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      • KCI등재후보

        발효기법을 이용한 SD rat의 갱년기 비만 치료효과에 관한 연구

        이정운,이영철,김동현,나혜숙,마진열 한국임상약학회 2005 한국임상약학회지 Vol.15 No.2

        In our study, osteoporosis was induced by ovariectomized in female Sprague-Daweley (SD) rats, and the prevention and treatment efficacy of the climacteric disease the ostmenopausal type I pattern was examined by using the experimental substance soybeans and arowroot. No clinical signs and mortality after continuous oral administration of experimental substances for 14 weeks were not observed, however, the weight of experimental animals underwent ovariectomized was increased significantly in comparison with control group (p<0.01). The atrophy of the uterus due to T3 group was 23.64% after 7 weeks, 24.44% after 14 weeks (in comparison with N.C. group), and it was statistically significantly increased. In regard to the change of blood cells, it was observed that platelets were statistically significantly reduced in the ovariectomized group, and administered orally experimental substances continuously for 7 weeks, in all groups administered experimental substances, it was found that platelets had the tendency to be increased more than N. C. group. In regard to He change of blood biochemistry, removed the ovary, the concentration of ALP showed the tendency to be increased than control group, and particularly in T3 group, it was increased significantly. In regard to the concentration of cholesterol, in comparison with negative control group, it was reduced 68% at 7 weeks and 35% at 14 weeks. After ovariectomized, the amount of estrogen was found to be reduced by 21.37% in comparison with control group, it showed the tendency to be increased by 4.49% in T1 group and 7.62% in T2 group, the concentration of estrogen in each group showed the tendency to be increased than negative control group, and in T3 group, it was increased to 100.46% and 117.65% in T4 group, and it was increased more than control group. Based on the above experimental results, in the experimental animals female rats, because of the hormonal imbalance induced by ovariectomized, a large mount of fat is accumulated in the body and due to it osteoporosis, obesity, hypertension, hyperlipidemia, fat of the liver, arteriosclerosis, diabetes, and other metabolic diseases were developed. Hence, when the experimental substance Extraction of ferment arrowroot was orally administered continuously for 14 weeks, it was thought that a certain proportion of the hormonal balance was maintained that functioned as a substance interfering the accumulation of fat, and it was considered to be of help in the treatment of not only osteoporosis Type I, but also for the prevention and treatment of various endocrinal diseases.

      • KCI등재

        한국 소아와 청소년의 대사증후군 유병률과 경향성: 2001, 2005년 국민건강영양조사 자료분석

        이정운,이경희 대한임상건강증진학회 2009 Korean Journal of Health Promotion Vol.9 No.1

        Background Metabolic syndrome is a cluster of conditions including abdominal obesity, high blood pressure, elevated fasting glucose, high triglyceride, and low HDL-cholesterol. Up to now, there have only been a few studies about this disorder. Our aim was to show the prevalence and trends of metabolic syndrome in Korean children aged 10 to 18yrs using the Korean National Health and Nutrition Examination Surveys (KNHNES) administered in 2001 and 2005. Methods The data for analysis were obtained from KNHNES 2001 and 2005. We analyzed 667 boys and 621 girls from KNHNES 2001 and 479 boys and 420 girls from HNHNES 2005. Results The prevalence of metabolic syndrome in Korean children was 10.3% (boys 13.1%, girls 7.2%) in 2001 and 9.5% (boys 11.5%, girls 7.3%) in 2005. There was no significant increase in metabolic syndrome between 2001 and 2005. The numbers of children with high triglyceride and low HDL-cholesterol were especially higher than the other risk factors of metabolic syndrome in both 2001 and 2005. The prevalence of metabolic syndrome increased significantly with the increase in body mass index (OR = 1.42 in 2001, OR = 1.58 in 2005, P < 0.001), and leukocytes (OR = 1.33, P = 0.001) Conclusions The prevalence of metabolic syndrome in Korean children was 10.3% in 2001 and 9.5% in 2005. With the rise in the prevalence of metabolic syndrome, especially in obese children, the prevention and management of metabolic syndrome risk factors in young children will be a critical focus of public health and clinical practice. 연구배경 대사증후군은 복부비만, 고혈압, 혈당상승, 중성지방 상승, HDL 콜레스테롤의 저하가 동반되는 질환으로, 인슐린저항성을 특징으로 하는 심혈관질환 위험인자이다. 하지만 한국의 소아, 청소년을 대상으로 한 대사증후군 연구는 부족한 실정이다. 따라서 본 연구는 최근 표준화된 한국 소아 성장도표와 정상 혈압 참고치를 기준으로, 2001년과 2005년 국민건강영양조사를 분석하여 한국인 소아 청소년의 대사증후군 유병률과 그 경향성을 알아보고자 한다. 방 법 2001년과 2005년 국민건강영양조사에 참가한 10 ~ 18세의 소아를 대상으로 하였고, 2001년 조사에서 남자 667명, 여자 621명, 2005년 조사에서 남자 479명, 여자 420명의 설문조사, 검진자료를 분석하였다. 결 과 전체 대사증후군의 유병률은 2001년 자료에서는 10.3%(남자 13.1%, 여자 7.2%)였고, 2005년 자료에서는 9.5%(남자 11.5%, 여자 7.3%)였으며, 2001년과 2005년의 차이는 없었다. 대사증후군 항목 중에는 중성지방 상승, HDL 콜레스테롤 저하가 다른 항목에 비해 높은 유병률이 관찰되었고, 체질량지수가 증가함에 따라(OR = 1.58, P < 0.001), 백혈구수가 증가함에 따라(OR = 1.33, P = 0.001), 다른 요인들을 보정한 후에도 대사증후군의 유병률이 증가하였다. 결 론 한국 소아 청소년의 대사증후군 유병률은 2001년에는 10.3%, 2005년에는 9.5%로 조사되었다. 한국에서 소아의 대사증후군은 점점 증가하고 있으며 특히 비만아에서 대사증후군은 중요한 건강문제로 제기되고 있다. 따라서 소아기부터 대사증후군을 적극적으로 예방하고 치료하는 노력이 필요할 것으로 생각된다.

