황기桃紅湯이 Endotoxin으로 유발된 白鼠의 血栓症에 미치는 영향

田炳薰,李鎭弘,鄭鉉雨,禹元洪,鄭遇悅 대한동의병리학회 1993 동의생리병리학회지 Vol.8 No.-

연구배경 : 최근의 死亡率중에 腦血管系疾患이 차지하고 있는 比率이 대단히 높기 때문에 氣와 血의 이론적 관계인 "氣爲血之帥, 氣行則血行." 의 관점하에서 腦血管系疾患중의 하나인 血栓病을 동의학적 병리론에 의거하여 "瘀血"의 범주에 속할 것으로 사료되기 때문에 補氣之劑인 황기를 君藥으로하고 活血祛瘀之劑인 桃仁과 紅花를 加하여 실시하기로 하였다. 그리하여 본 연구가 임상에서 血栓症治療에 應用할 수 있는지를 考察하고, 작게는 東醫學 發展의 이론적 뒷받침이 되었으면 하는 바램에서 시행하였다. 방법 : 황기도홍탕이 1첩분량(318.75g)을 100ml로 減壓濃縮하여 0.2mg/kg의 endotoxin을 試料投與 1시간 후에 白鼠의 尾靜脈에 注入하고 4시간이 경과되면 urethane 痲醉下에서 心臟採血 하였다. 결과 : 血小板數와 FDP는 對照群에 비하여 增加 또는 減少되었지만 有意性은 나타내지 않았다. 그러나 prothrombin time과 fibrinogen량은 對照群에 비하여 有意性있게 短縮 또는 增加하였다. 결론 : 황기도홍탕이 endotoxin으로 誘發된 白鼠의 血栓症에 미치는 影響은 有意한 것으로 나타났다. 그렇기 때문에 黃?桃紅湯이 腦血管疾患 뿐만 아니라 瘀血性疾患에 임상적으로 응용하면 보다 높은 치료효과를 거두리라 思料된다 This study was performed to investigate the effect of Whangkidohongtang(황기도홍탕) on the intravascular coagulation induced by endotoxin in rats. The intravascular coagulation was induced by injecting endotoxin in the caudal vein of rats. And these rats were treated with extract of Whangkidohongtang(황기도홍탕)1.0ml/200g (GroupⅠ) and Whangkidohongtang(황기도홍탕) 2.0ml/200g (groupⅡ), which were administered orally. Then, the number of blood cells, platelets, concentration of prothrombin time, fibrinogen and FDP(fibrin-fibrinogen degradation products) were measured. The following results were obtained : 1. The number of platelets increased in the GroupⅡcompared with the control group, but it is not significant. 2. The prothrombin time was shortened significantly in the GroupⅡcompared with the control group. 3. The concentration of fibrinogen increased significantly in the trial group compared with the control group. 4. The degree of concentration of FDP decreased significantly in the trial group compared with the control group, but it is not significantly. According to the above results, it is considered that Whangkidohongtang(황기도홍탕) has the significant effects on thrombosis. Therefore, Whangkidohongtang(황기도홍탕) seems to be applicable to the diseases related to thrombosis.

글루콘산 생산을 위한 최적 배양조건

홍성란,이현절,정봉우,김춘영 全北大學校 1995 論文集 Vol.39 No.-

The production of gluconic acid by Aspergillus niger KCTC 2119 was studied. The Optimal culture conditions, such as initial pH, temperature, inoculum size and medium composition were established. Maximum overall gluconic acid productivity, 0.13g/L · hr was obtained when the cultivation was carried out at 33℃ and initial pH 5.5 for 72 hrs, with medium containing 110g/L glucose, 0.5g/L (NH_4)_2SO_4, 0.2g/L KH_2PO_4, 1.0g/L MgSO_4·7H_2O, and 0.1g/L corn steep liquor. The metabolic parameters such as specific growth rate, cell and gluconic acid yields were estimated for process improvement.

