2003년 국내 중증급성호흡기증후군 진료 현황 및 문제점 분석

이진수,김은실,정문현,백제중,정선화,안주희,최영화,이선희,고철우,김성범,김민자,박승철,기현균,송재훈,최상호,김양수,이상오,조용균,박영훈,정숙인,김연숙,이흥범,손창희,장성희,정희진,김우주 대한감염학회 2004 감염과 화학요법 Vol.36 No.3

목적 : 2002년 말 중국에서 SARS가 발생한 이후 국내에서도 2003년 10월까지 총 3명의 추정환자, 17명의 의심환자가 보고되었다. 향후 추가적인 SARS의 유행이 우려되는 상황에서, 그간의 SARS 환자 진료에 있어서의 실질적인 준비사항, 진료 현황 등에 대한 조사를 통해 문제점을 파악하여, 향후 더 나은 대비가 될 수 있도록 개선점을 제시하고자 하였다. 재료 및 방법 : SARS로 의심되는 환자를 진료 경험이 있는 병원의료진을 대상으로 2003년 10월에 설문조사를 실시하였다. 설문에는 SARS 환자 진료 시의 실질적인 조치, 진료 현황, 병실, 응급실 및 외래에서의 격리 시설과 준비사항, 보건당국의 관리와 지원에 관한 사항을 포함하였다. 결과 : 대상이 되는 22개 병원 중 17개(17/22, 77.2%) 병원이 설문에 응하였다. SARS 환자를 위한 격리실은 응급실, 외래, 일반병실 및 중환자실에서 각각 9개(9/17, 52.9%), 5개(5/17, 29.4%), 15개(15/16, 93.7%), 4개(4/16, 25%) 병원에서 음압처리가 되어있지 않은 일인실 혹은 다인실이 사용되었고, 1개(1/16, 6.3%) 병원에서만 일반병실에서 음압격리실이 운영되었다. 입원환자의 진찰 시 개인보호구의 착용은 거의 모든 의료기관에서 이루어졌다. 보건당국에서 SARS지정병원의 시설 등을 사전에 확인한 곳은 1곳(1/12, 8.3%)이였고, 14개 병원(14/15, 93.3%)에서는 보건당국에 의뢰한 검사결과를 통하 받지 못하였다. 결론 : 의료기관에서 SARS 환자용 격리실뿐만 아니라 기존의 격리실 설비 등이 미흡하였으며, 특히 중환자실 및 외래의 준비가 더욱 부족하였다. 보건당국의 의료기관에 대한 종합적인 지원이 부족하였고, 병원과의 원활한 연계가 잘 이루어지지 않았다. SARS 만이 아닌 격리를 필요로 하는 질환의 적절한 진료를 위해 향후 병원 시설의 정비와 정부차원에서의 보다 구체적이고 실질적인 대책마련이 필요하다. Background : There was an worldwide outbreak of the Severe Acute Respiratory Syndrome (SARS) originated from China in late 2002. During that period three cases of suspected SARS and 17 cases of probable SARS were reported in Korea. With the concerns about the reemergence of SARS-coV transmission, it is important to be prepared for any possibility. So, this study is aimed to analysis the past measures in managing SARS and propose the amendatory plans to improve the preparedness. Materials & Methods : Questionnaires were collected among clinicians with any experience in managing the probable or suspected SARS cases in Oct. 2003. 17 out of 22 hospitals responded to the questionnaire. The contents in the questionnaire were practical activities, personal equipments, response plans, isolation facilities in emergency centers, outpatient clinics, general wards and intensive care units, and relationship with the public health department. Results : The dedicated isolation rooms in emergency centers, outpatient clinics, general wards, and intensive care units were prepared in 9 (9/17, 52.9%), 5 (5/17, 29.4%), 15 (15/16, 93.7%), and 4 (4/16, 25.0%) hospitals, respectively. Except for one hospital that newly made negative pressure room for SARS, single or multi-bed rooms without airborne infection control were used in all the other hospitals. The personal precaution principles were kept quite well in general wards. Before the designation of SARS hospital by the public health department prior evalution to see if the hospital was suitable for managing SARS was conducted in only 1 (1/12, 8.3%) hospital. The results of laboratory diagnosis were reported back in 1 (1/15, 6.6%) hospital. Conclusions : The isolation facilities which can control airborne infection were almost deficient not only for SARS but also for other respiratory transmissible diseases. For the infection control of transmissible diseases including SARS, more investment is needed on medical facilities and comprehensive support from the public health department required.

