Plenary Session 2 : PS-2-1 ; Outcomes of hepatitis B virus recurrence after liver transplantation: a multicenter analysis in Korea

( Hee Yeon Kim ),( Jong Young Choi ),( Dong Goo Kim ),( Myoung Soo Kim ),( Soon Il Kim ),( Shin Hwang ),( Sung Gyu Lee ),( Kwang Woong Lee ),( Kyung Suk Suh ),( Young Seok Han ),( Dong Lak Choi ),( Se 대한간학회 2012 춘·추계 학술대회 (KASL) Vol.2012 No.-

Background: The outcome of hepatitis B virus (HBV) infection after liver transplantation (LT) was improved by hepatitis B immunoglobulin (HBIG) and nucles(t)ide analogue (NUA). However, HBV recurrence after LT is critical because the recurrence is occasionally accompanied by a progressive destruction of graft and poor survival. The aims of this study were to investigate the significance HBV recurrence and identity factors associated with HBV recurrence. Methods: From October 1999 to February 2011, a total of 2684 consecutive LT recipients who underwent HBV-associated LT were retrospectively enrolled from 7 transplantation centers in Korea. Results: Prophylaxis regimens were HBIG monotherapy (67.7%) or a combination of HBIG with NUA (22.3%). The recurrence rate of HBV was 6.1% (164 recipients) during mean follow-up duration of 10.9 years. The median time from transplantation to recurrence was 2.1 years (0.1-7.9 years). Of the 1,071 patients with hepatocellular carcinoma (HCC) prior to LT, 155 patients (14.5%) had HCC recurrence after transplantation, and 48 patients (31.0%) had HBV recurrence. Of the 48 patients with recurrence of both HBV and HCC, 25 patients (52.1%) experienced HBV recurrence after HCC recurrence. In the multivariate analysis, pretransplant HCC, pretransplant HBV DNA above 5.5 log copies/mL was independent clinical factors influencing HBV recurrence after LT. The mortality rate among the recipients with HBV recurrence was 34.1% (56 recipients). Mean overall survival was 6.4 years in the HBV-recurrence group and 9.9 years in the HBV-nonrecurrence group (p<0.001). HBV recurrence was not an independent prognostic factor for overall survival. HCC recurrence was the most important factor for overall survival. Conclusions: The overall outcome of LT in HBV-related liver disease was excellent with the current prophylaxis regimen Choon Hyuck David Kwon,8 Suk-Koo Lee8 Pretransplant HBV DNA and HCC were important factors for HBV recurrence. HBV recurrence after LT did not significantly influence on the overall survival without combining of HCC recurrence.

BEZ235 (PIK3/mTOR inhibitor) Overcomes Pazopanib Resistance in Patient-Derived Refractory Soft Tissue Sarcoma Cells

Kim, Hee Kyung,Kim, Sun Young,Lee, Su Jin,Kang, Mihyeon,Kim, Seung Tae,Jang, Jiryeon,Rath, Oliver,Schueler, Julia,Lee, Dong Woo,Park, Woong Yang,Kim, Sung Joo,Park, Se Hoon,Lee, Jeeyun Neoplasia Press 2016 Translational oncology Vol.9 No.3

<P><I>BACKGROUND:</I> Although pazopanib treatment has become the standard chemotherapy in salvage setting for metastatic sarcoma patients, most patients progress after pazopanib treatment in 4 to 6 months. After failure to pazopanib, patients have limited options for treatment. Therefore, subsequent therapy in patients who failed to pazopanib is urgently needed and the use of patient derived cells or patient derived tumors for accompanying testing with various pharmacological inhibitors could offer additional treatment options for these patients. <I>METHODS:</I> Patient derived tumor cells were collected from ascites at the time of progression to pazopanib and a 13-drug panel was tested for drug sensitivity. We confirmed the results using <I>in vitro</I> cell viability assay and immunoblot assay. We also performed the genomic profiling of PDX model. <I>RESULTS:</I> The growth of patient derived tumor cells was significantly reduced by exposure to 1.0 μM AZD2014 compared with control (control versus AZD2014, mean growth = 100.0% vs 16.04%, difference = 83.96%, 95% CI = 70.01% to 97.92%, <I>P</I> = .0435). Similarly, 1.0 μM BEZ235 profoundly inhibited tumor cell growth <I>in vitro</I> when compared to control (control versus BEZ235, mean growth = 100.0% vs 7.308%, difference = 92.69%, 95% CI = 78.87% to 106.5%, <I>P</I> < .0001). Despite the presence of CDK4 amplification in the patient-derived tumor cells, LEE011 did not considerably inhibit cell proliferation when compared with control (control vs LEE011, mean growth = 100.0% vs 80.23%, difference = 19.77%, 95% CI = 1.828% to 37.72%, <I>P</I> = .0377). The immunoblot analysis showed that BEZ235 treatment decreased pAKT, pmTOR and pERK whereas AZD2014 decreased only pmTOR. <I>CONCLUSION:</I> Taken together, upregulation of mTOR/AKT pathway in sarcoma patient derived cells was considerably inhibited by the treatment of AZD2014 and BEZ235 with downregulation of AKT pathway (greater extent for BEZ235). These molecules may be considered as treatment option in STS patient who have failed to pazopanib in the context of clinical trials.</P>

