서울의 Penicillinase Producing Neisseria Gonorrhoeae 발생빈도(1994)

김재홍,안진균,정성재,김영태,김중환,김시영,이석종,이홍렬,서호석,김경훈,권혁진,정우권,고우석,이용석,안필수,오준규,오용섭 대한화학요법학회 1996 대한화학요법학회지 Vol.14 No.1

Background : In recent years gonorrhoea has been panendemic and remains one of the most common Sexually Transmitted Diseases in the world, especially in developing countries. Objective & Method : For the detection of a more effective therapeutic regimen and assessing the prevalence of Penicillinase Producing Neisseria Gonorrhoeae(PPNG), Ive have been trying to study the patients who have visited the VD Clinic of Choong-Ku Public Health Center in Seoul since 1980 by means of the chromogenic cephalosporin method. Results : In 1994, 168 strains of N. gonorrhoeae were isolated, among which 109 (64,9% ) were PPNG. Conclustion : Our results suggests that the prevalence of PPNG in Seoul is still increasing.

하악골에 발생한 골막 골육종

김태우,김승범,권혁찬,문선재,윤정훈,김형준,차인호,육종인,김진 대한악안면성형재건외과학회 2002 Maxillofacial Plastic Reconstructive Surgery Vol.24 No.1

Periosteal osteosarcoma is a distinct entity of malignant bone tumor with characteristic clinical, morphological, and histological features within the group of juxtacortical osteosarcoma. Periosteal osteosarcoma is predominantly located in the tubular long bones, and extremely rarely involving the jaws. A case of periosteal osteosarcoma of the right mandible is presented. A 27-year-old woman complained of the gingival swelling and bleeding tendency of the right posterior mandible. Clinical examination revealed a reddish brown strawberry-like swelling on the affected mucosa, which measured 1.5㎝×1.5㎝. The tumor was located on the lingual cortex of the mandible and extended into the surrounding soft tissues. Microscopically, the tumor consisted exclusively of atypical chondroblastic cells with a small osteoblastic area. A minimal bone marrow involvement was noted and the adjacent cortex was free of tumor. These findings suggested that the tumor originated from the periosteal cambium layer, which lies between the periosteal fibrous layer and the cortex of mandible.

한국인 혀동맥의 형태

김희진(KIM Hee Jin),강민규(KANG Mill Kyu),김진학(KIM Jm Hak),박재한(PARK Jae Han),이상섭(LEE Sang Heon),이상헌(LEE Sang Sup),정인혁(CHUNG In Hyuk2) 대한체질인류학회 1997 대한체질인류학회지 Vol.10 No.2

연구자들은 한국인 어른 남녀 시신의 머리와 목 61 을 대상으로 깊은 층 육안해부를 시행하여 혀동맥의 형태를 조사하였다 혀동맥이 일어나는 유형은 위갑상동맥, 혀동맥, 그리고 얼굴동맥이 바깥목동액에서 따로 가지를 내어 나뉘는 경우가 563% 호 가장 않았으며, 얼굴동맥과 혀동맥이 강은 가지에서 얼어나 나뉘는 경우 (312%), 그리고 위 강상동액과 혀동맥이 같은 가지에서 나뉘는 경우 (12 5%) 등이 있었다. 혀동맥과 혀동맥의 둘째 부분은 덮는 목뿔혀근 과의 영대학적 관계는 각각 혀동맥의 첫째 부분이 목뿔혀근 뒤에서 심하게 휘어져 깊은 층으로 들어가는 유형 (41 2 %), 그리고 혀동맥의 첫째 부분이 목뿔혀근의 뒤쪽 근육모셔리 바로 뒤흘 지나 깊은 층으로 들어가는 경우가 661% 로 가장 많았다 목뿔혀근 깊은층에서 혀동맥의 둘째 부분이 달리는 양상은 급하게 위쪽으로 꺾역 달리다가 다시 앞쪽으로 꺾여 혀의 깊은 곳으로 들어가는 경우와 목뿔빼에서 혀쪽으로 완만한 굽이플 이루며 올라가는 경우가 비슷한 반도로 관찰되었다. 입안바닥에 분포하는 혀밑동맥이 혀동맥 셋째 부분에서 나오는 경우슨 전체의 590% 에서만 관창되었으며 그 외는 대부분 얼굴동맥의 턱끝 및동맥 가지가 턱옥뽕근응 옳고 입안바닥에 분포하였다. 따라서 연구자들은 한국인 업안바 닥에는 혀동액이 전체의 59%에서만 분포하며 그외는 영굴동액의 턱끝밑동맥 가지 , 그리고 기타 다른 동맥의 가지들이 분포한다는 사실을 확인하였다