Effects of Pilger Rolling and Heat Treatment on Microstructure and Corrosion Resistance of Ag-electroplated 304 Stainless Steel Tubes

Hyun Park,Woo‑Jin Lee,Jae‑Han Son,Han‑Kyun Shin,Sung‑Kyu Hong,Hyo‑Jong Lee 대한금속·재료학회 2022 METALS AND MATERIALS International Vol.28 No.8

We introduce a cost-effective method that combines electroplating with metal cold working processes to manufacture compositetubes with robust corrosion resistance. First, a 3-step electroplating process was developed to form an adhesive anduniform Ag coating on the outer wall of a 304 stainless steel tube. The process consisted of a Ni-strike step for removing thepassivation layer of the initial 304 tube, Cu deposition for smoothing the surface by adding a buffer layer, and Ag deposition. To reinforce the interfacial adhesion between the electroplated layers and the 304 tube and increase the area of the Ag coating,a pilger rolling or pilger rolling + heat-treatment process was performed after the Ag electroplating process. Scanningelectron microscopy of the composite tubes after each process indicated that the as-deposited Ag coating changed fromhaving a rough to smooth surface after only pilger rolling and with additional heat treatment. Electron backscatter diffractionanalysis of the microstructures and textures of the tubes revealed that dynamic recrystallization occurred extensively duringpilger rolling, resulting in the formation of a relatively defect-free grain structure without heat treatment. Furthermore,electrochemical polarization curves determined that the Ag-coated composite tubes are superior to the uncoated 304 tubein terms of corrosion resistance under Cl−atmosphere, owing to the formation of a AgCl passivation layer during testing. Surface analysis of the composite tubes suggests that the properties of the AgCl passivation layer are related to the grainsize of the Ag coating and the density of plastic-deformation-induced defects.

에어컨 냉각 팬용 브러쉬레스 DC 전동기의 역기전력 분석에 대한 연구

조정현,김지현,정정원,황흥식,이치우 경성대학교 공학기술연구소 2012 공학기술연구지 Vol.18 No.-

Compared to conventional dc motors having the combination of commutators and brushes, a brushless DC (BLDC) motor is one of the highly efficient motors due to its electrical commutation without a brush, and this feature allows the BLDC otor to be more suitable for an application requiring no maintenance due to mechanical wear between a commutator and a brush. Also, the BLDC motor has a few benefits over both a dc motor and an induction motor such as high dynamic response, high efficiency, logn life span, and low noise in wide speed-torque region. This paper investigates the variation of voltage induced in phase windings in a BLDC motor in several cases with respect to stack length, steel grade, and coil material. This study is numerically conducted and it is verified from the theoritical point of view by comparing the result of simulation with that of experimental measurement.

Streptococcus anginosus 균혈증에 동반된 상완 골수염 및 주변부 연조직 농양 1예

한우진,조문숙,이정현,안홍대,윤규현,서종구,김진용,김수연,박윤수,서일혜,조용균 대한감염학회 2008 감염과 화학요법 Vol.40 No.5

Streptococcus anginosus is a normal flora found in multiple body sites and belongs to the Streptococcus milleri group, It has often been associated with pyogenic infection, such as periodontitis, endocarditis, pulmonary abscess and abdominal or cerebral abscess. Also uncommonly, it can cause osteomyelitis. A 42-year-o1d man was admitted due to gastric ulcer perforation. At 12th hospital day, left humeral osteomyelitis and soft tissue abscess developed, Streptococcus anginosus grew in blood culture, He was treated with intravenous penicillin and surgical debridement of the necrotic tissue which lead to a satisfactory result. We report a rare case of Streptococcus anginosus-induced humeral osteomyelitis and soft tissue abscess.

핵산 내성세균 Micrococcus sp. BCNU121의 생리적 특성에 관한 연구

이현채,주우홍 昌原大學校 基礎科學硏究所 1997 基礎科學硏究所論文集 Vol.9 No.-

The strain BCNU121 among the isolated strains is hexane-tolerant Gram-positive coccus. This strain showed catalase positive, oxidase negative and arginine dihydrolase positive reaction, and formed the cluster of cells. Also this strain hydrolyzed gelatin and grew at nutrient agar with 7.5% NaCl. On the basis of the above date, this strain BCNU121 have been identified as Micrococcus sp. The optimal condition for growth was determined.

