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        Whole-Body Muscle MRI in Patients with Hyperkalemic Periodic Paralysis Carrying the SCN4A Mutation T704M: Evidence for Chronic Progressive Myopathy with Selective Muscle Involvement

        이영,형수,효은,한석,남태승,신하영,최영철,김승민 대한신경과학회 2015 Journal of Clinical Neurology Vol.11 No.4

        Background and Purpose Hyperkalemic periodic paralysis (hyperKPP) is a muscle sodium-ion channelopathy characterized by recurrent paralytic attacks. A proportion of afected individuals develop fxed or chronic progressive weakness that results in signifcant disability. However, little is known about the pathology of hyperKPP-induced fxed weakness, including the pattern of muscle involvement. Te aim of this study was to characterize the patterns of muscle involvement in hyperKPP by whole-body magnetic resonance imaging (MRI). Methods We performed whole-body muscle MRI in seven hyperKPP patients carrying the T704M mutation in the SCN4A skeletal sodium-channel gene. Muscle fat infltration, suggestive of chronic progressive myopathy, was analyzed qualitatively using a grading system and was quantifed by the two-point Dixon technique. Results Whole-body muscle MRI analysis revealed muscle atrophy and fatty infltration in hyperKPP patients, especially in older individuals. Muscle involvement followed a selective pattern, primarily affecting the posterior compartment of the lower leg and anterior thigh muscles. The muscle fat fraction increased with patient age in the anterior thigh (r=0.669, p=0.009), in the deep posterior compartment of the lower leg (r=0.617, p=0.019), and in the superfcial posterior compartment of the lower leg (r=0.777, p=0.001). Conclusions Our whole-body muscle MRI fndings provide evidence for chronic progressive myopathy in hyperKPP patients. Te reported data suggest that a selective pattern of muscle involvement—afecting the posterior compartment of the lower leg and the anterior thigh—is characteristic of chronic progressive myopathy in hyperKPP.

      • KCI등재

        인문치료 패러다임

        이영 범한철학회 2010 汎韓哲學 Vol.56 No.1

        Humanities therapy is an interdisciplinary study which has the aim of preventing and curing the problems related to mind, i.e., the disease of mind, in order to secure mental health and well-being. Because humanities therapy is a new-born discipline, it has to fulfill many academic components, especially the identity, and method. The purpose of the paper is to suggest an outline of humanities therapy paradigm. To do so, I shall discuss a way of securing the identity of humanities therapy and then of finding its basic components and methods. The identity of humanities therapy is discussed in comparison with those fields such as medical therapy, psychological therapy, and religious therapy which are related closely to humanities therapy. After discussing the identity problem, I shall suggest an outline of basic components of humanities therapy by using the Kuhn's notion of paradigm. 인문치료학은 마음과 관련된 문제들을 예방하고 치유하여 정신적 건강과 행복을 확보하기 위해 인문학 및 관련 분야들이 공동으로 참여하여 이론과 방법을 개발하는 분야이다. 신생 연구 분야로서 인문치료학이 학으로서의 뿌리를 내리기 위해서는 학문적 요소들을 구비해야 하는데 그 중에서도 특히 인문치료의 정체성, 목적, 방법 등이 규명되어야 한다. 이 글의 목적은 인문치료 패러다임의 윤곽을 제시함으로써 그러한 요청에 대답하는 데 있다. 우선 이 글은 인문치료의 정체성을 확보하는 방식을 검토하고 이어서 인문치료를 구성하는 기본 요소와 방법을 검토할 것이다. 인문치료의 정체성은 의학치료, 심리치료, 종교치료와 같은 인문치료와 밀접한 관계에 있는 분야들과의 비교를 통하여 분석된다. 인문치료의 정체성을 확보하는 방식을 논의한 이후에 과학 방법론에서 제시된 쿤의 패러다임 개념을 이용하여 인문치료 방법을 구성하는 요소와 방법을 구체적으로 검토할 것이다.

      • KCI등재후보

        심장에 발생한 악성 섬유성 조직구종 1 예

        이영,송규상,남재만,전은석,김선영,복희,성인환,경주 대한내과학회 1988 대한내과학회지 Vol.35 No.5

        A case of a 58-year-old man with malignant fibrous histiocytoma (NFH) of the right ventricle is presented and the 9 previous reports of this rare cardiac tumor are reviewed. The chest PA showed cardiomegaly and small nodular densities in the right lower lung field. There were multiple perfusion defects in the right lung an perfusion lung scan. On echocardiogram, dilated right atrium and ventricle, mass on RVOT, tricuspid regurgitation and moderate pericardial effusion were noted. No lesions were noted in the liver, kidney, spleen, or pancreas on ultrasound. The microscopic view of the tumor showed a storiform pattern of fibroblasts, histiocytes, multinuclear giant cells and inflammatory cells. The patient died during open heart surgery for tumor resection.