광섬유를 이용한 고감도 압력센서의 개발

김창원,권대혁,김진섭,이정희,손병기 경북대학교 센서기술연구소 1995 연차보고서 Vol.1995 No.-

KOH 수용액을 이용하여 실리콘 식각공정기술을 확립하였으며, 이를 이용하여 실리콘 기판 위에 스트레스 균형이 이루어진 150 ㎚-Si_3N_4/300 ㎚-SiO_2/150 ㎚-Si_3N_4 두께를 가지는 구조의 평탄한 3층 유전체 멤브레인을 제작하였다. 본 실험에서 사용되는 파장인 1.3 ㎛ 근방에서 다이아프레임의 광투과도는 약 50 %로 광반사막으로 사용이 불가능하였다. 따라서, 다이아프레임 뒷면에 약 1000 Å의 금을 증착하여 N/O/N/Au박막의 광투과도를 수 %정도로 감소시킴으로써, 센서의 광반사막으로 사용할 수 있었다. source fiber를 단일모드로 했을 때 다이아프레임의 크기에 따라 감도는 각각 0.52㎻/torr(3×3 ㎟), 0.65 ㎻/torr(4×4 ㎟), 0.77 ㎻/torr(5×5 ㎟)였다. 광손실을 최소화하기 위해 광전송용 다모드 광섬유를 사용하였을 때는, 2×2 ㎟의 다이아프레임의 크기에 대해 0∼800 torr의 넓은 측정범위에서 거의 선형적인 압력특성을 나타내었다. Using KOH solution, silicon etching technology has been established and stress-balanced flat 600 ㎚ thick triple dielectric membrane(150 ㎚-Si_3N_4/300 ㎚-SiO_2/150 ㎚-Si_3N_4) on silicon substrate has been fabricated. At the wavelength of the sensor light source near 1.3 ㎛, the optical transmittance of the diaphragm was about 50 %, it was impossible to be used as a reflecting film. To decrease to a few percents, the back-side of the diaphragm was deposited 1,000 Å thick gold layer, which is sufficient enough to be used as a light reflection layer of the sensor. When was used 8/126 ㎛ single-mode fiber, the respective sensitivities for diaphragm size were 0.52 ㎻/torr(3×3 ㎟), 0.65 ㎻/torr(4×4 ㎟), 0.77 ㎻/torr(5×5 ㎟). When was used 62/126 ㎛ multi-mode fiber for the light transmission to minimize optical loss, the pressure characteristics was showed almost linearly curve in a wide pressure range, 0 torr∼800 torr, for the 2×2 ㎟ diaphragm in dimensions.

1995년 서울지역 거주자에서 발생한 Plasmodium Vivax에 의한 Malaria 1예

김영선,박기령,어은경,최진혁,이정수,정화순 梨花女子大學校 醫科大學 醫科學硏究所 1996 EMJ (Ewha medical journal) Vol.19 No.2

Malaria has a wordwide incidence of more than one thousand to three thousand million clinical cases and results in approximately 200 to 300 million deaths per year. Although Korea was an endemic area of Malaria, it was nearly eradicated from the country. However, indigenous cases of malaria have been reported since 1994. Recently, we experienced a case of Plasmodium vivax infection in a resident of Seoul. A 25-year old young man who had no history of being abroad, blood transfusion nor parenteral use of drug visited our hospital due to fever and chill for 4 days. A peripheral blood smear demonstrated Plasmodium vivax infection. He was treated with hydroxychoroquine and premaquine without relapse.

갑상선기능항진증성 근병증 1예

김진석,박현영,장혁,김요식,조광호 圓光大學校 醫科學硏究所 2005 圓光醫科學 Vol.20 No.2

The effect of neuropeptides on secretion of Interleukin-8(IL-8)

Kim, Kyung-Jun,Park, Sang-Hyuk,Choi, Kyoung-Kyu,Park, Sang-Jin 大韓齒科保存學會 2006 Restorative Dentistry & Endodontics Vol.31 No.3

