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관상동맥 질환에서 CD14 유전자형에 따른 세균 및 Heat Shock Protein에 대한 반응의 차이
한주용,최수연,조현주,김화평,강현재,구본권,김남중,김효수,손대원,오병희,박영배,최윤식 대한감염학회 2007 감염과 화학요법 Vol.39 No.1
Background : CD14 is the receptor for lipopolysaccharides and heat shock protein (HSP), which has been suggested being associated with increased risk of coronary artery disease (CAD). We investigated whether the response to infectious agents or HSP is different according to CD14 polymorphism in Koreans. Materials and Methods : Antibody titers to Helicobacter pylori, Chlamydia pneumoniae, and human HSP60 (hHSP60) were measured in 48 patients with stable CAD and in 41 healthy controls by ELISA. CD14 genotype was determined by PCR and high-sensitivity C-reactive protein (hs-CRP) was measured. Results : Seropositivity to C. pneumoniae and H. pylori, and antibody titer to hHSP60 were not significantly associated with the presence of CAD. CD14 genotype distribution was 31 TT (35%), 43 CT (48%), and 15 CC (17%). To compare the response to the infectious organism and hHSP60, we divided study population into 3 groups; CAD patients with non-TT genotype (group I, n=30), CAD patients with TT genotype (group II, n=18), and normal controls (group III, n=41). Seropositivity to C. pneumoniae and H. pylori, and antibody titer to hHSP60 were not significantly different among 3 groups. Though hs-CRP level was significantly different among 3 groups, post-Hoc analysis showed that hs-CRP level was not significantly different between group I and group II (group I: 1.6[1.1-3.5] mg/L and group II: 0.35[0.1-2.0] mg/L). Conclusions : This study suggests that the inflammatory responses to infectious organisms and HSP do not differ according to the CD14 genotype in Koreans. 목적 : 만성적인 세균 감염이나 자가 면역 반응이 동맥경화와 연관되어 있다는 주장이 제기되어 왔다. CD14은 lipopolysaccharides (LPS)와 heat shock protein(HSP)의 수용체로 C(-260)→T 다형성이 관상동맥 질환의 위험과 관련되어 있다고 제안되어 왔다. 본 연구에서는 한국인에서 CD14 다형성에 따른 LPS와 HSP에 대한 반응성을 염증표지자를 측정하여 살펴보고자 하였다. 재료 및 방법 : 안정형 관상동맥 환자 48명과 정상 대조군 41명을 대상으로 Chlamydia pneumoniae, Helicobacter pylori 항체 및 인체 HSP60 (hHSP60) 항체 역가를 enzyme-linked immunosorbent assay (ELISA) 방법으로 측정하였다. CD14 유전자형은 중합효소연쇄반응을 이용하여 결정하였고 hs-CRP를 측정하였다. 결과 : C. pneumonias 및 H. pylori 항체 양성 여부 및 항체 역가, 그리고 hHSP60에 대한 항체 역가는 안정형 관상동맥 질환의 유무와 유의한 상관관계는 없었다. CD14 유전자형의 분포는 TT 30명(39%), CT 31명(40%), 그리고 CC 16명(21%)이었다. 관상동맥 질환 군에서 TT 유전자형은 38%, 대조군에서는 32%로 TT 유전자형과 관상동맥 질환의 유무와는 유의한 상관관계가 발견되지 않았다(P>0.05). CD14 유전자형에 따라 C. pneumonias와 H.pylori 감염 및 hHSP60에 따른 반응에 차이가 있는지 여 부를 알아보기 위해, 관상동맥 질환 군을 다시 TT 유전자형 군과 non-TT 유전자형 군으로 나누어, 전체적으로 세군에서 항체 양성률과 역가를 비교하였다(I군: CD14 TT 유전자형을 가진 안정형 관상동맥 환자, II군: CD14 TT 유전자형을 가진 안정형 관상동맥 환자, III군: 정상 대조군). 세 군에서 C. pneumonias와 H. pylori 항체 양성률 및 hHSP60 항체 역가에는 유의한 차이가 없었다. 세 군사이에 hs-CRP 값에 유의한 차이가 있었지만, post-Hoc분석에서 II군의 hs-CRP 값이 I군에 비해 유의하게 높지는 않았다(0.35 [0.1-2.0] mg/L in group II vs. 1.6 [1.1-3.5]mg/L in group I, P>0.05). 결론 : 본 연구는 한국인에서 CD14 유전자형에 따라 LPS나 HSP에 대한 반응이 유의하게 다르지 않음을 시사한다.