유전자 알고리즘에 의한 모발로봇의 자세/위치 제어

한성현,이우송,김윤구,김홍래,조창제 한국공작기계학회 2006 한국공작기계학회 추계학술대회논문집 Vol.2006 No.-

This paper proposed trajectory tracking control of Mobile Robot. Trajectory tracking control scheme are Real coding Genetic-Algorithm and Back-propergation Algorithm. Control scheme ability experience is proposed by simulation.

면역성 혈소판감소성 자반증 및 호중구감소증을 동반한 궤양성 대장염 2예

남승우,양석균,김진천,지현숙,김우건,정훈용,박주상,홍원선,민영일 大韓消化器病學會 1999 大韓消化器病學會誌 Vol.33 No.1

수직 평행채널의 벽면에 부착된 단일 모듈의 3차원 자연대류 열전달

추홍록,유갑종,김현우 경북대학교 산업기술연구소 1996 産業技術硏究誌 Vol.24 No.-

The present experimental study investigated the 3D natural convection heat transfer in a parallel vertical channel with protruding single module on the PCB. The materials used for the vertical PCB was epoxy-resin. Air was used as the cooling fluid. The flow fields in the channel was visualized by means of the smoke-method. Also, local temperature measurements were made along the vertical PCB. Results were obtained for channel ratios of 0.2, 0.3, 0.4, 0.5, 0.7, 0.9, 1.2, 1.5 and ∞, Rayleigh numbers ranging from 4.94×10 exp (3) to 8.02×10 exp (6) and the module thickness ratios of 0.1, 0.2, 0.3. By analyzing the experimental results, the mean Nusslet number increased as module thickness ratios increased. Correlation relating the mean Nusselt number to the modified channel Rayleigh number is proposed.

HMG-CoA 환원효소 억제제에 의한 ICAM-1 유전자의 발현조절

김현진,정효균,홍우정,김군순,조영석,김도희,채수흥,구본정,송민호,노흥규,김영건 충남대학교 의과대학 지역사회의학연구소 2001 충남의대잡지 Vol.28 No.1

Background : ICAM-1 act as one of major adhesion molecules in the atherosclerotic lesion. ICAM-1 expression is mainly regulated at the level of transcription and depend on IFN-γ signal transduction pathway in which the STAT1 transcrption factor is a critical intermediate. IFN-γreceptor not only initiates tyrosine 701 phosphorylation of STAT1 by Jak1 and Jak2, but also phosphorylates serine 727 through the activation of Raf-1/MAP kinases. HMG-CoA reductase inhibitors have anti-atherosclertic effects, beyond normalization of hypercholesterolemia, by directly acting on endothelial cells, macrophages and vascular smooth muscle cells. HMG-CoA reductase inhibitors suppress the synthesis of isoprenoid intermediates such as geranylgeranyl-pyrophosphate or farnesylpyrophosphate. These effects results inhibitors suppress the synthesis of isoprenoid intermediates such as geranylgeranyl-pyrophosphate or farnesylpyrophosphate. These effects results inhibition posttranslational farnesylation and geranyl-geranylation processing of small GTP-binding preoteins and inhibition of normal signaling activities. Method : We made several 5'-deletion constructs of rat ICAM-1 promoter and analyzed the promoter activities by measuring the luciferase activity after transfection into ECV304 cells and smooth muscle cells. We checked the level of total and phosphorylated STAT1 protein by immunoblot analysis using specific antibodies. Results : Lovastatin inhibits IFN-γ-induced ICAM-1 gene expression in the ECV304cell. The cells pretreated with PD98059, MEKK inhibitor showed significantly low ICAM-1 RNA induction with IFN-γ stimulatio. IFN-γ induced phosphorylation of tyrosine 701 was not significantly changed by the pretreatment of lovastatin. But lovastatin suppresses IFN-γ-induced phosphorylation of ERK1/ERK2 which are responsible for the seine 727 phosphorylation in STAT1. Conclusion : We showed that HMG-CoA reductase inhibitors, lovastatin, suppresses IFN-γ mediated ICAM-1 gene expression through the inhibition of transcription. HMG-CoA reductase inhibitor suppresses IFN-γ-induced phosphorylation of serine 727 in STAT1 through the modulation of MAP kinases.