본 연구는 치수조직, 치은, 치주인대로부터 배양된 조직을 SP (Substance P)로 4시간, SP, CGRP (Calcitonin Gene-related Peptide), Tumor necrosis factor-α (TNF-α)로 8시간 자극 후 RNase Protection Assay를 시행하고, IL-8의 분비량을 측정해 다음 결과를 얻었다. 1. IL-8 mRNA는 모든세포에서 발현됐다. 2. IL-8 mRNA 발현은 SP (10^(-5)M)와 SP (10^(-8)M)로 4시간 자극 시 증가되지 않았다. 3. IL-8 mRNA 발현은 SP (10^(-4)M)와 CGRP (10^(-6)M)로 8시간 자극 시 증가되지 않았다. 4. TNF-α (2 ng/㎖) 자극 시, IL-8 mRNA 발현이 증가됐다. 5. 치은 세포를 CGRP (10^(-6)M)로 8시간 자극 시, IL-8 분비량이 증가했다 (p < 0.05). 6. 치주인대 세포를 SP (10^(-4)M)로 8시간 자극 시 IL-8 분비량이 증가했다 (p < 0.05). We investigated the secretion of Interleukin-8 (IL-8) from ginviva and periodontal ligament stimulated with Substance P (SP) and Calcitonin Gene-related Peptide (CGRP). Gingiva (GF), periodontal ligament (PDLF) and pulp (PF) tissues were collected from extracted instact 3rd molars. Cultured cells were stimulated with different concentrations of SP for 4 hrs, and stimulated with SP, CGRP and Tumor Necrosis Factor-α (TNF-α) for 8 hrs. Then RNase Protection Assay was carried out. ELISA was performed using supernatants of stimulated cells for quantitative analysis of IL-8. Results were assessed using supernatants of stimulated cells for quantitative analysis of IL-8. Results were assessed using student t-test with significance of P < 0.05. According to this study, the results were as follows: 1. IL-8 mRNA was detected in all type of cells studied (PF, GF and PDLF). 2. IL-8 mRNA expression was not increased after stimulating 4 hrs with SP (10^(-5)M) and SP (10^(-8)M) compared with Mock stimulation in all type of cells studied. 3. IL-8 mRNA expression was not increased after stimulating 8 hrs with SP (10^(-4)M) and CGRP (10^(-6)M) compared with Mock stimulation in all type of cells studied. 4. TNF-α (2 ng/㎖) increased the expression of IL-8 mRNA in all kind of cells studied. 5. The secretion of IL-8 from GF was increased 8 hrs after the stimulation with CGRP (10^(-6)M) (p < 0.05). 6. The secretion of IL-8 from PDLF was increased 8 hrs after the stimulation with SP (10^(-4)M) (p < 0.05). Calcitonin Gene-related Peptide (CGRP) increased Interleukin-8 (IL-8) which plays an important role in chemotaxis of neutrophil in Calcitonin Gene-related Peptide (CGRP) gingival tissue, whereas Substance P increased the secretion of IL-8 from periodontal ligament.

만성 심부전환자의 혈액에서 측정한 Tumor necrosis factor-α 및 Interleukin-6의 임상적 의의

김명구,김성구,박상호,한대희,강진환,변정득,심규혁,최병조,방덕원,온영근,현민수,권영주 순천향의학연구소 2001 Journal of Soonchunhyang Medical Science Vol.7 No.2

Background and objectives: Many conditions are responsible for the pathophysiology and progressive mechanisms of congestive heart failure. More recently, it has also become evidence that another class of biologycally activated molecules generically reffered to as cytokine these are also over expressed in congestive heart failure. Therefore, the purpose of this study was to measure concentrations of tumor necrosis factor-α(TNF-α), interleukin-6(IL-6) in mild to severe symptoms of heart failure and compare their values with those found in normal control and analysed correlation relationship between cytokine level, clinical findings and hemodynamic indicies. Subjects and Methodology: Levels of TNF-α and IL-6 were measured on pulmonary artery during cardiac catheterization in heart failure patients(n=32) and normal subjects(n=8) as well as physical examination and echocardiogram. Cytokines assay were performed on plasma using commercially available ELISA(Enazyme-Linked Immunosorbent Assay) kits. Results: Although the levels of TNF-α and IL-6 tend to increase in congestive heart failure group, the cytokines level was not made significantly statistical difference between congestive heart failure group and controls. When analyzing the correlation between the levels of PCWP(pulmonary capillary wedge pressure) and cytokines(TNF-α, IL-6), respectively, there were statistically significant correlation coefficient 0.32,(p<0.05), 0.39(p<0.01). The cytokine IL-6 and pressure of pulmonary artery were significant correlation.(correlation coefficient 0.36, p<0.02) More significantly, there was correlated with TNF-α and IL-6.(correlation coefficient 0.57, p<0.001) Conclusions: There was tended toward high concentration of TNF-α & IL-6 in congestive heart failure and significant difference for PCWP between TNF-α & IL-6, thus may be correlated with development and progression in congestive heart failure.

CA1 신경세포의 수상돌기에 국소 적용된 glutamate에 의한 AMPA 수용체 활성화

해마, 수상돌기, 시납스 漢陽大學校 精神健康硏究 1999 精神健康硏究 Vol.18 No.-

청소년 스트레스 요인과 PC방 이용과의 관련성

김상아,전진용,구민성,박웅섭,정상혁 大韓神經精神醫學會 2003 신경정신의학 Vol.42 No.6

Objectives : This study was designed for the evaluation of relationships between PC-Bang (the place where people surf the internet, play computer games and etc) visit and stress in adolescents. Methods : 66 adolescents in city of Kangnung were interviewed in June, 2000. The independent variables were general characteristics of adolescents, the characteristics related to school activities and the length of time using PC-Bang. The amount of stress was measured by the Korean version BEPSI (Brief Encounter Psychosocial Instrument) scale. Results : The multiple regression analysis shows that the BEPSI score of female was higher than that of male by 0.18 (p<0.05) and the adolescents with more communication with their friends scored lower 4.04 (p<0.001) than others in the BEPSI. As the time used in PC bang increased, the BEPSI score was also increased 0.18 point per hour (p<0.01). Conclusion : This result shows that the time of PC-Bang usage is significantly related with the BEPSI score of adolescents.