뇌 자기공명영상상 뇌량 병변의 호전을 보인 Marchiafava-Bignami병 1예

정재훈,성기범,안무영,신현길,박형국 대한신경과학회 1999 대한신경과학회지 Vol.17 No.5

CAPD환자에서 복강내 도관 말단부의 위치에 따른 도관전위율 및 도관유지율의 비교

정용희,이태원,김희진,임천규,김명재 대한신장학회 2001 대한신장학회잡지 Vol.20 No.3

濕式法에 依한 輝安鑛으로부터 三酸化 안티모니의 製造에 關하여

오재현,김준수,고인용,정원용 연세대학교 산업기술연구소 1979 논문집 Vol.11 No.1

An investigation on the production of high purity Sb₂O₃was carried out by means of the acid leaching process from the roasted ore of stibnite. The approach of these studies has been to investigate purity, particle size, recovery and crystal structure of Sb₂O₃obtained through the subsequent treatments of leaching, hydrolysis and neutralization under various conditions. The results obtained in these experiments are summarized as follows; 1) It was possible to use dilute hydrochloric acid to extract Sb₂O₃from the roasted stibnite. Because of the prior roasting treatment, the contamination of impurities could also be reduced in the final products. 2) The rate of extraction of Sb₂O₃from the roasted stibnite was increased concentration of hydro-chloric acid as increased amount of addition of the acid. 3) The yield of Sb₂O₃obtained by hydrolysis of SbCl₃was increased with increasing temperature of hydrolysis. 4) The crystal structure of Sb₂O₃obtained by hydrolysis of SbCl₃at 20℃(room temperature) was confirmed as a orthorhombic crystal structure which is the same as that of valentinite. The recovery of Sb₂O₃from the roasted ore appeared to be nearly 100% under optimum conditions.

지방과 도시인의 交通手段 利用實態 및 態度 比較硏究

고재홍,안미영,홍기원,차재호,구정숙 서울大學校 社會科學大學 心理科學硏究所 1993 心理科學 Vol.2 No.-

지방과 도시인의 도로교통 이용실태 및 태도 조사 결과를 보고하였다. 지방을 대표하는 지역으로 경상남도 거창읍을, 그리고 도시는 서울특별시 강남구 대치동을 선정하였고, 각 지역에서 800명(400 부부쌍)의 무선표본을 대상으로 질문지로 조사하였다. 조사내용을 출퇴근 길의 교통수단이용, 외출시의 교통수단이용, 자가용의 이용및 소유실태, 운전면허 소지 및 취득실태, 교통사고경험, 대중교통수단에 대한 평가 및 관련 태도 등이었다. 조사결과, 도시와 지방간의 현재의 교통수단 이용에서의 차이를 파악할 수 있었을 뿐 아니라, 후속연구에서 교통수단이용의 변화를 평가할 수 있는 기저선이 마련되었다. Two representative samples of married couples. one(n=400 couples) from Dae-Chi Dong in Seoul and another(n=400 couples) from the town of Ku-Ch'ang in South Kyung-sang Province were studied through a questionnaire. The questionnaire dealt with (1)transportation uses in commuting to work (2)transportation uses on weekends. (3)types of automobiles owned and the uses to which they are put. (4)statistics related to obtaining and possessing driver licenses. (5)experience of traffic accidents, and (6)attitudes regarding the public trasportations and policies. The study as designed to provide a baseline for future studies on the transportation statistics as well as gauging the urban-rural difference in automobile culture.

비임균성의 요도염에서 Azithromycin과 Doxycycline의 치료효과 비교

김정수,김재홍,노영석 한양대학교 의과대학 1999 한양의대 학술지 Vol.19 No.2

Currently, there is no single-dose therapy that is effective in the treatment of nongonococcal urethritis. Azithromycin is a new azalide antibiotic and has activity in vitro against Chlamydia trachomatis, and its novel pharmacokinetics suggest that single dose may be effective in the treatment of non-gonococcal urethritis. The aim of this study is to find out the efficacy and safty of Azithromycin in the treatment of males with uncomplicated non-gonoccocal urethritis. 32 patients were given a single 100mg oral dose of Azithromycin and 30 patients were treated with doxycyclin 100mg bid for 7 days. Follow-ups after one and two weeks to examine for cure and adverse events were made. The result showed that 27 out of 32 patients treated with Azithromycin were cleared of urethritis and 24 out of 30 patients treated with doxycycline were cleared of urethritis. Single dose azithromycin shows a similar effectiveness as a 7-day regimen of doxycycline and the patient's compliance has also improved.

