파랑에 의한 항내진동의 제어에 관한 실험적 연구

최한규,이선용 江原大學校 産業技術硏究所 1994 産業技術硏究 Vol.14 No.-

This study is to investigate harbor oscillation phenomenon according to combination of the wall structures by model experiment in a three dimensional wave basin. Six different types of wall combination were chosen through combination of erect wall, erect dissipation block, and san beach, wave height at selected points in the harbor were measured by electronic wave gage. Test results show that the wall structure composed solely of erect walls showed generally highest harbor oscillation. Since natural beach shows lower reflection than erect dissipation block do, we thought it would be more efficient to use natural beach for improved harbor oscillation. The result showed, however, that the erect dissipation block are more efficient than natural beach to attain less harbor oscillation. The reason seens that the erect dissipation blocks have better capability to control breaking wave on the surface of the structure.

프레탈^(R)정(실로스타졸 50mg)에 대한 실로졸^(R)정의 생물학적 동등성

최한곤,권기철,이승호,김학미,박병주,유봉규,이종달,이경희,하정희,우종수,박인숙,최진석,용철순 한국병원약사회 2003 병원약사회지 Vol.20 No.1

Bioequivalence of two cilostazol tablets, the Pletaal^(R)(Korea Otsuka Pharmaceutical Co., Ltd.) and the Cilozol^(R)(Hanmi Pharmaceutical Co., Ltd.), was evaluated according to the guideline of KFDA, Sixteen normal male volunteers(age 20~29 years old) were divided into two groups and a randomized 22 cross-over study was employed. After two tablets containing 50㎎ of cilostazol were orally administered. blood was taken at predetermined time intervals and the concentration of cilostazol in plasma was determined with an HPLC method using UV detector. The pharmacokinetic parameters(C_(max), T_(max) and AUC_(t)) were calculated and ANOVA was utilized for the statistical analysis of parameters. The results showed that the differences in C_(max), T_(max) and AUC_(t) between two tablets were 4.99%, 1.74% and 7.68%, respectively. The powers(1-β) for C_(max), T_(max) and AUC_(t) were83.92%, 80.12% and 85.03%, respectively. Detectable differences(Δ) and confidence intervals were all less than 20%, and confidence interval of all the parameters were also less than 20% at the significance level(α) of 0.05. All of these parameters met the criteria of KFDA for bioequivalence, indicating that Cilozol^(R) tablet is bioequivalent to Pletaal^(R) tablet.

자궁경부 종양에서 Nested PCR을 이용한 인유두종 바이러스 16형 및 18형의 검출과 임상적 의의

최규연,이종국,최승도,배동한,김휘준,김민관 순천향의학연구소 1999 Journal of Soonchunhyang Medical Science Vol.5 No.2

The aim of this study is to estimate the prevalence of HPV types(16, 18) in cervix of gynecologic patients and to elucidate the relationship of HPV types(16, 18) and clinical characteristics. Human papilloma virus(HPV) has attracted attention as one of the viruses linked to human cancers. Numerous clinical, epidemiological, and molecular studies indicate that certain genital HPV types are associated with cervical carcinoma. Of 100 types of HPV identified today, at least 40 have been found in the anogenital mucosa. A classification of these types into three groups with differing pathogenicity has been proposed: HPV type 6, 11, 42, 43, and 44 are detected more frequently in benign lesions such as condylomata; HPV type 31, 33, 35, 51, 52, and 58 are found more often in low grade squamous intraepithelial lesions than invasive lesions; and HPV 16, 18, 45, and 56 are predominant in high grade squamous intraepithelial lesions and invasive carcinoma. To detect HPV types prevalent in carcinoma of the uterine cervix, a type-specific, sensitive polymerase chain reaction(PCR)-based assay for HPV types 16, 18 was applied to 18 cervical carcinomas(15 squamous cell carcinomas and 3 adenocarcinomas), 21 cases of cervical intraepithelial neoplasia(CIN), and 42 samples of cervicitis and histologically normal. DNA extraction from cervical swab was done using DNAzol™(MBI, USA) and Nested PCR was done using HPV detection kit(Bioneer, Korea). The amplified product was analyzed directly on the basis of the site of ethidium bromide-stained band visible after agarose gel electrophoresis. The results were as follows 1. The positivity rates of HPV type 16 and HPV type 18 were 12.5%(90/718), 2,5%(18/718). so, HPV 16 positive cases(12.5%) was five folds as HPV 18 positive cases(2.5%) 2. Forty eight percents(39/81) of HPV 16 or HPV 18 positive cases were CIN, microinvasive cancer. 3. Age, Gestation number, Clinical stage, Histologic cell type in relation to HPV types were not statistically significant.

