated and 64 down-regulated transcripts in PDLSCs, and 218 up-regulated and 231 down-regulated transcripts in DPSCs. In addition, anatomical structure development and anatomical structure morphogenesis gene ontology (GO) terms were over-represented in all three different mesenchymal stem cells and GO terms related to blood vessels, and neurons were over-represented only in DPSCs. Conclusions: This study demonstrated the genome-wide gene expression patterns of STRO-$1^+$ mesenchymal stem cells derived from dental tissues and bone marrow. The differences among the expression profiles of BMSCs, PDLSCs, and DPSCs were shown, and 999 candidate genes were found to be definitely up- or down-regulated. In addition, GOstat analyses of regulated gene products provided over-represented GO classes. These data provide a first step for discovering molecules key to the characteristics of dental stem cells.
Kim, Young-Sung,Kim, Su-Hwan,Kim, Kyoung-Hwa,Jhin, Min-Ju,Kim, Won-Kyung,Lee, Young-Kyoo,Seol, Yang-Jo,Lee, Yong-Moo Korean Academy of Periodontology 2012 Journal of Periodontal & Implant Science Vol.42 No.6
Purpose: This study was performed to establish an experimental rabbit model for single-stage maxillary sinus augmentation with simultaneous implant placement. Methods: Twelve mature New Zealand white rabbits were used for the experiments. The rabbit maxillary sinuses were divided into 3 groups according to sinus augmentation materials: blood clot (BC), autogenous bone (AB), and bovine-derived hydroxyapatite (BHA). Small titanium implants were simultaneously placed in the animals during the sinus augmentation procedure. The rabbits were sacrificed 4 and 8 weeks after surgery and were observed histologically. Histomorphometric analyses using image analysis software were also performed to evaluate the parameters related to bone regeneration and implant-bone integration. Results: The BC group showed an evident collapse of the sinus membrane and limited new bone formation around the original sinus floor at 4 and 8 weeks. In the AB group, the sinus membrane was well retained above the implant apex, and new bone formation was significant at both examination periods. The BHA group also showed retention of the elevated sinus membrane above the screw apex and evident new bone formation at both points in time. The total area of the mineral component (TMA) in the area of interest and the bone-to-implant contact did not show any significant differences among all the groups. In the AB group, the TMA had significantly decreased from 4 to 8 weeks. Conclusions: Within the limits of this study, the rabbit sinus model showed satisfactory results in the comparison of different grafting conditions in single-stage sinus floor elevation with simultaneous implant placement. We found that the rabbit model was useful for maxillary sinus augmentation with simultaneous implant placement.
Kim, Hawk,Lee, Je-Hwan,Joo, Young-Don,Bae, Sung Hwa,Hyun, Myung Soo,Lee, Jung-Hee,Kim, Dae-Young,Lee, Won-Sik,Ryoo, Hun Mo,Kim, Min Kyoung,Park, Jae-Hoo,Lee, Kyoo-Hyung Springer International 2012 Annals of hematology Vol.91 No.9
<P>Recently, a less toxic regimen comprising reduced cyclophosphamide (Cy), fludarabine, and anti-thymocyte globulin (ATG) (Cy-Flu-ATG) was used to condition high-risk patients scheduled for allogeneic hematopoietic cell transplantation (alloHSCT) instead of standard Cy-ATG in patients with severe aplastic anemia (AA). We performed a randomized phase III study to compare the regimen-related toxicities (RRTs) of two different conditioning regimens: Cy-ATG vs. Cy-Flu-ATG. Patients in the Cy-ATG arm received Cy at 200 mg/kg. Those in the Cy-Flu-ATG arm received fludarabine (Flu) at 150 mg/m(2) and Cy at 100 mg/kg. A total of 83 patients (40 in the Cy-ATG and 43 in the Cy-Flu-ATG) were enrolled. Seventy-nine patients had AA and four had MDS. All predefined RRTs were significantly lower in patients of the Cy-Flu-ATG arm (23.3 vs. 55.0 %; p = 0.003). Infection with identified causative organism and sinusoidal obstruction syndrome, hematuria, febrile episodes, and death from any cause tended to be more frequent in Cy-ATG arm but did not differ significantly between arms. There was no difference in neutrophil engraftment failure (2.5 vs. 2.33 %; p = 0.959), acute graft-versus-host disease (GvHD) (15.0 vs. 23.3 %; p = 0.388), and chronic GvHD (16.7 vs. 16.2 %; p = 0.961) between Cy-ATG and Cy-Flu-ATG arms. The 4-year survival rate did not differ between the Cy-ATG and Cy-Flu-ATG arms. Preconditioning with Cy-Flu-ATG was superior to that afforded by Cy-ATG in terms of reducing RRT levels without increasing engraftment failure.</P>
Kim, Hawk,Lee, Won-Sik,Lee, Kyoo-Hyung,Bae, Sung Hwa,Kim, Min Kyoung,Joo, Young-Don,Zang, Dae Young,Jo, Jae-Cheol,Lee, Sang Min,Lee, Je-Hwan,Lee, Jung-Hee,Kim, Dae-Young,Ryoo, Hun-Mo,Hyun, Myung Soo,K Springer International 2015 Annals of hematology Vol.94 No.5
