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박윤수,안지현,이태경,김보라,태현진,박준하,신명철,조준휘,원무호 대한중환자의학회 2020 Acute and Critical Care Vol.35 No.4
Background: Few studies have evaluated the effects of hypothermia on cardiac arrest (CA)- induced liver damage. This study aimed to investigate the effects of hypothermic therapy on the liver in a rat model of asphyxial cardiac arrest (ACA). Methods: Rats were subjected to 5-minute ACA followed by return of spontaneous circulation (RoSC). Body temperature was controlled at 33°C±0.5°C or 37°C±0.5°C for 4 hours after RoSC in the hypothermia group and normothermia group, respectively. Liver tissues in each group were collected at 6 hours, 12 hours, 1 day, and 2 days after RoSC. To examine hepatic inflammation, mast cells were stained with toluidine blue. Superoxide anion radical production was evaluated using dihydroethidium fluorescence straining and expression of endogenous antioxidants (superoxide dismutase 1 [SOD1] and SOD2) was examined using immunohistochemistry. Results: There were significantly more mast cells in the livers of the normothermia group with ACA than in the hypothermia group with ACA. Gradual increase in superoxide anion radical production was found with time in the normothermia group with ACA, but production was significantly suppressed in the hypothermia group with ACA relative to the normothermia group with ACA. SOD1 and SOD2 levels were higher in the hypothermia group with ACA than in the normothermia group with ACA. Conclusions: Experimental hypothermic treatment after ACA significantly inhibited inflammation and superoxide anion radical production in the rat liver, indicating that this treatment enhanced or maintained expression of antioxidants. Our findings suggest that hypothermic therapy after CA can reduce mast cell-mediated inflammation through regulation of oxidative stress and the expression of antioxidants in the liver.
Can Religion Save Our Health?: Quasi-Experimental Evidence from the U.S.
박윤수 한국개발연구원 2018 KDI Journal of Economic Policy (KDI JEP) Vol.40 No.1
There is a large amount of empirical literature reporting that people who regularly attend religious services tend to have better health outcomes. However, it remains an unanswered question as to whether the observed correlation reflects any causality. Exploiting exogenous changes in church attendance driven by law changes in 21 states of the U.S., I find tentative but suggestive evidence that the observed strong correlation between religious participation and health is likely to be driven by endogenous selection.
MICP 미생물을 이용한 하수슬러지의 고형화/안정화에 관한 연구
박윤수,이재영 한국폐기물자원순환학회 2017 한국폐기물자원순환학회 학술대회 Vol.2017 No.05
하수처리장의 증가와 함께 하수슬러지의 발생량 또한 매년 상승하고 있으며, 2025년은 2006년 대비 2배가 더 발생하게 된다. 이러한 하수슬러지는 주로 해양투기와 재활용에 의하여 처리되어 왔으나, 가장 단순하고 저렴한 방식이었던 해양투기가 2012년 01월부터 전면금지가 되었다. 현재 하수슬러지의 처리방법 중 재활용은 약 56% 정도를 차지하고 있다. 이 중 재활용은 매립지의 복토재, 건설자재, 토목자재, 시멘트 원료화 등으로 활용되고 있다. 지금까지 재활용 처리방법 중 매립지의 복토재로 재활용하는 것이 많은 연구가 진행되어 왔으나 친환경적인 처리방법 및 MICP 미생물에 관한 고형화/안정화 연구는 아직 미흡하다고 판단된다. 따라서, 본 연구에서는 MICP를 형성하는 미생물을 이용하여 하수슬러지를 고형화/안정화 한 후 매립지의 복토재로서 가능성을 보고자 한다. 이에 본 연구는 MICP를 형성하는 미생물의 생물학적 및 광물학적 분석을 하였으며 하수슬러지 및 고화제의 물리화학적 분석을 수행하였다. 본 연구를 위하여 하수슬러지의 고형화적 품질기준인 pH, 수분함량, 투수계수, 일축압축 강도, 유해물질 함량 분석을 실시하였다. 또한, MICP를 형성하는 미생물에 의하여 하수슬러지가 고화처리 된 것인지 확인하기 위하여 탄산칼슘의 광물학적 분석을 병행하여 고형화/안정화에 대한 신뢰성을 갖고자 한다.
박윤수,유왕근,한삼성,공미진 보건의료산업학회 2019 보건의료산업학회지 Vol.13 No.3
Objectives: The purpose of this study was to analyze the association between health status and physical activity levels in older adults (over 65 years) in Korea. Methods: The participants were selected from the database of the Seventh Korea National Health and Nutrition Examination Survey (KNHANES Ⅶ), conducted by the Korea Centers for Disease Control and Prevention in 2017. A chi-square test and logistic regression analysis were used to analyze data. Results: The findings showed that health conditions such as hypertension and diabetes were related to physical activity levels of the older adults. In addition to health status, social and economic factors such as gender, age, and geographic region should be considered in order to initiate the practice of aerobic and strength exercise in the older adults. Conclusions: To initiate physical activity levels in the older adults, it is necessary to consider support for costs involved, policies required for the development of integrated exercise programs, expansion of public exercise facilities, and improved facilities
박윤수,허용수,정승문 한국경영과학회 2016 한국경영과학회 학술대회논문집 Vol.2016 No.4
In order to provide a good quality of electric power service to a user power techniques to infer a causal relationship in accordance with the situation and therefore the analysis of the data collected from the base environment is required. This study was designed based on the LOD energy platform with access to the information associated with the user to configure a common service architecture based on whether the IoT based power management and conditions are defined in the connection means between the data and based on this.
Clinical Outcomes of Tuberculosis in Renal Transplant Recipients
박윤수,최준용,조정호,장경희,송영구,김유선,김준명 연세대학교의과대학 2004 Yonsei medical journal Vol.45 No.5
Tuberculosis (TB) is an important cause of morbidity and mortality in renal transplant recipients. Rifampin has a potent sterilizing activity, but it reduces the serum concentrations of the immunosuppressive agents. Moreover, the possible contribution made by mycobacterial infection to the incidence of graft rejection or renal dysfunction remains unclear. In this study, we investigated the recurrence of TB and graft survival duration according to rifampin usage, and we evaluated the factors that could influence the duration time until the recurrence of TB. Seventy-eight TB patients diagnosed after kidney transplantation were studied. Pulmonary TB was diagnosed in 26 of the 78 patients (33.3%), pleural TB in 23 (29.5%), combined pulmonary and pleural TB in 5 (6.4%), miliary TB in 19 (24.4%), and intestinal TB in 2 patients. In the pulmonary (pulmonary TB and pleural TB) TB group, no differences in graft survival and the TB free duration period were observed between the rifampin usage subgroup and the non- rifampin usage subgroup. In the extrapulmonary TB group, no difference was found in mean graft survival time between the rifampin usage subgroup and the non-rifampin usage subgroup, but the rifampin usage subgroup showed that the TB had a tendency to recur later than for the non-rifampin usage subgroup (87±8 vs. 44±7 months, respectively, p=0.30). The factor affecting the duration period until the recurrence of TB was the treatment duration (RR=0.761, p=0.030). This study suggests that rifampin does not affect graft survival in renal transplant recipients in whom immunosuppression is carefully monitored. Also, the study results indicate that rifampin may prevent a recurrence of extrapulmonary tuberculosis. Prolonged treatment appears to be appropriate for renal transplant recipients with TB.