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하은희,조수헌,김선민,주영수,한상환,하미나,권호장,홍윤철,김창엽 大韓産業醫學會 1998 대한직업환경의학회지 Vol.10 No.1
Group occupational health service programme started in 1990 is one of the measures to cope with limited human and financial resources in occupational health. The programme has expanded rapidly to include 52 institutions, private as well as public, all over the country. In spite of its potential impact on health of employees and practice of occupational health in small and medium sized industries, comprehensive evaluation in terms of quality has not been tried. This study has aims to develop the criteria to assess the quality of newly developed group occupational health service programme, and to investigate the quality of institutions, and finally to develop policies for the quality improvement. 1) Criteria development : By defining occupational health services, in particular for small and medium sized industries, as one of the primary health care, followings are included as core elements of qualitative occupational health programme; accessibility, continuity, comprehensiveness, technical quality, intersectoral collaboration, emphasis on preventive services, community participation, and adequacy. Again each element is divided into five major components of national health system infrastructure developed by the World Health Organization; development of health resources, organized arrangement of resources, delivery of health care, economic support, and management. In turn, each component is categorized into three aspects of quality assessment, structure, process and outcome. Expert panel selected several criteria for each category to evaluate the programme. Criteria were modified according to each group of interviewees, to produce two sets of questionnaire, one for chief operating officer and another for nurses in the institutions, and the chief operating officer and workers in the workplace. 2) Subject : Of all 52 institutions, 25 voluntarily participated in the survey. At individual institution, chief operating officer and practicing nurses were interviewed in depth. After intensive education for interviewees, every interviewees, every interview was performed with standardized guideline and questionnaire. The quality of the 'Group occupational health service programme' was found to be lower than expected. Especially in continuity, comprehensiveness, technical quality, community participation and adequacy, lower quality in structural aspect was commonly identified throughout all the institutions,. Quality in terms of accessibility and continuity highly varied among institutions., To improve quality of the programme, more comprehensive and systematic programme such as accreditation has to be introduced. In addition, human resources, governmental fund and information systems for individual workers are to be developed. As a long range plan, integration of occupational health services into the national health systems and pooling of financial resources and planned allocation should be considered.
유전자 재조합 사람 IFN-beta인 제네베타와 베네세린의 생물학적 활성의 비교
하종천,이협준,박봉환,김진숙,유대근,남상윤 전주대학교 자연과학종합연구소 2003 전주대학교 자연과학연구소 학술논문집 Vol.15 No.1
Background: Recombinant IFN-beta products have been approved for the treatment of several diseases. Recently, Inbionet, Co. has successfully developed rhIFN-beta product, Genebeta. This study was performed in a purpose of confirming the biological activity of Genebeta by comparison with another recombinant IFN-beta, Beneserin which was already approved. Methods: In vitro antiporliferative activity, regulation of MHC class I expression, antiviral activity, regulation of natural killer cell cytotoxicity were studied for functional comparison of these two rhIFN-beta products. Results: Proliferation assay data showed that two recombinant IFN-beta inhibited T cell and Daudi cell proliferation to a similar extent. When antiviral activity was compared, there was no significant difference between them. The treatment of these two rhIFN-beta also resulted in a similar level of upregulation of class I expression on the surface of A549 cells. Cytotoxicity experiment against tumor cells revealed that both of rhIFN-beta could enhance NK cell cytotoxicity to comparable level. Conclusion: All comparison data indicated that rhIFN-beta products, Genebeta and Beneserin have comparable potentials as a biological response modifier.