클렌부테롤의 피부투과에 미치는 경피흡수촉진제의 영향

최한곤,이종달,유봉규,용철순 한국약제학회 2003 Journal of Pharmaceutical Investigation Vol.33 No.1

Clenbuterol, a selective β_2-adrenergic receptor stimulant, has been introduced as a potent bronchodilator for patients with bronchial asthma, chronic obstructive bronchial disease, chronic bronchitis and pulmonary emphysema. The percutaneous permeation of clenbuterol was investigate in hairless mouse skin after application of 50/50 buffer(pH 10)/propylene glycol solvent mixture. The enhancing effects of various penetration enhancers such as terpenes, non-ionic surfactants, pyrrolidones, fatty acids and some other enhancers on the permeation of clenbuterol were evaluated using Franz diffusion cell. Among terpenes studied, 1,8-cineole was the most effective enhancer, which increase the permeability of clenbuterol approximately 39.33-fold compared with the control without penetration enhancer, followed by menthone with enhancement ratio of 23.57. Nonionic surfactants did not have significant enhancing effects. N-Lauryl-2-pyrrolidone increased the permeability of clenbuterol approximately 4.51-fold compared with the control. Lauric acid increased the permeability of clenbuterol approximately 35.57-fold with decreasing the lag time from 2.64 to 0.52 hr. Oleic acid, linoleic acid, the permeability of clenbuterol 9.24-fold compared with that without enhancer.

LED배열을 이용한 광Vector-Matrix 곱셈에 관한 연구

최평석,박한규 연세대학교 산업기술연구소 1984 논문집 Vol.16 No.2

인코히어런트광은 이용하여 vector-matrix 곱셈기를 LED 배열 및 lens계, mask 등으로 구성하였다. 입력 vector 는 LED 배열로 나타내었으며 matrix 는 mask 상에 면적변조방식으로 부호화 하였다. 곱셈의 결과는 lens계를 통하여 photodiode 배열로 검출하였으며 하나의 채널로 출력을 관찰하기 위해 analog multiplexer를 사용하였다. vector 및 matrix의 원소가 양의 실수 및 복소수일 경우에 대하여 출력파형을 관찰하였으며 특히 복소수 data일 경우 mask 상에 부호화 하는 방법을 제시하였다. The vector-matrix multiplier using incoherent optical illumination is constructed with a LED array, lens system and mask. The input vector is represented by a LED array and the matrix is encoded on a film by the mask modulation method. The result of multiplication is detected by a photodiode array through the lens system, and an analog multiplexer is used for looking at output signal on the channel. When the elements of a vector and matrix are positive number and complex number, the output signal is observed. Finally an encoding method in case of complex data is suggested.

흰쥐에서 다시마 식이가 메트폴민의 체내동태 및 당 흡수에 미치는 영향

최한곤,장보현,이종달,김정애,유봉규,용철순 한국약제학회 2003 Journal of Pharmaceutical Investigation Vol.33 No.3

Drug interactions with food, on occasion, led to serious nutritional and functional changes in the body as well as alterations of pharmacological effect. It, therefore, should be necessary to take drug interactions with food into consideration for effective and safe therapeutics. Diabetes mellitus is a heterogeneous group of disorders characterized by abnormal glucose homeostasis, resulting in hyperglycemia, and is associated with increased risk of microvascular, macrovascular, and neuropathic complications. However, the precise mechanism of diabetes mellitus remins unclear. Three basic objectives in the care of diabetic patients are maintaining optimal nutrition, avoiding hypo-or hyperglycemia and preventing complications. Laminaria japonica is a brown macroalgae which can be used as a functional diet due to high content of diatery fiber. the purpose of this study was to investigate the effect of Laminaria japonica diet on the pharmacokinetics of metformin which are frequently used in the treatment of diabetes. Diabetic rats induced by strep-tozotocin were employed in this study. Blood concentrations of oral hypoglycemic agent, metformin, were measured by HPLC and resultant pharmacokinetic parameters were calculated by RSTRIP. The mechanisms of drug interaction with food were evaluated on the basis of pharmacokinetic parameters such as k_(a), t_(1/2), C_(max), t_(max), and AUC, C_(max), and k_(a), and increase in t_(max), compared to those with normal diet. This oral glucose test showed that Laminaria japonica diet could lower blood glucose level probably through either inhibiting the activity of disaccharidases, intestinal digestive enzymes, or delaying the absorption of glucose. More studies should be followed to fully understand pharmacokinetic changes of metformin caused by ong-term Laminaria japonica diet.