생약추출물 유도형 Nitric Oxide Synthase 저해활성 검색

류재하,이소영,박재현,이화진,장세란,은진희,김남이,정연수,장미경,최영은,이숙현,손행자,안한나,고혜진 숙명여자대학교 약학연구소 2001 약학논문집-숙명여자대학교 Vol.17 No.-

Nitric Oxide (NO), derived from L-arginine, is produced by two types (constitutive and inducible) of nitric oxide synthase (NOS: cNOS and iNOS). The NO produced in large amounts by the iNOS is known to be responsible for the vasodilation and hypotension observed in septic shock and inflammation. The inhibitors of iNOS, thus, may be useful candidate for the treatment of inflammatory diseases accompanied by the overproduction of NO. We prepared alcoholic extracts of herbal drugs which have been used for the treatment of inflammation in oriental medicine. We have screened the inhibitory activity of NO production in lipopolysaccharide (LPS)-activated macrophages after the treatment of these extracts. Among the 81 kinds of extracts of herbal drugs, 34 extracts showed potent inhibitory activity of NO production above 50% at the concentration of 50 (μg/ml. The inhibitory activities of NO production were also evaluated for several solvent fractions at three different concentrations. Especially, hexane soluble fractions of Agrimonia pilosa, Hydrangea serrata, Machilus thunbergii, Prunella vulgaris, Saussurea lappa, Tussilago farfara, and ethyl acetate soluble fractions of Angelica gigas, Ostericum koreanum, Torilis japonica, Perilla frutescence showed moderate activity at 10 and/ or 25 (μg/ml. These fractions are promising candidates for the study of the activity-guided chromatographic purification of active compounds.

지진응답평가를 위한 비선형 약산법의 오차해석

박진화,강병두,노필성,김재웅 동아대학교 환경문제연구소 2003 硏究報告 Vol.25 No.2

Recently, a variety of methods are proposed to solve the problems shown in a existing performance-based design of structure. The most accurate one among analysis methods for the performance evaluation of structure is nonlinear time history analysis. However, the approximate analysis methods in aspect of practicality and simplicity are needed. Even though there are linear capacity spectrum method and nonlinear capacity spectrum method through nonlinear static analysis as the representative approximate methods, a repetitive calculation process is consumed and the result is also likely to be inaccurate. Therefore, this research presents nonlinear direct spectrum method which directly enables nonlinear maximum response to derive, after obtaining the yielding strength and the frequency of structure from pushover curves, without going through a series of calculation processes. Also, it is proposed to compare and examine the accuracy and practicality through an example structure.

공무원 교육훈련 및 전이에 관한 연구 : the Difference in the Cognition of the Male and Female Sex Civil Servants of Kyonggi provincial office

정재화,강여진,최호진 대진대학교 2001 大眞論叢 Vol.9 No.-

The Purpose of this study is to test of the hypothesis that is the difference in the cognition of the male and female sex civil servants on training and transfer of the civil servants. The contents of this study consists of the explanation on conception and purpose of the civil servants's training-transfer, the examination on pre-researches of several scholars, the build of several hypothesises, and the experimental outcomes result from the questions to the male and female sex civil servants of Kyonggi provincial office. In conclusion, We knows that is a clear difference in cognition of the male and female sex civil servants on training and transfer of the civil servants, finds that the female sex civil servants have more positive cognition than the male sex civil servants on training and transfer of the civil servants. Also, this study provide us with a point of current events that is important a use of the female sex civil servants to improvement or development of the public organization.

L1210 세포증식에 대한 Glycyrrhizin의 억제작용 기전

殷載淳,徐龍勳,權鎭,柳東和,吳贊鎬,蘇俊魯,全焄,黃甲洙 우석대학교 의약품개발연구소 1996 藥學硏究誌 Vol.1 No.-

The purpose of this research was to investigate the mechanism of inhibitory action of Glycyrrhizin(GZ) on the proliferation of mouse leukemia cell-line, L1210 cells. The cytotoxic activity was tested using a colorimetric tertrazolium assay(MTT assay), the apoptosis was tested using flow cytometry. Nitric oxide(NO) production form mouse peritoneal macrophage was tested using a Griess method and the phagocytosis of human polymorphonuclear cells was tested using a lucigenin chemiluminescence. GZ ingibited the proliferation of L1210, BALB/c 3T3 cells and mouse thymocytes at 50 ug/ml/ GZ did not affect nitric oxide production from mouse peritoneal macrophages in vitro, but ingibited nitric oxide production from lipopolysaccharide and y-interferon treated macrophages. Macrophages of GZ-administered mice accelerated NO production. The proliferation of L1210 cells apoptosis of L1210 cells were induced by co-culture with macrophage of GZ-administered mice. The apoptosis of L1210 cells were induced by co-culture with macrophage of GZ-administered mice. GZ increased the phagocytosis of human polymorphonuclear cells. These results suggest that GZ inhibit the proliferation of L1210 cells not only as a direct cytotoxic agent o tumor cells, but also by the enhancement of NO production and phagocytic activity.