Communication : Variations of SST around Korea Inferred from NOAA AVHRR Data
Yong Q. Kang,Sang Bok Hahn,Young Sang Suh,Sung Joo Park 大韓遠隔探査學會 2001 大韓遠隔探査學會誌 Vol.17 No.2
The NOAA AVHRR remotely sensed SST data, collected by the National Fisheries Research and Development Institute (NFRDI), are analyzed in order to understand the spatial and temporal distributions of SST in the sea near korea. Our study is based on 10-day SST images during last 7 years (1991-1997). For a time series analysis of multiple SST images, all of images must be consistent exactly at the same position by adjusting the scales and positions of each SST image. We devised an algorithm which automatically detects cloud pixels from multiple SST images. The cloud detection algorithm is based on a physical constraint that SST anomalies in the ocean do not exceed certain limits (we used ±3℃ as a criterion of SST anomalies). The remotely sensed SST data are tuned by comparing remotely sensed data with observed SST at coastal stations. Seasonal variations of SST are studied by harmonic fit of SST normals at each pixel and the SST anomalies are studied by statistical method. It was found that the SST anomalies are rather persistent for one or two months. Utilizing the persistency of SST anomalies, we devised an algorithm for a prediction of future SST. In the Markov process model of SST anomalies, autoregression coefficients of SST anomalies during a time elapse of 10 days are between 0.5 and 0.7. The developed algorithm with automatic cloud pixel detection and rediction of future SST is expected to be incorporated to the operational real time service of SST around Korea.
변동성, 거래량과 시계열상관 : 원-달러 환율의 경우 Evidence from the Korean Won-Dollar Exchange Rate
주상영,한상범 한국금융연구원 2003 금융연구 Vol.17 No.1
이 연구는 일별 원-달러 환율을 대상으로 시계열상관의 결정요인을 규명하고자 하였으며, 시계열상관에 영향을 미칠 수 있는 변수로 변동성과 거래량에 주목하였다. 변동성의 증가는 원-달러 환율변화율의 시계열상관을 감소시키는 것으로 나타났는데, 이 관계는 최근 들어 약화된 것으로 보인다. 그러나 거래량 증가가 시계열상관을 감소시키는 효과는 최근에도 여전히 지속되는 것으로 나타났다. 변동성이나 거래량이 시계열상관에 영향을 미치는 과정에는 외환시장 참여자의 거래행태가 일정한 역할을 하는 것으로 보인다. Unlike major international currencies, Korean won-dollar exchange rates exhibit high autocorrelation as well as time-varying patterns in daily frequency. We examine the volume-autocorrelation relationship as well as the volatility-autocorrelation relationship in the Korean FX market. We specify the model so that the first-order autocorrelation of daily won-dollar returns can depend on the volatility and volume, and find that increase in them tend to lower the intensity of autocorrelation. While the role of volatility becomes weak in recent periods, however, the volume effect persists. The evidence is in favor of the interpretation that time varying autocorrelations are related to the heterogeneous trading behavior of market participants.
Variations of SST around Korea Inferred from NOAA AVHRR Data
Kang, Yong-Q.,Hahn, Sang-Bok,Suh, Young-Sang,Park, Sung-Joo The Korean Society of Remote Sensing 2001 大韓遠隔探査學會誌 Vol.17 No.2
The NOAA AVHRR remotely sensed SST data, collected by the National Fisheries Research and Development Institute (NFRDI), are analyzed in order to understand the spatial and temporal distributions of SST in the sea near korea. Our study is based on 10-day SST images during last 7 years (1991-1997). For a time series analysis of multiple SST images, all of images must be consistent exactly at the same position by adjusting the scales and positions of each SST image. We devised an algorithm which automatically detects cloud pixels from multiple SST images. The cloud detection algorithm is based on a physical constraint that SST anomalies in the ocean do not exceed certain limits (we used $\pm$3$^{\circ}C$ as a criterion of SST anomalies). The remotely sensed SST data are tuned by comparing remotely sensed data with observed SST at coastal stations. Seasonal variations of SST are studied by harmonic fit of SST normals at each pixel and the SST anomalies are studied by statistical method. It was found that the SST anomalies are rather persistent for one or two months. Utilizing the persistency of SST anomalies, we devised an algorithm for a prediction of future SST. In the Markov lprocess model of SST anomalies, autoregression coefficients of SST anomalies during a time elapse of 10 days are between 0.5 and 0.7. The developed algorithm with automatic cloud pixel detection and rediction of future SST is expected to be incorporated to the operational real time service of SST around Korea.
양말단에 서로 다른 관능기를 갖는 PEO를 합성하기 위한 Sila-protected Amino Functionality Initiator의 합성
김용주,한애란,성용길 동국대학교 자연과학연구원 1994 자연과학연구 논문집 Vol.14 No.-
A new initiator, potassium N-[2-(2,2,5,5-tetramethyl-1-aza-2,5-disila cylopentyl) ethyl] methyl amide, was synthesized with sila-protected amino functionality for well-defined heterobifunctional PEO. The synthesized initiator was identified by IR, ¹H-NMR, GC-Mass and GC.