흰쥐중심편도체핵에서 Neurotensin 면역양성세포의 다리옆핵으로의 투사

박인식,최정화,박봉수,백선용,김봉선,김재봉,김진정 대한해부학회 1996 Anatomy & Cell Biology Vol.29 No.2

익수환아의 예후에 영향을 미치는 인자에 관한 연구

김용배,정대봉,조수형,조남수,박영봉,박상기,김춘호,양은석,문경래 大韓應急醫學會 1998 대한응급의학회지 Vol.9 No.3

Drowning is the second most common cause of accidental death of children in Korea. But the study of near-drowning is very rare in Korea. The purpose of our study is to determine the factors that may influence survival on the basis of submersion time, consciousness state upon admission to hospital, the kinds of water, laboratory findings and neurological outcomes. The survey was performed by a retrospective cohort study on 28 near-drowning victims of less than 15 years of age who were admitted to the emergency room in the Chosun University Hospital between May 1988 & May 1997. The results were as follows :1)Sex distribution was 22 males and 6 females. 2) Submersion time was <5 minutes in 9 cases, 5-9 minutes in 6 cases, 10-14 minutes in 5cases, 15-19 minutes in 3 cases, ≥20 minutes in 5cases. 3) Comatose patients upon arrival were 6/7 cases in the death group(86%) and 2/21 cases in the improved group(10%). They had unfavorable outcomes(P<0.05). 4) The first PH value was mean 7.02±0.12 in the death group and mean 7.31±0.13 in the improved group. There was a statistically significant difference between the death and the improved group(P<0.05) 5) The patients who gad increased blood glucose concentration were all 7 cases in the death group and 12/22 cases in the improved group(54%). The mean blood glucose concentration was mean 424.7235.6㎎/㎗ in the death group and mean 140.182.7㎎/㎗ in the improved group. There was a statistically significant difference between the death and the improved group(P<0.05). 6) The patients who had pulmonary edema upon arrival were all 7 cases in the death group and 1/21 cases in the improved group(46%). They had unfavorable outcomes(P<0.05). 7) The patients who had been submerged more than 15 minutes were all 7 cases in the death group and 6/21 cases in the improved group(5%). They had unfavorable outcomes(P<0.05). We conclude that pediatric victims of near-drowning can be assigned to high or low likelihoods of unfavorable our outcomes with the use of five variables ; comatose mentation upon arrival decreased initial blood pH, increased initial blood glucose concentration, pulmonary edema, and maximum submersion time estimated longer than fiften minutes. This prediction rule may be useful if it can be validated in another cohort.

Transthyretin의 Glutathione 자동산화 촉진작용

박종근,정신,김재휴,김수한,강삼석,이제혁,안봉환 대한신경외과학회 1994 Journal of Korean neurosurgical society Vol.23 No.8

When reduced glutathione(GSH) was incubated at neutral pH and at 37°, its concentration decreased slowly with formation of oxidized glutathione(GSSG). Autooxidation of GSH was accelerated by Cu^(2+) and Hg^(2+), but not by other common mono-, di-, and tri-valent cations. Transthyretin was found to stimulate autooxidation of GSH in the presence or absence of Cu^(2+) and Hg^(2+). EDTA inhibited perfectly the autooxidation of GSH regardless of the presence of transthyretin. The stimulating activity of transthyretin was maximal at pH 7.0, declining progressively with increase or decrease of pH from 7.0. Sulfhydryl-blocking agents such as p-hydroxymercuribenzoic acid and Nethylmaleimide markedly inhibited the stimulating activity of transthyretin. Transthyretin stimulated autooxidation of other sulfhydryl compounds such as clithiothreitol and cysteine. However, it did not show a significant effect on autooxidation of sulfhydryl group of egg albumin and eye lens proteins. And transthyretin did not cause any oxidative change to thyroxine(T₄), 3, 5, 3Ltri iodo thyronine(T₃) and 3, 3: 5~triiodothpnine(rT₃) bound to it in the presence of GSH and Cu^(2+). The above results suggest that transthyretin may play a role in regulation of oxidized status of sulfhydryl groups in blood plasma and cerebrospinal fluid

