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알코올이 흰쥐의 신장 부분 절제-염 고혈압에 미치는영향
이원정 慶北大學校 1980 論文集 Vol.29 No.-
A relationship between arterial pressure and body fluid in the pathogenesis of partial nephrectomy (PN)-salt hypertension was examined in the rat. Hypertension was produced by removing 70% of total renal tissue and substituting 1% saline for drinking water 6 days after surgery. PN alone increased systolic blood pressure from 116±5 to 137±7 mmHg (p<0.01). The subsequent salt loading resulted in a further large increase on arterial pressure (162±7mmHg). The elevated pressure decreased to normal levels one day after intubation of 10 or 20% ethanol (1.5ml/100g BW) 3 times a day. When those rats were allowed to drink 1% saline again the arterial pressure increased to 169±6mmHg. One day following water intubation (1.5ml/100g BW) into those hypertensive rats, blood pressure did not change(160±10mmHg), but decreased to a normal level (129±5mmHg) two days after the water intubation. The subsequent salt loading led to a rapid elevation of blood pressure again (153±4mmHg). Blood pressure of sham-operated rat did not change whether they were given saline, water or ethanol. These results suggest that, in this type of hypertension, ethanol reduced blood pressure probably through the diuretic response and thus reducing the body fluid volume.
이원정,신민경,차승빈,유한상 대한수의학회 2013 JOURNAL OF VETERINARY SCIENCE Vol.14 No.4
Swine hepatitis E virus (HEV) is widespread throughout pigs in both developing and industrialized countries. This virus is an important zoonotic agent and a public concern worldwide. Infected pigs are asymptomatic, so diagnosing swine HEV relies on detection of the virus or antibodies against the virus. However, several obstacles need to be overcome for effective and practical serological diagnosis. In this study, we developed an enzyme-linked immunosorbent assay (ELISA) that used a purified recombinant capsid protein of swine HEV. The potential clinical use of this assay was evaluated by comparing it with a commercial kit (Genelabs Technologies, Diagnostics, Singapore). Results of the ELISA were highly correlated with those of the commercial kit with a sensitivity of 97% and specificity of 95%. ROC (receiving operator characteristic) analysis of the ELISA data produced a value of 0.987 (95% CI, 0.977∼0.998, p < 0.01). The cut-off value for the ELISA was also determined using negative pig sera. In summary, the HEV-specific ELISA developed in the present study appears to be both practical and economical.
Development of Standard Digital Images for Pneumoconiosis
이원정,최병순,김성진,박충기,박재성,태석,Kurt Georg Hering 대한의학회 2011 Journal of Korean medical science Vol.26 No.11
We developed the standard digital images (SDIs) to be used in the classification and recognition of pneumoconiosis. From July 3, 2006 through August 31, 2007, 531 retired male workers exposed to inorganic dust were examined by digital (DR) and analog radiography (AR) on the same day, after being approved by our institutional review board and obtaining informed consent from all participants. All images were twice classified according to the International Labour Office (ILO) 2000 guidelines with reference to ILO standard analog radiographs (SARs) by four chest radiologists. After consensus reading on 349 digital images matched with the first selected analog images, 120 digital images were selected as the SDIs that considered the distribution of pneumoconiosis findings. Images with profusion category 0/1, 1, 2, and 3 were 12, 50, 40, and 15, respectively, and a large opacity were in 43 images (A = 20, B = 22, C = 1). Among pleural abnormality,costophrenic angle obliteration, pleural plaque and thickening were in 11 (9.2%), 31(25.8%), and 9 (7.5%) images, respectively. Twenty-one of 29 symbols were present except cp, ef, ho, id, me, pa, ra, and rp. A set of 120 SDIs had more various pneumoconiosis findings than ILO SARs that were developed from adequate methods. It can be used as digital reference images for the recognition and classification of pneumoconiosis.
이원정,신재훈,So Young Park 대한결핵및호흡기학회 2013 Tuberculosis and Respiratory Diseases Vol.74 No.2
Background: The purpose of this study was to evaluate the relationship of pulmonary function impairment (PFI) and coronary artery calcification (CAC) by multi-detector computed tomography (MDCT), and the effect of pneumoconiosis on CAC or PFI. Methods: Seventy-six subjects exposed to inorganic dusts underwent coronary artery calcium scoring by MDCT, spirometry, laboratory tests, and a standardized questionnaire. CAC was quantified using a commercial software (Rapidia ver. 2.8), and all the subjects were divided into two categories according to total calcium scores (TCSs), either the non-calcified (<1) or the calcified (≥1) group. Obstructive pulmonary function impairment (OPFI) was defined as forced expiratory volume in one second/forced vital capacity (FEV1/FVC, %)<70, and as FEV1/FVC (%)≥70 and FVC<80 for restrictive pulmonary function impairment (RPFI) by spirometry. All subjects were classified as either the case (profusion≥1/0) or the control (profusion≤0/1) group by pneumoconiosis findings on simple digital radiograph. Results: Of the 76 subjects, 35 subjects (46.1%) had a CAC. Age and hypertension were different significantly between the non-calcified and the calcified group (p<0.05). Subjects with pneumoconiosis were more frequent in the calcified group than those in the non-calcified group (p=0.099). FEV1/FVC (%) was significantly correlated with TCSs (r=−0.316, p=0.005). Subjects with OPFI tended to increase significantly with increasing of TCS (4.82, p=0.028), but not significantly in RPFI (2.18, p=0.140). Subjects with OPFI were significantly increased in the case group compared to those in the control group. Conclusion: CAC is significantly correlated with OPFI, and CAC and OPFI may be affected by pneumoconiosis findings.
A Comparative Analysis on the Identification of the Bill of Lading Carrier
이원정 한국무역학회 2006 Journal of Korea trade Vol.10 No.2
Where the carrying vessel is under a time charter, the identification of the bill of lading carrier is one of the controversial issues in the law regulating carriage of goods by sea. Cargo claimants are often not sure whom they should sue - the shipowner or the time charterer, or indeed both. This article attempts to examine some national courts' attitudes toward the identification of the bill of lading carrier and to offer advice on how to deal with it. The comparative analysis of some national decisions shows that, in the absence of uniformity of international maritime law, the courts handling the identity of carrier problem often adopt different approaches. This article suggests that the identity of carrier problem must be approached from a commercial standpoint which takes account of the bill of lading holder's perception, placing more importance on the carrier's name on the heading of the bill of lading. Further, this article calls for an approach which will lead to joint liability of the shipowner and the time charterer when the bill of lading does not contain a clear statement as to the identity of the carrier on its face and or if the carrier is insolvent.