한국 정신장애의 역학 조사 연구[I] : 각 정신장애의 유병률

조맹제,함봉진,김장규,박강규,정은기,서동우,김선욱,조성진,이준영,홍진표,최용성,박종익,이동우,이기철,배재남,신정호,정인원,박종한,배안,이충경 大韓神經精神醫學會 2004 신경정신의학 Vol.43 No.4

Objectives : This study aims to estimate the prevalence of the DSM-IV psychiatric disorders in Korean population using the Korean version of Composite International Diagnostic Interview (K-CIDI). Methods : Subjects were selected by taking multi-stage, cluster samples of 7,867 adult household residents, 18 to 64 years of age, in ten catchment areas. Total 78 trained interviewers administered the K-CIDI to the selected respondents, from June 1 to November30,2001. Results : Total 6,275 respondents completed the interview. Some 33.5% of respondents reported at least one lifetime disorder, 20.6% reported at least one-year disorder, and 16.7% reported at least one-month disorder. The most common lifetime disorders were alcohol abuse/dependence (17.24%), nicotine dependence/withdrawal (11.19%), specific phobia (5.16%), and major de-pressive disorder (4.25%). The lifetime prevalence of substance abuse/dependence (0.25%) and schizophrenia (0.16%) was very low. Nicotine and alcohol use disorder showed very high male/female ratio. Mood disorder and anxiety disorder were more prevalent among female than male. Conclusion : The prevalence of psychiatric disorders was high. In comparison with other studies, remarkable differences in distributions of psychiatric disorders across the areas and times were observed.

3D Modeling of Lacus Mortis Pit Crater with Presumed Interior Tube Structure

Hong, Ik-Seon,Yi, Yu,Yu, Jaehyung,Haruyama, Junichi The Korean Space Science Society 2015 Journal of Astronomy and Space Sciences Vol.32 No.2

When humans explore the Moon, lunar caves will be an ideal base to provide a shelter from the hazards of radiation, meteorite impact, and extreme diurnal temperature differences. In order to ascertain the existence of caves on the Moon, it is best to visit the Moon in person. The Google Lunar X Prize(GLXP) competition started recently to attempt lunar exploration missions. Ones of those groups competing, plan to land on a pit of Lacus Mortis and determine the existence of a cave inside this pit. In this pit, there is a ramp from the entrance down to the inside of the pit, which enables a rover to approach the inner region of the pit. In this study, under the assumption of the existence of a cave in this pit, a 3D model was developed based on the optical image data. Since this model simulates the actual terrain, the rendering of the model agrees well with the image data. Furthermore, the 3D printing of this model will enable more rigorous investigations and also could be used to publicize lunar exploration missions with ease.

Spectral Deconvolution Analysis of Mafic Mineral in Irregular Mare Patches on the Moon

Hong, Ik-Seon,Yi, Yu,Park, Nuri The Korean Space Science Society 2022 Journal of astronomy and space sciences Vol.39 No.4

Irregular mare patches (IMPs), recently discovered on the Moon, are eruptions of magma on the lunar surface, and their origins are still in question. While prior studies on IMPs have mainly focused on optical image analysis, in this study, an analysis of the characteristics of minerals is performed exemplary for the first time. Modified Gaussian model (MGM) deconvolution was applied to the infrared spectrum to confirm the properties of the mafic mineral. Mafic minerals were analyzed for 6 olivine-rich (Ol-rich) IMPs out of 91 currently reported, and only 4 of them yielded results of significance. All four sites showed more abundance of Fe than Mg, and manifested a weak relationship with Mg-suite rock. However, a problem was discovered during the MGM application process due to pilot implementation. In order to solve this problem, it is required to adjust the MGM initial condition settings more precisely and to increase the signal to noise ratio of the observation data. Moreover, it is necessary to analyze the mineral properties for all IMPs considering minerals other than Ol and utilize them to deduce the origin of the IMPs.

3D Modeling of Lacus Mortis Pit Crater with Presumed Interior Tube Structure

Ik-Seon Hong,Yu Yi,Jaehyung Yu,Junichi Haruyama 한국우주과학회 2015 Journal of Astronomy and Space Sciences Vol.32 No.2

When humans explore the Moon, lunar caves will be an ideal base to provide a shelter from the hazards of radiation, meteorite impact, and extreme diurnal temperature differences. In order to ascertain the existence of caves on the Moon, it is best to visit the Moon in person. The Google Lunar X Prize(GLXP) competition started recently to attempt lunar exploration missions. Ones of those groups competing, plan to land on a pit of Lacus Mortis and determine the existence of a cave inside this pit. In this pit, there is a ramp from the entrance down to the inside of the pit, which enables a rover to approach the inner region of the pit. In this study, under the assumption of the existence of a cave in this pit, a 3D model was developed based on the optical image data. Since this model simulates the actual terrain, the rendering of the model agrees well with the image data. Furthermore, the 3D printing of this model will enable more rigorous investigations and also could be used to publicize lunar exploration missions with ease.

