강원도 유역의 유출 특성에 관한 연구(소양강댐 유역 중심으로)

최한규,백효선,이민섭 江原大學校 産業技術硏究所 2001 産業技術硏究 Vol.21 No.B

This study is finding the most appropriate model of kangwondo watershed. To synthesize earth hydrograph, It is found to several parameters which are used in existing hydrographes. then the synthestic hydrograph is compared and investigated wish many hydrographes of the rivers in kanwondo. These methods, Nakayasu, Clark, SCS are used to calculate the run-off of this watershed. When the calculated run-off is compared with real rating-curves, then it is found that the SCS method using the Clark's concentrantion time is the best way on this area having large watershed, long river length and gentle water slope, the Nakayasu method is more suitable on this area having small watershed, short river length and steep water slope. Also it is founded from analyzing run-off hydrographes, peak run-off and peak time that the Clark's method applied Kirpich's concentration time way is suitable in the area of kanwondo.

LED배열을 이용한 광Vector-Matrix 곱셈에 관한 연구

최평석,박한규 연세대학교 산업기술연구소 1984 논문집 Vol.16 No.2

인코히어런트광은 이용하여 vector-matrix 곱셈기를 LED 배열 및 lens계, mask 등으로 구성하였다. 입력 vector 는 LED 배열로 나타내었으며 matrix 는 mask 상에 면적변조방식으로 부호화 하였다. 곱셈의 결과는 lens계를 통하여 photodiode 배열로 검출하였으며 하나의 채널로 출력을 관찰하기 위해 analog multiplexer를 사용하였다. vector 및 matrix의 원소가 양의 실수 및 복소수일 경우에 대하여 출력파형을 관찰하였으며 특히 복소수 data일 경우 mask 상에 부호화 하는 방법을 제시하였다. The vector-matrix multiplier using incoherent optical illumination is constructed with a LED array, lens system and mask. The input vector is represented by a LED array and the matrix is encoded on a film by the mask modulation method. The result of multiplication is detected by a photodiode array through the lens system, and an analog multiplexer is used for looking at output signal on the channel. When the elements of a vector and matrix are positive number and complex number, the output signal is observed. Finally an encoding method in case of complex data is suggested.

월 PMP 개념의 적용에 관한 연구

최한규,김남원,최용묵,윤희섭 江原大學校 産業技術硏究所 2001 産業技術硏究 Vol.21 No.B

Normally at a flood season the operation of the dam depends on a short range weather forecast that makes many difficulties of the management at a dry season. It is needed to study the pattern of the long period rainfall. The concept of PMP(Probable Maximum Precipitation) was used for designing dam. From the concept, this study is applied the concept of monthly probable maximum precipitation for operating dam. It can be possible to let us know the appropriateness of a limiting water level at a rainy season. For the operation of dam at a dry season this study can predict roughly the flood season's pattern of precipitation by month or period, therfore the prediction of precipitation can rise efficient operation of a dam.

댐 하류 만곡부 하천에 대한 수리학적 특성 연구

최한규,백효선,이계윤 江原大學校 産業技術硏究所 2005 産業技術硏究 Vol.25 No.A

In order to accurately analyze the detailed hydraulic characteristics of the curved channel in the downstream of dam with the hydraulic structures such as bridge piers, RMA2 model which is one of two-dimensional models is applied to ChunCheon dam downstream curved channel. A series of hydraulic model tests are carried out for comparison studies. HEC-RAS model is also applied to the same site. There are no errors when velocities and water levels resulted from HEC-RAS model RMA2 model are compared with those of hydraulic model test on the straight channel. But, it is found that results of RMA2 model have a better agreement with those of hydraulic model test than those of HEC-RAS model on the curved channel with bridge piers. Additionally, RMA2 model can be predicted the eddy phenomena around bridge piers of the curved channel.

유량변동에 따른 소양강유역 수질의 통계학적 해석

최한규,백경원,최용묵,최진우 江原大學校 産業技術硏究所 2001 産業技術硏究 Vol.21 No.B

This research was conducted with the aim of efficiently managing large scale of rivers such like Songyang-river through predicting water quality change with analyzing the characteristics of the flowing in nutrients and pollutants. The main result will be used as basic data for effectively operating reservoirs through controling water quality and quantity. The relationship between quantity of flow and water quality was analyzed and pollution loading into the basin was estimated. Three areas of Soyang-river upstream and one area of Suip-cheon in Yanggu-gun were selected as research sites. Flow and water quality were measured simultaneously. The relation between quantity of discharge and pollution concentration and between quantity of discharge and pollution loading were analyzed by statistical method, respectively. We provided a rating curve through measuring quantity of discharge(collection quantity of discharge)and pollutograph and pollution loading curve through water quality data. Also, we analyzed the correlation between quantity of discharge per unit area and pollution loading per unit area in each basin. As resurt of this research, Buk-cheon spot revealed an excellent first grade water quality for the items including BOD5, DO, and SS. The correlation coefficient between Buk-cheon spot's quantity of discharge and pollution loading was 0.896~0.996, showing the validity of analysis applying correlation curve formula of quantity of discharge and pollution loading in the same spot. Also, pollution loading per unit area of the items including BOD5, COD, DO, SS, T-N, T-P increased as area of basins get increased following the sequence of Buk-cheon, Suip-cheon, Naelin-cheon spots.

