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혈액투석에 의해 치유된 중증의 Chlorophenoxy계 제초제 중독환자 1례
조수형,조남수,김성국 대한응급의학회 2002 대한응급의학회지 Vol.13 No.4
Chlorophenoxy herbicide poisoning is uncommon, but may produce severe sequelae. It's treatment is primarily the same as that used for poisonings with other drugs; gastric lavage, activated charcoal, etc. However, it's secondary treatment to enhance elimination has two options, alkaline diuresis or hemodialysis. We experienced a patient who had been poisoned with chlorophenoxy herbicide and had severe symptoms like comatose mentation, acute renal failure, rhadomyolysis, etc. The patient was treated by hemodialysis for 5 days and recovered from the acute state.
Current Challenges in Bacterial Transcriptomics
조수형,조유복,이수인,김자영,염혜지,김선창,조병관 한국유전체학회 2013 Genomics & informatics Vol.11 No.2
Over the past decade or so, dramatic developments in our ability to experimentally determine the content and function of genomes have taken place. In particular, next-generation sequencing technologies are now inspiring a new understanding of bacterial transcriptomes on a global scale. In bacterial cells, whole-transcriptome studies have not received attention, owing to the general view that bacterial genomes are simple. However, several recent RNA sequencing results are revealing unexpected levels of complexity in bacterial transcriptomes, indicating that the transcribed regions of genomes are much larger and complex than previously anticipated. In particular, these data show a wide array of small RNAs, antisense RNAs,and alternative transcripts. Here, we review how current transcriptomics are now revolutionizing our understanding of the complexity and regulation of bacterial transcriptomes.
급성 심근 경색의 진단에 있어서 cTn-T 추적 검사의 유용성
조수형,조남수 朝鮮大學校 附設 醫學硏究所 2009 The Medical Journal of Chosun University Vol.33 No.S
Purpose: Cardiac troponin T (cTn-T) is considered a specific marker for the diagnosis of myocardiac infarction(MI) but recent studies have shown cTn-T elevation in a various condition. Our purpose was to define diagnostic importance of cTn-T in acute myocardiac infarction. Methods: cTn-T was measured from stored plasma samples in 482 subjects. Patients were grouped according to the diagnosis of MI. Group Ⅰ (n=380) had no the diagnosis of MI, Group Ⅱ (n=102) had the diagnosis of MI. All group were measured cTn-T at visiting emergency department (ED), and follow up was done after 3 hours. The gaps of cTn-T for 3 hours were compared between the two group. Results: During the study period, 482 patients had elevated cardiac troponin-T levels. 102 patients(21%) had a diagnosis of AMI, but 380 patients (79%) had non-thrombotic troponin elevation. The follow up gap of acute MI group was significant elevation (mean value: 0.392), whereas other group was no significant elevation(mean value: 0.055) in our study (p<0.001). The known risk factor of MI had significant importance in our study (p<0.05). The positive predictive value for the diagnosis of AMI was 37% (95% CI, 29-45). The PPV of follow gap of cardiac troponin-T level higher than 0.4 ng/ml in the normal creatinine level was 97% but was as low as 25% for level of below 0.05 ng/ml for elderly patients with elevated creatinine level. Conclusion: The diagnosis of AMI should be based on the clinical presentation, but elevated troponin-T is a common finding and correlated with wrong diagnosis. The diagnostic importance of cardiac troponin-T was established when the follow up gap had a significant elevation and normal renal function.
조수형,조남수,김춘호,장정환 대한응급의학회 2001 대한응급의학회지 Vol.12 No.1
Background: It is well known that the final treatment for human organ failure is transplantation. However, in reality, the number of donors of organs is insufficient compared to the number of patients waiting for transplantation. Identification of potential organ and tissue donors is important to transplantation. The status of patients having a possibility for transplantation among the patients who visited the emergency room was reviewed, and the status of donations of organs after determination of brain death in the emergency room was reviewed. The present study was performed in order to seek methods of increasing the rate of procurement of organs. Methods: The records of patients who visited the emergency medical center of the present hospital from January 1, 1998, to December 31, 1999, were retrospectively analyzed. The patients were classified into three groups by interviewing the doctors in charge. Group I were those who were determined to be dead upon arrival at the hospital, Group II were those who left the hospital because of death or who were hospitalized in an irrecoverable state, and Group III were those who were determined to have died during the treatment in the emergency room. Results: The results of this study showed that the number of potential donors of organs among the total 33,783 patients who visited the emergency room during this time was 299 patients, including 91 patients in Group 1, 89 patients in Group 2, and 119 patients in Group 3. Among them, 137 patients were excluded as their ages were not proper, and 62 patients were excluded due to medically unsuitable diseases. The remaining 100 patients were understood to be potential organ-donating patients. Among them, 98 cases were lost as approach to transplantation was not accomplished, and only 2 cases were successful transplantations in the emergency room. The reasons for the deaths of the potential organ donors included 49 cases of trauma, 15 cases of cardiac disease, 8 cases of respiratory disease, 7 cases of cerebral vascular disease, and 11 other cases. Conclusion: Most patients that could be determined to be brain dead were lost without recognition of the possibility of transplantation, Although many potential organ-donating patients were seen, the actual rate of procurement of organs was very low. These results imply that it is necessary to have transplantation programs in emergency rooms in order to find patients with possible brain death and to raise the awareness and training of people engaged in medicine and of people in general. Increasing the rate of organ procurement requires that criteria for non-heart-beating donation be established and then applied in the emergency room, bearing in mind the possibility of transplantation from the time of initial treatment as serious patients. The criteria for predicting potential brain death should be prepared for prior to the determination of brain death, as presented by KONOS(Korean Network for Organ Sharing).