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Aberrant Expression of p53 in Basal Cell Carcinomas and Squamous Cell Carcinomas
Cho, Baik Kee,Park, Young Min,Choi, Sung Woo,Shim, Sang In CATHOLIC MEDICAL CENTER 1994 Bulletin of the Clinical Research Institute Vol.22 No.2
The p53 gene mutations have been found in a variety of human skin cancers. To date, most studies concerning p53 gene mutations in skin cancers were focused on squamous cell carcinoma (SCC) and its precancerous lesions such as actinic keratosis and Bowen's disease, especially related to ultraviolet light, but few on basal cell carcinoma (BCC). This study was aimed to investigate the aberrant expression rates of p53 mutant gene in BCCs as well as in SCCs and their changes depending upon their clinicopathologic characteristics. An immunohistochemical study was employed using the mouse monoclonnl antibody raised against recombinant human p53 in 30 BCCs and 16 SCCs. Also, clinical and histopathologic analysis by age, sex, site, duration and histopathologic classification were performed. p53 immunoreactivity was observed in 57% of BCCs and 75% of SCCs. In BCCs p53 immnoreactivity was incceased by up to 61% of cases (28/30) developed on the sun-exposed area. In SCCs p53 immunoreactivity (89%) on non-sun-exposed area was unexpectantly higher than that (57%) on sun-exposed area. No significant correlation between p53 immunoreactivity and clinicopathologic characteristics in BCCs and SCCs was noted. Mutations of p53 may play an important role of the pathogenetic sequence in a large part of BCCs as well as SCCs.
The Effects of Systemic Cytotoxic Drugs on Epidermal Langerhans Cells in Guinea Pigs
Cho, Baik Kee,Kang, Sung Bum,Kim, Jin Wou,Rhee, Jeong Ki,Houh, Won CATHOLIC MEDICAL CENTER 1987 Bulletin of the Clinical Research Institute Vol.15 No.1
This study was attempted to know the effects of systemic cytotoxic drugs, known to suppress the bone marrow cells, on epidermal Langerhans cells (LC) and to examine the possible role of the bone marrow in the maintenance of the epidermal LC population in guinea pigs. Intraperitoneal injection of cyclophos phamide (Cy) and methotrexate (MTX) were done eigher at once (300 mg/kg/day for Cy and 350 mg/kg for MTX) or consecutively for 10 days (30 mg/kg/day for Cy and 35 mg/kg/day for MTX). Total white blood cell (TWBC) count and epidermal LC count utilizing ATPase staining were done before and following administration of the cytotoxic drugs. The results were as follows: 1. Statistically significant LC reduction was observed in Cy-administered groups. 2. The decrease and then increase in LC numbers followed the tone marrow suppression and then recovery. 3. The degree of LC reduction and subsequent recovery correlated to the degree of the bone marrow suppression. 4. More than 15-25 days were required for the injured epidermis to regain normal LC number in Cy-administered groups. Above results presents evidence of the effects of the systemic cytotoxic drugs on epidermal LC-ATPase in guinea pigs and support the idea that LC are being replenished from the bone marrow following epidermal injury. Further studies are requred to know whether the LC recovery in numbers is due only to LC migrating from the bone marrow following the injury or also includes local recovery of LC injured, but not totally lost.
Distribution of Trombiculid Mites Collected from Wild Rodents in a Certain Area of Kyung-Ki Province
Cho, Baik Kee,Park, Byoung Chan CATHOLIC MEDICAL CENTER 1991 Bulletin of the Clinical Research Institute Vol.19 No.1
The purpose of this study is to investigate the distribution of the trombiculid mites, especially Leptotrombidium pallidum which is considered to be the most probable lector species of tsutsugamushi disease in Korea. Mites were collected from the wild rodents captured with Sherman traps in a certain area of Pyung-Taik Gun, Kyung-Hi Province from October 1989 to November 1990. The results were summarized as follows: 1. A total of 2, 419 trombiculid larvae belonging to 4 species of 3 genera was collected from 77 wild rodents of 69 Apodemus agrarius and 8 Crocidura species. 2. The species of trombiculid mites were L. Pallidum (96.4%), Neotrombicula Japonica (3.1%), L. Palpale (0.3%), Cheladonta ikaoensis (0.1%). 3. The average number of collected trombiculid mites per one wild rodent was 34.0 in A. agrarius and 9.4 in Crocidura species. 4. The total number of trombiculid mites collected from 10 wild rodents that were alive during the 5 consecutive collection days was 785, and 16.7% of the mites was collected in the first day, 44.2% in the second day, 21.7% in the third day, 17.1% in the fourth day and 0.4% in fifth day. The total number of trombiculid mites collected from the 4 wild rodents that were dead within the first day of collection was 71, and 93.0% of the mites was collected in the second day. 5. Most of the L. pallidum was collected in March, May, October and November and none in June, July and August. The numbers of L. pallidum per one wild rodent were 139.6 in October 1989, 125.5 in March 1990, 41 3 in October 1990, 33.1 in November 1990 and 30.5 in April 1990 in decreasing orders. From these results, A. agrarius was the main wild rodent from which L. pallidum was collected and the seasonal distribution of L. pallidum was partly correlated with the known seasonal distribution of tsutsugamushi disease in Korea.