프레탈^(R)정(실로스타졸 50mg)에 대한 실로졸^(R)정의 생물학적 동등성

최한곤,권기철,이승호,김학미,박병주,유봉규,이종달,이경희,하정희,우종수,박인숙,최진석,용철순 한국병원약사회 2003 병원약사회지 Vol.20 No.1

Bioequivalence of two cilostazol tablets, the Pletaal^(R)(Korea Otsuka Pharmaceutical Co., Ltd.) and the Cilozol^(R)(Hanmi Pharmaceutical Co., Ltd.), was evaluated according to the guideline of KFDA, Sixteen normal male volunteers(age 20~29 years old) were divided into two groups and a randomized 22 cross-over study was employed. After two tablets containing 50㎎ of cilostazol were orally administered. blood was taken at predetermined time intervals and the concentration of cilostazol in plasma was determined with an HPLC method using UV detector. The pharmacokinetic parameters(C_(max), T_(max) and AUC_(t)) were calculated and ANOVA was utilized for the statistical analysis of parameters. The results showed that the differences in C_(max), T_(max) and AUC_(t) between two tablets were 4.99%, 1.74% and 7.68%, respectively. The powers(1-β) for C_(max), T_(max) and AUC_(t) were83.92%, 80.12% and 85.03%, respectively. Detectable differences(Δ) and confidence intervals were all less than 20%, and confidence interval of all the parameters were also less than 20% at the significance level(α) of 0.05. All of these parameters met the criteria of KFDA for bioequivalence, indicating that Cilozol^(R) tablet is bioequivalent to Pletaal^(R) tablet.

횡문근융해증과 급성 신부전 및 범발성 혈관내 응고장애를 동반한 열사병 1예

최대은,박수진,권오경,이한규,이영모,이상주,나기량,이강욱,신영태 충남대학교 의학연구소 2003 충남의대잡지 Vol.30 No.2

Heat stroke is a life-threatening illness characterized by an elevated core body temperature that rises above 40% and central nervous system dysfunctions that results in delirium, convulsions, or coma. Heat stroke is subdivided into two forms, classic and exertional. Since strenuous exercise is one of the major exacerbating and precipitating factors, the incidence of exertional heat stroke is high among young adult, especially military personnel undergoing military training. Exertional heat stroke commonly causes rhabdomyolysis, lactic acidosis, acute renal failure, shock and pulmonary edema. We report a case of heat stroke with rhabdomyolysis, acute renal failure, disseminated intravascular coagulopathy(DIC) after strenuous exercise. A 18 year old man was admitted to the hospital because of loss of consciousness. He was a wrestler and he had tried to lose 6kg in weight by jogging and strenuous exercise on that summer day with hot temperature. The development of this illness was favoured by much clothes inappropriate for that environmental condition with a purpose to enhance sweating, and by restricted intake of water and food. On admission, the blood pressure was 80/50mmHg, and body temperature was 39.4℃ with stuporous mentality. Laboratory finding were as follows : in complete blood cell count, hemoglobin was 16.7g/dL and platelet count was 158,000/ mm³. In blood chemistry, AST 1061U/L, ALT 201U/L, BUN 30mg/dL, Cr 2.2mg/dL, LDH 941IU/L, CK 696IU/L were resulted. In arterial blood gas analysis, pH 7.39, pCO₂ 30mmHg pO₂ 86mmHg, HCO₃ 18.4mEq/L, O₂ saturation 96.7% were resulted. In urinalysis, specific gravity 1.025, protein 3+, erythrocyte 2+ were resulted. In brain imaging study, brain CT finding was normal. After appropriate treatments with rapid cooling, hydration and supportive care, he improved with alert mental status. On 2nd hospital day, in laboratory result, thrombocytopenia and coagulopathy were appeared and renal insufficiency was aggravated. So he was treated with platelet concentrate and fresh frosen plasma for DIC, and enough hydration for appropriate urine volume preservation. After all, On 22nd hospital day, he fully recovered and discharged. Nowadays, with followed for some duration, he is wellbeing with no complications.