개의 하악에서 막성골 중첩이식후 신연골 형성에 관한 연구

박세정,이동훈,이정형,조병채,백봉수 大韓成形外科學會 1999 Archives of Plastic Surgery Vol.26 No.3

The purpose of this study was to investigate the possibility of distraction osteogenesis in membranous onlay bone graft on the mandible and to clarify the histology of bone repair during distraction osteogenesis in the membranous onlay bone in a dog model. Four dogs, 5 months of age at the beginning of the experiment, were used for this study. The zygomatic arch was exposed in the subperiosteal plane and the full-thickness zygomatic arch was harvested to 3 centimeters in length. The lateral surface of the mandibular body was exposed in the subperiosteal plane and the membranous onlay bone graft was performed with firm contact using screws. The osteotomy on the membranous onlay bone graft and underlying mandibular body was carried down week 1 in dog 1, week 2 in dog 2, week 3 in dog 3, and week 4 in dog 4 after membranous onlay bone graft. The external distraction device was applied to the mandibular body. Mandibular distraction was started 7 days after the operation at a rate of 1mm per day for a total of 10 mm distraction over 10 days. After completion of distraction, the distraction device was left in place for 6 weeks bony consolidation of the distracted area. Radiographs were carried out at 2 weeks, 4 weeks and 6 weeks after distraction. New bone between the native underlying mandibular segments was generated in the distracted zone in all dogs. The new bone between the native underlying mandibular segments was generated in the distracted zone in all dogs. The new bone between segments of membranous onlay bone graft was not generated in dog 1, but it was generated in dogs 2, 3 and 4. However, in dog 2 and 3, the new bone between segments of the distracted membranous onlay bone graft presented less firmness with fibrous tissue than that of the native underlying mandibular segment. Histologically, the distracted gap between segments of the membranous onlay bone graft was composed of much fibrous tissue in the central zone while activated osteoblastic cells formed new bone in the margins of the distracted gap in dogs 2 and 3. In dog 4, there were abundant osteoblastic activities in the distracted gap and the new bone appeared as nearly-normal cortical bone. In conclusion, these findings suggested that membranous onlay bone graft had an osteogenic capacity and that distraction osteogenesis was possible in membranous onlay bone graft.

조루증의 치료에서 Paroxetine의 효과와 부작용

박광성,이재규,윤진상,권동득,오봉렬,류수방,박양일 全南大醫大 2001 전남의대학술지 Vol.37 No.1

뉴로-퍼지 가중치 제어 신경망 구조

朴秀峰,金在珥 東新大學校 1995 論文集 Vol.7 No.-

In the learning of the neural network, Learning rate largely depends on the algorithm of network implementation, and is closely related to the weight length and computing speed. In this paper, we propose an algorithm to design digital logic systems and hardware using weighted control neural network with neuro-fuzzy architecture. The network for weight-control based on the mathmetical proposition has been proposed. The proposition use AT MOST n, AT LEAST n. The proposed algorithm has been applied to design JK flip-flop and ROM. The simulations shows that the proposed algorithm can simplify design of hardware, improve processing speed of system and implement synapse with good learning in the large neural network.

해조류 에탄올 농도별 추출물의 항돌연변이원성 및 항균성

박제석,오명철,오창경,현재석,김봉오,김수현 濟州大學校工科大學産業技術硏究所 1996 尖端技術硏究所論文集 Vol.7 No.2

톳. 미역 및 다시마의 에탄올 농도별 추출물이 MMS. ICR191 및 sodium azide에 의해 유도되는 돌연변이원성의 억제효과 및 E. coli, B. subtilis 및 S. serevisiae에 대한 항균효과를 검정하였다. 톳의 90% 에탄올 추출물은 MMS와 ICR191에 대한 항돌연변이 원성이 각각 70 및 95% 이상으로 매우 높았으나, sodium azide에 대한 항돌연변이원성은 없었다. 미역의 에탄올 농도별 추출물은 30∼90% 에탄올 추출물에서 50% 이상의 항돌연변이 효과를 보았으나 MMS와 sodium azide에 대한 항돌연변이 효과는 없었다. 다시마의 30∼90% 에탄올 추출물의 ICR191에 대한 항돌연변이 효과는 70% 이상이었으나, MMS와 sodium azide에 대한 효과는 없었다. 에탄올 농도별 톳의 추출물들에 대한 항균성 검색 결과 70과 90% 추출물들이 E. coli와 B. subtilis에 대하여 뚜렷한 항균효과는 미역 추출물 보다 다시마의 추출물이 더욱 요과적이었다. 미역 추출물은 50% 추출물만이 S. cerevisiae에 대한 성장저지효과를 나타낸 반면, 다시마 추출물은 90% 에탄올 추출물에서는 시험된 모든 공시균주에 대하여, 그리고 70% 에탄올 추출물에서는 E. coli와 B. sutilis에 대하여 높은 성장저지효과를 나타내었다. Desmutagenic against MMS-, ICR191- and sodium azide-induced mutations, and antimicrobial effects against Escherichia coli, Bacillus subtilis and Saccharomyces cerevisiae by the extracts from Hizikia fusiforme. Laminaria japonica and Undaria pinnatifida with ethanol of a different concentrations were investigated. Desmutagenic effects against MMS and ICR191 of 90% ethanol extracts from Hizikia fusiforme were up 70 and 95%. respectively. no against sodium azide. Desmutagenic effects against ICR191 of 30∼90% ethanol extracts from Undaria pinnatifida and Laminaria japonica were up to 50 and 70%. respectively. but no against sodium azide and MMS. Antimicrobial effect of 70 and 90% ethanol extracts from Hizikia fusiforme had potent antimicrobial activities against E. coli and B. subtilis. Ethanol extracts from Laminaria japonica showed more effective antimicrobial effects than those from Undaria pinnatifida. Only 50% ethanol extract from Undaria pinnatifida showed growth inhibition effect against S. cerevisiae. Seventy percent ethanol extract from Laminaria japonica showed growth inhibition effect against all strains tested. while 90% ethanol extract showed against E. coli and B. subtilis.

