http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
Lee, Moon Hee,Han, Min Ho,Lee, Dae-Sung,Park, Cheol,Hong, Su-Hyun,Kim, Gi-Young,Hong, Sang Hoon,Song, Kyoung Seob,Choi, Il-Whan,Cha, Hee-Jae,Choi, Yung Hyun UNKNOWN 2017 INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE Vol.39 No.2
<P>In the present study, we investigated the cytoprotective efficacy of morin, a natural flavonoid, against oxidative stress and elucidated the underlying mechanisms in C2C12 myoblasts. Our results indicated that morin treatment prior to hydrogen peroxide (H2O2) exposure significantly increased cell viability and prevented the generation of reactive oxygen species. H2O2-induced comet-like DNA formation and gamma H2AX phosphorylation were also markedly suppressed by morin with a parallel inhibition of apoptosis in C2C12 myoblasts, suggesting that morin prevented H2O2-induced cellular DNA damage. Furthermore, morin markedly enhanced the expression of heme oxygenase-1 (HO-1) associated with the induction and phosphorylation of nuclear factor-erythroid 2-related factor 2 (Nrf2) and the inhibition of Kelch-like ECH-associated protein 1 (Keapl) expression. Notably, these events were eliminated by transient transfection with Nrf2-specific small interfering RNA. Additional experiments demonstrated that the activation of the Nrf2/HO-1 pathway by morin was mediated by the extracellular signal-regulated kinase (ERK) signaling cascade. This phenomenon was confirmed with suppressed Nrf2 phosphorylation and consequently diminished HO-1 expression in cells treated with a pharmacological inhibitor of ERK. Collectively, these results demonstrated that morin augments the cellular antioxidant defense capacity through the activation of Nrf2/HO-1 signaling, which involves the activation of the ERK pathway, thereby protecting C2C12 myoblasts from H2O2,-induced oxidative cytotoxicity.</P>
Vascular Protective Role of Samul-Tang in HUVECs: Involvement of Nrf2/HO-1 and NO
Choi, Eun Sik,Lee, Yun Jung,Seo, Chang Seob,Yoon, Jung Joo,Han, Byung Hyuk,Park, Min Cheol,Kang, Dae Gill,Lee, Ho Sub Hindawi Publishing Corporation 2016 Evidence-based Complementary and Alternative Medic Vol.2016 No.-
<P>Samul-Tang (Si-Wu-Tang, SMT), composed of four medicinal herbs, is a well-known herbal formula treating hematological disorder or gynecologic disease. However, vascular protective effects of SMT and its molecular mechanisms on the vascular endothelium, known as the central spot of vascular inflammatory process, are not reported. The aim of this study was to investigate vascular protective effects of SMT water extract in human umbilical vein endothelial cells (HUVECs). Water extract of SMT was prepared and identified by HPLC-PDA analysis. Expression of cell adhesion molecules (CAMs) and heme oxygenase-1 (HO-1) and translocation of nuclear factor-kappa B (NF-<I>κ</I>B) and nuclear factor-erythroid 2-related factor 2 (Nrf2) were determined by western blot. Nuclear localization of NF-<I>κ</I>B and Nrf2 was visualized by immunofluorescence and DNA binding activity of NF-<I>κ</I>B was measured. ROS production, HL-60 monocyte adhesion, and intracellular nitric oxide (NO) were also measured using a fluorescent indicator. SMT suppressed NF-<I>κ</I>B translocation and activation as well as expression of CAMs, monocyte adhesion, and ROS production induced by TNF-<I>α</I> in HUVECs. SMT treated HUVECs showed upregulation of HO-1 and NO which are responsible for vascular protective action. Our study suggests that SMT, a traditionally used herbal formula, protects the vascular endothelium from inflammation and might be used as a promising vascular protective drug.</P>
한국산 배의 Polyphenol 화합물군이 쥐의 면역기능에 미치는 영향
최희진,한호석,박정혜,배종호,우희섭,안봉전,배만종,김현구,최청 한국식생활문화학회 2003 韓國食生活文化學會誌 Vol.18 No.4
This study was conducted to investigate immunofunctional activity of the polyphenol fractions isolated from Korean pear. In the experimental of Rosette forming cell, the results showed that all the polyphenol fractions enhance the cell count compared with the control group. Especially polyphenol fraction II and III showed highly significant effect on Rosette forming cell, and allergy inhibition. After antigen challenge, histamine content of blood of the polyphenol groups was lowered to near the normal group.
稀薄溶液에서 有機色素分子와 陰이온 界面活性劑사이의 會合에 관한 效果
崔虎燮 群山大學校自然科學硏究所 1988 自然科學硏究 Vol.3 No.-
The metachromatic behavior leading to the formation of aggregation between organic dyestuffs and anionic surfactants was investigated spectroscopically by varying the concentration with the addition sufactants. The appearance of a new band(meta-band) is explained as a high aggregation of organic dye molecular at a range 300 through 400 S/D value in dye-surfactant complex system. The deminishing of a meta-band at the above 700 of S/D value due to attribute to redistribution and the formation of micelle by the drim.