찰옥수수연구 XVIII 시설하우스에서 2기작 찰옥수수 교잡종의 주요 생육특성 비교

나웅현,복태규,고혁수,백승우,조양희,이희봉 충남대학교 농업과학연구소 2013 농업과학연구 Vol.40 No.2

The major characteristics of the developed corn hybrids were compared at each different planting time; 1st time(April 28) and 2nd time(August 20), respectively. Among traits surveyed, stem height showed highly at 1st time than 2nd, while ear height, stem diameter and ear length were similar at two times. Sugar content of the used hybrids showed highly at 2nd planting time than 1st. Pericarp thickness was also high at 2nd planting time. Especially, among hybrids CNU99 was the highest in stem height and ear length, CNU11 and CNU56 were high in sugar content, and CNU51 and CNU124 were thiner than other hybrids in pericarp thickness. Accordingly, these hybrids will be planted and recognized in 2nd yield trial for superior corn hybrid selection.

차트 파싱을 이용한 한국어 구문 분석에 관한 연구

이웅재,정희연,김희연,김혜주 서울여자대학교 자연과학연구소 2001 자연과학연구논문집 Vol.13 No.-

In order to understand natural language, we have to follow the process "Input → Lexical Analysis → Syntactic Analysis → Semantic Analysis". Among those, "syntactic analysis" plays the most important role since it is able to be applied to various fields such as natural language query systems, natural language interface systems, text summary systems, and machine translation systems. It is also important to analyze a sentence containing ambiguity. In this paper, we propose an algorithm to parse the Korean language using chart. It is implemented using Prolog programming language.

대기중의 오존이 느티나무에 미치는 영향

이웅상,윤명희 명지대학교 자연과학연구소 1995 자연과학논문집 Vol.12 No.-

대기중의 오존이 느티나무(Zelkova serrata Nakai)에 미치는 영향을 open-top chamber를 이용하여 관찰하였다. 2개월동안 대기중의 오존에 노출시킨 식물의 광합성율과 엽록소함량은 activated charcoal로 filter한 chamber의 식물에 비해 각각 60%정도 낮았다. 증산율과 stomatal conductance 도 non-filtered chamber 내의 식물이 charcoal-filtered chamber내의 식물에 비해 40%정도 감소되었다. 그러나 오존에 의한 가시피해는 관찰되지 않았다. Effects of ambient ozone on Zelkova serrata were observed by using open-top chambers. Net photo synthesis rate and total chlorophyll content were about 60% decreased in non-filtered chamber plants compared with charcoal-filtered chamber plants were also 40% lower compared with charcoal -filtered chamber plants. However, no visible symptoms of ozone were observed.

鹽浴浸炭 後 高周波表面硬化處理된 軟綱의 磨耗特性에 관한 硏究

李相允,金凞雄,李準範 東亞大學校 1984 東亞論叢 Vol.21 No.3

This study has been performed to investigate into the improvement of wear resistance and hardness characteristics of mild steel heat treated by a combined technique, bath carbonizing and then induction surface hardening treatment, under various experimental conditions. The results obtained from the experiment are summarized as follows. (1) Optical micrographs have shown that at a given condition of output power microstructures generally vary as changes in the rate of travel during induction hardening and that martensitic transformation occurs for the travel rate of 0.33㎜/sec. (2) It has been found that for a given output power and the rate of travel as the carbonizing time increases the surface hardness and effective case depth are increased. (3) At the given output power and carbonizing time the surface hardness and effective case depth have been found to increase as the rate of travel decreases. (4) Wear test has shown that the weight loss of mild steel specimens treated by this combined heat treatment decreases as the rate of travel decreases at the given output power and carbonizing time, and that as the carbonizing time increases the weight loss of these mild steel specimens decreases at the given output power and rate of travel.

