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식도암에서 방사선 단독치료와 방사선 및 항암화학요법제 치료의 효과
천선희(Seon Hee Cheon),정현철(Hyun Cheol Chung),김주항(Joo Hang Kim),함영환(Yong Hwan Ham),박용준(Yong Jun Park),정재복(Jae Bock Chung),노재경(Jae Kyung Roh),이상인(Sang In Lee),박인서,최흥재,서창옥(Chang Ok Suh),김귀언(Gwi Eon Kim),노준규 대한내과학회 1988 대한내과학회지 Vol.35 No.5
N/A The role of adjuvant chemotherapy in the treatment of esophageal carcinoma was examined in a review of 84 patients. Between January 1984 to April 1988, 35 patients were treated with radiotherapy alone, 32 patients were treated with combined radiotherapy and chemotherapy (5-fluorouracil(5-Fu) and cisplatin), and 17 patients were untreated due to their economic problems. The 1 and 2-year survival rates among patients treated by radiation were 40% and 0%, respectively, whereas they were 28%, and 14% in patients treated with combined modality, and 40%, and 0% in patients without any treatment. In stage IV disease, the survivals at 1 and 2-years of patients with combined treatment were superior to the survivals of the radiotherapy alone treated group (p<0. 001), In both treatment groups, the actual survival rate was higher in patients with good Eastern Cooperative Oncology Group (ECOG) performance status (p<0.001). Treatment was well tolerated, and acute toxicity included esophagitis, stomatitis, and leukopenia. Late toxicities were predominantly manifestated as stricture, pneumonia, and mediastinitis. This combination of radiation therapy with infusional 5-FU and cisplatin is an effective and relatively well-tolerated regimen in the Treatment of esophageal cancer.
인체 폐암세포주에서 다약제내성유전자 표현과 Buthionine Sulfoximine 투여가 Cisplatin 및 Adriamycin 의 세포독성도에 미치는 영향
천선희(Seon Hee Cheon),유내춘(Nae Chun Yoo),김주항(Joo Hang Kim),김성규(Sung Kyu Kim) 대한내과학회 1994 대한내과학회지 Vol.46 No.5
N/A Objectives: Cisplatin and adriamycin have been proven to be the most effective drugs for lung cancer, However, repeated courses of chemotherapy frequently result in a decreased therapeutic response because of the emergence of an acquired drug-resistance. Recently it has been demonstrated that the resistance to cisplatin, adriamycin or alkylating agents may be due to elevated intracellular glutathione levels in human and rodent tumor cell lines. This study was aimed to investigate any relationship between intracellular glutathione levels and sensitivity to cisplatin and adriamycin, and whether cytotoxicity to cisplatin and adriamycin could be in- creased with buthionine sulfoximine. Methods: We used human SCLC cell line, NCI-H209, and three human NSCLC cell lines, NCI-H727, NCI- H810 and NCI-H1299. The multidrug resistance gene expression was investigated by RNA slot blot analysis. The intracellular glutathione levels was examined before and after administration of buthionine sulfoximine. Drug sensitivity assays were performed using a modified MTT method. Results: 1) The resistance to adriamycin and cisplatin in human lung cancer ce11 lines was closely related to MDR1 expression level rather than that of intracellular glutathione level. Cisplatin resistance seemed to be related to the glutathione level above some concentrations. 2) 5-Fluorouracil resistance seemed not to be related to MDR1 expression or glutathione level. 3) Buthionine sulfoximine was not effective on adriamycin and cisplatin cytotoxicity in MDR1 positive cells, but effective in MDR1 negative cells. Conclusion: It is suggested that buthionine sulfoximine is an effective supplement to adriamycin and cisplatin in MDR1 negative cells. And its effectiveness in human lung cancer patients needs a further clinical studies.
스토리맵 중심 언어중재가 정신지체아동의 이야기 이해와 산출에 미치는 효과
천선희(Seon Hee Cheon),김정미(Jung-Mee Kim) 한국언어청각임상학회 2007 Communication Sciences and Disorders Vol.12 No.3
배경 및 목적: 스토리맵은 이야기 텍스트의 이해를 촉진하기 위해 이야기문법 요소들을 사용하는 중재 방법이다. 이 연구는 초등학교 정신지체아동 3명을 대상으로 스토리맵 중심 언어중재를 실시하여 정신지체아동의 이야기 듣기 이해와 이야기 산출에 미치는 효과를 알아보고자 하였다. 방법: 중재는 16회기 동안 진행하였으며 매 회기마다 평가와 훈련을 실시하였다. 연구자는 아동에게 이야기를 들려준 다음 이야기 다시 말하기와 이해 과제를 실시하였다. 평가가 끝난 다음에는 이야기문법 질문을 통해 아동이 이야기문법 요소들을 확인하고 스토리맵을 완성할 수 있게 도왔다. 결과: 첫째, 세 아동 모두 이야기 이해 과제에 대한 수행 수준이 향상되었으며, 중재가 끝난 뒤에도 수행 수준이 향상된 것으로 나타났다. 둘째, 세 아동 모두 이야기문법 회상산출 능력이 향상되었으며, 중재가 끝난 뒤에도 향상된 산출 능력을 유지한 것으로 나타났다. 셋째, 세 아동 모두 이야기 회상 구성력이 향상된 것으로 나타났으며, 중재가 끝난 뒤에도 향상된 회상 구성력을 유지한 것으로 나타났다. 논의 및 결론: 이상의 결과를 통해 스토리맵 언어중재는 정신지체아동의 이야기 이해와 산출에 긍정적인 효과를 미친다고 볼 수 있다. 따라서 스토리맵 훈련은 학령기 정신지체아동의 이야기 담화능력을 향상시키는 중재 방법으로 시사하는 바가 크다. Background & Objectives: Story mapping is the intervention of a story-telling session by using grammar components to promote story comprehension. The purpose of this study was to evaluate the effects of language intervention based on story mapping on story comprehension and recall for children with mild mental retardation. Methods: Three children with mental retardation participated in this study. Intervention was conducted for 16 sessions and each session was composed of both probing and training. Each subject listened to the story the researcher told, and they were asked to retell the story and to perform comprehension tasks. After the completion of probing, the researcher told the subject a story, helped them to identify story grammar components, and assisted in the building of a story map. Results: First, the children’s performance was improved in all comprehension tasks and their performance was also progressed after the story mapping intervention. Second, the children showed improvement in producing story grammar components during story retelling tasks that remained after completion of intervention. Third, the children showed that their recall in all components was improved, and that it was maintained after completion of the intervention. Discussion & Conclusion: This study showed that story mapping intervention was effective in improving story comprehension and retelling for children with mental retardation.