      • KCI등재

        5 kW급 고분자 전해질 연료전지 스택의 운전 특성

        이정운,박달영,김재동 한국가스학회 2007 한국가스학회지 Vol.11 No.1

        78-cell proton exchange membrane fuel cell(PEMFC) stack with an effective electrode area of 295 cm2 were investigated its operational characteristics and effects of CO poisoning. When power output, 5.4 kW, was released at current density of 325 mA/cm2 for 6 hours, stablility of each cell was showed the small deviation of 2.3%. Carbon monoxide is a conventional contaminant in the fuel obtained from reforming processes with an important influence on the performance of the PEMFC. The studies of continuous injection of CO presented (5-20 ppm) with the time gave information about poisoning and recovery processes of the stack. 78개 셀의 전극유효 면적이 295 cm2인 고분자 전해질 연료전지(PEMFC) 스택의 운전특성과 CO 피독 에 대한 영향을 조사하였다. 전류밀도 325 mA/cm2에서 출력 5.4 kW를 6시간 유지시키는 동안 셀들의 전 압편차는 2.3%로 매우 안정함을 보였다. 개질과정의 부산물로 생성되는 CO는 PEMFC의 성능에 중요한 영향을 끼치는 스택의 주 오염물질중의 하나이다. 시간에 따른 연속적인 CO 피독 실험(5-20 ppm)은 스택 의 피독과 재생과정의 route를 알 수 있었다.

      • KCI등재

        장기운전에 따른 5kW급 고분자 전해질 연료전지 스택의 특성

        이정운,박달영,김재동 한국가스학회 2007 한국가스학회지 Vol.11 No.3

        The performance of PEMFC stack can be improved significantly by optimizing the design and operating conditions. As a result, the performance of daily operation showed slight deviation (0.02- 0.9%) after accumulated DSS operation for 500 hrs but the stack performance was stable. Therefore, it is confirmed that it would be improved the life-time of stack and operation reliability for the commercialization of PEMFC system. 스택의 디자인과 운전조건을 최적화하여 PEMFC stack의 성능을 상당히 증진시킬수 있다. 그러한 결과 로, 500시간의 DSS(Daily Start-up & Shutdown) 누적 운전후에 일별 운전성능은 조금의 편차가 있었지만 (0.02-0.9%), 스택의 성능은 거의 변화가 없음을 알 수 있었다. 따라서 PEMFC 시스템의 상용화를 위해서 는 스택의 수명 및 운전의 신뢰성을 향상시켜야 한다.

      • KCI등재

        국내 원자력발전소 인적오류사례의 추이 분석

        이정운,이용희,박근옥 대한인간공학회 1996 大韓人間工學會誌 Vol.15 No.1

        A total of 77 unanticipated trip cases induced by human errors in Korean nuclear power plants were collected from the nuclear power plant trip event reports and analyzed to investigate the areas of high priority for human error reduction. Prior to this analysis, a classification system was made on the four task-related categories including plant systems, work situations, task types, and error types. The erroneous actions affecting the unanticipated plant trips were indentified by reviewing carefully the description of trip events. Then, the events with erroneous action were analyzed by using the classification system. Based on the results for the individual cases, human error occurrences were counted for each of the four categories, also for the selected pairs of categories, to find out the relationships between the two categories in aspects of human errors. As a result, the plant systems, work situations, and task types, and error types which are dominant in human error occurrences were identified.

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