한의진단명과 진단요건의 표준화 연구 II (표준화 실례) : 2차년도 연구결과 중간 보고

양기상,최선미,최승훈,안규석,박경모,박종현,김성우,신승호,정우열,전병훈,고현,김정범,신상우,김성훈,김동희,권영규,엄현섭,장혜옥 한국한의학연구원 1996 한국한의학연구원논문집 Vol.2 No.1

The diagnostic requirements were suggested and explained regarding the systems of differentiation of symptoms and signs in the second year study of standardization and unification of the terms and conditions used for diagnosis in oriental medicine. The systems were as follows; - differential diagnosis according to condition of body fluid, differentiation of syndromes according to the state of qi and blood, differential diagnosis according to relative excessiveness or deficiency of yin and yang(氣血陰陽津液辨證) - differentiation of diseases according to pathological changes of the viscera and their interrelation - analyzing and differentiating of febrile diseases in accordance with the theory of the six channels(傷寒辨證) The individual diagnosis pattern was arranged by the diagnostic requirements in the following order : another name(異名), notion of diagnosis pattern, index of differentiation of symptoms and signs(辨證指標), the main point of diagnosis, analysis of diagnosis pattern(證候分析), discrimination of diagnosis pattern(證候鑑別), a way of curing a diseases(治法), prescription(處方), herb in common use(常用藥物), diseases appearing the diagnosis pattern(常見疾病), documents(文獻調査). This study was carried out on the basis of the Chinese documents and references.

비만증 환자에서 한약제에 의한 체중 감소효과

Oh, Seung-Joon,Jeong, In-Kyung,Kim, Young-Seol,Choi, Young-Kil,Paeng, Jeong-Ryung,Bae, Jung-Hwan,Shin, Hyun-Dae 경희대학교 동서의학연구소 1999 INTERNATIONAL SYMPOSIUM ON EAST-WEST MEDICINE Vol.1999 No.1

Seung-Joon Oh, In-Kyung Jeong, Young-Seol Kim, Young-Kil Choi, Jeong-Ryung Paeng¹, Jung-Hwan Bae and Hyun-Dae Shin²Department of internal Medicine, College Medicine, Endocrine Research Institute¹. Department of Rehabilitation, College of Oriental Medicine², Seoul, korea. Bady Fat Reduction Effects of Red Ginseng Compound Preparation on the Patients with Obesity. Proceedings of International Symposium on East-West Medicine, Seoul. 244-254, 1999.-Obesity can be defined as a metabolic disease due to an increased state of fat tissues caused by an imbalance of calorie intake and use. Recently, in Korea by improvement and westernization of food intake, along with decrease in exercise activities, the prevalence of obesity has increased greatly. Our objectives were to study stability and effects of decrease in body fat by administering red ginseng compound preparation (known to have body fat decreasing effects in laboratory animals) to obesity patients on low calorie diets. Changes in weight and body fat were measured while carrying out calorie-restricted diets on patients for 4 weeks, then administering red ginseng compound preparation for another 4 weeks. The patients were 20 people whose BMI were 25kg/㎡ or over and whose percent body fat was also 30% or over when tested by bioelectrical conductivity. 1. Changes in weight were from 70.04kg(base line) to 67.43kg(after taking red ginseng compound preparation). 2. In similar sense, BMI decreased from 27.12kg/㎡(base line) to 26.56kg/㎡(after dieting), and further to 26.01kg/㎡ (after taking red ginseng compound preparation). The BMI seemed to decrease significantly compared to the baseline after the use of red ginseng compound. 3. Waist hip ratio was changed from 0.8858(base line) to 0.8728, but it was statistically insignificant. 4. The percent body fat was 35,16%(base line), 33.87%(after dieting), and 31.68%(after taking red ginseng compound preparation). 5. Complete blood cell count and blood chemisrty remained unaffected by the administration. 6. In concern to endocrinologic studies, T3 decreased from 118.7 to 98.2ng/dL, and T4 increased from 8.8 to 9.2㎕/ dL. Epinephrine showed a tendency to decreased from 0.27 to 0.25 ng/mL, and norepinephrine increased from 0.39 to 0.44ng/mL. 7. Leptin was not changed. 8. Some patients complained adverse effects; constipation(5 patients, may be due to diet therapy), fatigue (2 patients), pruritus(2 patients), flushing(s patients), dizziness(3 patients) and epigastric discomfort(2 patients). However their symptoms were mild, so medication did not stopped. In conclusion, loss of weight without significant side effects was observed during low calorie diet and red ginseng compound preparation administration. This is thought to be in relation to sympathetic nerve system rather than adrenal gland. Also, further long0term studies should be required, since the observed results were based on short-term changes in weight.