Lunar Pit Craters Presumed to be the Entrances of Lava Caves by Analogy to the Earth Lava Tube Pits

Hong, Ik-Seon,Yi, Yu,Kim, Eojin The Korean Space Science Society 2014 Journal of Astronomy and Space Sciences Vol.31 No.2

Lava caves could be useful as outposts for the human exploration of the Moon. Lava caves or lava tubes are formed when the external surface of the lava flows cools more quickly to make a hardened crust over subsurface lava flows. The lava flow eventually ceases and drains out of the tube, leaving an empty space. The frail part of the ceiling of lava tube could collapse to expose the entrance to the lava tubes which is called a pit crater. Several pit craters with the diameter of around 100 meters have been found by analyzing the data of SELENE and LRO lunar missions. It is hard to use these pit craters for outposts since these are too large in scale. In this study, small scale pit craters which are fit for outposts have been investigated using the NAC image data of LROC. Several topographic patterns which are believed to be lunar caves have been found and the similar pit craters of the Earth were compared and analyzed to identify caves. For this analysis, the image data of satellites and aerial photographs are collected and classified to construct a database. Several pit craters analogous to lunar pit craters were derived and a morphological pit crater model was generated using the 3D printer based on this database.

Lunar Pit Craters Presumed to be the Entrances of Lava Caves by Analogy to the Earth Lava Tube Pits

Ik-Seon Hong,Yu Yi,Eojin Kim 한국우주과학회 2014 Journal of Astronomy and Space Sciences Vol.31 No.2

Lava caves could be useful as outposts for the human exploration of the Moon. Lava caves or lava tubes are formed when the external surface of the lava flows cools more quickly to make a hardened crust over subsurface lava flows. The lava flow eventually ceases and drains out of the tube, leaving an empty space. The frail part of the ceiling of lava tube could collapse to expose the entrance to the lava tubes which is called a pit crater. Several pit craters with the diameter of around 100 meters have been found by analyzing the data of SELENE and LRO lunar missions. It is hard to use these pit craters for outposts since these are too large in scale. In this study, small scale pit craters which are fit for outposts have been investigated using the NAC image data of LROC. Several topographic patterns which are believed to be lunar caves have been found and the similar pit craters of the Earth were compared and analyzed to identify caves. For this analysis, the image data of satellites and aerial photographs are collected and classified to construct a database. Several pit craters analogous to lunar pit craters were derived and a morphological pit crater model was generated using the 3D printer based on this database.

Department of High and Applied Mathematics, Odessa National Maritime University with an Educational Telescope System

Eunsol Kim,Yong Ha Kim,Ik-Seon Hong,Jaehyung Yu,Eungseok Lee,Kyoungja Kim 한국우주과학회 2015 Journal of Astronomy and Space Sciences Vol.32 No.2

At the suggestion of the NASA Meteoroid Environment Office (NASA/MEO), which promotes lunar impact monitoring worldwide during NASA’s Lunar Atmosphere and Dust Environment Explorer (LADEE) mission period (launched Sept. 2013), we set up a video observation system for lunar impact flashes using a 16-inch educational telescope at Chungnam National University. From Oct. 2013 through Apr. 2014, we recorded 80 hours of video observation of the unilluminated part of the crescent moon in the evening hours. We found a plausible candidate impact flash on Feb. 3, 2014 at selenographic longitude 2.1° and latitude 25.4°. The flash lasted for 0.2 s and the light curve was asymmetric with a slow decrease after a peak brightness of 8.7 ± 0.3 mag. Based on a star-like distribution of pixel brightness and asymmetric light curve, we conclude that the observed flash was due to a meteoroid impact on the lunar surface. Since unequivocal detection of an impact flash requires simultaneous observation from at least two sites, we strongly recommend that other institutes and universities in Korea set up similar inexpensive monitoring systems involving educational or amateur telescopes, and that they collaborate in the near future.