<P>The practical usefulness of Helicobacter pylori eradication for immune thrombocytopenia (ITP) patients is still controversial. However, some ITP patients respond to H. pylori eradication. We conducted a multi-center, open label, prospective phase II study to define the efficacy and toxicities of H. pylori eradication as the first line treatment for persistent or chronic ITP patients with moderate thrombocytopenia. Patients with persistent or chronic ITP showing moderate thrombocytopenia (30??10(9)/L??platelet count??70??10(9)/L) and positive C(13)-urea breath test (UBT) were selected. Medication consisted of lansoprazole 30 mg, amoxicillin 1000 mg, and clarithromycin 500 mg orally twice daily for a week. Complete response (CR) rate at 4 weeks, 3 months, 6 months, 12 months, and maximal response was 19.2, 50.0, 50.0, 26.9, and 65.4%, respectively. Overall response rate (ORR) at 4 weeks, 3 months, 6 months, 12 months, and maximal response was 19.2, 57.7, 65.4, 30.8, and 69.2%, respectively. Median maximal platelet count during the first 3 months was 110??10(9)/L (range, 40-274). Median time to CR was 8 weeks (95% CI?=?5.429-10.571). Median time to ORR was 4 weeks (95% CI?=?1.228-6.772). Only per-protocol population was a response predictor for ORR at 3 months (70.0%, p?=?0.054) and maximal ORR (80.0%, p?=?0.051), but not for CR at 3 months (60.0%, p?=?0.160). Therefore, eradication of H. pylori is an effective and durable first line treatment for persistent or chronic ITP with moderate thrombocytopenia with high ORR and rapid onset in this study.</P>
일조시간 분석의 객관화를 위한 점분석 방식 개선방안 연구
김경상(Kim Kyoung-Sang),김지현(Kim Ji-Hyun),송규동(Song Kyoo-Dong) 한국건축친환경설비학회 2008 한국건축친환경설비학회 학술발표대회 논문집 Vol.- No.-
The existing building code regulates the minimum distance between buildings and the minimum required sunshine hours for winter solstice to ensure the right of sunshine. Especially, the minimum sunshine hours have been guaranteed by the constitution after the right for the people to live in a healthy and comfortable environment was established. However, the existing regulation on the sunshine hours only considers the duration of sunshine hours, but ignores the minimum amount of sunlight. In addition, analyzing of method has not established suitable standard yet. For that reason, each different process of studies bring incompatible results. It should a consider matter that it can be change the right of sunshine and will affect to many legal aspect in our society. Therefore, to solve the contradictable problem between various existing analysis methods fo sunshine, this study suggested compute pertinent form and size of grid to improve point analysis, and then proposes basic data to amend program which is applied point analysis that can reduce a relative rate of error not more than 5%.
DGI를 이용한 4면형 아트리움의 형태변수별 눈부심 평가
김경상(Kyoung-Sang Kim),김지현(Ji-Hyun Kim),송규동(Kyoo-Dong Song) 한국생활환경학회 2011 한국생활환경학회지 Vol.18 No.3
The importance of an atrium's skylight is to let the daylight in. However the more area of the skylights you design, the more daylights the indoor can get. Therefore there are some problems occurred for example, the increase of cooling load and discomfort glares. Although there are some studies of the amount of lights in the atrium but the study of evaluating discomfort glare has not been sufficient due to difficulties in selecting observer's location and the direction of occupant's eyes. Accordingly basic data of resolving the glare problem is also insufficient when the atrium is designed. Atrium WI, orientation and PAR are used in this study as various configurations of the atrium and those configurations are compared and analyzed in order to figure out the probability of potential glare in it. As a method for evaluating glare occurrence, the observer's position was fixed in the center of the atrium well and hemispherical view was rendered by the fisheye option of RADIANCE program. Then, find glare command was used to find glare sources and glare index command with DGI (Daylight Glare Index) parameters was used to calculate DGI values. As a result, when the direct sun was viewed from the observer position and the reflection was occurred by a glazing area of its walls the value of DGI was higher than 28, which indicates intolerable glares. Therefore it is judged that if the evaluation of glares is considered by various configurations derived from this study, it can be used as basic data of designing the atrium efficiently without the discomfort glares.
김경규(Kyoung-Kyoo Kim),박경남(Kyung-Nam Park) 한국산업정보학회 2008 한국산업정보학회논문지 Vol.13 No.1
본 논문에서는 광류를 이용한 적응 블록 정합 움직임 추정 방법을 제안하였다. 제안 방법에서는 먼저 각 화소의 시간 경사값과 공간 경사값을 미분필터를 통하여 계산한 후, 이 경사값들로부터 최소자승 추정법을 이용하여 광류를 추정하여 탐색영역의 위치와 크기를 결정하였다. 특히 움직임 특성에 따라 탐색영역을 결정함으로써 움직임 추정 오차가 큰 영역인 크고 복잡한 움직임을 갖는 영상에 대해서 뛰어난 성능을 갖는다. 다양한 움직임 특성을 가지는 실험 영상들에 대한 기존의 방법과 제안한 방법의 움직임 추정 성능 평가를 위한 컴퓨터 모의실험을 통하여, 제안한 방법이 움직임이 크고 복잡한 영상에 대해서 기존의 방법에 비해 우수한PSNR을 나타냄을 확인하였다. In this paper, we present an adaptive block matching motion estimation using optical flow. In the proposed algorithm, we calculate the temporal and spatial gradient value for each pixel value from the differential filter, and estimate the optical flow which is used to decide the location and the size of the search region from the gradient values by least square optical flow algorithm. In particular, the proposed algorithm showed a excellent performance with fast and complex motion sequences. From the computer simulation for various motion characteristic sequences, The proposed algorithm shows a significant enhancement of PSNR over previous blocking matching algorithms.