전국 10개 종합병원 중환자실 환자의 직장내 Vancomycin-resistant Enterococci(VRE) 보균율, 보균의 위험요인 및 유전적 다양성 조사

정희진,송준영,엄중식,김우주,최선주,최정현,이혁,정문현,이광미,신동현,손보라,최종성,우흥정,권정아,이경원,최강원,박승철 대한감염학회 2002 감염 Vol.34 No.5

디이젤기관의 연소특성에 관한 연구(Ⅰ)

최두석,김창현,조규상,류정인 忠南大學校 産業技術硏究所 1987 산업기술연구논문집 Vol.2 No.1

A Computer program for the precombustion chamber type 4 cycle C.I.engine using two-zone model and quasi-steady model has been developed. Comparing with experimental results, the calculated results have about 10% of deviation. Through the numerical analysis, the direction of optimum engine design condition can be obtained as follows; 1) From the numerical solution, the optimal driving points of experimental engine are as follows. Engine speed is 2500 - 3000rpm and the injection timing is 15-20。BTDC, When the economy of fuel is considered, and when the engine is driven under 2100 rpm and fuel is injectioned at 25。BTDC, the maximum output can be obtained. 2) The maximum cylinder pressure increase about 3% at every 400 rpm, and increase about 20% whenever the injection time is advanced at 5 degrees. 3) The volumetric efficiency decrease about 9% at every 400rpm.

원형 플레이트 형태에 따른 초음파 부상 장치의 진동특성에 관한 연구

정상화,최석봉,차경래,김현욱,김광호,박준호 한국공작기계학회 2005 한국공작기계학회 춘계학술대회논문집 Vol.2005 No.-

In the semiconductor and optical industry the non-contact transportation is required for reducing the damages. The ultrasonic levitation is the solution of the problem. In this paper, the ultrasonic levitation system and 3 disk-type stator for levitation various object are proposed. The vibration modes of disks are analyzed with FEM and designed with the analysis results. The 3D vibration profiles of the disks are measured by Laser scanning vibrometer for verifying the vibration characteristics of the system. The amplitudes of the disks and the levitation heights of object are measured for evaluating the performance.