Methotrexate 치료를 받고 있는 활동성 류마티스 관절염 환자에서 etanercept의 유효성과 안전성에 관한 연구

최병렬,강태영,정청일,이혜순,엄완식,김태환,전재범,유대현,배상철 대한내과학회 2004 대한내과학회지 Vol.66 No.5

목적 : 류마티스 관절염을 앓고 있는 한국인 중에 기존 DMARDs로 치료 실패하였고, 고정용량의 MTX를 복용하고 있는 환자들에 있어서 etanercept의 유효성과 안전성을 평가하고자 하였다. 방법 : 기존 DMARDs로 치료 실패한 활동성 류마티스 관절염 환자 76명을 대상으로 하여 단일군, 공개시험을 하였다. 대상 환자들은 고정용량의 MTX를 복용하면서 etanercept 25 mg을 1주일에 두 번 피하 주사하였으며 12주간 투여하였다. 유효성은 ACR 20, ACR 50,조조강직 시간으로 평가하였고, 약제의 안전성은 이상반응 등으로 평가하였다. 결과 : 대상 환자는 총 76명으로 평균 연령은 45.2세, 남자 5명, 여자 71명이었다. 84.4%인 54명이 12주째에 ACR 20을 만족하였고, 53.1%인 34명이 12주째에 ACR 50을 만족하였다. 조조 강직 시간은 치료 전 203.3분에서 치료 12주째 42.6분을 평균 74.5% 호전되었다. 가장 흔한 이상반응은 주사부위 반응이었다. 이외에도 상기도 감염, 오심, 안면부종 등이 발생하였으나 심각한 부작용은 없었다. 결론 : etanercept는 효과적이고, 안전한 류마티스 관절염 치료 방법이며 특히 MTX치료에도 불구하고 활동성인 류마티스 관절염에 기대되는 치료라고 할 수 있다. Background : This study was performed to investigate the efficacy and safety of etanercept in active rheumatoid arthritis patients with stable dose of methotrexate in Korean. Methods : In a 12 week, single arm, open trial, we assigned 76 patients with active rheumatoid arthritis who had an inadequate response to disease-modifying antirheumatic drugs. Patients received twice-weekly subcutaneous injections of etanercept 25 ㎎ while containing to receive methotrexate at a stable dose of 7.5~25 ㎎ per week. The clinical response was defined as the percent improvement in disease activity according to the criteria of the American Collage of Rheumatology (ACR) at 12 weeks. Results : Etanrecept led to significant improvements in disease activity and was safe and well tolerated. At 12 week, 84.4% of the patients receiving 25 ㎎ of etanercept achieved a 20% ACR response, and 53.1% of those receiving etanercept achieved a 50% ACR response. The most common adverse event was injection-site reaction. Other advanse events were upper respiratory infection, nausea, and facial edema, but there were no serious adverse events associated with etanercept. Conclusion : In active rheumatoid arthritis patients, etanercept was safe, well tolerated, and provided rapid clinical improvements.

강재 슬릿형 댐퍼를 부착한 철근콘크리트조 골조의 거동

신종익,이정한,송한범,강대언,오상훈,차승렬,이용재,김상대,이원호 대한건축학회 2004 대한건축학회 학술발표대회 논문집 - 계획계/구조계 Vol.24 No.1(구조계)

This study investigates the performance of the reinforced concrete frame with the steel plate slit damper. The test was carried out to investigate the structural behavior between the reinforced concrete bare frame and the reinforced concrete frame with the steel plate slit damper. The test results showed that the energy absorption capacity of the damped-frame was several times larger than that of the bare frame. For the damage by the input energy is concentrated on the steel plate slit damper, the ductilities of the former structure were increased and the damaged frame can be reused after exchange the steel plate slit damper.

