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선희식(Hee Sik Sun),김부성(Boo Sung Kim),정인식(In Sik Chung),한준열(Joon Yeol Han),채현석(Hyun Suk Chae),최재경(Jae Kyung Choi),박수헌(Soo Heon Park),정일건(Il Gun Chung),안중현(Joong Hyun Ahn),정규원(Kyu Weon chung) 대한소화기학회 1993 대한소화기학회지 Vol.25 No.5
Lipoma of the upper gastrointestinal tract is a rare benign tumor. Usually lipomas look like submucosal tumor with yellow, smooth surface. We present 2 cases of gastric lipoma and duodenal lipma with review of literatures. These were diagnosed by means of the fibroptic endoscopy. The gastric lipoma is located in the anterior wall of antrum and causes intermittent gastric outlet obstruction. The duodenal lipoma is located in the greater curvature of duodenal bulb. Those lesions were successfully removed by endoscopic polypectomy without complications.
Yersinia enterocolitica의 급성 충수염에서 원인균으로서 가능성
손태준(Tae Joon Son),김동희(Dong Hee Kim),조윤주(Yun Ju Jo),채정돈(Jeong Don Chae),홍부환(Boo Hwan Hong),강재희(Jae Hee Kang),이태석(Tae Seok Lee),한준길(Jun Gil Han) 대한외과학회 2009 Annals of Surgical Treatment and Research(ASRT) Vol.76 No.4
Purpose: With increasing frequency, Yersinia enterocolitica is being recognized as an important bacterial cause of acute gastrointestinal infection with abdominal pain. In addition, the association of Y. enterocolitica infections with acute appendicitis has been suggested. This study was undertaken to ascertain whether Y. enterocolitica is a possible infectious agent in acute appendicitis. Methods: Between December 2007 and April 2008, 162 patients who underwent appendectomy for presumed appendicitis, enrolled in this prospective study. After surgical excision of appendix, a portion of each specimen was cultured for Y. enterocolitica with highly selective media (Cefsulodin-Irgasan-Novobiocin agar). Results: Pathologically, 150 of the patients had appendicitis and 12 patients had normal appendices. Only one of the 150 patients (0.7%) with appendicitis was found to be culture positive for Y. enterocolitica, while it was not detected from normal appendices. Conclusion: The authors were unable to implicate Y. enterocolitica as a major pathogen in acute appendicitis within the Seoul area. However, we thought there to be more need for investigation for association of Y. enterocolitica with acute appendicitis over a broader area and season.
과량의 구리를 지속적으로 투여한 쥐에서 시간적 변화에 따른 간 손상의 전자현미경적 소견
한남익 ( Nam Ik Han ),최상덕 ( Sang Duk Choi ),정규원 ( Kyu Won Chung ),남순우 ( Soon Woo Nam ),한준열 ( Joon Yeol Han ),최상욱 ( Sang Wook Choi ),이영석 ( Young Sok Lee ),선희식 ( Hee Sik Sun ) 대한소화기학회 2003 대한소화기학회지 Vol.41 No.5
Background/Aims: This study was designed to clarify the sequential morphologic changes of copper overloaded-rat liver. Methods: The Sprague-Dawley rats were divided into three groups according to copper and penicillamine administration: Group I. normal control injected with lipiodol; Group II, treated with copper only; Group III, treated with copper plus D-penicillamine. Liver tissues were stained with hematoxylin-eosin and rubeanic acid. In order to elucidate the ultrastructural changes of the liver, transmission electron microscopic examination was also performed. Results: Electron microscopic findings in copper-treated group were characterized by a number of copper-containing lysosomes at pericanalicular ectoplasm, normal sized and bizarre mitochondria with small vacuoles (at 2 weeks), dilated bile canaliculi with decreased microvilli (at 3 weeks), disruption of sinusoidal border (at 4 weeks), microsteatosis (at 5 weeks), a Councilman body-like inclusion in sinusoid and round hepatocytes undergone coagulation necrosis in sinusoid (at 7 weeks), increased collagen bundles in Disse space and loss of microvilli (at 12 weeks). There were increased copper containing granules in hepatocytes of copper plus D-penicillamine treated group, but normal ultrastructural findings were observed. Conclusions: These findings indicate that hepatic injury induced by copper overload is caused by deranged copper metabolism in the lysosome of the hepatocytes and administration of D-penicillamine in copper stressed rats seems to be effective for the restoration of hepatocyte function and morphologic changes. (Korean J Gastroenterol 2003;41:374-381)