인체 혈장에서 염산시프로플록사신(시프로플록사신으로서 250㎎) 정량을 위한 HPLC 분석법의 유효성검토
하용화,조성희,천성국,서성훈,류재환,최영욱,이경태 한국약제학회 2004 Journal of Pharmaceutical Investigation Vol.34 No.4
A simple HPLC method with ultraviolet detection of ciprofloxacin in human plasma was developed and validated. After protein precipitation with trichloroacetic acid, chromatographic separation of ciprofloxacin in plasma was achieved at 50℃ with a C_18 column and methanol-phosphate mixture (pH 2.5), as mobile phase. Quantitative determination was performed by ultraviolet detection at 278 nm. The method was specific and validated with a limit of quantification of 100 ng/ml. The infra- and inter-day coefficients of variation were between 1.67% and 10.55% and accuracy between 92.01% and 106.09%. The method has been successfully applied in a bioavailability study of 250 ㎎ ciprofloxacin hydrochloride tablet.
하영록,김훈,유승,정성필,김승환,유인술 대한응급의학회 2002 대한응급의학회지 Vol.13 No.4
Purpose: The purpose of this study is to determine for upper abdominal pain, the accuracy of emergency abdominal ultrasonography (EAU) performed by emergency physicians with limited training. Methods: Two PGY-3 emergency physicians, who had received 2 hours of hands-on training, including the normal anatomy of a biliary system, liver, kindney, spleen, and pancreas, and who had studied the pathologic findings for another month were the subjects of this study. They used a Sonosite 180? to perform EAU on patients with upper abdominal pain within 2 months after training. We determined the agreement between the radiologist’s abdominal ultrasonography(RAU) and EAU by using Kappa statistics. Results: A total of 59 patients were enrolled. The agreement between the EAU and the RAU findings was 0.97, 0.88, 0.79, 0.73, 0.62, and 0.57 for gall bladder (GB) distension, cholelithiasis, GB wall thickening, duct dilatation, choledocholithiasis, and pericholecystic fluid, respectively (p<0.05). Conclusion: The results of EAU, performed by emergency physician with limited training on patients suffering from upper abdominal pain had a significant agreement with the RAU. However, more educations and cautions are warranted for diagnosing pericholecystic fluid and choledocholithiasis.
분말사출성형을 통해 제조된 17-4 PH STS의 인장특성에 미치는 초기 충진율과 열린 기공의 영향
하태권,성환진 국립7개대학공동논문집간행위원회 2005 공업기술연구 Vol.5 No.-
Powder injection molding (PIM) makes use of the shaping advantage of injection molding and is applicable to metals and ceramics. PIM delivers structural materials in a shaping technology, previously restricted to polymers. In this study, the 17-4 PH stainless steel powders with average diameters of 6-14 μm were injection-molded into flat tensile specimens. Sintering of the compacts was carried out at the various temperatures ranging from 1350oC for Ih. In the case of the compacts made with 10-μm powder, sintering temperature was taken from 200-1350oC to investigate the effect of relative density on the tensile properties.
윤성일,남숭환,이봉하 공주영상정보대학 2002 논문집 Vol.9 No.-
OOP 언어인 Java, C++는 대표적인 객체지향 언어로서 널리 사용되고 있다. 이들 언어의 특징은 c1ass를 이용하며 다양한 cast방법에 의한 효율적인 프로그래밍 작성이 용이하다는 것을 볼 수 있다. 본 연구에서는 cast의 효율적인 설계방법과 작성기법들에 대하여 연구하였다. 클래스를 이용하여 모듈을 세분화 조립하는 경우 프로그램 성능향상에 현저히 드러난다. 또한 프로그램활용 목적에 따라 유용성, 이식성, 확장성 등을 고려하여 시스템을 디자인하는 것이 중요하다는 것이다. 쉬운 조작으로 많은 효과를 이를 수 있는 것이 COP언어의 특징이다. OOP 언어는 또한 컴파일 시간과 실행시간에 리턴하는 값이 다른 경우 프로그램에 치명적인 영향을 미치기 때문에 class를 이용한 casting 방법을 이용하는데 상당한 주의가 요구되는 것을 위의 예로 보았다. 이로서 향후 연구과제는 실행시간 리턴 값, 오브젝트 참조 값, 메모리의 효율적 사용방법을 위해 새로운 cast 연산자들인 const_cast, dynamic_cast, reinterpret_cast, static_cast의 효율적인 기능을 분석하는데 있다.