Cortical Stroke in Parietal Lobe Misdiagnosed as Carpal Tunnel Syndrome

Kim, Seok-Won,Ju, Chang-Il The Korean Neurosurgical Society 2007 Journal of Korean neurosurgical society Vol.41 No.5

A 56-year-old woman presented with the numbness and pain in the left hand in the 1st, 2nd and 3rd finger area that developed suddenly 7 days prior to admission. In nerve conduction velocity test, the deterioration of nerve conduction velocity as well as the reduction of the potential amplitude were detected. After diagnosis of carpal tunnel syndrome, the open median nerve release was performed. Nonetheless, the preoperative symptoms did not change. The magnetic resonance images [MRI] of brain revealed a cerebral infarction in sensoricortical area of parietal lobe. The patient was referred to the department of neurology, and after conservative treatment, her symptoms were improved.

A Multicenter Analysis of Clinical Features and Long-Term Outcomes of POEMS Syndrome in Korea

Kook Hye Won,Jang Ji Eun,Min Chang-Ki,Yoon Dok Hyun,Kim Kihyun,Bang Soo-Mee,Park Yong,Lee Jae Hoon,Yoon Sung-Soo,Kim Jin Seok 대한의학회 2024 Journal of Korean medical science Vol.39 No.2

Background: POEMS syndrome is a rare form of plasma cell dyscrasia characterized by polyneuropathy, organomegaly, endocrinopathy, monoclonal proteins, and skin changes. Owing to its low incidence, there are few reports regarding this syndrome. This multicenter study included 84 patients diagnosed with POEMS syndrome in South Korea. Methods: We retrospectively evaluated 84 patients diagnosed with POEMS syndrome at 8 hospitals in South Korea between January 2000 and October 2022. The clinical characteristics and treatment outcomes were analyzed. Results: The median patient age was 53 years (range, 26–77 years), and 63.1% of the patients were male. All patients had peripheral neuropathy, and 81 (96.4%) had monoclonal plasma cell proliferation. Plasma vascular endothelial growth factor levels were available for 32 patients with a median of 821 pg/mL (range, 26–12,900 pg/mL). Other common features included skin changes (54.2%), volume overload (71.4%), and organomegaly (72.6%). Of the 84 patients, 75 received initial treatment (local radiotherapy, 6 [8.0%]; chemotherapy, 17 [22.7%]; both chemotherapy and local radiotherapy, 9 [12.0%]), upfront autologous stem cell transplantation (ASCT), 43 (57.3%; with induction chemotherapy, n = 12, 16.0%; without induction chemotherapy, n = 31, 41.3%). The median follow-up duration was 40.7 months. The 5-year overall survival (OS) was 78%, and the 5-year progression-free survival (PFS) was 55%. Patients who underwent upfront ASCT and were diagnosed after 2014 had a longer OS and PFS. Conclusion: The demographics of Korean patients with POEMS syndrome were similar to those reported previously. Because of the introduction of new treatment agents and the reduced rate of transplant-related mortality related to ASCT, the treatment outcomes of Korean patients with POEMS syndrome have improved in recent years.

측면 방사선 촬영 자세의 표준화를 위한 정상 척추의 시상면 정렬의 분석

김민석(Min-Seok Kim),정석원(Seok-Won Chung),황창주(Changju Hwang),이춘기(Choon-Ki Lee),장봉순(Bong-Soon Chang) 대한정형외과학회 2005 대한정형외과학회지 Vol.40 No.7