정신분열병 환자의 반응시간

최형식,정범석,김한규,송현주,이재원,김창윤 大韓神經精神醫學會 2000 신경정신의학 Vol.39 No.5

연구배경: 주의력은 인지적인 정보처리과정(information processing)의 가장 기본적인 단계이다. 반응시간 (reaction time)은 주의력을 가장 잘 반영하는 검사 중 하나로서, 자극이 제시된 후 반응이 시작되기까지 반응 여부를 결정하는데 걸리는 시간인 판단 시간(decision time)과 반응이 시작되면서 목표에 도달할 때까지 시간인 운동시간(motor time)으로 나누어 볼 수 있다. 기존의 연구결과로는, 정신분열병 환자군에서 반응시간의 수행이 떨어져 있다는 보고는 많이 되어왔으나 차이가 없다는 보고도 있으며, 판단시간과 운동시간 중 어느 부분에 장애가 있는지 명확하지 않다. 또한 반응시간 측정값은 질병의 진단적 유형(diagnostic subtype), 증상, 경과 등의 영향을 받으며 개체간의 변동(inter-individual variation)이 크고, 같은 피험자라도 측정시점이 다를 때마다 차이를 보이는 개체내 변동(intra-individual variation)이 커서 검사결과마다 차이를 보이고 있는 상태이다. 목적: 환자군은 개체간 변동이 크고 다른 임상적 요소에 의해 영향받는 점을 고려하여, 임상적으로 안정적인 경과에 있는 정신분열병 환자만을 대상으로 정상인 군과 반응시간의 차이를 비교하고자 하였다. 또한 반응시간을 판단시간과 운동시간으로 나누어 측정하여 각각을 비교분석 하고자 하였고, 개체내 변동이 큰점을 고려하여 25회 반복 측정을 실시하고 이에 따른 변동의 경향성을 조사하고자 하였다. 방법: DSM-Ⅳ에 의해 '정신분열병'으로 진단된 환자로서, 급성기 이후 항정신병약물을 유지하고 있으며BPRS(brief psychiatric rating scale) 30점 이하의 임상적으로 안정적인 상태가 3개월 이상 유지된10명이 환자군으로 포함되었고, 정상인은 자원자 10명이 포함되었다. 검사도구는 비엔나 테스트 시스템 반응유닛(Reation Unit) 파라미터 S8을 이용하였다. 총 6가지의 자극이 무작위로 1측정시기(session) 당 총 32회 주어지고, 피험자는 이중 특정 자극에 8번만 반응하도록 되어 있다. 시작 전 1회 연습 후 총 25측정시기를 5분 간격으로 반복하였다. 반응 시간을 판단시간과 운동시간의 합으로 정의하고 세 가지 모두 컴퓨터를 이용하여 자동 측정되었다. 반응·판단·운동 시간의 비교에는 반복 측정을 고려한 분산분석(repeated measures analysis of variance)을 사용하였다. 결과: 환자군은 정상인에 비하여 유의하게 반응시간의 수행속도가 저하되어 있었다(p<0.01). 판단시간과 운동시간으로 나누어 볼 때, 환자군에서 판단시간이 유의하게 느렸고(p<0.01), 운동시간은 수행저하의 경향을 보였으나 통계적으로 유의하지는 않았다. 25회 반복측정시 양군 모두 측정시기에 따른 유의한 변화를 보였고(p<0.01), 환자군의 반응시간은 개체간의 차이뿐 아니라 개체내 변동이 큰 경향을 보였다. 옳게 반응한 횟수(correct response)는 환자군에서 저하되는 경향을 보였으나 통계적으로 유의하지는 않았다. 고찰: 정신분열병 환자군에서 판단시간이 유의하게 저하된 것은, 반응시간의 저하가 운동요소 보다는 인지적 요소에 의한 것임을 시사하는 것으로, 정보처리과정의 기본적인 단계인 주의력 장애를 보여주는 것으로 생각된다. 비교적 안정적이고 임상적인 특성이 동일한 환자군에서도 반응시간이 대조군에 비해 큰 개체간 차이와 개체내 변동성의 경향을 보였으며, 이는 단순한 측정오차라기 보다는 정신분열병 환자군의 인지기능의 특성을 반영하는 것으로 생각된다. 중심단어:정신분열병·반응시간·판단시간·운동시간·개체간 변동·개체내 변동. The reaction time(RT) has been known to reflect attention that controls the flow of information processing. Extensive research has demonstrated cognitive impairment in schizophr-enia subjects using RT taske. However, little work has been done examining the relative contribution of DT(decision time) and MT(motor time) to slowed RT in schizophrenics. Also, recent investigators have observed that schizophrenic patients exhibit larger intra-individual variability in RT than do normal comparison subjects. The purpose of this study, using multi-stimulus convergent RT task, was to explore the speed of RT, relative contribution of decision time(DT) and motor time(MT) to slowed RT, overall sequential profile in 25 repeated-time measurements in 10 schizophrenic out-patients and 10 normal control subjects. Overall reaction time and decision time were slower in schizophrenic subjects than in normal controls. The motor time was not shown to be significantly different between the two groups with 0.05 significance level, although there was some trend indicating schizophrenic subjects were slower consistently in repreated measurements over time. These results suggested that the slower reaction time in schizophrenic subjects was mostly determined by cognitive component, decision time rather than motor time. Sequential profile of repeated measurements showed greater intraindividual and interindividual variations in schizphrenics than in normal controls. These results indicate that high variabilities are not merely measurement errors but characteristic of schizophrenic psychopathology. KEY WORDS: Schizophrenia·Reaction time·Decision time·Motor time·Inter-individual variation·Intra-individual variation.

Bochner 방법을 응용한 Shigella의 약제내성 제거

최정현,이제철,설성용 慶北大學校 醫科大學 1991 慶北醫大誌 Vol.32 No.1

To study the optimal curing condition on selective medium described by Bochner et al. and modified medium, six strains of S. flexneri and 2 strains of S. sonnei were tested for minimum inhibitory concentration(MIC) of quinaldic acid and cured resistance pattern. Also, changing patterns of elimination according to incubation temperature were investigated at 37℃ and 42℃. MICs of Shigella on original Bochner medium and modified medium were 50 5o 400㎍/㎖. But MICs of Shigella were above of 400㎍/㎖ on the Bochner's medium excluding tetracycline and sodium phosphate. There were no differences in MIC between at 37℃ and 42℃. On the Bochner's medium, losses of drug resistance were more effective than other medium and cured resistance pattern was partial or total of original resistance, regardless of incubation temperature. Frequencies of curing were low on modified Bochner's medium, but most of cured resistance pattern were total resistance of Shigella. Frequencies of curing at 42℃ were similar to 37℃, but some strains showed resistance loss only at 42℃. MICs of 8 strains of Shigella were above of 400㎍/㎖ and no strains detected resistance loss on the both tryptic soy agar and tryptic soy broth.

