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김곤섭,Eung-goo Lee,Yong-hwan Kim,정태성,Yong-seung Shin,Gee-wook Shin,Hui-guen Cha,Mi-rim Park 대한수의학회 2003 Journal of Veterinary Science Vol.4 No.2
Map of Soluble Proteins from Salmonella enterica Serovar Enteritidis byTwo-Dimensional ElectrophoresisMi-rim Park, Eung-goo Lee, Yong-hwan Kim, Tae-sung Jung, Yong-seung Shin, Gee-wook Shin, Hui-guen Cha and Gon-sup Kim*Institute of Animal Medicine, College of Veterinary Medicine, Gyeongsang National University, Jinju 660-701, KoreaReceived May 17, 2003 / Accepted July 23, 2003J. Vet. Sci. (2003), 4(2), 143-149JOURNAL OFVeterinaryScience*Corresponding author: Gon-sup Kim Laboratory of Veterinary Biochemistry, Collage of Veterinary Medicine, Gyeongsang National University, 900 Gazwa, Jinju 660-701 Korea Tel: +82-55-751-5823, Fax: +82-55-751-5803 E-mail: gonskim@nongae.gsnu.ac.kr
Carbamazepine-Induced Hepatotoxicity
( Gee Young Yun ),( Seok Hyun Kim ),( Heok Su Eun ),( Jong Seok Ju ),( Eaum Seok Lee ),( Byung Seok Lee ) 대한간학회 2017 춘·추계 학술대회 (KASL) Vol.2017 No.1
Introduction: Carbamazepine is a potent anticonvulsant agent with proven efficacy in the treatment of partial and tonic-clonic seizures. An epileptic man diagnosed Lennox-Gastaut syndrome with intractable epilepsy, treated with therapeutic dosages of carbamazepine developed severe hepatitis and hepatic insufficiency. He had a positive response to withdrawal of the drug and supportive care with hepatotonics. The liver injury pattern was hepatocellular type, and the modified Roussel Uclaf Causality Assessment Method scale (RUCAM score) was 8, suggesting adverse drug reaction of carbamazepine. Herein, we report a case of hepatotoxicity secondary to carbamezepine use. Case-Report: A 43-year-old South Korean man with Lennox-Gastaut syndrome visited emergency room (ER) because of the general weakness. Blood work revealed acute liver dysfunction with aspartate aminotransferase, 1737U/L; alanine aminotransferase, 1392 U/L; and international normalized ratio, 1.83 The total bilirubin and alkaline phosphatase levels were 5.70 mg/dL, and 95U/L respectively. He had normal baseline laboratory results before increasing the dose of carbamazepine. Hepatitis A immunoglobulin M and hepatitis B surface antigen were negative, and hepatitis C RNA levels were undetectable. Hepatitis E immunoglobulin M, Cytomegalovirus immunoglobulin M, Ebstein-Barr virus viral-capsid antigen immunoglobulin M was also all negative. On the other hand, the hepatitis B surface antibody was positive. Other etiologies, including autoimmune disease, common toxins, drugs, and iron- or copper-induced insult were considered. However, anti-smooth muscle, anti-mitochondrial, and antinuclear antibodies were all negative, and the serum copper, ceruloplasmin, and 24-hour urine copper levels were in the normal ranges. He usually taked carbamazepine 600mg orally every day and increased the dose of carbamazepine to 1200mg orally every day for strict control of the epilepsy, 3 weeks ago before visiting ER. And the TDM level of the carbamazepine surpassed the normal limit. He did not report any use of alcohol or illicit drugs. The RUCAM score was 8. These findings strongly suggested drug-induced liver injury. Abdomino-Pelvic CT was performed, and it revealed that there was no biliary structure problem. As a result, carbamazepine was immediately discontinued and the patient was managed with supportive care via hepatotonics. He showed improvement of the clinical and laboratory abnormalities, with aspartate aminotransferase and alanine aminotransferase levels of 30 and 8, respectively, after 8 weeks. (Figure) Conclusion: This case report describes a 43-year-old man with epilepsy who experienced liver injury after carbamezepine administration. Usually, the mechanism of the carbamezepine-induced hepatotoxicity is explained by idiosyncratic reaction, irrelevant with dose-dependent effect. However, our case was related with the dose of the carbamazepine. Therefore, our case emphasizes that liver function tests and the TDM level of the carbamazepine should be monitored periodically after administration of carbamazepine.