송화분이 고지방 식이 섭취 흰쥐의 혈청과 간장에 미치는 영향
이영주(Young-Ju Lee),박무희(Mu-Hee Park),황성원(Sung-Won Hwang),배만종(Man-Jong Bae),한준표(Joon-Pyo Han) 한국식품영양과학회 1994 한국식품영양과학회지 Vol.23 No.2
6주간 고지방식이를 섭취한 흰쥐에 있어 송화분과 탈지 송화분이 혈청과 간장에서의 지방 축적과 대사에 미치는 효과를 관찰하였다. 혈청에서의 total lipid, total cholesterol 농도는 고지방 식이군에 비해서 탈지 송화분과 송화분 투여군이 유의적으로 감소하였다. 혈청에서는 triglyceride 농도는 탈지 송화분과 송화분 투여군이 고지방 식이군과 비교했을때 뚜렷한 감소를 보였으며, 이는 정상군과 비슷한 농도를 나타내었다. 혈당 농도는 송화분, 탈지 송화분 투여군에서 유의성 있게 감소하였다. 간장을 조직학적으로 관찰한 결과, 고지방식이로 인한 조직의 지방 침착은 송화분 투여군에서 다소 억제함을 보였다. 이상의 결과를 미루어 볼 때 송화분은 동맥경화중 및 순환기계 질환의 예방과 치료에 효과적일 것으로 사료된다. Effect of pine pollen and defatted pine pollen on lipid accumulation and metabolism in serum and liver were investigated with rats fed high fat-supplemented diets for 6 weeks. Concentrations of total lipid and total cholesterol in serum significantly decreased in the experimental groups(treated with pine pollen and defatted pine pollen) compared with the control group. Concentration of triglyceride in serum was remarkably lower than that of control group. This was similar to that of normal group. Concentration of glucose in serum was significantly lower in the experimental group. It was observed from photographs of hepatic tissue in rats that pine pollen inhibits the lipid accumulation induced by high fat diets.
위식도역류질환에서 십이지장위식도역류 - 장시간 보행성 식도내 pH및 빌리루빈의 동시측정에 의한 평가
최명규(Myong Gyu Choi),박수헌(Soo Heon Park),방춘상(Choon Sang Bang),한준열(Joon Yul Han),김재광(Jae Kwang Kim),최규용(Kyu Yong Choi),정인식(In Sik Chung),정규원(Kyu Won Chung),선희식(Hee Sik Sun),박두호(Doo Ho Park) 대한소화기학회 1996 대한소화기학회지 Vol.28 No.4
N/A Background/Aims: Esophageal reflux damage may be produced by agents other than acid and the term alkaline esophagitis has been applied. Methods using esophageal pH monitoring to assess duodenogastroesophageal reflux have been suggested but gastric neutralization has made these methods difficult to prove conclusively. The purpose of this study were to investigate the role of duodenogastroesophageal reflux in gastroesophageal reflux disease(GERD) and to understand the relationship between pH and duodenogastroesophageal reflux. Methods: we performed simul- taneous esophageal pH and bilirubin rnonitoring(Bilitec 2000, Synetics) in 14 symptomatic patients with gastroesophageal reflux and 10 healthy controls. Abnormal gastroesophageal reflux was defined when the percent total time of pHC4 or bilirubin absorbance 0.14 exceeded the 95th percentile of the range obtained in healthy volunteers. Results: Abnormal gastroesophageal reflux was diagnosed in 12(85.7%) of 14 patients, who could be categorized into 3 acid refluxers, 1 bile refluxer or 8 combined acid and bile refluxers. All 6 patients with severe esophagitis(grade 2 by Savary Miller classification) were combined acid and bile refluxers and had markedly prolonged acid and bile reflux compared to 8 patients with normal or mild esophagitis(% total time of pH 4(mean+SE): 13.4+2.96 vs 5.0+1.8, p<0.05; % total time of bilirubin absorbance 0.14(mean+SE): 25.2+4.6% vs 7.9+3.8%, p<0.05). Mean pH of esophageal refluxate during bile reflux episode lasting longer than 5 minutes was 6.0(7.1% for pH C4, 8.8% for pH 4 5, 26.6% for pH 5-6, 47% for pH 6-7 and 8.3% for pH7). 4) 8 patients with a symptom index greater than 25% experienced 24 reflux symptoms of which 12(50.0%) were associated with acid reflux, 5(20.8%) were associated with bile reflux and 7(29.2%) were not associated with bile or acid reflux. Conclusions: Alkaline esophageal reflux is a misnomer. Esophageal pH monitoring does not adequately identify symptomatic non-acidic duodenogastroesophageal reflux. Patients with com- bined acid and bile reflux are more likely to develop severe esophagitis. (Korean J Gastroenterol 1996; 28:469 - 476)
정대영 ( Dae Young Cheung ),김재광 ( Jae Kwang Kim ),김진일 ( Jin Il Kim ),한준열 ( Joon Yeol Han ),정규원 ( Kyo Won Chung ),선희식 ( Hee Sik Sun ) 대한소화기학회 2005 대한소화기학회지 Vol.45 No.4
Background/Aims: As a preliminary study to test the possibility of oral transmission of hepatitis C virus (HCV), many investigations in order to detect the extrahepatic localization of HCV have been performed. In this study, we examined the presence of HC