뇌동맥류 파열 환자에서 증후성 뇌혈관연축의 발생 및 회복에 영향을 미치는 인자들

최석민,석종식,권정택,민병국,황성남,김영백,홍현종 대한신경외과학회 1996 Journal of Korean neurosurgical society Vol.25 No.10

To determine the factors affecting development and recovery of symptomatic vasospasm. the author analysed the results of patients with ruptured intracranial aneurysms treated by nimodipine and prophylactic “triple0H” therapy. From January 1991 to December 1995. 199 patients underwent surgery for ruptured intracerebral aneurysms. Combined hypervolemic hemodilution was initiated at the time of admission. Induced hypertension was added immediately after surgery(aneurysmal neck clipping). All patients received nimodipine intravenously or orally until the 14th day of SAH Sixty patients underwent surgery on Day 0 through 2 after attacks of subarachnoid hemorrhage(Goup A) 105 patients on Day 3 through 14(Group B). and 35 patients after Day 14(Group C). Of 199 patients. 76(38%) patients suffered from symtomatic vasospasm. Symptomatic vasospasm occured in 34% of Group A patients. 33% of Group B patients. and 5% of Group C patients. Symtomatic vasospasm occured more frequently in the older age group. the Fisher group 3 and Hunt & Hess grades 3, 4 and 5 groups. Of 76 patients who suffered from symptomatic vasospasm. 47(62%) patients recovered completely. The author analysed the relationship between recovery rate and sex, age. Hunt & Hess agrde and Fisher group among these 76 patients. Recovery rates between these groups were not significantly different. Based on this experience the author believes that Hunt-Hess grade. Fisher group and age are important factors affecting symptomatic vasospasm development.

초정밀 광소자 정렬 스테이지의 구동 특성에 관한 연구

정상화,차경래,김현욱,최석봉,김광호,박준호 한국공작기계학회 2005 한국공작기계학회 춘계학술대회논문집 Vol.2005 No.-

As the optical communication is introduced to the backbone network at first and becomes a general communication method of network, the demand of kernel parts of optical communication such as PLC(Planar Light Circuit), Coupler, and WDM(Wavelength Division Multiplexing) element increases. The alignment and the attachment technology are very important in the fabrication of optical elements. In this paper, the driving mechanism of ultra precision stage is studied with the aim of optimal design of stage. The travel and the resolution of stage are investigated. The hysteresis of the stage is generated because of PZT actuator. The hysteresis and the inverse hysteresis are modeled in X, Y, and Z-axis motion. The input data of desired displacement to the stage according to input voltage is obtained from the inverse hysteresis equation. In the result of experiments with the input data, the errors due to hysteresis are well compensated.

인슐린종에 의한 측두엽 간질 발작 1례

최현경,김정기 대한신경정신의학회 2000 신경정신의학 Vol.39 No.2

저자들은 50대 여성에서 인슐린종에 의해 발생한 간질 발작에서 인슐린종의 제거 이후, 저혈당이 교정된 상태에서도 지속적인 이상 뇌파를 보인 예를 경험하였다. 환자는 간질 발작 이외에 저혈당의 일반적인 증상인 두통, 진전, 발한, 창백, 심계 항진 등을 거의 보이지 않아 오랫동안 측두엽 간질로 진단되어 항전간제를 사용하였다. 뇌파에서 좌측 측두엽에 이상을 보였고 인슐린종을 성공적으로 제거하고 저혈당이 교정되어 간질이 소실되었는데도 뇌파의 이상 소견이 지속되었다. 본 증례에서 혈당의 농도가 낮은데도 불구하고 환자가 전혀 저혈당의 증상을 느끼지 못하였다. 낮은 혈당에서도 glycosy Hb A1c의 농도가 정상에 가까워 뇌의 glucose uptake 가 유지되고 sympathoadrenal activation 과 counteregu-latory hormones으 반응이 감쇠되는 경우가 있다고 한다. 본 증례에서도 glycosy Hb A1c가 4.0%로 정상에 가까웠다. 저혈당에 의한 간질의 기전에 대하여서 간질의 역치를 감소시킨다는 설과 국소적인 뇌의 산소 소모를 감소시킨다는 설이 있어왔다. 최근에는 국소적인 뇌손상이 간질 유발의 원인이라는 설이 우세한데 excitotoxic mechanism으로 설명되고 있다. 증례에서 뇌파의 이상소견이 지속되었던 것은 국소적인 뇌 손상의 기전과 일치하는 결과로 생각되며 지속적인 뇌파의 추적 관찰이 필요할 것으로 여겨진다. Authors experienced a case of insulinoma which was initially misdiagnosed as idopathic tem-poral lobe epilepsy with automatism. This patients did not show other hypoglycemic symptoms except seizure. It has been reported that some of the patients with insulinoma are unaware of hypoglycemia and are at increased risk for seizures and coma. These patients would have normal glucose uptake in the brain and consequently no sympathoadrenal activation would begin, resulting in an awareness of hypoglycemia. It this case, abnomal EEG pattern consistent with a complex partial seizure remained after successful operation. Recent reports indicate that hypoglycemia is capable of killing neurons in the brain . An endogenous neurtoxin is produced and is released by the brain into tissue and cerebrospinal fluid. Endogenous excitotoxins produced during hypoglycemia may explain the tendency toward seizure activity often seen clinically. We suggest that persistent abnormalities of EEG in this case may be related to focal neuronal damage in hypoglycemia.