심인성 색전 요인이 없는 뇌경색 환자에서 경식도 심초음파와 Acoustic Quantification을 이용한 대동맥 탄성의 평가

이종민,윤호중,임효영,박지원,김휘열,전희경,문건웅,정욱성,채장성,김재형,최규보,홍순조 대한순환기학회 2000 Korean Circulation Journal Vol.30 No.8

공동주택 바닥충격음 차폐성능평가 실태에 관한 연구

윤웅기 ; 이성호 ; 조백희 김천대학교 2002 김천대학교 논문집 Vol.23 No.-

Now, Resident in apartment is over 50% in our country.

한국판 분열형 성격척도의 타당화 예비연구

함웅,김묘은,이흥표,양익홍,문희옥 大韓神經精神醫學會 1997 신경정신의학 Vol.36 No.2

In order to product and develop questionnaire which can assess the schizotypal personality by model of criteria in DSM-Ⅲ-R, it was presented following question in this study. First, for the validation and manufacture of scale and sub-subscale that assess overall feature, nine characteristics of the schizotypal personality disorder, this study was concerned with validity, reliability and factor-analysis results of schizotypal personality questionnaire. Second, we would by present how schizotypal personality disorder trend is connected with trait-anxiety, hopelessness and self-concept. Also the difference is compared with. Finally, 396(male 216 Ss/53,8%, female 180 Ss/45.5%) college students with mean age 21.2 years were sampled. Raine(1991)'s schizotypal personality questionnaire(SPQ) which assess nine characterisitics of schizotypal personality disorder in DSM-Ⅲ-R was translated and used. In this results, Raine's schizotypal personality questionnaire was appeared to have high internal validity, split-half reliability and test-retest reliability. Also, 6 factors were affirmed by empirical confirmation through factor-analysis. 6 factors have been very reliable internal validity that ranges from .78 to .83. In these 6 factors, idea of reference, odd or eccentric behavior and odd speech were corresponded to the category model after DSM-Ⅲ-R in Raine's scale. 'Cognitive, perceptive' dimension was centered of factor 1, 'Emotive, affective' dimension was centered of factor 2, social anxiety and constricted affect were constituted to 2nd factor. No close friends, schizoid trend and suspiciousness of schizotypal characteristics were constituted to 3rd factor by 'interpersonal relationship' dimension. These empirical outcomes which confirmed through factor-analysis were very valid and connected much to Raine's scale which assessed schizotypal personality disorder, thus possibility of development and manufacture of schizotypal personality disorder scale through item revision was lighten. In 2nd study the higher schizotypal personality disorder trend, trait-anxiety and hoplessness were higher. But on the contrary, self-concept was lower. The group of high score in schizotypal personality questionnaire had more trait-anxiety and hopelessness than the group of low score in schizotypal personality questionnaire. Contrastly, positive self-concept was high in the group of low score. Also the most predictable variable to the trait-anxiety was factor 2, predictable power R²of factor 2 was 29.1%. To the hopelessness, factor 2 was the most powerful predictable variable. Predictable power of factor 2 was 11.2%, also. In self-concept, factor 2 explained 20.8% of self-concept, thus it was presented that factor 2 had the most powerful explanatory quantity. In these consequences, the factors which have meaningful connection to the trait-anxiety, hopelessness and low self-concept within 6 factors were really factor 2, 3, 1. Among these factors, "Emotive' feature of factor 2 including social anxiety and constricted affect have the most effect on trait-anxiety, hopelessness and self-concept. And next to factor 2, the isolated interpersonal relation which include no close friends and schizoid trend was some influential variable. Also peculiar, unusual preceptual experience, eccentric belief and magical thinking had some effect though small. The college students who had strong schizotypal personality trend had more social anxiety and more constricted emotional empathic ability, less self-expression, less social skill than common college sudents. These elements threaten, interrupt and retard identity establishment and intimacy-seeking which are important developmental tasks within this period. These experiences is accepted to ego-dystonic to schizotypal college students who have some or moderate reality testing, adaptive ability. Moreover, These peoples would feel locus of contol externally, not internally and would have more control-failure experiences. All these elemets elevate anxiety level, give rise to low self-concept and low expectation to the future. These outcomes all confirmed questions which presented in this study.

금속재료의 기계적 물성과 피로한도의 상관 관계

윤웅기 ; 조백희 ; 이성호 김천대학교 2000 김천대학교 논문집 Vol.21 No.-

The dynamic fatigue-life equation is applied to the uniaxial tensile test. On this study, we show that the fatigue limit values can be extracted from the tensile testing data. Consequently, those experi-ments can be correlated and the fatigue limit can be found by the tensile test. The theory is verified by comparing the theoretical fatigue limit from tensile test to experimental fatigue limit from fatigue test. The results can be used to find the reliable fatigue limit by tensile test.