에지특징에 근거한 이미지영역 분리와 DCT를 이용한 얼굴 인식

박수봉,이인범 東新大學校 1998 論文集 Vol.10 No.-

In this paper, we propose a face recognition algorithm which extract characteristics of image using edge and DCT(Discrete Cosine Transform). In this algorithm, training vectors of neural networks is the extracted data. With the same luminesce and distance, the fixed CCD camera, human face was captured. Edge characteristics of face images is concentrated in eye bows and mouth. Therefore, using edge characteristics of face images, it was segmented with square region. we determined this area to the characteristics region of face images, and contains eye bows, eyes, nose and mouth. Also, after executing DCT for this square region, we extracted feature vector. This feature vector was normalized and set the input vector of neural networks. Simulation results show 100% recognition for 30 face images when face images were learned and 94% recognition rate when face images weren't learned. Also, in case of DCT processing, the proposed algorithm reduced 55% operation time than to process all face images.

Xanthomonas sp. EPS-1의 Exopolysaccharide생산을 위한 무기염류의 영향

박석규,손봉수,이상원,서권일,김홍출 순천대학교 기초과학연구소 1995 基礎科學硏究誌 Vol.6 No.-

For the production of high viscosity exopolysaccharide from Xanthomonas sp. EPS-1 which isolated and identified from soils, optimum concentration of inorganic salts were investigated : 0.2% KH_2PO_4, 0.05% MgSO_4·7H_2O, 0.3% NaCl, 0.005% CaCO_3, 0.007% FeSO_4·7H_2O, 0.005% MnSO_4·7H_2O. When EPS-1 strain was cultivated at 30℃ for 72 hours in a jar fermentor (impeller speed 300 rpm, aeration rate 3 vvm, 2 liter), polymer content, product rate and yield(Y_p/s) was 18.4g/ℓ, 0.26g/ℓ/h and 37%, respectively.

실온에서 Al-SiO_2-Si(100)_p형 계의 경계면 반응

박동수,손기수,이원식,박봉두 慶北大學校 物理化學硏究所 1985 硏究論文集 Vol.6 No.-

실온에서 알루미늄 산화층(SiO_2)-반도체〔Si(100)_p형〕 소자의 경계면 반응을 Ar^+이온 sputter총을 부착한 AES로 수행했다. SiO_2-Si 경계면은 Si-Si 결합, Si-O 결합의 두 가지 상태를 갖고 있으며, 경계면 넓이는 약 30Å였다. Al-SiO_2-Si 반도체 소자의 경계면 반응은 SiO_2 속의 자유 실리콘이 알루미늄 표면으로 확산되고, 알루미늄과 SiO_2 경계면에 대량의 자유 실리콘이 존재한다. Al-interfacial layer(SiO_2)-semiconductor Si(100)_p-type structures were investigated by the Auger Electron Spectroscopy. The results of depth profiling Ar^+ -ion sputtering are presented for the SiO_2-Si(100)_p-type cell. In the interface, Silicon exists in only two distinct bonding states: Si-Si or Si-O bonding. The exact width of the interface is known as indefinite, but here we estimate it approximately 30Å. The results of depth profiling Ar^+ -ion sputtering are also presented for the Al-SiO_2-Si(100)_p-type cell. Metal(Si) atoms from deposited interfacial oxide layer were observed on the Al surface. The interfacial reaction takes place between Al and the interfacial layer at the room temperature. The diffusion of metal(Si) atoms from the interfacial layer towards the Al surface is suspected to play a role in degradation effect in the MIS solar cells.