Analysis of Nitrification by Aerated Multilayer Biofilm Developed on the Gas - permeable Membrane
( Gee Bong Han ) 한국물환경학회 1996 한국물환경학회지 Vol.12 No.2
개스투과성 막위에 형성된 미생물막 해석을 위해 컴퓨터를 이용한 해법을 변형 적용하였다. 미생물 막은 균일한 두층의 막이 지지층에 직각으로 형성된다고 가정하였다. 다층 미생물막 형성은 막내외의 기질의 농도에 대한 물질수지 관계를 이용하여 설명하였다. 컴퓨터를 이용한 수치해석으로 모의 실험을 하였다. 자가영양 질산박테리아의 전체적인 미생물 막에 대한 영향 등을 설명하였다. 각층의 미생물막은 각각의 막을 형성하는 미생물 및 기질의 조건 등에 따라 해석되었다. 성숙된 다층 미생물막은 nitrosomonas와 nitrobacter가 위아래 각각의 층에서 우점종으로 해석되었다. A computer model was modified to describe a biofilm distributed on the gas permeable support. The biofilm was assumed to grow in the direction perpendicular to the support as two homogeneous layers. Derivation and development of the multilayer biofilm model was illustrated by describing mass balance equations on substrate concentrations within the biofilm and reactor bulk liquid. A numerical evaluation was implemented on a computer to obtain simultaneous numerical solution of applicable differential equations. The equations described mass balance on biomass and substrates under non-steady state conditions and provided an illustration to indicate the effect of parameter and reactor condition of autotrophic nitrifiers to overall biofilm reactions. Model behavior was discussed according to the performance of each biofilm layer. Spatial distribution of homogeneous microorganisms and substrates in the film were described in each condition of developed layer. The completely developed multilayer biofilm included inner and outer layer dominated by nitrosomonas and nitrobacter respectively.
Neuroprotection of Lithium is Associated with Inhibition of Bax Expression and Caspase 8 Activation
Gee-youn Kwon,Soo-kyung Kim 대한생리학회-대한약리학회 2001 The Korean Journal of Physiology & Pharmacology Vol.14 No.5
<P> Neuroprotective properties of lithium were investigated by using <I>in vivo</I> NMDA excitotoxicity model. The appearance of TUNEL positive cells was prominent within 24 h of NMDA (70 mg/kg, i.p.) injection in the regions of the cortex, hippocampal formation, and thalamus of mouse cerebrum. NMDA treatment resulted in the extensive enhancement of Bax immunoreactivity in the cortical and hippocampal regions. NMDA also increased the immunoreactivity of caspase 8 in the similar regions of the mouse cerebrum. However, the increased immunoreactivity of Bax and caspase 8 were dramatically attenuated by chronic lithium pretreatment (lithium chloride, 300 mg/kg/d, i.p. for 7∼10 days). At the same time, lithium ion blocked the appearance of TUNEL positive cells, and the morphological assessment indicated an effective neuroprotection by lithium against NMDA excitotoxicity. Although the exact action mechanism of lithium is not straightforward at this time, we propose that the inhibition of Bax and caspase cascade is involved in the neuroprotective action of lithium.
벼 種間交雜 O. sativa L.×O. grandiglumis Prod.에서 戾交雜과 胚珠培養의 效率性
Gee Jung Yu(柳基鉦),Tae Soon Kwak(郭泰淳),Kyung Ho Kang(姜京鎬),Huhn Pal Moon(文憲八) 한국육종학회 1997 한국육종학회지 Vol.29 No.4
For the successful production of F₁ plants and backcrossed progenies, various factors concerning seed-setting and plant recovery from ovules were evaluated in the interspecific cross between Hwaseongbyeo (AA) and O. grandiglumis (CCDD). Ovule culture time was quite critical for plant regeneration from cultured ovules with its highest rate at 15 days after pollination. Plants were not recovered from ovules less than 7 days or more than 21 days after pollination. Hormones applied to plants during booting stage significantly affected seed-setting and plant regeneration. For the seed-setting, GA₃ was most effective with single or combined treatments. 2, 4-D proved quite effective for plant regeneration, showing 80% regeneration rate in 2, 4-D 110ppm treatment and 85% in combined treatment, 2, 4-D 110ppm+NAA 50ppm+Kinetin 75ppm. When F₁ was used as female parent for backcross, seed-setting was quite low due to the severe shattering and abnormal embryo development. Non-clipping and successive pollination method was proved quite effective in preventing of shattering, resulting in elevated seed-setting and plant regeneration compared with the conventional clipping method. Embryo development was increased by successive backcross, reaching the highest rate of 6.3% at BC₃F₁ generation. The same trend was observed for plant regeneration rate, 2, 4% at BC₂F₁ and 100% at BC₃F₁ generation.