최재식,윤봉국,하승백,정원섭,이호인 한국공업화학회 2003 응용화학 Vol.7 No.2
Direct Methanol Fuel Cell (DMFC) is based on the technology of Polymer Electrolyte Membrane Fuel Cell. DMFC has several features of environmentally benign generation of electricity and high mobility for portable electronics etc., but its main problem to overcome for commercialization is the high cost of noble metal catalysts. In this study, it was found that the Pt/C catalyst supported on carbon nano fiber had the highest catalytic activity among the catalysts supported on several carbons. The newly developed Pt/C alternative catalyst had higher catalytic activity for methanol oxidation than the Pt/C catalyst supported on Vulcan XC-72.
Doxylamine Succinate 과다복용 환자에서 발생한 횡문근융해증 1예
임호섭,최종순 고신대학교의과대학 2008 고신대학교 의과대학 학술지 Vol.23 No.4
Doxylamine succinate is an antihistamine, classified as hypnotics and sedatives by the Ministry of Health and Welfare, and it can be obtained easily as an over-the-counter medicine. After doxylamine overdose, the anticholinergic effects of this drug can also lead to nausea, vomiting, and ileus as well as urinary retention, and patients often have dry mouth, absence of sweating, flushing, fever, and dilated pupils. Although Rhabdomyolysis seems unusually common with doxylamine poisoning, it can lead to acute renal failure and serious complications. A careful observation is needed, because disseminated intravascular coagulation, metabolic acidosis, acute cardiomyopathy, respiratory distress, compartment syndrome and peripheral neuropathy can occur in doxylamine intoxication. We report a case of rhabdomyolysis after doxylamine overdose.
Azithromycin으로 치료한 임신 중 쓰쓰가무시병 1예
김광석,최진욱,서호종,김기훈,박성호,서광섭,고성만,김순혜,김호정 대한감염학회 2001 감염 Vol.33 No.5
We report a case of tsutsugamushi disease in a 26 year-old pregnant woman who was treated with azithromycin. Her gestation period was 27 weeks and she admitted with fever, rash, and eschar on the right shoulder. Currently recommended medications for the treatment of scrub typhus are doxycycline or chloramphenicol. But, these drugs are class D drugs according to the U.S. Food and Drug Administration (FDA) Fetal Risk Summary, so they couldn't be used to treat pregnant women. Recently, a few case reports suggested that azithromycin, a relatively new macrolide antibiotic, was effective and safe for the treatment of scrub typhus in pregnant women. And, there is no evidence that azithromycin causes harmful effects to the developing fetus or to children. On the basis of current in vivo test that confirms the effectiveness of azithromycin, it may be the drug of choice for the treatment of scrub typhus in pregnant women and children. (Korean J Infect Dis 33:380-382, 2001)
한국산 감잎의 Polyphenol 화합물의 생리활성물질의 화학구조 및 효소저해효과
안봉전,최희진,손준호,우희섭,한호석,박정혜,손규목,최청 한국식생활문화학회 2003 韓國食生活文化學會誌 Vol.18 No.5
The lyophilization of the solution extracted from 60 percent of acetone applied to persimmon leaves, the compounding process in accordance with the solution's concentration, and the gel filteration through Sephadex G-50 of biologically activated substances obstructing enzyme activity, such as tyrosinase, xanthine oxidase, and angiotesin converting enzyme (ACE) led to the assumption that polyphenol was the compound serving as biologically activated substances obstructing enzyme activity. Xanthine oxidase involved in pruine metabolism oxidizes hypoxanthine to xanthine and xanthine to uric acid. In the continuous study for natural compound, nine flavan-3-ois have been isolated from the persimmon leaves. The structures of (+)-catechin, (+)-gallocatechin, procyanidin B-1, pyrocyanidin C-1, prodelphinidin B-3, gallocatechin-(4α→8)-catechin, procyanidin B-7-3-O-gallate, procyanidin C-1-3'-3''-3'''-O-trigallate and (-)-epigallocatechin-(4β→8)-epigallocatechin-(4β→8)-catechin were established by NMR and their inhibitory effect on xanthine oxidase activity was investigated. Procyanidin C-1-3'-3''-3'''-O-trigallate showed 94%, 90.69%, 80.90% inhibition at 100(μ)M and inhibited on the angiotension converting enzyme respectively. Procyanidin B-7-3-O-gallate and procyanidin 1-3'-3''-3'''-O-trigallate showed 66%, 63% inhibition at 100(μ)M and inhibited on the xanthine oxidase competitively. Procyanidin C-1-3'-3''-3'''-O-trigallate showed 70% inhibition at 100(μ)M inhibited on the thyrosinase competitively.
중간세공탄소를 담체로 사용한 직접메탄을 연료전지용 Pt/C 촉매제조
하승백,김현수,최재식,정원섭,이호인 한국공업화학회 2003 응용화학 Vol.7 No.2
For the direct methanol fuel cell, the expensive cost of Pt is one of the most important factors. In this study, various kinds of support were synthesized and chosen for highly dispersed catalysts which need less amount of Pt and show higher activity. A mesoporous carbon was selected as a support which has 5 times larger specific surface area than Vulcan XC-72, a commercial support. Such a large surface area gave an advantage in the dispersion of Pt, but a disadvantage in electric conductivity which could be solved by increasing the carbonizaton temperature in the preparation of mesoporous carbon. These prepared mesoporous carbons were used as supports of Pt. Among the catalysts, the catalyst using mesoporous carbon carbonized at 1000 ℃ showed better activity than the catalyst using Vulcan XC-72 as a support showing the best activity. From the XRD analysis, the activity was proportional to the dispersion of Pt.