목적: 양팔의 자세 변화에 따르는 척추의 시상면 정렬의 차이를 분석하고, 환자에게서 가장 기능적인 시상면 정렬을 재현 할 수 있는 측면 기립 방사선 촬영 자세를 제시하고자 하였다. 대상 및 방법: 정상 성인 남자 30명에 대해 제7 경추와 제1 천추의 피부 표면에 표식자를 부착시킨 후 전 척추측면 기립 방사선 촬영을 시행하였다. 팔을 내리고 서있는 자세(자세 A), 견관절을 각각 30°, 90° 굴곡한 자세(자세 B, C), 양팔을 끌어안은 자세(cross-arm position) (자세 D), 견관절을 90° 굴곡시킨 후 팔을 수평봉에 얹은 자세(자세 E)를 취하게 하여, 자세 변화에 따른 시상 수직축(sagittal vertical axis), 흉추 후만각, 요추 전만각, 천추 전경각의 차이에 대해 분석하였다. 결과: 자세 A에서 E의 평균 시상 수직축은 각각 +1.47±2.06 cm, -0.58±2.96 cm, -2.11±2.67 cm, +0.16±2.38 cm, -0.51±2.70 cm으로 일차원 분산분석(one-way ANOVA)을 시행한 결과 그룹간의 유의한 차이를 보였고(p<0.001), Duncan의 사후검증결과 자세 A와 D는 차이가 없는 것으로 판단되어 자세 D가 자세 A에 대해 가장 유사한 자세로 나타났다. 흉추 후만각, 요추 전만각, 천추 전경각은 자세간의 유의한 차이를 보이지 않았다. 결론: 양팔을 끌어안은 자세(crosss-arm position)는 평상시 서있는 자세와 가장 유사한 기능적인 시상면 정렬을 구현할 수 있는 자세로 생각된다. Purpose: To analyze the difference in sagittal balance based on different positions of both arms and to promote the proper lateral spine view which can reconstruct the most functional posture of sagittal balance. Materials and Methods: We applied X-rays to thirty healthy male adults with no spinal diseases after application of marks on the skin surface at the location of the C7 and S1 vertebrae with the following five postures, standing lateral position with both arms neutral (posture A) with both shoulders flexed thirty degrees and ninety degrees (postures B and C) with both arms crossed (posture D) with both shoulders flexed ninety degrees and with both arms on a parallel bar (posture E). We analyzed the differences of the sagittal vertical axis, thoracic kyphotic angle, lumbar lordotic angle, and sacral inclination angle after the postural changes. Results: The average sagittal vertical axis value from posture A to E was 1.47±2.06 cm, -0.58±2.96 cm, -2.11±2.67 cm, 0.16±2.38 cm, and -0.51±2.70 cm. We discovered that five postures were statistically different (one-way ANOVA, p<0.001) and that posture D was the closest to posture A (Duncan's multiple comparison test). However we did not observe any statistical differences among the thoracic kyphotic angle, the lumbar lordotic angle, and sacral inclination angle postures. Conclusion: We can reconstruct the functional sagittal alignment in the cross-arm position, which is the closest to the normal standing position.

Operation Range‑Optimized Silver Nanowire Through Junction Treatment

Jae‑Chan Lee,Jong‑Sung Lee,Phillip Won,Jung Jae Park,Seok Hwan Choi,Seung Hwan Ko,Byoung‑Joon Kim,이소연,Young‑Chang Joo 대한금속·재료학회 2020 ELECTRONIC MATERIALS LETTERS Vol.16 No.5

In past decades, stretchable conductors have been investigated for a wide range of applications, and the operation strain rangeof such devices varies by application. To commercialize stretchable devices, it is necessary to optimize the deformation ofstretchable electrodes based on a given device elongation range. Therefore, we investigated the deformation mechanics ofa silver nanowire (AgNW) electrode on an elastomeric substrate depending on its junction treatment method. At low-strain(< 15%), a thermally annealed AgNW electrode showed more stable resistance than a laser-welded AgNW electrode. Conversely,at high strain (> 20%), the thermally annealed AgNW electrode rapidly increased in resistance, while the laser-weldedAgNW electrode showed lower resistivity change. By in situ surface analysis and a repetitive tensile test, we observed thatthe thermally annealed AgNW electrode shows less cracking at low strain but the laser-welded AgNW electrode exhibitsfracturing of individual nanowires at low strain. Furthermore, at high strain, laser-welded AgNWs could slide to reducestress during elongation, resulting in a smaller change in resistance compared to that of thermally annealed AgNW electrode. These results indicate that optimization of adhesion is necessary to fabricate stretchable devices based on deformation range.