      • KCI등재
      • KCI등재

        한국어 ‘또’와 중국어 ‘又’의 대조 연구

        이영 부산대학교 인문학연구소 2017 코기토 Vol.- No.83

        In this article, the Korean character ‘또’ with multi-layer characteristics is compared with Chinese character ‘又’ in the vocabulary meaning, modal meaning, grammatical meaning. And we have learned that : In terms of vocabulary meaning, Korean‘또’ has additional and concession meaning of “not only, but also”, which ‘又’ does not have. On the contrary, the continuous meaning and antagonistic meaning of Chinese ‘又’ as an independent semantic field are actively used. In terms of modal meaning, when Korean ‘또’ is expressed in the format of ‘난+또’, it states speaker’s “surprising” or “be at ease” while information is heard from the listener. However, when Chinese ‘又’ is used in a negative sentence or rhetorical question, it states the propositional premise and emphasizes the chosen result is clear from the propositional premise or the accuracy of the behavior or opinion. In terms of grammatical meaning, Chinese ‘又’ is used more frequently than Korean ‘또’ in habitual sentences. Same quantifiers can be connected before and after ‘又’, that states the quantity and number of times. Common usages, ‘又……又……’, ‘既(是)……又 (是)……’ can state two attributes in one matter or two behaviors exist at the same time. 본고에서는 다층적 성격을 지닌 한국어의 ‘또’와 그에 대응하는 중국어의 ‘又’를 어휘적 의미, 양태적 의미, 통사적 측면에서 대조적으로 분석하였다. 어휘적 의미에서 ‘또’의 부가의 의미에 속하는 ‘그 밖에 더’의 의미와, 양보의 의미가 ‘又’에는 없다. 반면, ‘又’의 연속의 의미와 대립의 의미는 하나의 독립적인 의미 영역으로 활발히 사용되고 있다. 양태적 의미에서 ‘또’는 ‘난+또∼’의 형식으로 화자가 상대방으로부터 수정받은 정보에 놀람과 안도의 마음을 나타낸다. 중국어의 부정문, 반어문에서 화자는 ‘又’를 사용하여 명제의 전제를 끌어내며, 그 전제와 상관없이 화자가 선택한 결과나, 혹은 화자가 취할 행위나 주장의 정확성을강조하고 있다. 통사적 측면에서 중국어의 ‘又’는 한국어의 ‘또’에 비하여 관용적인 쓰임이 훨씬 많다. ‘又’는 앞뒤에 동일한 수량어를 자유롭게 공기하면서 그수량이나 횟수가 많음을 나타낸다. 또한 ‘又……又……’, ‘既(是)……又 (是)……’의 관용적인 쓰임으로 사물의 두 가지 속성이나 어떤 행위나 상태가 동시에 존재함을 나타낸다.

      • KCI등재
      • KCI등재

        일본의 조선사 연구의 권위 나카무라 히데다카(中村榮孝)의 왜구 서술의 논리적 전개와 문제점 -『일본과 조선(日本と朝鮮)』을 중심으로-

        이영 역사교육학회 2015 역사교육논집 Vol.55 No.-

        Nakamura Hidetaka, an editorial officer of the Japanese Government-General of Korea, is also one of the best authorities on the Korean history of Japan after World War Ⅱ. And he has been estimated as a trailblazer in the field of research on the history of international relations of East Asia. In this article, I studied the characteristics and problems of the description of Korean history and Japanese pirates. As a result of this examination, it was verified that his view of history was reflected in his description. That was so-called ‘Kogoku shikan(皇國史觀)’ the thought that the Japanese emperor will and has to rule the whole world in the future, therefore Japan can justify their invasion policy and rationalize their colonial government (in the years 1910-45) on Korea. For example, He emphasized repeatedly the lethargic, incompetence and toadyism of the ruling class of the Koryo(高麗) dynasty in his description. Such a attitude in description can be also verified concerning Japanese pirates of the late Koryo dynasty. He falsified the fact of Japanese pirates as the problem of the conflict and confrontation between the ruling class of Koryo and its governance class. Contrary to this, he did not consider the domestic situation of Japan at that time including the internal war between the South and North court (in the years 1336-92). He had described the Japanese pirates by excluding ‘Japan’ completely. It was this period that the family of the Japanese emperor was divided into two courts and fought each other, Samurai as vassals, violated and attacked the emperor and his family, and the fact of Japanese pirates in the late Koryo dynasty were the troops of the South court which has been evaluated as the legitimate government since the Meiji(明治) Modernization of Japan. Nakamura, an enthusiastic adherent of ‘Kogoku shikan(皇國史觀)’, struggled to conceal the embarrassing part of the Emperor’s history and in the pursuit of this purpose he had falsified the history of Korea and consequently Japan’s history too.

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