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( Myung Jin Lee ),( Kye Hyung Kim ),( Jong Youn Yi ),( Su Jin Choi ),( Chung Jong Kim ),( Nak Hyun Kim ),( Kyoung Ho Song ),( Pyoeng Gyun Choi ),( Ji Hwan Bang ),( Wan Beom Park ),( Eu Suk Kim ),( San 대한내과학회 2014 대한내과학회 추계학술대회 Vol.2014 No.1
In Vitro Antiviral Activity of Ribavirin Against Severe Fever with Thrombocytopenia Syndrome Virus Myung Jin LEE1, Kye-Hyung KIM1, Jongyoun YI2, SuJin CHOI1, Chung-Jong KIM1, Nak- Hyun KIM1, Kyoung-Ho SONG1, Pyoeng Gyun CHOI1, Ji-Hwan BANG1, Wan Beom PARK1, Eu Suk KIM1, Sang-Won PARK1, Hong Bin KIM1, Nam Joong KIM1, Myoung- Don OH1 Seoul National University College of Medicine, Korea1, Pusan National University School of Medicine, Korea2 Background: Severe fever with thrombocytopenia syndrome (SFTS) is an emerging infectious disease caused by a novel Bunyavirus, severe fever with thrombocytopenia syndrome virus (SFTSV). No effective antiviral therapy is proven yet, but clinical use of ribavirin (RBV) has been tried. We investigated the antiviral effect of RBV against SFTSV in vitro. Methods: To test for cytotoxicity of RBV, Vero cells were treated with different concentrations of RBV (3.90 to 500 μg/mL, two-fold dilution) and analyzed by cell viability MTS assay 48h post-infection. To determine antiviral activity of RBV against SFTSV, Vero cells were infected with SFTSV strain Gangwon/Korea/2012 at 100 TCID50 (50% tissue culture infective dose) per well in a 96-well plate, and RBV was added at the concentrations showing no or minimal cytotoxicity. Viral RNAs were extracted from the culture supernatants and quantifi ed using one-step real-time reverse transcription- PCR to amplify the partial large segment of SFTSV. Statistical analysis was done by one-way ANOVA with Tukey`s post hoc test. Results: Cytotoxicity due to RBV was not observed at RBV concentration =31.3 μg/ mL. Viral RNAs at 24h post-RBV treatment were reduced with increasing RBV concentrations (1-32 μg/mL), compared with those of mock-treated cells (P <0.01, Figure). Half maximal inhibitory concentration (IC50) of RBV was 3.69 μg/mL at 24h post-RBV treatment. Conclusions: Our study shows that RBV has antiviral effect against SFTSV in a dose-dependent manner. Further studies are required to evaluate the effi cacy of RBV in SFTS.
김종완,진승훈,김병익,김태균,김영순 대구대학교 과학기술연구소 2001 科學技術硏究 Vol.8 No.1
The definition of data mining is the non-trivial extraction of implicit, previously unknown and potentially useful knowledge from data. Also, data mining has been worked on various fields such as database, machine learning, statistics, expert systems, and data visualization, and is a process consisting of these techniques. In many E-Commerce applications, it is important to build personalized profiles of individual users from their transaction histories. These profile constitute models of individual user behavior and can be specified with sets of rules learned from user transactional histories using various data mining techniques. In this paper, we present a MAS (multi-agent system) for customer management which maintains personal user information automatically, commands retrieval of products according to user preference, and builds personalized profiles of user.
A Reading of the Film Today And The Other Days : Based on the Analysis of Narrative
( Kim¸ Jong-wan ) 동국대학교 영어권문화연구소 2016 영어권문화연구 Vol.9 No.3
This thesis attempt to compare and analyse with Text today and the other day’s narrative style. So, I put to practical use narratology by a theoretical basis. First of all, I am trying to analyse Text’s narrative by Roland Barthes, next rereading with Steven Cohan’theory is composed. All through Text film’s internal analysis, I come up with narrative strategy prescibing the characteristic and research the sufficient propriety in narrative’s meaning. Also, some signs to be use with the object of Text film’s analysis is described and involved in Gerard Genette’time and Steven Cohan’s focalization code. Of course, this work of re-evaluation is establishing the sense of sight of narrative aethetic characteristics in Text film’s narrative structure. And then a outcome that the director try narrative strategy shows spilting occurrence against the narrative style from the formal and functional perspective, that could search the reason from reinterpretation out of the concept of Text film. Therefore a conclusion that I attempts narrative analysis could explore that the narratology make u nderstanding to all principle upholding sign system, signifing reader’s trying interpretation. In order that the narratological personality reflect in the Text film, I did focus on analyse elements of the distinguishing narrative form and function, attempt aesthetic reinterpretation of the Text film today and the other day.