Safety and efficacy of dietary supplement (gintonin-enriched fraction from ginseng) in subjective memory impairment: A randomized placebo-controlled trial

Lee Woo-Jin,Shin Yong-Won,Chang Hyeyeon,Shin Hye-Rim,Kim Won-Woo,Jung Seok-Won,Kim Manho,Nah Seung-Yeol 한국한의학연구원 2022 Integrative Medicine Research Vol.11 No.1

Background: Gintonin inhibits β-amyloid production, increases acetylcholine level in the brain, and promotes neurogenesis. We evaluated the efficacy of gintonin-enriched fraction (GEF) in improving the cognitive performance in subjective memory impairment. Methods: In this 8-week, randomized, assessor and participant blinded, placebo–controlled study, participants with subjective memory impairment but preserved cognitive function (Korean Mini-Mental State Examination [K-MMSE] score ≥23) were assigned to GEF 300mg/day or placebo. K-MMSE, Korean versions of the Alzheimer's disease assessment scale, color-word stroop test (K-CWST), clinical dementia rating, and Beck depression inventory-II were evaluated along with the safety profiles. The primary outcome was set as the change in the K-MMSE. Results: Seventy-six participants complete the study protocol. After 8 weeks, there was no inter-group difference in the primary or secondary outcome score changes. However, GEF group showed an improvement in the K-MMSE scores (P= 0.026), and in the number of correct answers in both word reading (P= 0.008) and color reading (P= 0.005) of K-CWST, although only the improvement in the K-CWST scores were higher than the minimum clinically important difference. The frequency of adverse events was comparable between the groups and all were of mild severity. Conclusion: GEF is safe but might not be effective in treating subjective memory impairment within the current study setting. However, GEF showed a trend of improving the global cognition and the frontal executive function. Further large-sized studies with longer follow-up period are warranted. Clinical trial registration: This clinical trial was registered at Clinical Research Information Service of Korea Centers for Disease Control and Prevention: KCT0004636. Background: Gintonin inhibits β-amyloid production, increases acetylcholine level in the brain, and promotes neurogenesis. We evaluated the efficacy of gintonin-enriched fraction (GEF) in improving the cognitive performance in subjective memory impairment. Methods: In this 8-week, randomized, assessor and participant blinded, placebo–controlled study, participants with subjective memory impairment but preserved cognitive function (Korean Mini-Mental State Examination [K-MMSE] score ≥23) were assigned to GEF 300mg/day or placebo. K-MMSE, Korean versions of the Alzheimer's disease assessment scale, color-word stroop test (K-CWST), clinical dementia rating, and Beck depression inventory-II were evaluated along with the safety profiles. The primary outcome was set as the change in the K-MMSE. Results: Seventy-six participants complete the study protocol. After 8 weeks, there was no inter-group difference in the primary or secondary outcome score changes. However, GEF group showed an improvement in the K-MMSE scores (P= 0.026), and in the number of correct answers in both word reading (P= 0.008) and color reading (P= 0.005) of K-CWST, although only the improvement in the K-CWST scores were higher than the minimum clinically important difference. The frequency of adverse events was comparable between the groups and all were of mild severity. Conclusion: GEF is safe but might not be effective in treating subjective memory impairment within the current study setting. However, GEF showed a trend of improving the global cognition and the frontal executive function. Further large-sized studies with longer follow-up period are warranted. Clinical trial registration: This clinical trial was registered at Clinical Research Information Service of Korea Centers for Disease Control and Prevention: KCT0004636.

Safety of a Traditional Korean Medicine, Cheonggan extracts (CGX)

Jang-Woo Shin,Jung-Hyo Cho,Dong-Seok Seo,Nak-Won Sung,Min Kwon,Chang-Gue Son 대한한의학회 2009 대한한의학회지 Vol.30 No.6

부갑상선호르몬 분비가 저하된 혈액투석 환자에서 저칼슘투석액 사용시 칼슘감지수용체의 유전자 다형성에 따른 호르몬 분비의 변화

박태진 ( Tae Jin Park ),서장원 ( Jang Won Seo ),백관미 ( Kwan Mi Pack ),장재원 ( Jai Won Chang ),양원석 ( Won Seok Yang ),김순배 ( Soon Bae Kim ),이상구 ( Sang Koo Lee ),박수길 ( Su Kil Park ),박정식 ( Jung Sik Park ) 대한신장학회 2007 Kidney Research and Clinical Practice Vol.26 No.4