해조류를 이용한 항생재 대체 사료 첨가제 개발

박진용,김진욱,이희현,이송애,김진욱,이재화 신라대학교 자연과학연구소 2005 自然科學論文集 Vol.14 No.-

우리나라의 항생제 남용 문제는 세계적으로 심각 하다고 한다. 이러한 문제를 해결하기 위해서 정부는 다양한 정책을 도입하고 있으며 특히 축산물의 항생제 남용 문제를 해결하기위해 사료 관리법을 강화하여 항생제 사용을 억제하고 있어 항생제를 대체 할 물질이 필요하다. 이런 문제를 해결하기 위해서 우리나라의 다양한 해조류를 이용한 항생제 개발을 통해서 항생제 남용 문제를 해결하고 소비자들에게 믿을 수 있는 축산물을 제공 할 것으로 보인다. Feed official law was strengthened recently. The antibiotic use is suppressed with feed official law reinforcement. The antibiotic transfer material is necessary. To use the seaweeds and transfer the antibiotic. It is a possibility of a high income. This is new bio industry. This the goods production which is competitive power is possible. It is a possibility of eating the livestock where also the consumers are good.

서울특별시의 재정력 실태 및 개선방안 : 지방재정조정제도의 개선을 중심으로 Reform of Grant-In-Aid System

정재화,강여진,최호진 대진대학교 2002 大眞論叢 Vol.10 No.-

The Purpose of this study seeks to present the financial capacity improvement plan of Seoul metropolitan government that focus on reform of grant-in-aid system. The contents of this study consists of the explanation on conception, style and purpose of grant-in-aid system, the examination on financial problem of Seoul metropolitan government due to several changing conditions, and the investigation on improvement plan to enhance the financial capacity of Seoul metropolitan government. In conclusion, We presents that should be to reform of grant-in-aid system by a important method to strengthen the financial capacity of Seoul metropolitan government. Also, that reform should be to carry in the direction of to enhance or reorganize benevolence's criteria and limits.

사군자탕이 L1210 세포를 이식한 마우스의 면역세포에 미치는 영향

殷載淳,金大根,柳東和,權鎭,徐龍勳,蘇俊魯,全焄,吳贊鎬 우석대학교 의약품개발연구소 1997 藥學硏究誌 Vol.2 No.-

The purpose of this research was to investigate effects of Sa-Kunja-Tang(SKT) on immune cells of L1210 cell-transplanted mice. The apoptosis and T lymphocytes subopoulation were tested using a flow cytometry, and the proliferation was tested using a MTT assay. Nitric oxide production from mouse peritoneal macrophage was tested using a Griess reagents, and the phagocytic activity of mouse peritoneal macrophage was tested using a lucigenin chemiluminescence. SKT suppressed apoptosis of T-lymphocytes induced by L1210 transplantation. SKT decreased nitric oxide production from mice peritoneal macrophages increased by L1210 transplantation, and the phagocytic activity decreased by L1210 transplantation. These results suggest that SKT suppresses T lymphocyte apoptosis and macrophage activity in L1210 transplanted mice.

봉출 추출물의 nitric oxide synthase 저해활성

이화진,김지선,류재하 숙명여자대학교 약학연구소 2005 약학논문집-숙명여자대학교 Vol.22 No.-

Nicotinamide Adenine Dinucleotide Phosphate (NADPH) has antioxidant effect in the body and thus decreases the symptoms of senility. The development of a transdermal delivery formulation for NADPH is a very difficult task, due to its rapid decomposition by oxidation, low partition coefficient into stratum corneum, high molecular weight and electrical charge at neutral pH in aqueous solution. The purpose of this work is to test several anti-oxidants as the stabilizing agent for NADPH in the aqueous formulation, and to study the effect of these agents on the in-vitro iontophoretic transport through hairless mouse skin. The stability of NADPH in aqueous solution with/without various antioxidants such as butylated hydroxy toluene (BHT), resveratrol, a-tocopherol and Vitamine C was studied. BHT an a-tocopherol (0.01 % w/w) exhibited minimal stabilizing effect, however resveratrol and vitamine C showed significant stabilizing effect. Stabilizing effect of vitamine C was proportional to the concentration in aqueous solution. Although vitamine C increased the stability ofNADPH significantly, it decreased flux of NADPH in a concentration dependent fashion, therapeutic amount ofNADPH can be delivered through skin using iontophoresis and These results suggest that, in order to develope a efficient iontophoresis formulation, it is important to choose a stabilizing agents which are not only potent in stabilizing effect but also not competitive for the delivery of NADPH.

박테리오신의 특징과 응용

박진용,주치언,김진욱,이상현,이재화 신라대학교 자연과학연구소 2006 自然科學論文集 Vol.15 No.-

Bacteriocins are antibacterial proteins produced by bacteria that kill or inhibit the growth of other bacteria. Many lactic acid bacteria produce a high diversity of different bacteriocins. Since food safety has become an increasingly important interantional concern, the application of antimicrobial peptides from lactic acid bacteria that target food pathogens without toxic or other adverse effects has received great attention. This article gives an overview of bacteriocin applications, and characteristics.