食用油脂類에 對한 免疫生物學的 硏究

朴炳哲,文宰奎,朴榮吉,金杏順,安年衡,金度勳,金正勳,安榮根,李相根,鮮于演 圓光大學校 1990 論文集 Vol.24 No.2

食用油脂는 健康維持에 必須的인 營養素이다. 그러나 食用油脂는 脂肪을 構成하는 脂肪酸의 種類와 攝取하는 量에 따라 健康을 保衛하는 必須的인 食品의 成分이 되기도 하고 有害한 影響을 끼칠 수도 있어서 脂質代謝와 關連된 疾病 뿐만아니라 老化를 促進하고, 乳房癌, 大腸癌等의 癌發生과도 關連된 것으로 밝혀져 있다. 本 硏究는 우리生活環境에서 食用으로 接할 수 있는 10種의 油脂에 對한 免疫生物學的인 活性에서 究明한 結果 對照群인 참기름食餌群에 比해 올리브유食用群은 全般的으로 體液性 및 細胞性免疫을 有意性있게 增加시켰으나, 大食細胞의 活性과 末梢循環白血球數는 有意性없는 減少를 보였고, 動物性 油脂인 牛脂食餌群과 植物性 油脂인 옥수수기름食餌群, 들기름食餌群, 米糠油食餌群, 大豆油食餌群, 菜種油食餌群 및 고추씨기름食餌群에서는 全般的으로 體液性 및 細胞性免疫, 大食細胞의 活性 및 末梢循環白血球數를 有意性있게 減少시켰다. This study was performed to investigate the effects of edible oils and fats on the immunobiological responses in ICR male mice. Ten groups of experimental diets, such as sesame oil diet, beef tallow diet, lard oil diet, olive oil diet, corn oil diet, perilla oil diet, rice polishing oil diet, soybeen oil diet, rape seed oil diet, and red pepper seed oil diet were fed adlibitum to the ICR male mice for 27 days. The results of this study were summarized as followings. 1. Both humoral and cellular immune responses, phagocyte activity, and number of leukocytes in sesame oil group were increased. However, the increasing rate of body weight and the weight retios of spleen and thymus to body were generally decreased. 2. Hemagglutination titer(HA) and rosette forming cell(RFC) of the beef tallow group and the lard group were significantly lower than the sesame oil group(P<0.01), but the lard group significantly increased Arthus reaction and delayed type hypersensitivity(DTH)(P<0.01). 3. Arthus reaction, DTH, and RFC of the olive oil group were significantly higher than the sesame oil group(P<0.01). 4. DTH of the corn oil group was significantly higher than the sesame oil group(P<0.01) whereas phagochyte activity was significantly lower(P<0.01). But no statistically significant differences were found between the two groups in the humoral immune response. 5. HA, PFC, DTH, RFC, phagocyte activity, and number of leukocytes of the perilla oil group and the rice polishing oil group were significantly lower than the sesame oil group(P<0.01). 6. Both humoral and cellular immune responses, phagocyte activity, and number of leukocytes of the soybeen oil group, the rape seed oil group, and the red pepper oil group were significantly lower than the sesame oil group(P<0.01).

운동 중 지방 대사에 대한 고찰

이근일,백병주,김의영,김도준,조용철,정훈,조재혁 龍仁大學校 體育科學硏究所 2002 體育科學硏究論叢 Vol.12 No.1

Glucose-fatty acid cycle is very important because it explains that fatty acid influences glucose level. Glucose-fatty acid cycle is the key factor to understand how endurance training which aids fat oxidation and carbohydrate stored in skeletal muscle influence mitochondria level. However, it is not certain whether glucose-fatty acid cycle influences exercising skeletal muscle of human being. As an energy resource, training increases use of fatty acid, endurance ability, and oxidation of triglyceride. During high level training, catecholamine secretions and restraint of fatty acid use caused by insulin increases dramatically, this results in reduction of free fat acids and reunification of free fat acids into triglyceride. Training restrains insulin activity and reduces plasma acid density, however, elite athletes have high triglyceride-fatty acid cycle. Although enzyme's activities and mitochondira's density increase after training, it's not certain that enzyme's activities is major factor in restraint of fatty acid oxidation in exercising muscle cells. Stores of fat leads to increases of fat oxidation, performance and reduces use of carbohydrate, however, there is no absolute evidence to support these results.

분리 핵을 이용한 Trichoderma koningii의 형질전환

민경렴,박희문,하영칠,정재훈 충남대학교부설 생명공학연구소 1991 생물공학연구지 Vol.1 No.-

Trichoderma koningii의 영양요구성 돌연변이주인 CUT 121로부터 얻은 원형질체를 야생형인 ATCC 26113의 핵과 혼합하여 PEG 용액을 처리한 결과, 독립영양형의 형질전화체가 30% 이상의 빈도로 생성되었다. 이 독립영양형 군체로부터 얻은 분리체 중의 하나는 xylanase의 활성이 야생형보다 3배 가량 증진되었으며, 다른 세포외 다당류 분해효소능도 야생형과 유사한 수준을 나타내었다. 분리체의 DNA 함량, 인위적인 분리양상 및 동위효소 양상 등을 조사 분석한 결과, 독립영양형의 형질전환체는 실험에 사용된 두 핵간의 유전물질교환에 의하여 생성된 형질전환체로 판명되었다. 이상의 결과로부터 Trichoderma속 균류의 균주개량법으로, 핵전이법이 통상의 원형질체 융합법보다 효율적인 것으로 판명되었다. When protoplasts from auxotrophic mutant of Trichoderma koningii CUT121(Lys^-, Met^-) were mixed with isolated nuclei of wild type T. koningii ATCC 26113 and treated with PEG solution, protrophic colonies were produced with frequency of more than 30 percent. One of segregants from prototrophic colonies showed increased xylanase activity and other polysaccharide-hydrolyzing activities comparable to those of wild type strain. Through measurement of DNA contents, induced segregation, and analysis of isozyme patterns, it was revealed that the prototrophic colonies were transformants resulted from exchange of genetic materials between the two kinds of nuclei used. These results suggest that nuclei transfer technique is more efficient than conventional protoplast fusion technique for strain improvement of Trichoderma species.