Purpose : Low level of parathyroid hormone (PTH) is a risk factor that might cause hip fracture in dialysis patients. Low calcium dialysate (LCD) has been suggested as an approach to increase PTH level. The calcium- sensing receptor (CaSR) polymorphism is known to be associated with the sensitivity to extracellular calcium. Methods : We prospectively investigated the role of genetic polymorphism of CaSR codon 990 as one cause of the different parathyroid responses to LCD in maintenance hemodialysis (HD) patients. 48 patients, using 3.5 mEq/L calcium dialysate, with intact PTH below 100 pg/ml for the last one year underwent HD sessions on 2.5 mEq/L calcium dialysate for 12 weeks. Serum intact PTH, total calcium, phosphorus, alkaline phosphatase (ALP) and bone-specific ALP (BAP) were measured monthly. The CaSR gene from peripheral lymphocytes was amplified to confirm the genotype by polymerase chain reaction. Results : According to the CaSR genetic polymorphism, subjects were divided into 3 groups, A/A (14.6%), A/G (45.8%) and G/G (39.6%). Twelve weeks later, intact PTH (48.5±25.4 to 89.0±49.4 pg/mL, p<0.01), and ALP (78.7±25.7 to 87.4±27.2 IU/L, p<0.01) increased significantly in G/G group, but not in non-G/G groups. However, BAP significantly increased in both G/G group (24.3±11.9 to 29.5±10.6 U/L, p<0.01) and in non-G/G groups (21.4±4.5 to 26.1±9.1 U/L, p<0.01). During the study period, levels of corrected total calcium and phosphorus were not significantly changed. Conclusion : The CaSR polymorphism, G/G genotype, strongly influenced the responsiveness of parathyroid gland to LCD, compared with non-G/G genotypes. However, bone formation may occur actively on LCD, irrespective of CaSR genetic polymorphism.

Endoscopy and Imaging Modalities/Basic Science of Gastrointestinal Disorders/Miscellaneous : Changing Pattern Of Digestive And Liver Disease In Korea, 1990-2006 Year; A Single Center Study

( Jung Hyun Kwon ),( Sang Woo Kim ),( In Sik Chung ),( Myung Gyu Choi ),( Kwan Woo Nam ),( Jung Pil Suh ),( Jae Hyuck Chang ),( Won Haing Hur ),( Yu Kyung Cho ),( Jae Myung Park ),( In Seok Lee ) 대한소화기학회 2007 SIDDS Vol.9 No.-

Background/Aims: Westernization in many Asian countries have changed lifestyles and diets, so once rare diseases have now become prevalent. The aim of this study is to investigate the changing pattern of digestive and liver disease in Korea, from 1990 to 2006. Methods: We extracted data specific gastrointestina (GI) disease based on the International Classification of Diseases code from the in-patients records at the Kangnam St. Mary`s Hospital in 1990, 1996 and 2006. This hospital is a tertiary-care hospital in Seoul, Korea, which has a capacity of 800 beds. Results: The admission rate for GI disease increased between 1990 and 2006. Overall in-patients were 1,623 persons in 1990, 2,368 persons in 1996 and 4,166 persons in 2006. The mean age of in-patients increased as time went by. A stomach cancer was the most common diagnosis during all periods, but its prevalence has decreased. Colon cancer ranked the 7th in 1990, but markedly increased and now ranks the second. The third was a hepatocellular carcinoma. The bile duct and gallbladder cancer, pancreas and esophageal cancer ranking followed with little interval change. In cases of cancer patients, a regular admission dramatically increased for chemotherapy. The number of patients admitted with pre-malignant neoplasm of stomach and colon increased remarkably with the development of endoscopy. The liver transplant, inflammatory bowel discase, and reflux esophagitis emerged form mid-1990s with greater frequencies, yet much below the levels found in the West. The admission rate for peptic ulcer, especially ulcer bleeding remained relatively stable, despite a decreased rate for ulcer perforation. Liver cirrhosis, hepatitis, cholelithiasis with cholecystitis-cholangitis, appendicitis, hemorrhoid and gastritis all decreased. Conclusions: The stomach cancer is the leading cause of admission, despite a recent decline. Colon cancer showed a marked rise. The liver transplant, inflammatory bowel disease and reflux esophagitis were new diagnosis with an increased tendency.