Aorto-carotid bypass in patients with Takayasu arteritis

Hong Seok Han,Kyoung Won Yoon,Seon-Hee Heo,Yang Jin Park,Young-Wook Kim,Dong-Ik Kim 대한외과학회 2017 Annals of Surgical Treatment and Research(ASRT) Vol.93 No.3

Purpose: Takayasu arteritis is an indication for bypass surgery when this condition results in severe cerebrovascular ischemia due to occlusion of the carotid arteries. We reviewed the patients with Takayasu arteritis who received aortocarotid bypass due to cerebrovascular ischemia. Methods: A retrospective review was performed on 19 patients with Takayasu arteritis who underwent aorto-carotid bypass from March 2002 to April 2015. Results: All patients were female and the mean of their age was 40.6 ± 15.3 years. Eleven patients (57.9%) underwent aorto-uni-carotid bypass and 8 patients (42.1%) underwent aorto-bi-carotid bypass. Five patients (26.3%) whose postoperative blood pressure was not controlled suffered an intracranial hemorrhage within 8 days after bypass surgery. Of the patients with an intracranial hemorrhage, 2 patients (10.5%) expired on 26 days and 7 years after surgery, and 3 patients (15.8%) resolved spontaneously. One patient (5.3%) expired due to an intracranial infarction 9 years after bypass surgery. The intracranial ischemic symptoms resolved after bypass surgery in all of the surviving patients. None of the patients experienced anastomosis site complication postoperatively. Conclusion: Aorto-carotid bypass is effective for treating Takayasu arteritis with cerebrovascular ischemia, and the results suggest that postoperative blood pressure should be strictly managed to prevent intracranial hemorrhage.

Endoscopist-Driven Sedation Practices in South Korea: Re-evaluation Considering the Nationwide Survey in 2019

( Seon-young Park ),( Jun Kyu Lee ),( Chang-hwan Park ),( Byung-wook Kim ),( Chang Kyun Lee ),( Hong Jun Park ),( Byung Ik Jang ),( Dong Uk Kim ),( Jin Myung Park ),( Jae Min Lee ),( Young Sin Cho ),( 대한소화기기능성질환·운동학회 2022 Gut and Liver Vol.16 No.6

Background/Aims: This study aimed to determine changes in endoscopist-driven sedation practices 5 years after the first nationwide survey in 2014 by the Korean Society of Gastrointestinal Endoscopy (KSGE). Methods: A 59-item survey covering current practices was electronically mailed to all members of the KSGE in 2019. Results: In total, 955 (12.8%) out of 7,486 questionnaires were returned. A total of 738 (77.7%) out of 955 respondents attended dedicated sedation education programs. The American Society of Anesthesiologists class was recorded by 464 (51.2%) out of 907 respondents. The recording rate was higher in respondents who completed sedation education (p=0.014) and worked in general or tertiary hospitals (p<0.001). Compared to that reported in the previous survey, the reported use of propofol was higher in 2019. The respondents had higher satisfaction scores for propofol-based sedation compared with midazolam monotherapy (p<0.001). The rates of oxygen supplementation (p<0.001) and oxygen saturation level monitoring (p<0.001) during sedative endoscopy were higher in 2019 than in the previous survey. A total of 876 (98.4%) out of 890 respondents reported a separate recovery bay, and 615 (70.5%) out of 872 respondents reported that personnel were assigned solely to the recovery bay. Conclusions: Endoscopist-driven sedation and monitoring practices in 2019 were significantly different than those in 2014. The respondents favored propofol-based sedation and utilized oxygen supplementation and monitoring of O₂ saturation more frequently in 2019 than in 2014. (Gut Liver 2022;16:899-906)

Fabrication of Compound K-loaded Polymeric Micelle System and its Characterization in vitro and Oral Absorption Enhancement in vivo

Hong, Sun-Mi,Jeon, Sang-Ok,Seo, Jo-Eun,Chun, Kyeung-Hwa,Oh, Dong-Ho,Choi, Young Wook,Lee, Do Ik,Jeong, Seong Hoon,Kang, Jae Seon,Lee, Sangkil Korean Chemical Society 2014 Bulletin of the Korean Chemical Society Vol.35 No.11

Compound K (CK) was formulated as polymeric micelles (PM) using Pluronic$^{(R)}$ F-127 to enhance the oral absorption of CK, an intestinal bacterial metabolite of ginseng protopanaxadiol saponin. The physicochemical properties of Ck-loaded PM were characterized and an in vitro transport study using the Caco-2 cell system as well as an in vivo pharmacokinetic study using SD rats was carried out. The hydrodynamic mean particle size of CK-loaded PM (CK-PM) was $254{\pm}23.45nm$ after rehydration and the drug loading efficiency was ca. 99.9%. The FT-IR spectroscopy, X-ray diffraction, differential scanning calorimetry and scanning electron microscopy data supported the presence of a new solid phase in the PM. The $P_{app}$ value of in vitro Caco-2 cell permeation of CK-PM and the oral absorption of CK was enhanced about 1.2-fold and 2.6-fold compared to CK suspension, respectively, showing that the present PM formulation enabled an enhancement of oral CK absorption.