N₂O₃계 거대고리 리간드와 전이금속 이온과의 착물 형성에 관한 연구

최규성,박휴범,유한준 慶南大學校 附設 基礎科學硏究所 1992 硏究論文集 Vol.4 No.-

The stability constants of the complexes of transition metal ions(Co²+, Ni²+, Cu²+, and Zu²+) with N₂O₃-donor macrocyclic lignads such as 1,15-diaza-3,4 : 12,13-dibenzo-5,8,11-trioxacy-cloheptadecane(NenOdienH₄)and 1,15-diaza-3,4 :12, 13-dibenzo-5, 8, 11-trioxacyclooctade-cane( NtnOdieH₄)have been determined by polarographic method in MeOH solution at 25℃. From the results, the followings have been obstained, 1. In MeOH solution, transition metal ions from a 1:1 complex with these ligands. 2. The order complex stability constants of transition metal ions these ligands is Co(II) < Ni(II) <Cu(II) < Zn(II), the same as the natural order of stability proposed by Williams-Irving. 3. The order of stability constants of Ni(II), Cu(II) ions is NenOdienH₄> NtnOdienH₄, of Co(II), Zn(II) ions is NenOdienH₄< NtnOdienH₄.

강원도 유역의 유출 특성에 관한 연구(소양강댐 유역 중심으로)

최한규,백효선,이민섭 江原大學校 産業技術硏究所 2001 産業技術硏究 Vol.21 No.B

This study is finding the most appropriate model of kangwondo watershed. To synthesize earth hydrograph, It is found to several parameters which are used in existing hydrographes. then the synthestic hydrograph is compared and investigated wish many hydrographes of the rivers in kanwondo. These methods, Nakayasu, Clark, SCS are used to calculate the run-off of this watershed. When the calculated run-off is compared with real rating-curves, then it is found that the SCS method using the Clark's concentrantion time is the best way on this area having large watershed, long river length and gentle water slope, the Nakayasu method is more suitable on this area having small watershed, short river length and steep water slope. Also it is founded from analyzing run-off hydrographes, peak run-off and peak time that the Clark's method applied Kirpich's concentration time way is suitable in the area of kanwondo.

불규칙한 수심단면에서 쇄파대 부근의 파고변형

최한규,강장수,이철응 江原大學校 産業技術硏究所 1997 産業技術硏究 Vol.17 No.-

The objective of this paper is to develop two numerical model for predictiong the wave height with set-up/down near the surfzone on a arbitrary beach profile. Two wave models, regular wave model and random wave model, are based on the energy flux equation with the energy dissipation effects. The developed numerical models are verified by comparison of numerical results with analytical solutions that are derived under the simple conditions. The characteristics of parameters included in each model are then investigated and decided to the range of behaviour by the sensitivity analysis. For sensitivity analysis, we carried out total 46 laboratory tests. Finally, the developed numerical models are applied to the field where the wave height near the surfzone has been measured. From the applications fo numerical models, it is concluded that the developed numerical models may accurately predict the wave height with the set-up/down near the surfzone on a arbitrary beach profile.

다시마 식이가 흰쥐에서 글리피지드의 체내동태에 미치는 영향

최한곤,장보현,이종달,유봉규,용철순 한국약제학회 2003 Journal of Pharmaceutical Investigation Vol.33 No.2

Drug interactions with food, on occasion, lead to serious nutritional and functional changes in the body as well as alternations of pharmacological effect. It, therefore, should be necessary to take drug interactions with food into consideration for effective and safe therapeutics. Diabetes mellitus is a heterogeneous group of disorders characterized by abnormal glucose homeostasis, resulting in hyperglycemia, and is associated with increase risk of micovascular, macrovascurlar, and neuropathic complications. However, the precise mechanixm of diabetes mellitus remains unclear. Three basic objectives in the care of diabetic patients are maintaining optimal nutrition, avoiding hypo- or hyperglycemia and preventing complications. The purpose of this study was to investigate the effect of Laminaria japonica diet on the absorption, distribution, metabolism and excretion of glipizide which are frequently used in the treatment of diabetes. Diabetic rats induced by streptozotocin were employed in this study. Blood concentrations of oral hypoglycemic agents were measured by HPLC and resultant pharmacokinetic parameters were calculated by RSTRIP. The mechanisms of drug interaction with food were evaluated on the basis of pharmacokinetic parameters such as k_a, t_1/2, C_max, t_max, and AUC. Administration of glipzide in normal rats treated with Laminaria japonica diet showed significant increase in AUC, k_a, t_1/2, t_max and decrease in C_max, compared to those without Laminaria japonica diet. This might result from adsorption of glipizide on components of Laminaria japonica, causing delayed absorption. Administration of glipizide in diabetic rats treated with Laminaria japonica diet showed significant increase in t_1/2 and t_max, and decrease in C_max, compared to those without Laminaria japonica diet. This might also result from adsorption of glipizide on components of Laminaria japonica, causing delayed absorption and flattened blood concentration of glipizide. The oral glucose test showed that Laminaria japonica diet could lower blood glucose level probably through either inhibiting the activity of disaccharidases, intestinal digestive enzymes, or delaying the absorption of glucose. More studies should be followed to fully understand pharmacokinetic changes of glipizide caused by long-term Laminaria japonica diet.