CO2 해양 지중저장 공정설계 및 모니터링 기술개발

허철(Cheol Huh),강정원(Jeong-Won Kang),문일성(Il-Sung Moon),장대준(Dae-June Chang),최항석(Hang-Seok Choi),민동주(Dong-Joo Min),강성길(Seong-Gil Kang) 대한조선학회 2011 대한조선학회 학술대회자료집 Vol.2011 No.6

이산화탄소 포집 및 저장기술(Carbon dioxide Capture and Storage, CCS)이 기후변화 대응 기술로서 국내외적으로 주목 받고 있다. CCS 기술은 발전소 및 제철소 등 대규모 발생원에 서 배출되는 CO2를 포집, 파이프라인이나 선박 등을 통해 수송, 그리고 이를 지중에 장기간 저장하는 저장공정으로 이루어진다. 본 연구에서는 CO2 해양지중저장 실용화를 위한 CO2 물성 특성, 수송·주입 공정설계, 선박 수송 안전성, 중간저장 개념설계 그리고 저류층 내 CO2 거동 안전성 평가를 위한 탄성파 모니터링 기술을 개발하고 있다. 본 논문에서는 이에 대한 연구내용을 정리하고 주요 결과를 소개하고자 한다. Carbon dioxide Capture and Storage(CCS) is regarded as one of the most promising options to response climate change. CCS is a three-stage process consisting of the capture of carbon dioxide, the transport of CO2 to a storage location, and the long term isolation of CO2 from the atmosphere for the purpose of carbon emission mitigation. To carry out demonstration and commercialization of CO2 marine geological storage, property analysis focused on the hydrate phase equilibrium, process design of transport and injection, safety analysis of CO2 carrier, design of offshore intermediate storage facility and seismic wave propagation modeling were studied. In this paper, major results of these studies were introduced and summarized.

제주물을 이용한 기능성 및 혼합음료의 개발방향 설정에 관한 연구

고성보(Ko, Seong-Bo),현창석(Hyun, Chang-Seok),강경원(Kang, Kyung-Won) 한국산학기술학회 2011 한국산학기술학회논문지 Vol.12 No.5

세계적으로 건강기능식품의 주변 환경은 매우 빠르게 변하고 있다. 2012년 세계기능성 음료시장은 269억달 러 규모, 아태지역 시장은 136억달러 규모가 될 것으로 전망하고 있다. 국내 먹는 샘물 시장은 2008년 4,400억원 규 모를 형성하고 있고, 제주삼다수의 매출액은 891억원이다. 그러나 “제주삼다수”라는 브랜드는 한계성을 지니고 있다. 이에 대한 방안으로 제주물의 품질 우수성을 알리는 포괄적인 광고가 필요하며, 제주 물을 이용한 기능성 음료 및 혼 합음료 개발의 성공 가능성을 높이기 위해서 제주워터(Jeju Water)라는 글로벌 통합브랜드 개발이 필요하다. 기능성 및 혼합음료 제품개발시 제주지역의 농산물의 기능성을 적극 활용해 물산업과 제주의 1차산업을 연계해 농산물의 과 잉생산 처리와 고부가가치화를 촉진시킬 필요가 있다. The environment of the health food in the world has been changed very rapidly. The world market volume of functional drinks in 2012 will be estimated at $ 26.9 billion, and Asia-Pacific market is expected to be $ 13.6 billion. The domestic market volume of bottled water in 2008 was 440 billion won, and "Jeju Samdasu" sales was 89.1 billion won. But the brand of "Jeju Samdasu" has the limits. As a solution, the comprehensive advertising of the excellence quality of Jeju water is required. To increase the likelihood of success in development of functional and mixed drinks by the water is necessary to develop a global integrated brand. In developing the functional and mixed drinks by the water, we apply the functionality of the Jeju agricultural products actively, and connect Jeju Water industry with Jeju agricultural industry, which promote the overproduction control and the high value- added agricultural products.