흰쥐에서 다시마 식이가 메트폴민의 체내동태 및 당 흡수에 미치는 영향

최한곤,장보현,이종달,김정애,유봉규,용철순 한국약제학회 2003 Journal of Pharmaceutical Investigation Vol.33 No.3

Drug interactions with food, on occasion, led to serious nutritional and functional changes in the body as well as alterations of pharmacological effect. It, therefore, should be necessary to take drug interactions with food into consideration for effective and safe therapeutics. Diabetes mellitus is a heterogeneous group of disorders characterized by abnormal glucose homeostasis, resulting in hyperglycemia, and is associated with increased risk of microvascular, macrovascular, and neuropathic complications. However, the precise mechanism of diabetes mellitus remins unclear. Three basic objectives in the care of diabetic patients are maintaining optimal nutrition, avoiding hypo-or hyperglycemia and preventing complications. Laminaria japonica is a brown macroalgae which can be used as a functional diet due to high content of diatery fiber. the purpose of this study was to investigate the effect of Laminaria japonica diet on the pharmacokinetics of metformin which are frequently used in the treatment of diabetes. Diabetic rats induced by strep-tozotocin were employed in this study. Blood concentrations of oral hypoglycemic agent, metformin, were measured by HPLC and resultant pharmacokinetic parameters were calculated by RSTRIP. The mechanisms of drug interaction with food were evaluated on the basis of pharmacokinetic parameters such as k_(a), t_(1/2), C_(max), t_(max), and AUC, C_(max), and k_(a), and increase in t_(max), compared to those with normal diet. This oral glucose test showed that Laminaria japonica diet could lower blood glucose level probably through either inhibiting the activity of disaccharidases, intestinal digestive enzymes, or delaying the absorption of glucose. More studies should be followed to fully understand pharmacokinetic changes of metformin caused by ong-term Laminaria japonica diet.

다시마 식이가 흰쥐에서 글리피지드의 체내동태에 미치는 영향

최한곤,장보현,이종달,유봉규,용철순 한국약제학회 2003 Journal of Pharmaceutical Investigation Vol.33 No.2

Drug interactions with food, on occasion, lead to serious nutritional and functional changes in the body as well as alternations of pharmacological effect. It, therefore, should be necessary to take drug interactions with food into consideration for effective and safe therapeutics. Diabetes mellitus is a heterogeneous group of disorders characterized by abnormal glucose homeostasis, resulting in hyperglycemia, and is associated with increase risk of micovascular, macrovascurlar, and neuropathic complications. However, the precise mechanixm of diabetes mellitus remains unclear. Three basic objectives in the care of diabetic patients are maintaining optimal nutrition, avoiding hypo- or hyperglycemia and preventing complications. The purpose of this study was to investigate the effect of Laminaria japonica diet on the absorption, distribution, metabolism and excretion of glipizide which are frequently used in the treatment of diabetes. Diabetic rats induced by streptozotocin were employed in this study. Blood concentrations of oral hypoglycemic agents were measured by HPLC and resultant pharmacokinetic parameters were calculated by RSTRIP. The mechanisms of drug interaction with food were evaluated on the basis of pharmacokinetic parameters such as k_a, t_1/2, C_max, t_max, and AUC. Administration of glipzide in normal rats treated with Laminaria japonica diet showed significant increase in AUC, k_a, t_1/2, t_max and decrease in C_max, compared to those without Laminaria japonica diet. This might result from adsorption of glipizide on components of Laminaria japonica, causing delayed absorption. Administration of glipizide in diabetic rats treated with Laminaria japonica diet showed significant increase in t_1/2 and t_max, and decrease in C_max, compared to those without Laminaria japonica diet. This might also result from adsorption of glipizide on components of Laminaria japonica, causing delayed absorption and flattened blood concentration of glipizide. The oral glucose test showed that Laminaria japonica diet could lower blood glucose level probably through either inhibiting the activity of disaccharidases, intestinal digestive enzymes, or delaying the absorption of glucose. More studies should be followed to fully understand pharmacokinetic changes of glipizide caused by long-term Laminaria japonica diet.

3차원 분자 모델을 사용한 재료내의 저장 에너지 계산에 관한 연구

최덕기,유한규 대한금속재료학회 2004 대한금속·재료학회지 Vol.42 No.5

This paper addresses a theoretical approach to calculate the amount of the stored energy during a deformation using atomistic level simulation. During a deformation, only a small percent of the energy input is stored in the material, and most of input energy is converted into heat. The cause of the temperature rise within materials is traditionally credited to dislocations, vacancies and other defects. An atomistic material model for fcc such as copper is used to calculated the stored elastic energy. The potential energy is obtained by a molecular dynamics (MD) simulation. Two different states are considered for comparison: one is a perfect state and the other is a state with dislocations. The calculated potential energies in these two states are compared. The difference in the potential energies is considered the amount of the stored elastic energy of dislocations. The conversion factor, i.e., the fraction of the input energy that is stored as elastic energy within a material is then calculated. (Received December 22, 2003)