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Fluoroquinolone계 항생제의 경구투여에 따른 양식넙치 및 조피볼락의 체내 잔류량의 변화
조미라,김진우,박미선,김풍호,김동수 경성대학교 공학기술연구소 2008 공학기술연구지 Vol.15 No.-
The residue depletions of fluoroquinolones were investigated in the olive flounder (Paralichthys olivaceus) and black rockfish (Sebastes schlegeli) after 840 hours treatment with medicated feed at a dose 20 mg/kg·bw/day The bloods of samples were taken at 5, 10, 24, 48, 72, 120, 168, 216, 312, 480, 720, 840 and 960 hour after treatment. Fluoroquinolones concentrations were detected by high performance liquid chromatography equipped with UV detector. The recovery rates of fluoroquinolones in fish samples ranged 91.95~99.69%, 93.43~97.54% and 92.99~97.87% for the concentration of 0.1, 0.5, 1.0 ㎍/g, respectively In the blood of olive flounder, the concentrations of ciprofloxacin, enrofloxacin, norfloxacin and sarafloxacin detected at 10, 10, 24 and 24 hour after treatment were 6.433 ㎍/g, 6.065 ㎍/g, 11.8334 ㎍/g and 10.3168 ㎍/g as maximum level, respectively In the black rockfish, ciprofloxacin, enrofloxacin, norfloxacin and sarafloxacin at 24, 24, 24 and 10 hour after treatment were 8.2634㎍/g, 8.0276㎍/g, 7.2888㎍/g and 9.3787㎍/g as maximum level, respectively On the other hand, ciprofloxacin enrofloxacin, norfloxacin and sarafloxacin were not detected at 840, 480, 720 and 720 hours after treatment in the olive flounder, and at 720, 480, 720 and 480 hours after treatment in the black rockfish, respectiveley.
( Dong Jin Kim ),( Hyun Seok Kang ),( Hyuk Soon Choi ),( Hye Jin Cho ),( Eun Sun Kim ),( Bo Ra Keum ),( Hyong Gin An ),( Ji Hoon Kim ),( Yeon Seok Seo ),( Yong Sik Kim ),( Hyung Joon Yim ),( Yoon Tae 대한간학회 2011 Clinical and Molecular Hepatology(대한간학회지) Vol.17 No.2
Background/Aims: Several studies suggested that serum cystatin C (CysC) is more useful than serum creatinine (Cr) for the assessment of renal function in patients with liver cirrhosis. This study evaluated the clinical significance of CysC in patients with cirrhotic ascites and normal Cr level. Methods: We enrolled patients with cirrhotic ascites and a normal serum Cr level (<1.2 mg/dL). GFR was measured by 99mTc-DTPA renal scan. Serum Cr, CysC, and Cr clearance (CCr) were measured on the same day. Significant renal impairment and severe renal impairment were defined as GFR <60 mL/min and GFR <30 mL/min, respectively. Results: Eighty-nine patients with cirrhotic ascites were enrolled in the study (63 men and 26 women; age, 55±11 years). Forty-seven (52.8%) and 42 (47.2%) patients were in Child-Pugh grade B and C, respectively. Serum Cr and CysC levels and GFR were 0.8±0.2 mg/dL, 1.1±0.3 mg/L, and 73.4±25.5 mL/min, respectively. Significant and severe renal impairment were noted in 28 (31.5%) and 2 (2.2%) patients, respectively. GFR was well correlated with serum Cr, CysC, and e-GFRMDRD, while it was not correlated with e-GFRC&G. In multivariate analysis, only CysC was significantly correlated with GFR (β, 45.620; 95% CI, 23.042-68.198; P<0.001). Serum CysC level was the only independent predictor for significant renal impairment. Conclusions: Significant renal dysfunction was not rare in patients with cirrhotic ascites, even their serum Cr level is normal. Serum CysC is a useful marker for detecting significant renal dysfunction in these patients.
자전거 스포츠 및 관광 서비스를 위한 스마트 헤드웨어 어플리케이션 개발
김범진(Beom-gin Kim),최유준(Yu-jun Choi),김성진(Sung-jin Kim),성광모(Kwang-mo Sung),서동현(Dong-hyeon Seo) 한국자동차공학회 2017 한국자동차공학회 부문종합 학술대회 Vol.2017 No.5
현대사회에서 자전거의 수가 많아진 만큼 자전거 사고도 급증하고 있다. 자전거 사고중 충돌 사고 시 대형사고로 이어지고 있으며 위험상황 시 적극적인 대처가 어렵기 때문에 사고를 사전에 예방하는 것이 매우 중요하다. 그렇지만 이에 따른 기술적 대책이 다른 선진국들에 비해 매우 부족한 실정이다. 전국의 자전거 사고 데이터와 수치지도(Digital Map)의 도로속성 정보를 기반으로 자전거 사고 위험존을 만들어졌고, 이를 활용하여 자전거 이용자에게 시의적절한 안전정보를 제공할 수 있도록 하는 방안이 제시되었다.1) 본 연구는 자전거 사고 위험 존 설정에 대한 기술적 활용의 일환으로서 모바일 어플리케이션의 인터페이스 제작과 시제품을 연구 개발을 목표로 한다. 이를 이루기 위해 자전거 사고 위험존을 기반한 네비게이션 모듈제작 후 헤드웨어 장치와 모바일 어플리케이션에 연동가능한 시제품을 제작함으로서 자전거 사고를 예방하고, 더 나아가 본 연구의 활용방안 등을 제시할 것이다.
김진아,유동수,손상욱,김애리,김일환 대한피부과학회 2001 大韓皮膚科學會誌 Vol.39 No.9
Lichen spinulosus is a benign follicular eruption seen primarily in younger persons and is frequently classified a disorder of kertinization. The lesion is characterized by the development of patches of small perifollicular papules that have a central horny spine. We report a case of lichen spinulosus developed in an 8-year-old male patient who had atopic dermatitis.
Dong Seok Lee,Gin Hyug Lee,Sang Gyun Kim,Kook Lae Lee,Ji Won Kim,Ji Bong Jeong,Yong Jin Jung,Hyoun Woo Kang 대한소화기내시경학회 2023 Clinical Endoscopy Vol.56 No.5
Background/Aims: We developed a new endoscopic submucosal dissection (ESD) simulator and evaluated its efficacy and realism foruse training endoscopists. Methods: An ESD simulator was constructed using polyvinyl alcohol hydrogel sheets and compared to a previous ESD simulator. BetweenMarch 1, 2020, and December 30, 2021, eight expert endoscopists from three different centers analyzed the procedure-relatedfactors of the simulator. Five trainees performed gastric ESD exercises under the guidance of these experts. Results: Although the two ESD simulators provided overall favorable outcomes in terms of ESD-related factors, the new simulator hadseveral benefits, including better marking of the target lesion’s limits (p<0.001) and overall handling (p<0.001). Trainees tested the usefulnessof the new ESD simulator. The complete resection rate improved after 3 ESD training sessions (9 procedures), and the perforationrate decreased after 4 sessions (12 procedures). Conclusions: We have developed a new ESD simulator that can help beginners achieve a high level of technical experience before performingreal-time ESD procedures in patients.