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Choi, Hayoung,Kim, Su-Young,Kim, Dae Hun,Huh, Hee Jae,Ki, Chang-Seok,Lee, Nam Yong,Lee, Seung-Heon,Shin, Soyoun,Shin, Sung Jae,Daley, Charles L.,Koh, Won-Jung American Society for Microbiology 2017 Antimicrobial Agents and Chemotherapy Vol.61 No.10
<P>Macrolide antibiotics are mainstays in the treatment of lung disease due to the Mycobacterium abscessus complex. Although previous studies have reported development of acquired macrolide resistance in this species, limited data are available on the outcomes of lung disease due to macrolide-resistant Mycobacterium abscessus subsp. abscessus. This study evaluated the clinical features, treatment outcomes, and molecular characteristics of macrolide-resistant isolates of M. abscessus subsp. abscessus. We performed a retrospective review of medical records and genetic analysis of clinical isolates from 13 patients who had acquired macrolideresistant M. abscessus subsp. abscessus lung disease between November 2006 and March 2016. Eleven (85%) patients had the nodular bronchiectatic form of the disease, and two (15%) patients had the fibrocavitary form. When acquired macrolide resistance was detected, 10 (77%) patients were on antibiotic therapy for M. abscessus subsp. abscessus, and three (23%) patients were on therapy for lung disease due to other nontuberculous mycobacteria. The median treatment duration after detecting resistance was 24.0 months (interquartile range, 16.0 to 43.0 months). Treatment outcomes were poor, and final sputum culture conversion was achieved in only one (8%) patient, after resectional surgery. All 13 clinical isolates demonstrated point mutations at position 2058 (n = 10) or 2059 (n = 3) of the 235 rRNA gene, which resulted in acquired macrolide resistance. This study indicates that treatment outcomes are very poor after the development of acquired macrolide resistance in patients with M. abscessus subsp. abscessus lung disease. Thus, more effective measures are needed to prevent development and effectively treat macrolide-resistant M. abscessus subsp. abscessus lung disease.</P>
( Hayoung Choi ),( Yun Su Sim ),( Tae Rim Shin ),( Dong-gyu Kim ),( Dong Won Park ),( Tai Sun Park ),( Ji-yong Moon ),( Sang-heon Kim ),( Tae-hyung Kim ),( Jang Won Sohn ),( Ho Joo Yoon ),( Hyun Lee ) 대한결핵 및 호흡기학회 2019 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.127 No.-
Background: The characteristics of bronchiectasis and its clinical implications in patients with previous pulmonary tuberculosis have not been well elucidated using a nationally representative database. Methods: We compared respiratory symptoms, comorbidities, lung function, quality of life, and socioeconomic status in post-tuberculosis subjects with bronchiectasis versus those without bronchiectasis participating in the Korean National Health and Nutritional Examination Survey 2007-2009. Results: The prevalence of bronchiectasis was 2.6% (n = 35) in the 1,352 subjects with previous pulmonary tuberculosis. Bronchiectasis subjects showed lower body mass index (BMI) (21.9 vs. 23.4 kg/m2, P = 0.002) and higher asthma rate (26.8% vs. 4.5%, P < 0.001) compared with those without bronchiectasis. There were no significant intergroup differences in age, lung function, respiratory symptoms, family income, and education. However, compared with subjects without bronchiectasis, bronchiectasis subjects showed lower EuroQoL five dimensions (EQ-5D) index (0.86 vs. 0.93, P = 0.010), which denotes the poor quality of life. Among EQ-5D components, there was a significant difference in the anxiety/depression component (38.5 vs. 12.1, P = 0.002) between two groups. Bronchiectasis subjects were associated with lower EQ-5D index (difference = 0.077, 95% confidence interval: 0.002-0.151), as compared with those without bronchiectasis, using multivariable linear regression with adjustment for demographic characteristics, BMI, education, and family income. Conclusion: The prevalence of bronchiectasis was 2.6% in the subjects with previous pulmonary tuberculosis. Post-tuberculosis subjects with bronchiectasis had higher asthma rate and reduced quality of life than those without bronchiectasis.
Hayoung, Choi,Sejong, Kim,Seung Yeop, Yang Department of Mathematics 2022 Kyungpook mathematical journal Vol.62 No.4
In this paper, we propose the notion of a distance between n points, called a g-metric, which is a further generalized G-metric. Indeed, it is shown that the g-metric with dimension 2 is the ordinary metric and the g-metric with dimension 3 is equivalent to the G-metric.