성인 지역사회 폐렴의 원인 미생물에 대한 전향적 다기관 연구 : Legionella, Leptospira, Hantaan virus and Orientia tsutsugamushi
김민자,정희진,손장욱,심희선,박대원,박승철,우준희,강재명,김유겸,신완식,김양리,이환종,김지희 대한감염학회 2001 감염 Vol.33 No.1
Background : Despite rigorous investigations, the etiology of community-acquired pneumonia remains unknown in about 50% of hospitalized patients. The diagnosis of the etiological agent is becoming more challenging and more critical as number of newer pathogens have been recognized in recent years. In the 3-year period prospective study we investigated adult patients with community-acquired pneumonia for Legionella, Leptospira, Hantaan virus and Orientia tsutsugamushi as potential etiologic agents. Methods : A prospective multicenter study was performed from May 1997 to April 2000. A total of 431 patients with community-acquired pneumonia under the inclusion criteria were examined for specific microbial diagnosis; sputum culture and PCR, and serologic teats including indirect immunofluorescence antibody (IFA) test for Legionella, and hemagglutination tests for Leptosoira, Hantaan virus and O. tsutsugamushi. Etiologic diagnosis was determined on the basis of the review of case record forms and specific laboratory diagnostic criteria. Results : During the study period a total of 385 sputum and 283 serum samples were examined. Legionella pneumonia was diagnosed in 2.3% (10/431) of the cases examined : 1.4% cases with PCR-positive (5/367) and 2.1% with positive IFA test (6/283). Leptospirosis and scrub typhus were diagnosed in 0.4% (1/252) and 2.0% (5/252), respectively. All 5 cases with scrub typhus occurred in late fall, and rash or eschar was not found. None of cases was Hantaan virus infection. Conclusion : The results suggest that Legionella, Leptospira, and O. tsutsugamushi should be considered in the etiologic diagnosis and empirical antibiotic therapy of community-acquired pneumonia. (Korean J Infect Dis 32:24∼31, 2001)
이종화,장봉기,박종안,박종영,김완종,우기민 한국환경독성학회 2004 환경독성보건학회지 Vol.19 No.3
Although numerous studies have shown that cadmium disturbs the normal biological processes in central nervous system the mechanism of toxicity is not well understood The present study has investigated the effect of cadmium on oxidative stress, Na+/K- ATPase activity and the aggregation of amyloid beta peptide(β-amylotd) in neuronal cell Ime, HT22 cell LC_(5) and LC_(50) of cadmium for HT22 cell resulted from MTT assay was 4 1 μM and 9 5 μM, respectively Cadmium(2 to 8 μM) dose-dependently increased the lipid peroxidation and decreased the content of glutathione Cadmium 4 μM showed a significant decrease in Na^(-)/K^(+) ATPase activity as compared with control group The aggregation of P-amyloid was accelerated in a dose-dependent manner by the treatment with 2 to 8 μM cadmium These results suggest that the neurotoxicity of cadmium can be mediated by the increase in oxidative stress and decrease in Na^(-)/K^(+) ATPase activity.
동종 골수이식 후 만성 이식편대숙주반응 환자에서 발생한 폐렴구균에 의한 수막뇌염 1예
신완식,김병욱,유진홍,김동집,김춘추,박종원,이종욱,김동욱,강문원,김양리 대한감염학회 1993 감염 Vol.25 No.3
Graft-versus-host disease (GVHD) is a frequent complication after bone marrow transplantation. Infectious complications are common in GVHD patients due to defect in cell-mediated immunity. A rare case of S. pneumoniae meningoencephalitis occured in a patient with extensive form of chronic GVHD after allogeneic bone marrow transplantation. He was immediately treated with full dosage of ceftriaxone and ampicillin. He suffered from various complications such as sepsis, acute renal failure, atelectasis, and seizure. Despite of aggressive treatment, he died probably due to renal shutdown and massive subacute cerebral infarction of left cerebral hemisphere. This report showed two unusual and rare features. First, the infection site was CNS rather than respiratory system. Second, the causative organism was S. pneumoniae, which is rare cause of CNS infection in immunocompromised patients.
탁충습,김완섭,김완종,김형기,남해선,한현각 순천향대학교 사회과학연구소 1999 순천향 사회과학연구 Vol.4 No.2
This study was done for the purpose of making an improved provision for sabbatical year program of the Soonchunhyang university. We made a comparison, between the provision for sabbatical year of Soonchunhyang university and those of other 16 universities in Korea, and proposed a new rule for sabbatical year program. The main features of the reformed plan are as follows. 1) Diversification of sabbatical year program based on a period of time and contents into two categories : research fellowship and reduction of the lecture time for duty per semester. 2) More detailed description of the purpose for sabbatical year program. 3) Relief of the qualification for application. 4) More strict prescription to the number of faculties for sabbatical year. 5) More definite prescription to the faculty's obligations. To be more progressive and competitive in 21st century for Soonchunhyang university, new approaches to program for faculty retraining including the sabbatical year rule are needed.