Pigmented Nevi on the Palms, Soles, and Genitalia in Korean
Cho, Baik Kee,Baek, Seung Churl,Kim, Chung Won CATHOLIC MEDICAL CENTER 1994 Bulletin of the Clinical Research Institute Vol.22 No.1
There was 2 views with regard to the treatment of pigmented nevi on the palms, soles, and genitalia. One advocated that pigmented nevi on these locations should be prophylactically removed to avoid their possible development into malignant melanoma, while the other belived that this is not practicable. Our purpose was to determine the incidence rates and clinical characteristics and to discuss the management of pigmented nevi, developed on these areas of Korean. We examined 1,537 Korean males, between the ages of 19 and 21 years, to evaluate the pigmented nevi on their palms, soles, and genitalia. The results were as follows; 1. At least 1 pigmented nevus appeared in 314 (20.4%) males on the palms,189 (12.3%) on the soles, and 117 (7.6%) on the genitalia. 2. The mean diameter of each nevus on the genitalia, soles, and palms was 4.5mm, 3.1mm, and 2.3mm respectively. 3. The color of the nevi was darkest on the penile shaft (4.3 points) and then glans penis (3.9 points), soles (3.2 points), palms (2.5 points) in decreasing orders of the points. 4. Most of the nevi were consistent with type 1 by Lever's clinical classification and their incidences were 357 on the palms, 211 on the soles, and 128 on the genitalia. Among the 21 nevi of type 2, 13 nevi appeared on the soles, and non of the type 3 and type 5 were found. 5. The distribution of the nevi on the palms was of a rather uniform and scattered pattern, whereas, on the soles, they were distinctly concentrated in the midfoot. The nevi on the glans penis (mucosal component) appeared larger and more irregular in outline than those on the penile shaft (cutaneous component). In present study, the plantar nevi were larger, darker, and had greater incidence of elevated type compared with the palmar nevi, and this observation has been allowed to progress to a biologically malignant phase. The authors therefore recommend that particular attention should be paid to the presence of pigmented nevi on the soles because of less favorable clinical characteristics of nevi.
The Mite Fauna of Korean House Dust (Ⅰ)
Cho, Baik Kee,Houh, Won CATHOLIC MEDICAL CENTER 1976 Bulletin of the Clinical Research Institute Vol.4 No.1
In this study there are no significant changes of serum K values in the traumatized group compared with the control group. It is obscure whether the results are due to healing state of wound site following trauma, hemodilution effect of circulating blood by blood loss and fluid replacement, or difference of species. It is necessary to continue experiments and study for further evalution of this problem.
Cho, Baik Kee,Jeong, So Hee,Lee, Dong Won,Park, Chul Jong,Lee, Sang Chin,Paik, Seung Churl,Cho, Sang Hyun,Yi, Jong Yuk,Kim, Tae Yoon,Kim, Jin Wou,Kim, Si Yong,Cheong, Ji Yun,Yang, Kyung Mee 대한의진균학회 2000 대한의진균학회지 Vol.5 No.1
이 트라코나졸은 약물역동학적으로 피부 각질에 친화성이 높고 투약 종료 후에도 4주간 지속되며 고용량 단기간 투여가 효과적이라는 것이 알려지면서 각화형의 수장부/족부 백선 치료에도 고용량단기간 투여법이 시도되고 있다. 본 연구는 각화형의 수장부/족부 백선 환자 97명을 대상으로 이트라코나졸 1일 400 mg을 7일간 투여하여 효과 및 안전성을 평가하였다. 투약 전, 투약 후, 투약 종료 4주후에 임상적, 진균학적으로 효과를 평가하여 임상적으로 73.8%에서 중등도 이상의 개선, 진균학적으로는 84.5%의 완치율을 얻었다. 97.6%의 환자에서 양호한 내약성을 나타내었고, 2.4%에서 위장관 증상, 피부 발진 등이 발생하였으나 특별한 치료 없이 호전되었다. 이상과 같은 결과로 각화형의 수장부/족부 백선 치료에 이트라코나졸 400mg 7일 투여는 효과적이면서 동시에 안전한 치료법임을 확인하였다. [의진균지 5(1): 7-12]